Syringocystadenoma papilliferum is s rare tumor of disputed origin that was first reorted by peterson in 1892. Theclinical features of syringocystadenoma papilliferum are not constant. It may be present at birth or develop later in life. Its appearance varies from an irregular, flat, grey or reddish area to a grey or dark brown. raised and cauliflower-like surface. Sometimes it is moist, flesh or pedunculated and occasionally a verrucous plaque, or cyst may be seen. The typical lesion occurs most frequently on the scalp, and is a hairless smooth plaque until puberty, when a nodular verrucous transformation occurs. A 39 years old male patient had egg sized (3*5cm) and yellowish red colored verrucous tumor mass on his epigastric area, which had grown up slowly for 7 years. The diagnosis of syringocysyadenoma papilliferum was confirmed by histological examination. We repoet a case of syringocystadenoma papilliferum in unusually large size on the epigastric area.
Adolescent ; Adult ; Diagnosis ; Humans ; Male ; Ovum ; Parturition ; Puberty ; Scalp

Gestational trophoblastic tumors including choriocarcinoma bave become one of the most curable human malignancies with an overall cure rate exceeding 90%. Although systemic chemotherapy is the initial treatment for chorio- carcinoma, some patients with chemotherapy-resistant choriocarcinorna can be treated by integration of cbemotherapy, surgery and radio- therapy. We report two cases of persistent localized choriocarcinoma which was treated by surgical intervention.
Choriocarcinoma* ; Drug Therapy ; Female ; Humans ; Neoplasm Metastasis ; Pregnancy ; Trophoblastic Neoplasms

The c-myc oncogene encodes a 62,000 daltons nuclear transcriptional factor and is believed to regulate cellular proliferation. Although its mechanism of action is incompletely understood, oncogene amplification followed by increased expression and ultimately the production of large amounts of specific protein seem to play a central role in the oncogene mediated progression of certain solid tumor, including breast and uterine cervical cancer. We used an Southern blot hybridization to explore the relationship between c-myc onco-gene and prognostic factors of endometrial cancer and analysed the tissues from the 21 patients with endometrial cancer and 4 control cases. Six of 21 patients (29%) with endometrial cancer had at least two fold gene amplification and none of the four normal controls revealed amplified sequences. Three of the four poorly differentiated specimens (75%) demonstrated c-myc gene amplification, whereas only three of 17 low and moderately differentiated specimens (17.6%) showed c-myc oncogene amplification. Thus tumor grade was significantly associated with c-myc oncogene amplification (p=0.002). The other known prognostic factors including stage, histologic cell type, myometrial invasion and lymph node metastases showed no statistically significant association with c-myc oncogene amplification, although they were correlated with increased amplification rate of c-myc oncogene. A much larger number of patients must be studied to determine the prognostic significance of c-myc oncogene amplification in endometrial carcinoma, although these preliminary data suggest that it may predict biologically aggressive behavior of endometrial carcinoma.
Blotting, Southern ; Breast ; Cell Proliferation ; Endometrial Neoplasms ; Female ; Gene Amplification ; Genes, myc ; Humans ; Lymph Nodes ; Neoplasm Metastasis ; Oncogenes* ; Uterine Cervical Neoplasms

In 1957, human skin infection by M. canis were firstly reported in Kyungsang province in Korea. Later, in 1960 new cases were also reported in the other province, the Choongchung. However, M. canis infection has been reported only sporadically in Seoul city. This extremely low incidenc in this area may not represent true negative rate but reflect lack of the alertness of .M. canis infection. During the years 1978 and 1979, 15 out-patients were diagnosed as M canis infection of the skin at the Department of Dermatology of Severance Hoapital, Yonsei University. These 15 patients were found to belong to six different families residing in the central Korea and never resided outside of that area, The Kyungki province. Majority of the cases(11/15) were clinically diagnosed as tinea corporis, as Kerion celsi and 4 cases were tinea capitis. Among them, combined infection by tinea capitis and tinea corporis were confirmed in two patients. Although the ages of the pateints were widely distributed from 2 to 36 years, children under age 10 were the major population among thern. Five domestic cats from 5 families were examined and confirmed to be infected by M. cams.
Animals ; Cats ; Child ; Dermatology ; Humans ; Korea* ; Microsporum* ; Outpatients ; Seoul ; Skin ; Tinea ; Tinea Capitis

BACKGROUND: A device using radiofrequency and infrared has been used as a nonablative method for producing noninvasive skin tightening. However, the method combining radiofrequency and infrared light has not been used widely for treating both skin wrinkling and tightening. OBJECTIVE: To investigate the efficacy of a new nonablative Korean medical device, AntiLax(TM) (Jeisys Medical, Seoul, Korea), which uses both radiofrequency and infrared light, on facial wrinkling and laxity. METHODS: Thirty-three patients with facial laxity and wrinkles were enrolled in this study. Three patients failed to complete the three treatment sessions spaced 4 weeks apart so, ultimately, 30 patients completed the scheduled procedure. Serial photographs of the patients were obtained during the study period. A final clinical assessment was made 3 months after the last treatment. Punch biopsies of the treatment areas were obtained 1 week before treatment and 1 month after the last treatment in five patients who agreed to undergo skin biopsies. RESULTS: Doctors' assessments of the photographs taken before and 3 months after the treatment observed marked differences in the effect of treatment on skin laxity, according to location, but no differences in the effect of treatment on skin wrinkling, according to location. The efficacy of treatment of both skin laxity and wrinkling increased with the number of treatments. Patient satisfaction scores paralleled the clinical improvements observed. Secondary benefits reported by patients 3 months after treatment included decreased pore size, reduced sebum secretion, and improved skin texture. The side effects were mild and limited to transient erythema, edema, and rare vesicle formation. Histopathologically, there were increased, thickened collagen fibers 1 month after the last treatment, as compared to pretreatment. However, quantitative morphometric methods are needed to evaluate the histological changes objectively. CONCLUSION: Noninvasive radiofrequency combined with infrared light appears to be a safe, effective method for treating skin laxity and facial wrinkles.
Biopsy ; Collagen ; Edema ; Erythema ; Humans ; Light ; Patient Satisfaction ; Sebum ; Skin ; Skin Aging

Background: Periprosthetic osteolysis is a prevalent complication following total ankle arthroplasty (TAA), implicating various cytokines in osteoclastogenesis as pivotal in this process. This study aimed to evaluate the relationship between osteolysis and the concentrations of osteoclastogenesis-related cytokines in synovial fluid and investigate its clinical value following TAA. Methods: Synovial fluid samples from 23 ankles that underwent revision surgery for osteolysis following TAA were analyzed as the osteolysis group. As a control group, we included synovial fluid samples obtained from 23 ankles during primary TAA for osteoarthritis. The receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin (OPG) ratio in these samples was quantified using sandwich enzyme-linked immunosorbent assay techniques, and a bead-based multiplex immunoassay facilitated the detection of specific osteoclastogenesis-related cytokines. Results: RANKL levels averaged 487.9 pg/mL in 14 of 23 patients in the osteolysis group, with no detection in the control group’s synovial fluid. Conversely, a significant reduction in OPG levels was observed in the osteolysis group (p = 0.002), resulting in a markedly higher mean RANKL/OPG ratio (0.23) relative to controls (p = 0.020). Moreover, the osteolysis group had increased concentrations of various osteoclastogenesis-related cytokines (tumor necrosis factor-α, interleukin [IL]-1β, IL-6, IL-8, IP-10, and monocyte chemotactic protein-1) in the synovial fluid relative to the control group. Conclusions Our results demonstrated that periprosthetic osteolysis was associated with osteoclastogenesis activation through an elevated RANKL/OPG ratio following TAA. We assume that RANKL and other osteoclastogenesis-related cytokines in the synovial fluid have clinical value as a potential marker for the development and progression of osteolysis following TAA.

Continuous electroencephalographic (EEG) monitoring is the widely used method of operative surveillance during carotid endarterectomy. EEG changes have been well known when cerebral ischemic event occurs during the carotid endarterectomy. But in our country intraoperative EEG monitoring during the operation was not popular and was not reported yet. We have experienced four patients showing EEG changes during the operation. EEG monitoring was performed using four channel differential montages in four patients with carotid artery disease. We evaluated the changes of EEG monitoring during the carotid endarterectomy. We also performed somatosensory evoked potentials (SEP) monitoring to backup the EEG monitoring which could miss the small embolic subcortical infarction. They revealed significant EEG changes which were the decreased fast activities and increased slowing during the carotid cross clamping. They were normalized after insertion of shunt. In one subject EEG change reappeared while the shunt was inserted, because the shunt was kinked, In all subjects, the significant changes of SEP were not observed after declamping of ICA or reposition of kinked shunt. There were not any immediate postoperative neurologic deficits in all patients. EEG monitoring might be considered as an useful method to detect ischemic changes during carotid endarterectomy and to know whether the inserted shunt is working well, Key Words : Intraoperative neuromonitoring, Carotid endarterectomy.
Carotid Artery Diseases ; Cerebral Infarction ; Constriction ; Electroencephalography ; Endarterectomy, Carotid* ; Evoked Potentials, Somatosensory ; Humans ; Neurologic Manifestations

Maternal serum alpha-fetoprotein(MSAFP) has been a world wide screening test for open neural the tube defect. But elevation of MSAFP is related to not only neural tube defect, but also incorrect gestational age, congenital anomalies such as congenital nephrosis, esophageal and intestinal obstruction, low birth weight, oligohydroamnios, fetal death and chromosomal anomalies. If MSAFP is elevated, gestational age, congenital anomalies such as neural tube defect, multiple pregnancy and fetal death must be evaluated by ultrasound. When the ultrasound is nondiagnostic, amniotic fluid AFP(AFAFP) levels are measured and if AFAFP is elevated, presence or absence of aetylchoineststarase(AChE) is determined to rule out the false positive of amniotic AFP. Amniotic AChE test yielded detection rate of open spina bifida of 99%, 98% for anecephaly and a false-positive rate of 0.34%. We report a case with elevated AFAFP and positive amniotic AChE result in one fetus of the twin pregnancy conceived by ICSI and ZIFT, but in which targeted ultrasound findings were normal, maintained the pregnancy to term and normal twin was delivered by elective cesarean section.
Acetylcholinesterase ; alpha-Fetoproteins ; Amniotic Fluid* ; Cesarean Section ; Female ; Fetal Death ; Fetus* ; Gestational Age ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Intestinal Obstruction ; Mass Screening ; Nephrosis ; Neural Tube Defects ; Pregnancy ; Pregnancy, Multiple ; Pregnancy, Twin* ; Sperm Injections, Intracytoplasmic* ; Spina Bifida Cystica ; Ultrasonography ; Zygote Intrafallopian Transfer ; Zygote*

The prevalence of Behcet's disease is the highest in the East Asian and the Medi-terranean countries. Behcet's disease is also distributed in the Asian countries, but the nationwide survey has not been performed in Korea yet. The Korean Study Group for Behcet's Disease, founded in 1999, conducted a multicenter, retrospective survey on epidemiologic and clinical features of the patients with Behcet's disease from 20 hospitals around the nation from 1997 to 1999. Of 3,497 patients, 1,527 were classified into complete or incomplete type of Behcet's disease according to the revised Shimizu's classification. The sex ratio was 1:1.75 with the female predominance. Geographical distribution showed the highest frequency in Seoul (38.5%). Clinically, 98.8% had oral ulcers, 83.2% had genital ulcers, 84.3% had skin lesions and 50.9% had ocular lesions. As for the minor clinical manifestations, articular symptoms were the most frequent. The pathergy test showed positive in 15.4% of patients and revealed a higher positive rate in males (20.2%) than in females (12.7%). In conclusion, we performed the first multicenter study on Behcet's disease in Korea and revealed the female predominance, higher frequency of ocular lesions, and lower positivity of pathergy test in the patients.
Adolescence ; Adult ; Aged ; Behcet's Syndrome/complications/*epidemiology ; Child ; Child, Preschool ; Female ; Human ; Infant ; Korea/epidemiology ; Male ; Middle Age ; Prevalence ; Retrospective Studies ; Sex Distribution