Central retinal vein occlusion(CRVO) is a common retinal vascular disorder with potentially blinding complications. Author evaluated the 21 cases of central vein occlusion in aspects of age, laterality, change of visual acuity, axial length, associated diseases and complications. The results were as follows; 1. The patients were comprised of 8 males and 13 females and the average age was 49.2 +/- 12.5 years. 2. The left eye was affected more than the right eye. 3. The initial visual acuity was below 0.1 in 76.2%. 4. The mean axial length of the aftected eyes(23.03 +/- 0.69mm) was shorter than that of their control group(23.53 +/- 0.69mm) (P=0.01). 5. The most common associated disease was hypertension (33.3%) and the next was diabetes mellitus (9.5%) and arteriosclerosis (9.5%). 6. The most common complication was cystoid macular edema (42.9%). Retinal and disc neovascularization was occmed in 19.4%.
Female ; Male ; Humans

In order to evaluate the effect of topical dapiprazole, an alpha-adrenergic receptor blocker, in reversing mydrisis by 1% tropicamide and 2.5% phenylephrine, we studied 89 subjects. 0.5% dapiprazole in one eye of each subject after full dilatation of both pupils. The pupillary diameter was calibrated, and thereafter statistical analysis was performed with student paired t-test. Thirty minutes after instillation of dapiprazole, there was a highly significant difference of the decreasing rate in pupil size between the dapiprazole treated eyes and the control eyes(p<0.001). The time for complete reversal of mydriasis was also at least 4 hours shorter in the dapiprazole treated eyes than the control eyes(p<0.006). This study suggests that 0.5% dapiprazole is effective in reversing mydriasis caused by 1% tropicamide and 2.5% phenylephrine, and also effective in making the eyes comfortable in a shorter time.
Dilatation ; Humans ; Mydriasis* ; Phenylephrine* ; Pupil ; Tropicamide

As noe of causes of epipora, anatomic abnormality of nasolacrimal duct, has been treated with dacryocystorhinostomy. Recently, the development of nasal endoscopy has made it easy to observe the intranasal sturcture. Thus, authors investigated the effect of nasal endoscopic dacryocystorhinostomy used in combination with microdrill and nasal endoscopy in those patients, with nasolcrimal obsturction at the time of dacryocystorhinography. From 1995 to April 1997, twenty-four patients have been treated by the intranasal dacryocystorhinostomy using the microdrill with follow up more than six months. All patients had been tested by preoperative intranasal exam and was measured radiologically preoperative`s size of lacrimal sac. The nasal endoscopy using microdrill had shown success rate of 83.3 percent and the surgerywas more successful as the size of preoperative lacrimal sac was larer without any complication. The formation of accurate bone foramen did not remarkably differ from the skin incisio at the time of operation. Therefore, dacryocystorhinostomy using microdrill can be useful for the treatment of lacrimal canal obstruction, especially with the proper operating equipment.
Dacryocystorhinostomy* ; Endoscopy ; Follow-Up Studies ; Humans ; Lacrimal Apparatus Diseases ; Nasolacrimal Duct ; Skin

The purpose of this study is to compare the diagnostic accuracy and usefulness of three-dimensional CT, two-dimensional CT in case of blow-out fracture. Two-dimensional CT, three-dimensional CT images of twenty-four blow-out fracture and soft tissue incarceration. Two dimensional CT was superior to three-dimensional CT in evaluating orbital bone fracture and soft tissue incarceration. But, three-dimensional CT was more useful to identify of orbital bone fracture than two-dimensional CT in associated facial bone fracture. Coexamination with two-dimensional axial & three-dimensonal CT was useful not only in the detection of fracture but in the evaluation of soft tissue incarcerated blow-out fracture.
Facial Bones ; Fractures, Bone ; Orbit ; Orbital Fractures*

To evaluate the effect of pterygium on corneal astigmatism and visual acuity, we checked the corneal curvature and visual acuity before and after the operation for pterygium in 126 eye. In the cases of Grade I, the mean change of the horizontal corneal curvature was +0.32D and the mean change of the vertical corneal curvature was +0.07D (P<0.05). In the cases of Grade II, the mean change of the horizontal corneal curvature was +0.54D(P<0.01) and the mean change of the vertical corneal curvature was +0.09D(P<0.05). All of the horizontal and vertical corneal curvature increased after removal of the pterygium, especially the horizontal curvature increased more than the vertical curvature. As the pterygium invades the cornea more extensively, the corneal curvature increased more markedly. After the operation for pterygium the visual acuity was improved 1 to 2 lines at the Han`s visual acuity table in some cases, but there was no statistical significance (P>0.5).
Astigmatism* ; Cornea ; Pterygium* ; Visual Acuity*

BACKGROUND: Beta-adrenergic receptor Kinase 1(betaARK1) is a serine/threonine kinase attached, which inhibits the coupling of beta-adrenergic receptor with G-protein. Myocardial betaARK1 level is usually elevated in heart failure and hypertrophy, but it is not known whether the circulating betaARK1 level is related with the degree of cardiac hypertrophy. This study was performed to evaluate the association of the betaARK1 level in circulating mononuclear leukocytes(MNL) in untreated hypertension with left ventricular mass in hypertensive patients. Method: Nineteen non-treated hypertensive patients were included for this study. High blood pressure was confirmed when systolic BP is over 150 mmHg or diastoli BP is over 95 mmHg. Echocardiography was performed to evaluate the degree of hypertrophy by measuring the left ventricular mass index(LVMI) and relative wall thickness(RWT), and test the LV function by measuring the ejection fraction(EF) according to ASE guideline. At the same time, blood was collected from each patient and MNL were isolated by gradient centrifuge with Ficoll-400. Total RNA was purified from MNL and semi-quantitative RT-PCR was performed. After reverse transcription, PCR was done with primers for human betaARK1 and GAPDH as external control. betaARK1 levels were expressed by ratio to GAPDH level and estimated the relations with clinical and Echocardiographic parameters. Result: We studied confirmed 19 hypertensive patients(10 men and 9 women, mean age of 50.6 years). Echocardiographically measured indices(mean+/-SD) were as follows; LVMI(137.3+/-30.6g/m2), PWT(0.53+/-0.09) and EF(54.6+/-8.5%). Ratio of betaARK1 levels to GAPDH was from 0.10 to 0.96 (0.62+/-0.25). betaARK1 levels were correlated with LVMI(correlation coefficient: r=.502, p=.029) and RWT(r=.627, p=.004). But Systolic BP(r=0.009, p=.93), diastolic BP(r=.07, p=.85) or EF(r=.045, p=.84) were not related to level of betaARK1. CONCLUSIONS: The betaARK1 level of circulating MNL was correlated well with the degree of the cardiac hypertrophy estimated by LVMI and RWT. This data suggests that activation of sympatho-adrenal system would exert a major role in developing cardiac hypertrophy and we can expect the decreased responsiveness to catecholamine in the heart of hypertensive patients. betaARK1 in circulating MNL might be used as a predictor or marker for LV hypertrophy in hypertensive patients.
beta-Adrenergic Receptor Kinases ; Cardiomegaly ; Echocardiography ; Female ; GTP-Binding Proteins ; Heart ; Heart Failure ; Humans ; Hypertension ; Hypertrophy ; Leukocytes, Mononuclear* ; Male ; Phosphotransferases ; Polymerase Chain Reaction ; Reverse Transcription ; RNA

No abstract available.
Down Syndrome*

It is recognized that rebleeding of traumatic hyphema may predispose patients to several complications including decreased visual acuity. We reviewed the medical records of 92 patients(92 eyes) with the diagnosis of nonperforating traumatic hyphema. The relative efficiencies of Aminocaproic acid and systemic Predisolone for reducing rate of rebleeding and their side effects were evaluated under the statistical analysis. Fourty-seven patients received an oral dosage of 50 mg/kg of Aminocaproic acid every 4 hours for 5 days(up to a maximum 30 gm/day), and fourty-five patients took an oral dosage of 0.6 mg/kg of Prednisolone daily in two devided doses. The frequency of rebleeding was not statistically significantly different between the aminocaproic acid treated group(4.3%, 2/47 patients) and the prednisolone treated group(6.7%, 3/45 patients). The developing rates of their acute adverse reaction were statistically different between the aminocaproic acid treated group(44.7%, 21/47 patients) and the prednisolone treated group(20%, 9/45 patients).
Aminocaproic Acid* ; Diagnosis ; Humans ; Hyphema* ; Medical Records ; Prednisolone* ; Visual Acuity

We analyzed early postoperative astigmatic changes, visual rehabilitation and complications with silicone intraocular lenses implanted through 3.2mm scleral pocket incision (group I. 68 eyes) and PMMA intraocular lenses implanted through 5.5mm scleral pocket incision(group 2. 103 eyes). Surgically induced astigmatism in group 1 was -0.17D at two days, -0.12D at one week, and -0.51D at two months. In group 2, it was -0.36D at two days, -0.46D at one week, and -0.72D at two months. There was a statistically significant difference between the two groups at 2 days and 1 week (p<0.05), thereafter no statistically significant difference between the two groups (p>0.05). 0.5 or better uncorrected visual acuity in group I was 74% at 2 weeks, 87% at 2 months while in group 2, it was 69% at 2 weeks, and 77% at 2 months. Postoperative complication in group I were two cases of IOL decentration(2.9%), two cases of anterior capsule contraction (2.9%), three cases of anterior chamber inflammation (4.4%), and two cases of posterior capsule opacity (2.9%). In group two, it were one case of hyphema (1%), one case of wound dehiscence (1%) , one case of anterior chamber inflammation (1%), and seven cases of posterior capsule opacity (6.8%). Our results indicate the 3.2mm scleral tunnel incision (group 1) was associated with a lower surgically induce astigmatism at 2 days and 1 week, and 8 faster visual rehabilitation than 5.5mm scleral tunnel incision (group 2), but anterior chamber inflainmation, anterior capsule contraction and IOL decentrations were more frequently developed in group 1.
Anterior Chamber ; Astigmatism* ; Cataract* ; Hyphema ; Inflammation ; Lenses, Intraocular* ; Phacoemulsification ; Polymethyl Methacrylate* ; Postoperative Complications ; Rehabilitation* ; Silicones* ; Visual Acuity ; Wounds and Injuries

The Flash Light Emitted Diode Flash Visual Evoked Potential(Flash VEP) is useful when patients are unable to cooperate sufficiently for a Pattern Reversal Visual Evoked Potential(RP-VEP). In order to evaluate the clinical utility of Flash VEP, we performed the PR-VEP and Flash VEP in 208 eyes of 104 normal persons. The average P100 latency(LaP100) was analyzed according to check size, age, sex, and the laterality of the eye. The LaP100 of PR-VEP stimulated with 8 X 8(120' X 96'), 16 X 16(60' X 48'), 32 X 32 (30' X 24') and 64 X 64(15' X 12') check size were 98.88 +/- 7.57msec(mean S.D msec) , 97.68 +/- 7.44msec, 96.31 +/- 7.21msec, 101.20 +/- 7.81msec, respectively. The LaP100 of PR-VEP stimulated with 32 X 32 check size at 3rd, 4th, 5th, 6th and 7th decades were 93.95 +/- 5.61msec, 94.70 +/- 7.71msec, 92.92 +/- 6.28msec, 97.78 +/- 6.24 msec, 102.79 +/- 5.27msec, respectively. The LaP100 of PR-VEP remained relatively stable until over 6th decade when it increased significantly (p<0.05). The LaP100 of FlashVEP in age of 3rd, 4th, 5th, 6th and 7th decade were 87.08 +/- 7.82msec, 91.07 +/- 8.46msec, 99.37 +/- 6.36msec, 105.30 +/- 7.82msec, and 111.62 +/- 5.54msec, respectively. The LaP100 of Flash YEP increased progressively with aging changes(p<0.05). There were no statistically significant differences between the left and right eyes(p>0.05), and between male and female(p>0.05) in the LaP100 of both VEP. These results showed that LaP100 of PR-VEP changes according to the check size and patient's age. We should interprete the LaP100 of PR-VEP or Flash VEP after the processing of averaging its P100 according to the patient's.
Aging ; Humans ; Male