No abstract available.

No abstract available.
Ultrasonography*

Radiation retinopathy is a slowly progressive vaso-occlusive microangiopathy of the retina, following irradiation of the head and the eye. Factors in the pathogenesis of this condition include total radiation dosage, proximity of the treated site to the eye, concomitant chemotherapy and preexisting vascular disorders. We present three patients of radiation retinopathy, one of who was a diabetes and two were positive for the history of concomitant chemotherpy. All the patients developed asymmetrical retinal change after the external cephalic radiation of over 3500 cGy within eleven to twenty-one months. Fluorescein angiographic findings confirmed the typical ischemic features of radiation retinopathy. As these cases show, physicians need to be aware of this vision-threatening complication following cephalic radiation, especially in the high-risk groups.
Drug Therapy ; Fluorescein ; Head ; Humans ; Radiation Dosage ; Retina ; Retinaldehyde

Here we report an autopsy case of diabetic ketoacidosis (DKA) with severe hypertriglyceridemia (12,900 mg/dl). A 29-year-old woman with a history of type 1 diabetes was found dead at a motel. There was no injury on external inspection, but a lump of cheese-like material was noted in the heart at autopsy and peripheral blood plasma had a creamy appearance. After postmortem biochemical analysis, we made a diagnosis of DKA with severe hypertriglyceridemia and concluded that these unusual autopsy findings were caused by DKA and postmortem change. Uncontrolled diabetes often causes DKA and hypertriglyceridemia. To the best of our knowledge, this is the first report in Korea of DKA with severe hypertriglyceridemia diagnosed by autopsy.
Adult ; Autopsy* ; Diabetic Ketoacidosis* ; Diagnosis ; Female ; Heart* ; Humans ; Hypertriglyceridemia* ; Korea ; Plasma ; Postmortem Changes

OBJECTIVE: To understand the expression pattern of osteopontin on various histologic types of ovarian tumors. METHODS: We performed an immunohistochemical study on 90 paraffin embedded tissues including 80 ovarian epithelial tumors and 10 normal ovaries. We also performed a semiquantitative study of osteopontin mRNA on 12 fresh ovarian tumors, 2 normal ovaries and SKOV3 cell line. SAS 8.2 program was used for statistical analysis and Fisher's Extract test and Cochran-Mantel-Haenszel Statistics for analysis of the relationship between expression of osteopontin and histologic types. RESULTS: Among 55 carcinomas, over 50% of tumor cells expressed osteopontin in 14/14 clear cell, 11/ 12 endometrioid, 11/16 serous, and 5/15 mucinous types. The expression degrees were well correlated with the histologic types of carcinomas (p=0.002). Among 25 benign tumors, over 10% of tumor cells showed in 11/15 serous and 3/10 mucinous types (p=0.008). However, the degree of osteopontin expression was not related to the tumor grades or stages of ovarian cancer. Semiquantitative study for osteopontin mRNA showed 5-6 times higher in SKOV3 cell line as well as in serous adenocarcinomas, compared with the normal ovaries. However, there was no increase of osteopontin mRNA in benign or malignant mucinous tumors. CONCLUSION: Our findings suggest that the expression of osteopontin is not only present in ovarian cancers, but also in benign ovarian tumors.
Adenocarcinoma ; Cell Line ; Female ; Mucins ; Osteopontin* ; Ovarian Neoplasms ; Ovary ; Paraffin ; RNA, Messenger

PURPOSE: We report a patient with DiGeorge syndrome who was later diagnosed as mild metopic synostosis and received anterior 2/3 calvarial remodeling. METHODS: A 16-month-old boy, who underwent palatoplasty for cleft palate at Chungnam National University Hospital when he was 12 months old of age, visited St. Mary's Hospital for known DiGeorge syndrome with craniosynostosis. He had growth retardation and was also diagnosed with hydronephrosis and thymic agenesis. His chromosomal study showed microdeletion of 22q11.2. On physical examination, there were parieto-occipital protrusion and bifrontotemporal narrowing. The facial bone computed tomography showed premature closure of metopic suture, orbital harlequin sign and decreased anterior cranial volume. The interorbital distance was decreased(17mm) and the cephalic index was 93%. RESULTS: After the correction of metopic synostosis by anterior 2/3 calvarial remodeling, the anterior cranial volume expanded with increased interorbital distance and decreased cephalic index. Fever and pancytopenia were noted at 1 month after the operation, and he was diagnosed as hemophagocytic lymphohistiocytosis by bone marrow study. He however, recovered after pediatric treatment. There was no other complication during the 12 month follow up period. CONCLUSION: This case presents with a rare combination of DiGeorge syndrome and metopic synostosis. When a child is diagnosed with DiGeorge syndrome soon after the birth, clinicians should keep in mind the possibility of an accompanying craniosynostosis. Other possible comorbidities should also be evaluated before the correction of craniosynostosis in patients as DiGeorge syndrome. In addition, postoperative management requires a thorough follow up by a multidisciplinary team of plastic surgeons, neurosurgeons, ophthalmologists and pediatricians.
Bone Marrow ; Child ; Cleft Palate ; Comorbidity ; Craniosynostoses ; DiGeorge Syndrome ; Facial Bones ; Fever ; Follow-Up Studies ; Humans ; Hydronephrosis ; Infant ; Lymphohistiocytosis, Hemophagocytic ; Orbit ; Pancytopenia ; Parturition ; Physical Examination ; Sutures

Osteoma is a slowly growing benign tumor which mainly grows on the mandible and in the paranasal sinuses of the craniofacial region. Embryological, inflammatory, and traumatic theories make up the etiological basis of osteoma, but is still unclear and yet to be studied. We can classify osteoma by morphology and pathology into eburnated, cancellous, and mixed type, of which eburnated type is relatively common. Most osteomas accompany no symptoms, so they are often discovered accidentally by a radiological examination. They never develop into a malignant form, so that periodic observation is sufficient enough for management, but when they grow and invade intraorbitally or intracranially and then compress clinically important structures, need a surgical management, because of possibility of diplopia, exophthalmos, epiphora, blindness due to optic atrophy, mucocele, brain abscess, meningitis. A 52-year-old man complaining of right eye pain, diplopia, and exophthalmos was diagnosed a 4.5x3.0x 2.0cm sized fronto-ethmoidal osteoma by means of a three dimensional computed tomography. We experienced a osteoma removal through bicoronal incision, and orbital reconstruction with both rib and calvarial bone graft, and received satisfying results after 1 year follow-up, thereby report this case with a short review of references.
Blindness ; Brain Abscess ; Diplopia ; Exophthalmos ; Eye Pain ; Follow-Up Studies ; Humans ; Lacrimal Apparatus Diseases ; Mandible ; Meningitis ; Middle Aged ; Mucocele ; Optic Atrophy ; Orbit ; Osteoma* ; Paranasal Sinuses ; Pathology ; Ribs* ; Transplants*

PURPOSE: Dental CT software program can provide reformatted cross-sectional and panoramic images that cannot be obtained with conventional axial & direct coronal CT scan. The purpose of this study is to describe the method of the technique and to identify the precise anatomy of jaw. MATERIALS AND METHODS:We evaluated 13 mandibles & 7 maxillae of 15 subjects without bony disease who were being considered for endosseous dental implants. Reformatted images obtained by the use of bone algorithm performed on GE HiSpeed Advantage CT scanner were retrospectively reviewed for detailed anatomy of RESULTS: Anatomy related to neurovascular bundle(mandibular foramen, inferior alveolar canal, mental foramen, canal for incisive artery, nutrient canal, lingual foramen and mylohyoid groove), muscular insertion(mylohyoid line, superior & inferior genial tubercle and digastric fossa) and other anatomy(submandibular fossa, sublingual fossa, contour of alveolar process, oblique line, retromolar fossa, temporal crest & retromolar triangle) were well delineated in mandible. In maxilla, anatomy related to neurovascular bundle(greater palatine foramen & groove, nasopalatine canal and incisive foramen) and other anatomy(alveolar process, maxillary sinus & nasal fossa) were also well delineated. CONCLUSION: Reformatted images using dental CT software program provided excellent delineation of the jaw anatomy. Therefore, dental CT noftware program can play an important role in the preoperative assessment of mandible and maxilla for dental implants and other surgical conditions.
Alveolar Process ; Arteries ; Dental Implants ; Haversian System ; Jaw* ; Mandible ; Maxilla ; Maxillary Sinus ; Retrospective Studies ; Tomography, X-Ray Computed

The stercoral colitis is an inflammatory process involving the colonic wall related to fecal impaction. This rare condition usually has a poor prognosis. We experienced a death case where an 84 years old woman died of stercoral colitis complications after total knee arthroplasty surgery. The fatal complications were peritonitis with systemic inflammatory response syndrome, not accompanying bowel perforations. We would like to show the autopsy case of stercoral colitis and suggest the importance of early suspicion and treatment.
Arthroplasty ; Autopsy ; Colitis ; Colon ; Fecal Impaction ; Female ; Humans ; Knee ; Peritonitis ; Prognosis ; Systemic Inflammatory Response Syndrome

This a case report of airway obstruction due to mucous plug which occurred. as a complication of endotracheal intubation. This 16-year old patient was performed on endotracheal intubation for cardio-pulmonary resuscitation of cardiac arrest due to traume. He was comatous, tachypneic and increased pulse rate at 6 hours after intubation, then we found the uneven ventilation of both lung fields. We exchanged endotracheal tube after failure of suction and found airway obstruction due to mucous plug. After exchange of tube, suction of secretion and trachecstomy was performed. 3 days afterward, the patient was recovered from his poor pulmonary function, then transferred to the ward.
Airway Obstruction* ; Cardiopulmonary Resuscitation ; Heart Arrest ; Heart Rate ; Humans ; Intubation ; Intubation, Intratracheal* ; Lung ; Suction ; Ventilation