Peyronie's disease is a distressing disorder that pathophysiology and therapeutic subset of this disease are fairly not established. We studied the effectiveness of verapamil for Peyronie's disease which intralesionally injected with lO mg verapamil every 2 weeks for lO injections or more in 12 men among 15 men with Peyronie's disease at Pusan National University Hospital from May 1995 to May 1996. The mean age was 55.7 year-old (range 30-68). One case had failed prior steroid intralesional injection and four cases had failed prior vitamin E oral medication. The mean volume of plaque was approximated with 7.5 MHz high frequency ultrasound at 3.7ml (range 0.1- 8.4). The plaque causes the penile curvature which was discovered by questioning or intracavernosal injection of prostaglandin E1 in 9 cases (64.3%). Penile pain was rapidly resolved in all preexisting lO cases (lOO%). Of cases with the penile curvature on erection, angulation was decreased in 3 cases (33.3%). The penile rigidity on erection was inquired to be improved more or less in 4 cases (44.4%) with desirable sexual performance. Plaque volume and consistency were reduced in 6 cases (50%). We concluded the verapamil intralesional injection is one of the effective nonoperative therapeutic modality for Peyronie's disease because of the beneficial effects including complete pain relief, modest improvements in penile curvature and erectile function, decreased plaque volume and avoidance of disease progression without no adverse reactions.
Alprostadil ; Busan ; Disease Progression ; Humans ; Injections, Intralesional* ; Male ; Penile Induration* ; Ultrasonography ; Verapamil* ; Vitamin E ; Vitamins

Circadian rhythms of the substances related to lithogenesis such as volume, pH, creatinine, calcium, magnesium, uric acid, phosphorus, citrate and oxalate in urine of 10 healthy men who led method of urine sampling at 2 hours interval from 6 :00 were evaluated to midnight and a 6 hours : The urine volume, pH, excretory amounts and concentration of calcium, magnesium, uric acid, citrate and oxalate except creatinine and phosphorus in 24-hour fractionated urine were shown to increase during postprandial period between 8:00 and 10:00 and between 22:00 and midnight. The creatinine excretion was minimal variations in all fractionated urine. The phosphorus excretion was modestly pronounced about dinner, but low value between 10:00 and noon. Therefore, almost lithogenic and inhibitory substances in urine were relatively increased after breakfast and dinner so that lithogenesis were thought to be intimately concerned with diet.
Breakfast ; Calcium ; Circadian Rhythm ; Citric Acid ; Creatinine ; Diet ; Humans ; Hydrogen-Ion Concentration ; Magnesium ; Male ; Meals ; Phosphorus ; Postprandial Period ; Uric Acid