1.A Case of Acrokeratosis Verruciformis of Hopf.
Korean Journal of Dermatology 1984;22(3):323-326
A case report of a 6p-year-old man with crokeratosis verruciformis on the dorsa of hands & forearms is presented. This case is unusual in that the patient had late onset of the lesions and lack of a family history of the condition. Literatures are reviewed and possible linkage with Darier's disease is discussed.
Darier Disease*
;
Forearm
;
Hand
;
Humans
2.Diffuse Neonatal Hemangiomatosis.
Annals of Dermatology 2003;15(1):17-20
Diffuse neonatal hemangiomatosis (DNH) is a rare entity with the distinctive features of multiple hemangiomas of the skin and internal organs, which may result in a fatal outcome if wide-spread involvement of the internal organs. We report a case of DNH with cutaneous and hepatic involvement. The significant regression in the vascular lesions was achieved with systemic corticosteroid therapy.
Fatal Outcome
;
Hemangioma
;
Skin
3.A Case of Tubular Apocrine Adenoma.
Nack In KIM ; Tuk Woo LIM ; Kyung Dal KIM ; Nack In KIM
Annals of Dermatology 2002;14(2):102-105
Tubular apocrine adenoma(TAA) is a rare benign neoplasm usually found on the scalp. It has been designated as an apocrine histogenesis on the basis of its ultrastructural characteristics, enzyme, and immunohistochemical phenotype. Histopathologically the neoplasm consists of tubules or cysts, which show signs of apocrine secretion and sometimes needs to be differentiated from papillary eccrine adenoma. We report a typical case of TAA on nostril which shows differentiation toward apocrine in nature.
Adenoma*
;
Phenotype
;
Scalp
4.5 Cases of Solitary Mastocytoma.
Annals of Dermatology 1997;9(2):155-158
We report five cases of solitary mastocytoma. All patients were under one year of age and diagnosed as solitary mastocytoma based on clinicopathologic findings. Skin lesions were found on the right forearm, left hand, left leg, left elbow and left shoulder. They resolved themselves spontaneously resolution within 2 or 3 years.
Elbow
;
Forearm
;
Hand
;
Humans
;
Leg
;
Mastocytoma*
;
Shoulder
;
Skin
5.Two Cases of Sequential Cutaneous Lymphomas in Immunocompromised Individuals Who Received Chemotherapies.
Korean Journal of Dermatology 2015;53(3):248-250
No abstract available.
Drug Therapy*
;
Lymphoma*
6.Subcutaneous Panniculitic T-cell Lymphoma.
Annals of Dermatology 1998;10(3):179-184
Subcutaneous panniculitic T-cell lymphoma(SPTCL) is a rare subtype of peripheral T-cell lymphoma that clinically and histologically mimics benign panniculitis. SPTCL is characterized by subcutaneous nodules on the extremities and trunk. It has a tendency to occur mainly in female adults with eosinophilia, pruritus or hemophagocytic syndromes. Histopathologically, typical lesions of SPTCL show moderate to dense lymphocytic infiltrates in the subcutaneous fat, primarily involving the lobules. Early lesions may show only focal lymphocytic atypia: later lesions display karyorrhexis, necrosis and cytophagia. A 34-year-old woman presented with multiple, recurrent, tender subcutaneous nodules on the abdomen and extremities which she had had for 13 years. There was no hepatosplenomegaly or lymphadenopathy. Skin biopsy specimens revealed atypical small and large lymphocytic infiltrations in the subcutaneous tissue. Occasionally, histiocytes contained erythrocytes and lymphocytes in their cytoplasm. Immunohistochemical staining showed positive reactions to CD45RO and CD43. Negative reactions were seen to CD20, Leu-7 and lysozyme antigen. On the basis of the clinical & histological findings, we established the diagnosis of SPTCL.
Abdomen
;
Adult
;
Biopsy
;
Cytoplasm
;
Diagnosis
;
Eosinophilia
;
Erythrocytes
;
Extremities
;
Female
;
Histiocytes
;
Humans
;
Lymphatic Diseases
;
Lymphocytes
;
Lymphohistiocytosis, Hemophagocytic
;
Lymphoma, T-Cell*
;
Lymphoma, T-Cell, Peripheral
;
Muramidase
;
Necrosis
;
Panniculitis
;
Pruritus
;
Skin
;
Subcutaneous Fat
;
Subcutaneous Tissue
;
T-Lymphocytes*
7.Angiocentric T cell Lymphoma associated with Epstein-Barr Virus.
Annals of Dermatology 1999;11(4):292-296
Angiocentric T-cell lymphomas have been described as a distinctive clinicopathologic entity in the spectrum of peripheral T-cell lymphomas, with a prominent invasion of blood vessels by lymphomatous cells. In these conditions, the presence of Epstein-Barr virus (EBV) genomes has been demonstrated, suggesting that EBV might play a major role in their cause. Herein, we report a case of cutaneous angiocentric T cell lymphoma associated with the EBV. The patient was diagnosed with nasal angiocentric T cell lymphoma 5 months ago, and treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) combination chemotherapy. After three cycles of CHOP, skin lesions developed. A skin biopsy specimen showed an angiocentric and angioinvasive infiltrate containing some atypical lymphocytes. EBV encoded RNA (EBER) was demonstrated in lesional skin by in situ hybridization.
Biopsy
;
Blood Vessels
;
Cyclophosphamide
;
Doxorubicin
;
Drug Therapy, Combination
;
Genome
;
Herpesvirus 4, Human*
;
Humans
;
In Situ Hybridization
;
Lymphocytes
;
Lymphoma, T-Cell*
;
Lymphoma, T-Cell, Peripheral
;
Prednisolone
;
RNA
;
Skin
;
Vincristine
8.A Case of Pigmented Malignant Hidroacanthoma Simplex.
Korean Journal of Dermatology 2016;54(10):830-831
No abstract available.
9.A Clinical Study on Topical Vitamin A Acid In Acne Vulgaris.
Korean Journal of Dermatology 1976;14(4):305-313
In 1932, Harris, et al., reported that vitamin A had an anti-keratinizing effect on acne vulgaris, and in 1948, Straumfjord, somewhat over-enthusiastically reported that oral use of vitamin A also had a beneficial effect on acne. In spite of studies by Lynch and Cook (1947), and Andrew and Stokoe (1963), which questioned its effectiveness, the original enthusiasm for this regimen has not been completely dampened. Kligman (1969) reported that vitamin A acid (VAA), a metabolic end-product of vitamin A metabolism, produced a peeling effect and when applied topical was effective in tbe treatment of acne. The mechanism of action of VAA is incompletely understood, however, it is observed to cause, arnong other things, an increase in the speed of proliferation of the cells of the epidermis; dissolution of the intracellular lysosomes; increase in the rate of keratin formation and the conversion of hard keratin to soft keratin; and an increase in the secretion of the sebaceous glands. The effect of VAA in acne treatment is due to the increase in the secretion of the sebaceous glands which prevents the formation of comedones. It is believed that the increased spced of cell division, increased keratinization and softening of the keratin cause a weakening of the intercellular adhesion. These processes cause an acceleration of the flow of cells out of the sebaceoua glands which prevents the formation of comed.ones and forces existing comedones to the surface of the skin. For this study, thirty eight patients with acne vulgaris were selected from among the outpatients of Severance Hospital. They were divided into two groups. The first group was treated with application of vitamin A acid alone. The second group was treated concurrently with topical vitamin A acid and oral tetracycline. The results were a.s folIows: l. The group treated for three weeks with VAA alone showed significant improvement in up to 70 of the cases. 2. The group treated with VAA and oral tetracycline showed results which were sirnilar to the group on VAA alone. 3. In both groups. closed cornedones and papules gradually disappeared, however, the number of open com.dones increased in the first week, but decreased threafter, In combined therapy, pustules disappeared grad.ually just like the papules, but in therapy with VAA alone, the number of pustules increased during tbe first week and decreasd. thereafter. 4. In the group which was treated with VAA alone, undesirable side effects such as scaling, erythema, tightness, itching and burning sensation were seen, and also occasionally fissures, edema, pain and oozing were noted. In the group treated with combined therapy, similar findings were recorded.
Acceleration
;
Acne Vulgaris*
;
Burns
;
Cell Division
;
Edema
;
Epidermis
;
Erythema
;
Humans
;
Lysosomes
;
Metabolism
;
Outpatients
;
Pruritus
;
Sebaceous Glands
;
Sensation
;
Skin
;
Tetracycline
;
Tretinoin*
;
Vitamin A*
;
Vitamins*
10.Clinical Study On Topical Vitamin A Acid Derivetive (VAAD) in Acne Vulgaris.
Korean Journal of Dermatology 1977;15(4):415-421
Although many regimens for the acne therapy were proposed and vere used upto date, there is, no ideal choice of treatment. Since a certain relationship between the vitamin A and some dermatoses accompanied, with dyskeratoses had been proposed by Harris in 1932. many studies have been reported for the acne treatment with vitamin A topical or oral administration. (Straumfjord 1943, Lynch & Cook 1947, Anderson & Stokoe 1968). In 1969, Kligman observed the peeling effect of vitamin A acid (VAA), a metabolite of vitamin A, on the human skin and he experienced very good effect of VAA topical application on acne patients. Tbereafter, many authors studied about the VAA and reported the excellent effect on acne (McGills et al. 197l, Mills R Plewig 1972, Juhlin 1975). Moxeover, in 1976, Kim & Lee observed similar results with the authors mentioned above in its cure rate and side effects. In contrast to their high cure rate in those studies, however, its untoward side effects were freqvently elicited with severe intensity. So, author studied the effectiveness and side effects of VAAD which was changed in its chemical structure to diminish the side effects of VAA. Thirty-seven patients (M:F=4:33) were studied, and the results obtained were as follows. 1. The total number of lesions decreased significantly from third week and decreased by half in 4th. week. 2. The number of closed comedones decreased significantly from second week but the number of open comedones temporarily increased in 1st. week and decreased thereafter. 3. pustules and papul s continually decreased but new pustule formation developed in 3 patients and also disappeared in 4 weeks of treatment. 4. Allergic contact dermatitis was developed in 1 patient among 37 patients in 4th. week. 5. There were some undesirable side effects of scaling, pruritus, buming sensation in about 80% respectively, but its intensity was mild or moderate, and fissure, edema and exudation which appeared in VAA treatment were not observed. only a few patients complained tightness, erythema and pain. In comparison with VAA, the duration of treatment with VAAD was delayed about 1-2 weeks and the effectiveness in acne therapy with VAAD was almost equal to VAA therapy, and the side effects were markedly diminished.
Acne Vulgaris*
;
Administration, Oral
;
Dermatitis, Allergic Contact
;
Edema
;
Erythema
;
Humans
;
Pruritus
;
Sensation
;
Skin
;
Skin Diseases
;
Tretinoin*
;
Vitamin A*
;
Vitamins*