Objective To study the difference of CD4⁺ T cell count among different genotypes of HIV infected people in Xi'an from 2017 to 2021. Methods A total of 1 623 newly diagnosed AIDS patients in the AIDS prevention and control information system in Xi'an from 2017 to 2021 were selected. The genotypes of all the patients were sequenced, and the differences of CD4+T cell counts among different genotypes were analyzed. Results From 2017 to 2021, the main genotype of HIV infected people in Xi'an was CRF01_ AE（921/1623）、CRF07_ BC（145/1623）、CRF08_ BC (557/1623), the gene cluster is mainly CRF01_ AE (cluster 1) (185/ 1623) and CRF01_ AE (cluster 2) (1438/1623), where CRF01_ The average CD4⁺ T cell count of AE genotype was (146.26 ± 11.63)/μ L，CRF07_ The average CD4⁺ T cell count of BC genotype was (254.69 ± 15.49)/μ L，CRF08_ The average CD4⁺ T cell count of BC genotype was (217.96 ± 12.89)/μ L，CRF01_ The average number of CD4⁺ T cells in AE (cluster 1) was (185.58±12.79)/ μ L，CRF01_ The average number of CD4⁺ T cells in AE (cluster 2) was (179.90 ± 15.96)/ μ 50. There was significant difference in CD4⁺ T cell count among patients with different gene subtypes and gene clusters (P<0.05). Conclusion From 2017 to 2021, the main genotype of HIV infected people in Xi'an was CRF01_ AE, the gene cluster is mainly CRF01_ AE (Cluster 2), there were significant differences in CD4+T cell counts among patients with different gene subtypes and gene subsets, which could serve as a reference target for AIDS treatment in this Municipality.

Objective To understand the prevalence of chronic kidney disease (CKD) in the elderly in xuzhou area and the main related factors, and to provide a theoretical basis for the prevention and treatment of CKD. Methods Xuzhou gulou, mountain springs, deals for the city select venture, peixian county rural countryside, deals with the community (village) as unit, adopt the method of stratified cluster sampling, a random sample of urban and rural community people aged 60 to 79, and residents living longer than six months as investigation object, obtain 482 valid data, chronic kidney disease (CKD) sampling investigation, All subjects underwent conventional questionnaires, including gender, age, occupation, chronic disease history, family history, etc. Laboratory tests included, UA, SCr, FBG, 2H PBG, TG and TC levels. EGFR was calculated based on SCr, and logistic regression was used to analyze the independent risk factors for CKD in the elderly in community. Results Among 482 elderly patients, 259 were males and 223 were females, with an average age of (45.73±6.14) years. 63 patients with CKD were diagnosed, with a prevalence rate of 13.07%. The prevalence of chronic diseases was 20.33%(98/482) for hypertension, 15.15%(73/482) for hyperuricemia, 11.00%(53/482) for overweight or obesity, 8.71%(42/482) for hyperlipidemia and 6.430%(31/482) for diabetes. The prevalence of CKD in 70-79 year olds was significantly higher than that in 60-69 year olds (χ²=6.621 , P<0.05). There were statistically significant differences in age, hypertension, diabetes and hyperuricemia between 2 groups (P<0.05). Logistic regression analysis showed that advanced age, hypertension, diabetes and hyperuricemia were independent risk factors for CKD in elderly population in Xuzhou area (P<0.05). Conclusion The prevalence of CKD in the elderly in Xuzhou community is high, and the main risk factors are advanced age, diabetes, hypertension and hyperuricemia. It is necessary to actively carry out early screening of CKD and take effective preventive measures to effectively delay the development of CKD and prevent the occurrence of end-stage renal disease.