Search Results

4.The Atherogenic Index of Plasma is Associated With Cerebral Small Vessel Disease: A Cross-Sectional Study

Ki-Woong NAM ; Hyung-Min KWON ; Jin-Ho PARK ; Hyuktae KWON

Journal of Lipid and Atherosclerosis 2022;11(3):262-271

Objective: Recently, the lipid profile of atherogenic dyslipidemia has become important in cerebrovascular diseases. Atherogenic index of plasma (AIP), an index that reflects this lipid profile as a single number, has been proposed, but there are still few related studies in cerebrovascular disease. In this study, we evaluated the relationship between AIP and cerebral small vessel disease (cSVD) in health check-up participants. Methods: We assessed consecutive health check-ups participants between 2006 and 2013. cSVD was measured including the following three subtypes: white matter hyperintensity (WMH), lacuens, and cerebral microbleeds (CMBs). WMH quantitatively measured the volume, and lacunes and CMBs qualitatively evaluated the presence. AIP was calculated according to the following formula based on blood test results: AIP=log [triglyceride (mg/ dL)/high-density lipoprotein cholesterol (mg/dL)]. Results: A total of 3,170 participants were evaluated (mean age: 56.5 years, male sex: 53.8%). In multivariable linear regression analysis, AIP (β=0.129, 95% confidence interval [CI]=0.003–0.255) was associated with WMH. Age, hypertension, diabetes, lipid-lowering agents, and intracranial atherosclerosis were also associated with WMH volume. In multivariable logistic regression analysis, AIP (adjusted odds ratio=1.72 1.79, 95% CI=1.03– 2.90) showed close association with lacunes. Age and intracranial atherosclerosis were also related to lacunes. CMBs did not show a statistically significant association with AIP. Conclusion High AIP was associated with cSVD in health check-up participants. Since this close relationship was only seen in WMH and lacunes, these subtypes may have arisen from a more atherosclerosis-related pathology.

1.The clinico-pathological study of the torsions of the uterine adnexa .

2.Four cases of edward syndrome with abnomal prenatal ultrasonographic findings.

3.A case of body stalk anomaly antenatally detected by ultrasonogram.

4.The Atherogenic Index of Plasma is Associated With Cerebral Small Vessel Disease: A Cross-Sectional Study

5.A case of prenatal diagnosed ectopia cordis by ultrasonography.

6.The clinical epidemioiogic study of congenital anomalies in the newborn infants.

7.The usefulness of tumor markers SCCA and CEA in squamous cell carcinoma of the uterine cervix.

8.Case report: simultaneous squamous cell carcinoma of uterine cervix and renal cell carcinoma of kidney.

9.A case of intrauterine fetal death caused by the torsions and stricture of the cord.

10.The clinical epidemiologic study of congenital anomalies in the newborn infants.

Display Mode

Output Records

File Type