ObjectiveTo investigate the influential factors on the deaf children's hearing and speech rehabilitation.Methods43 deaf children were involved in our study. They performed the hearing thresholds, hearing ability, speech ability and learning aptitude tests.ResultsGender and hearing aid mode didn't correlate with the children's hearing and speech performance (P>0.05). Hearing thresholds had significant influence on the hearing ability (P<0.05), and the speech ability had a strong correlation with the children's learning aptitude (P<0.05). The multiple regression analysis showed that the hearing ability was a significant predictor of speech ability (P<0.001).ConclusionGiving hearing compensation timely and effectively and grasping the critical period of language development to do rehabilitation training as soon as possible are very important to deaf children's rehabilitation of hearing and speech ability.

Transient receptor potential(TRP) superfamily includes seven subfamilies and TRP channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family have been reported to be regulated by phosphatidylinositol 4,5-bisphosphate(PIP2). The regulation is complex and it can be activation or inhibition, involving multiple mechanisms and factors. This review summarizes the PIP2 regulation of several TRP channels of different superfamilies and the related pathophysiological significance.

Objective: To study the anti-inflammatory, analgesic and immunosuppressive action of Niuhuang Qianjin San (NQS). M ethods: The anti-inflammatory action of NQS was studied by the methods of rat pa w swelling and mouse ear swelling and the analgesic action by mouse body torsion method and K+ subcutaneous penetration method in rats.Immunosuppressive effec t was evaluated by peripheral T lymphocyte percentage, splenic lymphocyte transfor mation ratio, phagocytic function of intraperitoneal magocytes, the activity of delayed hypersensitivity, serum hemolysin level and the function of antibody-yie lding cells in mice. Results: NQS could obviously alleviate inflammation, increa se codeine's analgesic action and suppress immunity. The difference were signif icant (P<0.01) as compared with normal saline contr ol group.Conclusion:NQS exerts certain anti-inflammatory,analagisic and immunosu ppressive action.

Objective: To study the anti-inflammatory, analgesic and immunosuppressive action of Niuhuang Qianjin San (NQS). Methods: The anti-inflammatory action of NQS was studied by the methods of rat paw swelling and mouse ear swelling and the analgesic action by mouse body torsion method and K + subcutaneous penetration method in rats.Immunosuppressive effect was evaluated by peripheral T lymphocyte percentage, splenic lymphocyte transformation ratio, phagocytic function of intraperitoneal magocytes, the activity of delayed hypersensitivity, serum hemolysin level and the function of antibody-yielding cells in mice. Results: NQS could obviously alleviate inflammation, increase codeine's analgesic action and suppress immunity. The difference were significant (P

Objective To investigate the distribution and susceptibility of carbapenem resistant citrobacter freundii for rational antimicrobial therapy.Methods The C.freumdii were collected between January 2011 and December 2014 from inpatients.The minimum inhibitory concentration (MIC) were detected by an automated analyzer (VITEK 2) to analyze the characteristic of tested bacteria.Results (1) Of the 21 strains of carbapenemresistant citrobacter freundii,95％ were collected from urine,among which most of the strains were isolated from the Department of Transplantology (66.7％) and Urology (19％);(2) Antimicrobials Susceptibility test showed that Citmbacter freund were highly resistant to Cephalosporins and relevant beta-lactamase inhibitors.Even carbapenem were highly resistant.Imipenem had a resistance rate of 90％ (95％ confidence interval:70 to 99),Meropenem 85.7％ (95％ confidence interval:64 to 97),The drug resistance rate to Amikacin was only 4.8％,followed by Nitrofuran toin (10.5％) and Fosfomycin (15％).Conclusions Carbapenem resistant citrobacter freundii,which often causes urinary tract infection in our hospital,was characterized by multi-drug resistant (MDR).Monitoring of the Citrobaeter freundii should be strengthened to control the prevalence of drug resistance.

Objective To study the therapeutic effect of intravitreal injection of ranibizumab combined with vitrectomy for the treatment of neovascular glaucoma (NVG). Methods The clinical data of 21 NVG patients who had underwent vitrectomy were retrospectively analyzed. The patients were treated with intravitreal injection of ranibizumab 0.5 mg, then were given the vitrectomy after 3 to 5 d after treatment. The whole retinal photocoagulation was performed during the operation. Cataract surgery was combined in 16 patients, and ciliary photocoagulation was combined in another 15 patients. All patients were followed up for 6 to 12 months, and the intraocular pressure, visual acuity and neovascularization of iris (NVI) were observed. Results The rate of NVI symptoms resolving completely 3 weeks after operation was 80.95％(17/21). The intraocular pressure 1 week, 1 month, 3 months and 6 months after operation was significantly lower than that before operation: (18.6 ± 5.1), (14.3 ± 4.8), (12.8 ± 4.4), (15.1 ± 3.7) mmHg (1 mmHg=0.133 kPa) vs. (42.8 ± 7.3) mmHg, and there was statistical difference (P<0.05). Two months after operation, 2 cases were not able to control by chemicals, and were treated with transscleral cyclophotocoagulation. Six months after operation, the intraocular pressure was completely controlled in 15 cases, and conditionally controlled in 6 cases. No ocular hypotension occurred. The visual acuity was not improved in 4 cases, but the rest were improved in different degrees. Conclusions For the patients of NVG combined with vitreous hemorrhage and obvious proliferation, intravitreal injection of ranibizumab in the first place, and then combined with vitrectomy, whole retinal photocoagulation and ciliary photocoagulation can obtain good effect.

Background Endophthalmitis is a serious infectious eye disease.Efficient drug therapy plays a key role in the early stage.There have been few researches on teicoplanin treating endophthalmitis and pharmacokinetics in ocular tissue.Objective The present study was to investigate the intraocular pharmacokinetic course and feature of intravitreal administration of teicoplanin.Methods Thirty-three Japanese white rabbits were included in this study and randomized into 6 groups.The right eyes of the rabbits were used in experiment.5 g/L of teicoplanin was injected into the vitreous cavity,and vitreous and aqueous humor samples were extracted after 15 minutes,30 minutes,1,2,4,6,12,24,48,96 and 192 hours,and the concentration of teicoplanin was determined by bioassay.Results The logarithmic value of the concentration of teicoplanin was raised with the increase in the bacterial inhibition zone diameters,of which the equation of the regression curve was Y =0.174X-0.813(R2=0.999).A good linear relationship was presented within 1.0-80.0 mg/L.Single intravitreal injection of teicoplanin was compliant with the two-compartment model.Moreover,the distribution phase Tα1/2 and elimination phase Tβ1/2 of vitreous were 1.68 and 152.15 hours,separately.And Tα1/2 and Tβ1/2 of the aqueous humor were 2.83 hours and 70.56 hours,individually.The peak teicoplanin concentrations in the vitreous and aqueous humor were(358.47±21.53)mg/L and(102.17±9.54)mg/L at 1 hour,respectively and remained at(4.38±0.68)mg/L and(2.38±0.38)mg/L,respectively 192 hours later.Conclusions Intravitreal injection of 0.5 mg of teicoplanin can remain therapeutic concentration for a long time in the vitreous and aqueous humor.

Objective To explore the characteristic of SPECT/CT imaging of osteolytic lesions with increased bone metabolism and its correlation with CT manifestation. Methods Twenty?one cancer patients with bone metastases underwent 99 Tcm?MDP SPECT/CT imaging ( 13 males, 8 females; age: ( 60. 52 ± 6?85) years) were retrospectively studied. The imaging characteristic of the lesion with high uptake of 99Tcm?MDP was observed and the correlation between the lesion/background ( L/B ) ratio and CT manifestation were analyzed. One?way analysis of variance, two?sample t test and linear correlation analysis were used. Results A total of 111 lesions were found in 21 patients by 99 Tcm?MDP whole?body bone scan, and 125 le?sions were found by SPECT/CT imaging, including 111 lesions with increased bone metabolism and abnor?mal CT manifestation and 14 osteolytic lesions with decreased bone metabolism. In 111 lesions with in?creased bone metabolism, there were 23(20.72%) osteolytic lesions, 54 (48.65%) osteoblastic lesions and 34 (30.63%) mixed lesions. The L/B ratio of osteolytic lesions with increased bone metabolism (11.82± 6?61) was lower than that of osteoblastic lesions (20.03±13.24) and that of mixed lesions (25.42±19.51;F=6.00, P<0?05) . The CT value of osteolytic lesions with increased bone metabolism was higher than that of osteolytic lesions with decreased bone metabolism :(167.53±79.21) HU vs (88.63±49.16) HU; t=3?345, P<0.05. The L/B ratio of lesions with increased bone metabolism was positively correlated to CT val?ue(r=0.404, P<0?05). Conclusions A part of lesions with increased bone metabolism on SPECT/CT im?ages are osteolytic lesions. The L/B ratio of them is positively correlated to CT value. SPECT/CT imaging can reduce missed diagnosis and misdiagnosis.

Objective To explore the significance of 18fluorodeoxyglucose positron emission tomography(18F?FDG PET/CT)in the etiological diag?nosis of postoperative intestinal obstruction in patients with gastrointestinal cancer. Methods A total of 51 patients with postoperative intestinal ob?struction undergone 18F?FDG PET/CT were enrolled for the study. The images were interpreted by visual and semi?quantitative analysis(maximum standard uptake value,SUVmax). All the cases were confirmed by pathology and clinical follow?up for more than half a year. The sensitivity,specifici?ty and accuracy of 18F?FDG PET/CT for detecting malignant intestinal obstruction were calculated. Results Of the 51 patients,35 cases were con?firmed for malignant intestinal obstruction,and 16 cases were caused by other benign diseases. 18F?FDG PET/CT imaging was positive in 36 cases, and 33 cases were diagnosed as malignant and recurrent intestinal obstruction. Three cases of PET false?positive were peritonitis adhesion and anasto?motic inflammation. Two cases of PET false negative were peritoneal micrometastasis. The SUVmax of malignant lesions was 8.86±4.82,and the SUVmax of benign lesions was 2.05±1.95. The uptake of FDG was significantly higher in malignant intestinal obstruction than in benign intestinal obstruction (t=7.15,P<0.01). The sensitivity,specificity,and accuracy of 18F?FDG PET/CT diagnosis of malignant lesion were 94.3%,81.3%,and 90.2%, respectively. Conclusion The uptake of 18F?FDG in malignant intestinal obstruction was higher than that in benign intestinal obstruction. 18F?FDG PET/CT have a good diagnostic value for the intestinal obstruction of postoperative gastrointestinal cancer.