1.Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions.
Suni LEE ; Shoko YAMAMOTO ; Yasumitsu NISHIMURA ; Hidenori MATSUZAKI ; Kei YOSHITOME ; Tamayo HATAYAMA ; Miho IKEDA ; Min YU ; Nagisa SADA ; Naoko KUMAGAI-TAKEI ; Takemi OTSUKI
Biomedical and Environmental Sciences 2018;31(5):335-342
OBJECTIVEThe changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months 'Off to On' and 'On to Off' periods using negatively charged particle-dominant indoor air conditions (NCPDIAC).
METHODSSeven volunteers participated in the study, which included 'OFF to 3 months ON' periods (ON trials) for a total of 16 times, and 'ON to 3 months OFF' (OFF trials) periods for a total of 13 times.
RESULTSWith the exception of one case, serum amyloid A (SAA) levels decreased significantly during the ON trials.
CONCLUSIONConsidering that SAA is an acute phase reactive protein such as C reactive protein (CRP), this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes, since an increase in high-sensitive CRP is associated with the subsequent detection of these events.
Adult ; Air ; analysis ; Air Pollution, Indoor ; Environmental Monitoring ; Female ; Housing ; Humans ; Male ; Serum Amyloid A Protein ; metabolism
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