Objective To evaluate the clinical efficacy of Hybrid surgery for treatment of multi-level cervical spondylosis.Methods A total of 49 patients (26 males, 23 females) with cervical spondylosis treated with Hybrid surgery between June 2012 and April 2014 were retrospectively reviewed.There were 5 cases with cervical spondylitis radiculopathy (n=5), 10 cases with cervical spondylitis myelopathy (n=10) and 34 cases with mixed cervical spondylitis (n=34).Among the 49 patients, 10 underwent two-segment surgery (n=10) and 39 underwent three-segment surgery (n=39).The mean age of patients was 53.4 years (range from 43 to 62 years).Visual analogue scale (VAS), neck disability index (NDI) and Japanese Orthopedics Association Scores (JOA) were used to evaluate the clinical outcomes.Cervical radiography was used to observe the range of motions (ROM) in C2-C7 segments.Results Mean follow-up time was(42.6±2.2)months (ranging from 24 to 46 months).The mean VAS score for neck pain was significantly decreased from (6.9±1.4) preoperatively to (2.5±0.9) at 3 months postoperatively, and (0.7±0.6)during the last follow-up, respectively(P<0.05).The mean NDI score was significantly reduced from (24.6±8.6) preoperatively to (17.8±6.1) at 3 months postoperatively, and(13.8±4.2) during the last follow-up, respectively(P<0.05).The mean JOA scores increased from (11.9±2.8) preoperatively to(12.6±1.5)at 3 months postoperatively, and (14.8±1.4) during the last follow-up (P<0.05).The ROM of C2-C7 segment reduced from (44.2±8.1)°preoperatively to(34.1±6.8)°at 3 months postoperatively, and(30.4±9.5)°during the last follow-up(P<0.05).Conclusion The clinical outcomes of Hybrid surgery are excellent in the treatment of multilevel cervical spondylosis.The motion of the non-fusion segments is reserved and the decompression is complete.It could be an alternative treatment for multilevel spondylosis.