1.Mammographic findings of breast cancer: Emphasis on the tumor and microcalcifications.
Tae Myon KIM ; Hye Young CHOI ; Seung Yon BAEK ; Su Na CHOI
Journal of the Korean Radiological Society 1993;29(4):833-838
Most of the breast cancer revealed mass and/or microcalcifications on mammography. We analyzed morphologic characteristics of the masses and microcalcifications on mammography which confirmed as breast cancer pathologically. Of all 54 cases, 4 patients (7%) showed microcalcification only, 27 patients (50%), mass only, and the other 23 patients (43%), both microcalcification and mass on the mammography. The margin of the breast mass were ill-defined in 37 cases, well-defined in 8 cases, and well-defined with surrounding infiltration in 5 cases. The morphologic characteristics of the microcalcification were punctate-linear-V shape in 11 patients, punctate-linear shape in 9 patients, and punctate shape in 7 patients.
Breast Neoplasms*
;
Breast*
;
Humans
;
Mammography
2.Effect of presurgical nasoalveolar molding (PNAM) appliance and cheiloplasty on alveolar molding of complete unilateral cleft lip and palate patients.
Na Young KIM ; Shin Jae LEE ; Seung Hak BAEK
Korean Journal of Orthodontics 2003;33(4):234-245
The goal of the present study was to evaluate the effects of PNAM appliance and cheiloplasty on alveolar molding. Samples consisted of 16 unilateral cleft lip and palate infants (10 males and 6 female, mean age=37.0 days after birth, average alveolar cleft gap=10.46 mm), who were treated with PNAM appliances by one orthodontist and rotation- advancement cheiloplasty by one surgeon in Seoul National University Hospital. Average duration of alveolar molding treatment was 13.10 weeks and these patients were recalled at average 8.31 weeks after cheiloplasty. These patients' models were obtained at initial visit (T0, mean age : 37.0+/-27.89 days after birth), after successful alveolar molding (T1, mean age : 119.25+/-40.18 days after birth), and after cheilopasty (T2, mean age : 190.81+/-42.78 days after birth). Seven linear and five angular variables were measured using 1 : 1 photometry and soft ware program(V-ceph. Cybermed, Seoul, Korea). Paired t-test was performed to investigate statistical significance at p < 0.05 level. 1. The posterior parts of alveolar segments were the stable structures during alveolar molding treatment period and after cheiloplasty in infants. 2. The closure of cleft gap during alveolar molding was usually due to backward bending of the whole part of the greater segment. 3. Although forward growth of the greater segment was hindered by alveolar molding, it resumed after cheiloplasty. 4. Increase of anterior inter-segment angle after cheiloplasty was due to the molding effect of the lip scar pressuren
Cicatrix
;
Cleft Lip*
;
Female
;
Fungi*
;
Humans
;
Infant
;
Lip
;
Male
;
Palate*
;
Parturition
;
Photometry
;
Seoul
3.A Case of Cutaneous Zosteriform Metastatic Carcinoma Arising on the Healed Site of Herpes Zoster.
So Young NA ; Hye Young LEE ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2008;46(3):347-351
We report a case of a 67-year-old man presenting with a 2-week history of erythematous zosteriform indurated confluent nodules and plaques on the right chest which was affected by a herpes zoster infection one month ago. The previous history revealed an adenocarcinoma with malignant pleural effusion on the right lung (stage IV, T4N1M1) 3 months ago. Histopathologic findings showed tumor cells infiltrated throughout the dermis, forming focal glandular structures. We think that the case was the isotopic response in the form of an occurrence of a new skin disorder at the site of another unrelated and already healed skin disease. Many cases of isotopic response have been reported in Korean literature such as lichen planus, granuloma annulare, benign fibrous histiocytoma and reactive perforating collagenosis occurring on the healed site of herpes zoster infection. This is the first report of cutaneous metastatic carcinoma as an isotopic response in Korea.
Adenocarcinoma
;
Aged
;
Dermis
;
Granuloma Annulare
;
Herpes Zoster
;
Histiocytoma, Benign Fibrous
;
Humans
;
Lichen Planus
;
Lung
;
Pleural Effusion, Malignant
;
Skin
;
Skin Diseases
;
Thorax
4.A Case of Cellulitis Associated with Coral Injury.
So Young NA ; Hye Young LEE ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Annals of Dermatology 2008;20(4):212-215
Corals are the marine organism that belongs to the phylum Cnidaria, and are one of the common causes of superficial injury in the marine environment. In addition to acute reactions such as burning or stinging pain and erythema, coral injuries may present with complications such as foreign body reactions, bacterial infections, and/or localized eczematous reactions. A 23-year-old male presented with an erythematous edematous tender patch with centrally grouped vesicles on the left ankle; the injury had occurred during skin-scuba diving 2 days before. A biopsy of the lesion treated with hematoxylin-eosin stain showed epidermal necrosis with subepidermal blisters and neutrophilic panniculitis. Herein we report a case of cellulitis caused by the nematocyst stings of corals.
Anthozoa
;
Aquatic Organisms
;
Bacterial Infections
;
Biopsy
;
Bites and Stings
;
Blister
;
Burns
;
Cellulitis
;
Cnidaria
;
Diving
;
Erythema
;
Foreign Bodies
;
Humans
;
Male
;
Necrosis
;
Nematocyst
;
Neutrophils
;
Panniculitis
;
Young Adult
5.A Case of Metastatic Neuroendocrine Carcinoma of the Lung Concomitant with Adenocarcinoma of the Stomach.
Hye Young LEE ; So Young NA ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2008;46(4):533-537
Neuroendocrine tumors derive from the diffuse neuroendocrine system producing hormonal peptides and/or biogenic amines. Histologically neuroendocrine differentiation includes ultrastructural demonstration of neurosecretory granules and staining with immunhistochemical markers such as neuron-specific enolase, chromogranin, synaptophysin, and cytokeratin. Neuroendocrine carcinoma of the skin is rare but can be shown as an initial manifestation of metastatic neuroendocrine carcinoma as well as primary cutaneous neuroendocrine carcinoma. Histological differentiation between primary cutaneous Merkel cell carcinoma and metastatic neuroendocrine carcinoma of the skin is difficult and clinical correlation is important. We report a case of metastatic neuroendocrine carcinoma of the lung occurring on the scalp as a single nodule in a 65-year-old female who previously diagnosed with adenocarcinoma of the stomach.
Adenocarcinoma
;
Aged
;
Biogenic Amines
;
Carcinoma, Merkel Cell
;
Carcinoma, Neuroendocrine
;
Female
;
Humans
;
Keratins
;
Lung
;
Neuroendocrine Tumors
;
Neurosecretory Systems
;
Peptides
;
Phosphopyruvate Hydratase
;
Scalp
;
Skin
;
Stomach
;
Synaptophysin
6.A Case of Elephantiasis Nostras Verrucosa Caused by Recurrent Infection after Skin Grafting.
So Young NA ; Hye Young LEE ; Jin Ok BAEK ; Joo Young ROH ; Jong Rok LEE
Korean Journal of Dermatology 2009;47(3):365-367
Elephantiasis nostras verrucosa is an uncommon disorder that is characterized by dermal fibrosis, hyperkeratotic verrucous and papillomatous lesions and this is all caused by chronic non-filarial lymphedema secondary to infections, surgeries, tumor obstructions, radiations, congestive heart failure and obesity. We report here on a case of elephantiasis nostras verrucosa that occurred on the left lower leg of a 54-year-old woman who had a past history of extensive skin grafts and recurrent infection.
Elephantiasis
;
Female
;
Fibrosis
;
Heart Failure
;
Humans
;
Leg
;
Middle Aged
;
Non-Filarial Lymphedema
;
Obesity
;
Skin
;
Skin Transplantation
;
Transplants
7.A Case of Mucin - producing Cholangiocarcinoma in the Patient with Recurrent Cholangitis.
Na Young LEE ; Sun Young YI ; Il Hwan MOON ; Seung Yean BAEK
Korean Journal of Gastrointestinal Endoscopy 1998;18(6):957-962
Free-floating tumor debris or mucobilia as a cauae of intermittent obstruction has been described infrequently. A middle aged woman with intermittent jaundice caused by abundant mucus from an intrahepatic mucinous cholangiocarcinoma is presented. Symptoms of juandice, midepigastric pain and fever developed despited an intitial cholecystectomy and common bile duct stone extraction using endoscopic retrograde cholangography (ERCP). Intraductal mucin was diagnosed through on ERCP and confirmed intraoperatively and pathologically as the cause of the obstructive juandice. The patient remained asymptomatic and without evidence of disease for more than 2 years postoperatively. Description is presented of the patient who was admitted presented with recurrent cholangitis caused by profuse secretion of mucus by mucin-producing cholangiocaricnoma, with a review of relevant literature.
Cholangiocarcinoma*
;
Cholangiopancreatography, Endoscopic Retrograde
;
Cholangitis*
;
Cholecystectomy
;
Common Bile Duct
;
Female
;
Fever
;
Humans
;
Jaundice
;
Middle Aged
;
Mucins*
;
Mucus
8.Bone Signal Abnormality, as seen on Knee Joint MRI: Relationship between Its Location and Associated Injury.
Young Nam KIM ; Baek Hyun KIM ; Hoe Seok JUNG ; Eui Sung NA ; Hye Young SEOL ; In Ho CHA ; Hong Chul LIM
Journal of the Korean Radiological Society 1998;39(1):149-153
PURPOSE: The purpose of the study was to evaluate the relationship between the location of bone signalabnormality and associated injury, as seen on MR, in patients with acute knee joint injury. MATERIALS AND METHODS: Thirty-six patients with acute knee injury and bone signal abnormalities on MR were included in this study. Thefemur and tibia were each divided into six compartments, namely the anteromedial, medial, posteromedial,anterolateral, lateral, and posterolateral ; these were obtained in each knee joint. We evaluated the location ofbone signal abnormality and the corresponding arthroscopic or operative findings of injury to ligaments andmenisci. Cases with signal abnormalities involving more than three compartments were excluded. RESULT: Bonesignal abnormalities were demonstrated in 51 compartments. Most(84%, 43/51) were noted in the lateral half of theknee joint, the most common location being the tibio- posterolateral compartment(13/51). The femoro-lateral(11/51) and tibio- anterolateral compartment(8/51) were the next most common locations. All cases(13/13)with bone signal abnormality in the tibio- posterolateral compartment had tears at the anterior cruciate ligament,while 9 of 11 cases(81%) with abnormality in the femoro- lateral compartment had tears at the anterior cruciateligament. Six of eight cases(75%) with signal abnormality in the tibio- anterolateral compartment had tears at theposterior cruciate ligament ; 31 of 43 cases (72%) with abnormality in the lateral half of the knee joint hadtears at the medial collateral ligament. Six of eight cases(75%) with signal abnormality in the medial half of theknee joint had tears at the medial meniscus, but no lateral meniscal tear was found. Among patients with signalabnormality in the lateral half of the knee joint, the tear was lateral meniscal in nine of 43 cases(21%) andmedial meniscal in six of 43(14%). CONCLUSION: The location of bone signal abnormality, as seen on knee MR, inpatients with acute knee joint injury could be an important finding suggesting associated injury.
Collateral Ligaments
;
Humans
;
Inpatients
;
Joints
;
Knee Injuries
;
Knee Joint*
;
Knee*
;
Ligaments
;
Magnetic Resonance Imaging*
;
Menisci, Tibial
;
Tibia
9.Association between MSX1 SNPs and Nonsyndromic Cleft Lip with or without Cleft Palate in the Korean Population.
Na Young KIM ; Young Ho KIM ; Ji Wan PARK ; Seung Hak BAEK
Journal of Korean Medical Science 2013;28(4):522-526
The purpose of this study was to investigate the contribution of MSX1 gene to the risk of nonsyndromic cleft lip with or without cleft palate (NS-CL +/- P) in the Korean population. The samples consisted of 142 NS-CL +/- P families (9 with cleft lip, 26 with cleft lip and alveolus, and 107 with cleft lip and palate; 76 trios and 66 dyads). Three single nucleotide polymorphisms (SNPs: rs3821949, rs12532, and rs4464513) were tested for association with NS-CL +/- P case-parent trios using transmission disequilibrium test (TDT) and conditional logistic regression models (CLRMs). Minor allele frequency, heterozygosity, chi2 test for Hardy-Weinberg equilibrium, and pairwise linkage disequilibrium (LD) at each SNP were computed. The family- and haplotype-based association test programs were used to perform allelic and genotypic TDTs for individual SNPs and to fabricate sliding windows of haplotypes. Genotypic odds ratios (GORs) were obtained from CLRMs using R software. Although the family-based TDT indicated a meaningful association for rs3821949 (P = 0.028), the haplotype analysis did not reveal any significant association with rs3821949, rs12532, or rs4464513. The A allele at rs3821949 had a significant increased risk of NS-CL +/- P (GOR, 1.64; 95% confidence interval,1.03-2.63; P = 0.038, additive model). A positive association is suggested between MSX1 rs3821949 and NS-CL +/- P in the Korean population.
Alleles
;
Asian Continental Ancestry Group/*genetics
;
Cleft Lip/*genetics
;
Cleft Palate/*genetics
;
Female
;
Gene Frequency
;
Genotype
;
Haplotypes
;
Humans
;
Linkage Disequilibrium
;
Logistic Models
;
MSX1 Transcription Factor/*genetics
;
Male
;
Odds Ratio
;
*Polymorphism, Single Nucleotide
;
Republic of Korea
;
Risk Factors
;
Software
10.Clinical outcomes of and risk factors for secondary infection in patients with severe COVID-19: a multicenter cohort study in South Korea
Yong Sub NA ; Ae-Rin BAEK ; Moon Seong BAEK ; Won-Young KIM ; Jin Hyoung KIM ; Bo young LEE ; Gil Myeong SEONG ; Song-I LEE
The Korean Journal of Internal Medicine 2023;38(1):68-79
Background/Aims:
Secondary infection with influenza virus occurs in critically ill patients and is associated with substantial morbidity and mortality; however, there is limited information about it in patients with severe coronavirus disease 2019 (COVID-19). Thus, we investigated the clinical outcomes of and risk factors for secondary infections in patients with severe COVID-19.
Methods:
This study included patients with severe COVID-19 who were admitted to seven hospitals in South Korea between February 2020 to February 2021. Multivariate logistic regression analyses were performed to assess factors associated with the risk of secondary infections.
Results:
Of the 348 included patients, 104 (29.9%) had at least one infection. There was no statistically significant difference in the 28-day mortality (17.3% vs. 12.3%, p = 0.214), but in-hospital mortality was higher (29.8% vs. 15.2%, p = 0.002) in the infected group than in the non-infected group. The risk factors for secondary infection were a high frailty scale (odds ratio [OR], 1.314; 95% confidence interval [CI], 1.123 to 1.538; p = 0.001), steroid use (OR, 3.110; 95% CI, 1.164 to 8.309; p = 0.024), and the application of mechanical ventilation (OR, 4.653; 95% CI, 2.533 to 8.547; p < 0.001).
Conclusions
In-hospital mortality was more than doubled in patients with severe COVID-19 and secondary infections. A high frailty scale, the use of steroids and application of mechanical ventilation were risk factors for secondary infection.