We are reporting a case of 25-year-old male patient with elastosis perforance serpiginosa who showed multipte serpiginous plaques on his neck. Some of the lesions showed hypopigmented, hard, scar-tissue like plaques in the central part. Histologic examination showed hyperplasia and transepidermal elimination of elastic tissue. By electron microscopy, also, we could prove that the elastic fibers were increased in the dermis.
Adult ; Dermis ; Elastic Tissue ; Humans ; Hyperplasia ; Male ; Microscopy, Electron ; Neck

Neurologic studies were done on 7 neuro-Behcet's syndrome patients, admitted from June 1985 to June 1986. They were from 30 to 43 years of age with mean age nf 35. 3;3 were male and 4 female. Symptoms fitting more than 3 of the 4 major diagnostic criteria included in Shimizu's classification preceded the neurological symptoms in all 7 patients and they progressed to neuro-Behcet syndrome approximately 5 years after the appearance of the first major syrnptoms of Behcet's syndrome, Severe headache was seen in all 7 patients. Ataxia, dysarthria, increased DTR, and herniplegia. were other rnajor signs found and psychiatric symptoms were present in 2 cases. The cases were neurologically classified as brain stem syndrome in 3 male patients, meningo-encephalitic syndrome in 1, and mixed type in 3. Characterletic laboratory findinge were lncreaeed mononuclear celle in CSF, peripheial blood leukocytosis, and decreased lymphocyte blastogenesis.
Ataxia ; Behcet Syndrome* ; Brain Stem ; Classification ; Dysarthria ; Female ; Headache ; Humans ; Leukocytosis ; Lymphocyte Activation ; Lymphocytes ; Male

No abstract available.
Porokeratosis*

Crohns disease is a granulomatous isease of the gastrointetin 1 tract, especially terminal ileum, but may involve the lip, mouth, anus, skin, liver and bone. The skin is a common site of extraintestinal involvement in Crohns disease, with the perianil, perineal, and peristomal areas most frequently affected. Vulvar involvement, however, is an uncommon extraintestinal manifestantion of Crohns disease. We report a case of a 16-year-old girl with Crohns disease of the vulva and perianal region. A histopathologic study of the descending colon and vulvar skin showed noncaseating granulomatous reactions composed of lymphocytes, epithelioidell and giant cells. We were able to make the diagnosis of Crohns disease of the vulvar and the patient was treated with prednisolone and metronidazole.
Adolescent ; Anal Canal ; Colon, Descending ; Crohn Disease* ; Diagnosis ; Female ; Giant Cells ; Humans ; Ileum ; Lip ; Liver ; Lymphocytes ; Metronidazole ; Mouth ; Prednisolone ; Skin ; Vulva*

Apocrine gland carcinorna is a very rare cutaneous malignancy, By 1987, only about 35 cases are found in the literature. This lesion occurs predominantly in axillae of elderly individuals. It is a mostly asymtomatic nodule or cystic mass. We report herein a case of apocrine gland carcinoma in the right mammary area of 68-year-old male. Histopathological findings were characterized by a glandular arrangement of large cells with abundant. eosinophilic cytcplasm and evidence of decapitation secrtion. The cytoplasm of the tumor cells contained PAS-positive, diastase-resistant granules and lysozy ne. The patient was treated with wide superficial excision includirig t he enough marginal skin. After 20 months, large mass was cleveloped at. the same site and right axi lary lymph nodes were palpabled. Then we treated him by modified radical mastectomy with regional lymph node dissection.
Aged ; Apocrine Glands* ; Axilla ; Cytoplasm ; Decapitation ; Eosinophils ; Humans ; Lymph Node Excision ; Lymph Nodes ; Male ; Mastectomy, Modified Radical ; Skin

Apocrine gland carcinorna is a very rare cutaneous malignancy, By 1987, only about 35 cases are found in the literature. This lesion occurs predominantly in axillae of elderly individuals. It is a mostly asymtomatic nodule or cystic mass. We report herein a case of apocrine gland carcinoma in the right mammary area of 68-year-old male. Histopathological findings were characterized by a glandular arrangement of large cells with abundant. eosinophilic cytcplasm and evidence of decapitation secrtion. The cytoplasm of the tumor cells contained PAS-positive, diastase-resistant granules and lysozy ne. The patient was treated with wide superficial excision includirig t he enough marginal skin. After 20 months, large mass was cleveloped at. the same site and right axi lary lymph nodes were palpabled. Then we treated him by modified radical mastectomy with regional lymph node dissection.
Aged ; Apocrine Glands* ; Axilla ; Cytoplasm ; Decapitation ; Eosinophils ; Humans ; Lymph Node Excision ; Lymph Nodes ; Male ; Mastectomy, Modified Radical ; Skin

The epidermal cell-derived thymocyte activating factor (ETAF) produced by keratinocytes and endowed with IL-1 like activities, can potentiate or stimulate a variety of immune reactionsl. In addition to stimulating thymocyte proliferation, it enhanced IL-2 production by mitogen-stimulated lymphocytes. In this study, IL-2 activity stimulated by ETAF was investigated by using peripheral lymphocytes (PBL)and LBRM33 1A5 cell lines. The expression of HLA-DR antigen and the effect of r-IFN-gamma on IL-1 production by keratinocytes were also evaluated : 1. The HLA-DR positive cultured keratinocytes were obser ved in interferon (IFN), interferon-phorbol myristic acid (IFN-PMA) and interferon-lipopolysaccharide (IFN-LPS) groups. There was no HLA-DR expression in the control. PMA. and LPS group. 2. Il-1alpha from supernatants of cultured keratinocytes were produced by all groups including control group. The amounts of IL-1alpha produced by IFN, IFN-PMA and IFN-LPS groups were higher than the other groups. 3. There were no statistical differences between total IL-1alpha from cultured keratinocytes and control or other experimental groups. 4. In experiment for positivie control, the anrounts of IL-2 production by PBL and LBRM33 1A5 cell line were increased proportional to the concentration of added rIL-1. But there was no difference between groups above 1.0 U/ml and 0.5 fmol in LBRM33 1A5 cell line. 5. the production of IL-2 by PBL were increased by phytohemagglutinin (PHA), PHAPMA and PHA-LPS groups. There were no production of IL-2 in control, IFN, LPS, only LPS added group, and IL-1alpha. The IL-2 induced by PHA-PMA group was much higher than the other groups. The production of IL-2 was stimulated by IL-1 of supernatarnts and cell lysates from the cultured keratinocytes, but here was no correlation between IL-2 production and added IL-1. 6. The production of IL-2 by LBRM33 IA5 were increased by PHA, PHA-PMA and PHA-LPS groups. There were no production of IL-2 in the other groups. In summary, the results suggest that supernatants and cell lysates from cultured keratinocytes can stimulate the IL-2 production by human PBL and LBRM33 1A5 cell line. Therefore the ETAF can potentiate or stimulate the immune reactions and enhance IL-2 production by mitogen-stimulated lymphocytes.
Cell Line ; HLA-DR Antigens ; Humans ; Interferons ; Interleukin-1* ; Interleukin-2* ; Keratinocytes* ; Lymphocytes* ; Myristic Acid ; Thymocytes

A 38-year-old man presented with a 2-year history of recurreit irticaria, abdominal pain and arthralgia of his finger joints. These symptoms were not con rolled in spite of taking medication and had a tendence to be aggravated in the winter. Laboratory findings revealed hvpocomlementemia, hypergammaglobulinemia and a positive rect on with an ice cube test. Skin biopsy specimen taken from the urticarial lesion of the left upper arm showed leukocytoclastic vasculitis with perivascular neutrophilic infiltrition, nuclear dusts, and extravasation of red blood cells. We thus made the diagnosis of hypocomplementemic urtirarial vasculitis syndrome with cold urticaria. The patient was treatcd ith systemic corticosteroids and antihistamines.
Abdominal Pain ; Adrenal Cortex Hormones ; Adult ; Arm ; Arthralgia ; Biopsy ; Diagnosis ; Dust ; Erythrocytes ; Finger Joint ; Histamine Antagonists ; Humans ; Hypergammaglobulinemia ; Ice ; Neutrophils ; Skin ; Urticaria* ; Vasculitis*

Candida granuloma is a variant of chronic mucocutaneous candidasis associated with chronic infection mainly by Candida albicans in which the skin lesions are rather granulomatous and hyperkeratotic. To date a variety of defects of cell mediated immunity have been shown to be important. We describe a 2-year-old boy with cutaneous candida granuloma and immunologic dysfunction.
Candida albicans ; Candida* ; Child, Preschool ; Granuloma* ; Humans ; Immunity, Cellular ; Male ; Skin

Nerve sheath myxoma(NSM) is a rare cutaneous neoplasm of uncertain histogenesis. NSM can be divided into two groups; NSM1 (a myxoid NSM) and NSM2 (a cellular neurothekeoma). NSMs are characterized histologically by well-defined, lobular or plexiform dermal proliferation of stellate, spindle-shaped cells embedded in abundant myxoid stroma. A variable amount of nerve fascicles are entrapped within and around the tumor. Two variants of NSM share the same features to a certain degree but differ in cellularity and mucin deposition. We report two cases of NSMs with different clinical and histopathologic features.
Mucins ; Neurothekeoma*