In Asia, mammography following the injection of foreign materials into the breasts for cosmetic augmentation is frequently seen and diagnosis based on the typical radiologic findings is straightforward. We report the unusual radiologic findings in two patients with foreign body granulomas caused by injected foreign materials and discovered incidentally during screening work up. The mammographic findings were bilateral, hyperdense, spiculated masses, with occasional microcalcification, and at sonography, markedly hypoechoic, spiculated solid masses, located near the pectoralis muscle and partly extending into it, were observed. These radiologic findings mimicked malignancy.
Breast Neoplasms/radiography ; Case Report ; Cholesterol ; Diagnosis, Differential ; Esthetics ; Female ; Granuloma, Foreign-Body/etiology/*radiography/*ultrasonography ; Human ; Injections/adverse effects ; Mammography ; Middle Age ; Paraffin

Herpes zoster oticus (Ramsay Hunt syndrome) is characterized by facial nerve paralysis associated with vesticular eruptions and cochleovestibular symptoms. Many evidences have supported that it is caused by the reactivation of latent varicella-zoster virus in the geniculate ganglion. Recently we experienced a case 49-year-old man presented severe vertigo and a vesicular eruptions of auricle and external ear canal. It is an unusual variant of herpes zoster oticus that involves only vestibular nerve without facial nerve palsy and hearing loss. We believe this case results from reactivation of latent varicella zoster virus in the vestibular ganglion and report with a review of literatures.
Dizziness ; Ear Canal ; Facial Nerve* ; Ganglion Cysts ; Geniculate Ganglion ; Hearing Loss ; Herpes Zoster Oticus* ; Herpes Zoster* ; Herpesvirus 3, Human ; Humans ; Middle Aged ; Paralysis* ; Vertigo ; Vestibular Nerve*

No abstract available.
Orbit* ; Orbital Cellulitis*

BACKGROUND AND OBJECTIVES: Lateral semicircular canal (LSC) dysplasia is the most common congenital anomaly in the inner ear. The LSC dysplasia usually accompanies other inner ear anomalies, and the concurrent occurrence of the inner ear anomaly and the middle ear anomaly also has been reported. The purpose of this study was to investigate the LSC dysplasia among patients with middle ear cholesteatoma. MATERIALS AND METHOD: Medical record and temporal bone computed tomographic (CT) scan of cholesteatoma patients with the LSC dysplasia were analyzed retrospectively. RESULTS: There were four cases of the LSC dysplasia among 262 cholesteatoma patients (1.5%) during five years. Temporal bone CT scan showed short, dilated LSC and enlarged vestibule. The cochlea and the opposite side of the bony labyrinth were normal. All of the patients showed middle ear cholesteatoma occurring on the affected ear. Three patients showed mixed type of hearing loss, and the other one patient with Down's syndrome showed profound hearing loss on auditory brainstem response. In the velocity step test, two patients were normal, and one patient showed decreased response in the affected side. CONCLUSION: This study showed that the LSC dysplasia might be a relatively common inner ear anomaly encountered on the preoperative CT scan of cholesteatoma patients. The relationship between the LSC dysplasia and the development of middle ear cholesteatoma is not clear, and further studies are needed.
Cholesteatoma ; Cholesteatoma, Middle Ear* ; Cochlea ; Down Syndrome ; Ear ; Ear, Inner ; Ear, Middle* ; Evoked Potentials, Auditory, Brain Stem ; Exercise Test ; Hearing Loss ; Humans ; Medical Records ; Retrospective Studies ; Semicircular Canals* ; Temporal Bone ; Tomography, X-Ray Computed

BACKGROUND: The mechanism of salicylate ototoxicity is probably related to reversible biochemical or metabolic changes in the cochlea. Decreased cochlear blood flow seems to play an important role in salicylate ototoxicity. Several constituents of ginkgo extract have the action of increasing blood flow, antagonism of platelet activating factor and scavenger of free radicals. It might be thought that these activities of ginkgo extract could contribute to attenuate salicylate ototoxicity. OBJECTIVES: Whether the salicylate induced hearing loss could be attenuated by pretreatment with ginkgo extract. MATERIALS AND METHODS: Auditory brainstem response threshold changes were observed after the intramuscular injection of lysine salicylate(300mg/kg), or lysine salicylate with EGb 761(100mg/kg, single IP or 100mg/kg and 50mg/kg, IP, two times) pretreatment in each group of guinea pig. RESULTS: In the groups with Ginkgo extract pretreatment, the threshold changes were less severe and recovered earlier than in group with salicylate injection only(p<0.05). CONCLUSIONS: EGb 761 could attenuated the hearing loss after the injection of salicylate in guinea pig.
Animals ; Cochlea ; Evoked Potentials, Auditory, Brain Stem ; Free Radicals ; Ginkgo biloba* ; Guinea Pigs* ; Guinea* ; Hearing Loss ; Injections, Intramuscular ; Lysine ; Platelet Activating Factor

The mechanism of salicylate ototoxicity appears to be multifactorial and decreased cochlear blood flow seems to play an important role. The purpose of the study was to assess an effect of allpurinol, a blocker of free oxygen radicals(FORs) formation, on salicylate ototxicity in guinea pig. ABR threshold shifts were observed in group 1, treated with salicylate(300mg/kg, IM) and group 2, pretreated with allopurinol(50mg/kg, PO, two times) before injection of salicylate(300mg/kg, IM). In group 1, significant ABR threshold shift was measured in 1 hour(p<0.05) and maximum threshold shift was noted in 2-3 hours, with complete recovery in 6 hours, after injection of salicylate. In group 2, there was a little ABR threshold shift through 6 hours after injection of salicylate, except average 5dB shift in 4 hours. ABR threshold shift was significantly greater in group 1 than in group 2, after injection of salicylate(p<0.05). With above result, allopurinol, a blocker of FORs formation, could attenuated the hearing loss after the administration of salicylate in guinea pig, and FORs might play a role in salicylateinduced hearing loss.
Allopurinol* ; Animals ; Guinea Pigs* ; Guinea* ; Hearing Loss ; Oxygen

BACKGROUND AND OBJECTIVES: Exposure to noise results in pertubations of cochlear microcirculation. There is evidence that these events are mediated, in part, by the calcium channel. The subsequent decrease in cochlear blood flow may lead to hypoxia and predispose to the formation of free oxygen radicals. Saponin extracted from Korean red ginseng is generally known to enhance blood flow and scavenge for free oxygen radicals. MATERIALS AND METHODS: We investigated the effect of saponin (100 mg/kg) on the cochlear damage induced by noise exposure (1500 Hz narrow band noise, 115 dB, 12hours) in guinea pigs through auditory brainstem response (ABR) and with scanning electron microscopy (SEM), RESULTS: After noise exposure, the saponin pre-treated group showed a significant decrease in the ARR threshold compared with the saponin non- treated group. Also, SEM findings of the cochlea showed that there was a minimal structural change in the outer hair cells in the saponin pre-treated group. CONCLUSION: Saponin extracted from Korean red ginseng can attenuate noise induced cochlear damage in guinea pigs.
Animals ; Anoxia ; Calcium Channels ; Cochlea ; Evoked Potentials, Auditory, Brain Stem ; Guinea Pigs ; Hair ; Hearing Loss ; Microcirculation ; Microscopy ; Microscopy, Electron, Scanning ; Noise* ; Panax* ; Reactive Oxygen Species ; Saponins*

The transpetrosal transtentorial supra- and infratentorial combined approach has been used by many skull base surgeons for the total removal of large tumors in the cerebellopontine, petroclival, and dumbbell-shaped mass of the middle and posterior cranial bases. When surgeons use the retrolabyrinthine approach for hearing preservation, adequate exposure of the presigmoid dura might be hard to achive. In order to get a wider operating field with hearing preservation, the authors used the transpetrosal approach with partial labyrinthectomy for a large dermoid cyst in the cerebellopontine angle which extened to the middle cranial base through the Meckel's cave.
Cerebellopontine Angle ; Dermoid Cyst ; Hearing* ; Skull Base

A 22-year old female visited CNUH due to palpable neck mass. Cytologic examination of a fine needle aspiration was performed and the result was Pap class II. Routine chest x-ray shows solitary pulmonary nodule. For rule-out malignancy, FNA at neck mass was repeated and pathologic finding was dysplasia. She was admitted to MI department for evaluation of solitary pulmonary nodule and percutaneous needle aspiration was done. Pathologic diagnosis was adenoid cystic carcinoma. Thereafter, the lesions were treated by excisional biopsy of submandibular gland mass with left supraomohyoid neck dissection and wedge resection of right lower lobe at ENT department and thoracic and cardiovascular surgery department, respectively Final diagnosis was adenoid cystic carcinoma arising in submandibular gland with solitary lung metastasis. According to TMN staging system, surgical staging is stage IV of T2N0M1. Clinical follow-up to postoperative 13 months in this case showed that she is alive and well without evidence of recrrence.
Adenoids* ; Biopsy ; Biopsy, Fine-Needle ; Carcinoma, Adenoid Cystic* ; Diagnosis ; Female ; Follow-Up Studies ; Humans ; Lung* ; Neck ; Neck Dissection ; Needles ; Neoplasm Metastasis ; Salivary Glands* ; Solitary Pulmonary Nodule ; Submandibular Gland ; Thorax

BACKGROUND AND OBJECTIVES: Occlusion of semicircular canal has been used for otoneurologic and skull base surgery with preservation of postoperative hearing. However, research on healing process of the occluded bony semicircular canal is scarce. MATERIALS AND METHODS: We transected and occluded the lateral semicircular canal of guinea pigs using a surgical drill. Histopathologic changes of the temporal bones were observed up to the eighth postoperative week. RESULTS: The temporal bone specimens showed that ostcogenic cells proliferated from the perilymphatic fibrous mesh formed a new bone in the occluded portion of the lateral semicircular canal. Periosteal cells of the endosteum produced a compact bone layer lining the bony semicircular canal lumen. Periosteal layer produced a woven bone at the surgical defect of the lateral semicircular canal. CONCLUSION: This study shows that the perilymphatic fibrous mesh, the endosteum and the periosteal layer participated in osteogenesis in healing of the bony lateral semicircular canal after transection and occlusion.
Animals ; Ear, Inner* ; Guinea Pigs ; Hearing ; Osteogenesis ; Semicircular Canals* ; Skull Base ; Temporal Bone