1.Anesthesia and analgesia for common research models of adult mice
Siavash AHMADI‑NOORBAKHSH ; Mohammad Farajli ABBASI ; Maedeh GHASEMI ; Gholamreza BAYAT ; Nahid DAVOODIAN ; Ehsan SHARIF‑PAGHALEH ; Seyedeh Mahsa POORMOOSAVI ; Melika RAFIZADEH ; Maryam MALEKI ; Hesamaddin SHIRZAD‑ASKI ; Hossein Kargar JAHROMI ; Masoomeh DADKHAH ; Bahman KHALVATI ; Tahereh SAFARI ; Mohammad Amin BEHMANESH ; Seyed Esmaeil KHOSHNAM ; Gholamreza HOUSHMAND ; Sayyed Alireza TALAEI
Laboratory Animal Research 2022;38(4):271-286
Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven sub‑ optimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analge‑ sic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs’ side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analge‑ sic methods in some routine procedures on laboratory mice.
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