We measured the level of derivatives of reactive oxygen metabolites (d-ROMs test) and total antioxidant capacity (OXY-adsorbent test) in adult volunteers and assessed whether jidabokuippo affects the oxidative stress regulation system. Twenty subjects received jidabokuippo 7.5 g/day, and the d-ROMs test and the OXY-adsorbent test were carried out 72 hours after taking the study drug. The subjects were also assigned to one of two groups : a Favorable response group (n = 6) or a Non-favorable response group (n = 14). The Favorable response group had improvement of such signs and symptoms as stiff shoulders, constipation, and bruises.No significant difference was observed in the d-ROMs test.However, the OXY-adsorbent test at 72 h was significantly lower than that at the pre-administration (p = 0.0290). No significant differences were observed in either the d-ROMs test or the OXY-adsorbent test in the favorable response group. On the other hand, the d-ROMs test and the OXY-adsorbent test at 72 h were significantly lower than those at pre-administration in the non-favorable response group (p = 0.0279, p = 0.0413, respectively). These results indicate that jidabokuippo affects the oxidative stress regulation system in human.

We treated 5 patients with painful muscle cramp due to heat injury using Shakuyakukanzoto. According to their severities, 4 patients were classified with 1 st degree and 1 patient with 3rd degree heat injury. Painful muscle cramps in 4 patients with 1st degree were cured through a single dose of Shakuyakukanzoto. On the other hand, painful muscle cramps in 1 patient with 3rd degree was managed for 4 days after administration of Shakuyakukanzoto. No Shakuyakukanzoto complications were observed in any patient, nor contribution to rhabdomyolysis in 3 patients. Shakuyakukanzoto may be useful to prevent acute kidney injury due to rhabdomyolysis by controlling painful muscle cramps in heat injury.

Inflammatory swelling after viper bite envenomation has the potential for causing multiple organ dysfunctions. We report 2 cases of viper bite that were successfully treated with saireito. A 79-year-old man suffered viper bite envenomation. Saireito was administered to reduce the swelling of the right lower leg. The patient's symptom was improved without any complications. A 68-year-old man suffered the same condition. The swelling spread over the chest and tako-tsubo-like left ventricular (= apical ballooning cardiomyopathy) dysfunction developed. Saireito was administered to reduce the swelling of the left upper limb. The patient was discharged without any severe complications. Thus, saireito may be useful for the treatment of swelling due to viper bite envenomation.

‘Processed bushi powder for ethical dispensing’, or TJ-3022, is an Aconiti tuber (PAT) herbal drug, and TJ-3023 is newly-developed to contain a higher proportion of diester aconitine alkaloid. We measured reactive oxygen metabolite derivative levels (d-ROMs tests), and total antioxidant capacity (OXY-adsorbent tests) in healthy adult volunteers, to assess whether PAT affects the oxidative stress regulation system. Thirty-four subjects were assigned to one of two groups: a TJ-3022 group and a TJ-3023 group. No significant chronological differences were observed in the TJ-3022 group. No significant chronological differences were observed in the TJ-3023 group, either. These results indicate that PAT dose not affect the oxidative stress regulation system in humans.

We measured the level of derivatives of reactive oxygen metabolites (d-ROMs test) and total antioxidant capacity (OXY-adsorbent test) in adult volunteers and assessed whether jidabokuippo affects the oxidative stress regulation system. Twenty subjects received jidabokuippo 7.5 g/day, and the d-ROMs test and the OXY-adsorbent test were carried out 72 hours after taking the study drug. The subjects were also assigned to one of two groups : a Favorable response group (n = 6) or a Non-favorable response group (n = 14). The Favorable response group had improvement of such signs and symptoms as stiff shoulders, constipation, and bruises. No significant difference was observed in the d-ROMs test. However, the OXY-adsorbent test at 72 h was significantly lower than that at the pre-administration (p = 0.0290). No significant differences were observed in either the d-ROMs test or the OXY-adsorbent test in the favorable response group. On the other hand, the d-ROMs test and the OXY-adsorbent test at 72 h were significantly lower than those at pre-administration in the non-favorable response group (p = 0.0279, p = 0.0413, respectively). These results indicate that jidabokuippo affects the oxidative stress regulation system in human.

Heat-treated and detoxified Aconite tuber has many useful properties such as analgesic, diuretic, and cardiotonic effects. Two hundred forty-seven patients were treated with Aconite Tuber powder (1.5 - 8.0g/day) added to Kampo extract granules. The Visual Analog Scale (VAS) was used for the assessment of its pain-relieving effect. One hundred two patients improved dramatically (the pre/post administration VAS ratio was less than 50%), 84 improved (between 51 to 75%), and61did not improved (more than 76%). Three patients(1.2%) showed adverse reactions, such as tongue numbness, squeezing sensation of the bladder, anasarca. These reactions were not serious. This study suggests that Aconite tuber powder can be used more widely, especially for arthralgia and somatic pain with coldness in elderly patients.
Aconitum ; Powders ; Pain ; Cerebellar tuber ; Arthralgia

Shakuyakukanzoto is effective for pain primarily related to muscle contractions and the powder works rapidly after oral intake. We successfully treated a patient who presented with spastic convulsions by using shakuyakukanzoto. A 32-year-old man had injury to his left hand from a dog bite, resulting in tetanus. Intravenous propofol was chosen as a sedative at first. On day1, shakuyakukanzoto was also administered to control his spastic convulsions. It was effective in reducing his propofol dose and improving various symptoms such as priapism, abdominal pain, tremor, and insomnia. The patient was discharged from our hospital on day 14. This is the first report we know of tetanus treated with shakuyakukanzoto. And we believe that shakuyakukanzoto may be useful for the control of muscle spasms and the management of dysautonomia caused by generalized tetanus.
shakuyaku-kanzoh-toh ; Propofol ; Shakuyaku ; Tetanus Toxoid ; Treated with

Daikenchuto has been attracting nationwide attention in recent years, with its therapeutic efficacy on posto-perative complaints and complications. We treated three patients with acute abdomen using daikenchuto. They suffered from severe abdominal pains and abdominal radiographs showed small intestine gases. All three recovered from their pains or nausea after taking daikenchuto, and were discharged home without hospital admission. The use of daikenchuto against acute abdomen is recommended in emergency medicine.
Cases ; seconds ; Treated with ; Three ; Acute

In order to evaluate the effect of shuchi-bushi, a powder form of the aconite tuber, we examined changes in finger temperature (FT) and tissue blood flow (TBF). No significant differences were observed in FT between pre-administration and 90 min post-administration, however, FT at 72 min was significantly higher than that at the pre-administration (p=0.0736and p=0.0219, respectively). The FT at 72 h was also significantly higher than that at 90 min (p=0.0253). No significant differences were observed in TBF between pre-administration and 90 min, nor between the 90 min and 72 h. However, the TBF at 72 h was significantly higher than that at pre-administration (p=0.0219). A significant correlation was observed between the FT and TBF (p=0.0052). Our results suggest that shuchi-bushi may play a role in warming and increasing tissue blood flow in human.
Minute of time ; lower case pea ; Tissues ; lower case aitch ; Powders

Continuous suppressive antiviral medication for the treatment of repeated genital herpes is often carried out, but few treatments with Kampo have been reported. Here, we report experience with a case in which the repeated recurrence of genital herpes was treated successfully with hochuekkito.
A 34-year-old woman had experienced pregnancy twice and delivered twice. She had also had repeated recurrences of genital herpes from several years earlier, and been treated at a nearby doctor. Her recurring herpes did not resolve, however, and she visited our department. In addition to these recurrences, general fatigue and appetite loss were observed, which were regarded as Qi deficiency, and she was started on hochuekkito 7.5 g/day. The general fatigue disappeared two weeks after the treatment. Herpes recurrences also decreased gradually, and symptoms were no longer observed after medication was stopped less than a year later.
In this case, genital herpes recurrences were decreased, while symptoms such as general fatigue and appetite loss were also improved. Here, genital herpes recurrence was regarded as Qi deficiency, which was possible to treat with hochuekkito.