Lanolin is a complex material consisting of a mixture of numerous esters and polyesters of high-moleculer-weight alcohols and fatty acids, Lanolin allergy is important because lanolin is widely used as an emulsifier in topical medicaments and in numerous cosmetic preparations. We report a case of allergic contact dermatitis in a 27-year-old female. An erythematous pruritic rash develgood around the eyelid developed after applying a new eye cream and was aggravated after applying Cambison ophthalmic ointment. Patch testing showed positive reactions to Cambison ophthalmic ointment, 30% wool alcohol, Amerchol L101 and Nivea cream. A use test with 100% Cambison ophthalmic ointment base was positive
Adult ; Alcohols ; Dermatitis, Allergic Contact* ; Esters ; Exanthema ; Eyelids ; Fatty Acids ; Female ; Humans ; Hypersensitivity ; Lanolin* ; Patch Tests ; Polyesters ; Wool

BACKGROUND: Cryosurgery uses freezing temperatures to achieve specific effects on tissues, and this method has been used to treat various skin diseases for the last five decades. The modern cryosurgery is especially effective on the treatment of benign, premalignant and malignant lesions including keloid, hypertrophic scar and pigmented disease such as Ota nevus. The results of cryosurgery depend on such factors as types of cryogen, freezing and thawing time, and numbers of the freezing-thawing cycle. OBJECTIVE: The purpose of this study is to show differences among groups of disease, sites of treatment and applying methods through comparing freezing and thawing time. And specifying the optimum applying methods for the treatment of each specific disease is studied. METHOD: To attain the goal of the study, operation records of 224 patients, who received cryosurgical treatment at the Ewha Woman's University Dongdaemoon Hospital, have been analyzed. RESULTS: 1. The numbers of male and female patients of selected group were 74 and 150, respectively, and their ages between 2 and 54 years. Among the group, 42 patients had epidermal pigmentary disease, 77 had dermal pigmentary disease and 105 had scars. 2. Ratios of TT(thawing time) to FT(freezing time) were significantly different among groups of disease(p<0.05). 3. Ratios of TT to FT were significantly different among groups of treatment site(p<0.05). 4. Ratios of TT to FT showed great difference between the group of rolling method applied and one of pressure method applied(p<0.05). CONCLUSION: The output of this study indicates that the result of the cryosurgery tends to be heavily influenced by the surgical method that is employed. It also proves that the pressure method tends to inflict more severe cryoinjury on the tissues than the rolling method. Each different tissue shows different sensitivity to the cold injury, and the longer the thawing time is, the more cryoinjury of tissues occurs. Therefore, to achieve the maximum therapeutic result while minimizing the undesired effect, adequate surgical method should be selected and applied to each specific disease. This concept is introduced in this study as "Theory of Selective Cryolysis.".
Cicatrix ; Cicatrix, Hypertrophic ; Cryosurgery* ; Female ; Freezing ; Humans ; Keloid ; Male ; Nevus of Ota ; Skin Diseases

We report a case of cutaneous bronchogenic cyst accompanied by many lymphoid follicles histopathologically. A 6-year-old boy had an erythematous macule with a pinpoint-sized opening intermittently draining mucinous material on the anterior chest. Histopathologic findings showed an irregularly folded cystic structure extending from the deep dermis to subcutis. It was lined by ciliated pseudostratified columnar epithelium interspersed with PAS-positive goblet cells. Groups of submucosal glands, a strand of smooth muscle, and, interestingly several lymphoid follicles consisting of many mononuclear cells were also seen.
Bronchogenic Cyst* ; Child ; Dermis ; Epithelium ; Goblet Cells ; Humans ; Male ; Mucins ; Muscle, Smooth ; Thorax

Sinusoidal hemangioma is a rare variant of cavernous hemangioma. Clinically, it develops in adults and predominantly in females, and presents as a solitary painless subcutaneous nodule. Histological finding of the sinusoidal hemangioma shows a well-circumscribed lobular architecture in the subcutaneous tissue. The lobulated mass is composed of dilated sinusoidal thin-walled vascular channels, which have a pseudopapillary pattern and back-to-back arrangement without much intervening stroma. We report a case of sinusoidal hemangioma which can be differentiated from the other vascular tumors and has never been reported in Korea.
Adult ; Female ; Hemangioma* ; Hemangioma, Cavernous ; Humans ; Korea ; Subcutaneous Tissue

Intravascular papillary endothelial hyperplasia(IPEH) is a solitary slowly enlarging, often tender, blue to red elevated nodule. The predilection sites include the head and neck region, and the extremities, especially the fingers. Histologically, IPEH is characterized by the well-circumscribed intravascular papillary structures, which are formed by fibrous cores that are lined by endothelial cells. We report a case of intravascular papillary endothelial hyperplasia developed on the unusual site of lip.
Endothelial Cells ; Extremities ; Fingers ; Head ; Hyperplasia* ; Lip* ; Neck

Tufted angioma is a benign, slowly progressive angioma with typical histologic findings of small, circumscribed angiomatous tufts and lobules scattered in the dermis. More than 50% of cases occur during the first year of life, but rarely it develops late in life. There was only one reported case of tufted angioma after trauma in the English literature. We report a case of tufted angioma, which developed after electrocautery in a 61-year-old woman showing histologic features of typical tufted angioma.
Dermis ; Electrocoagulation* ; Female ; Hemangioma* ; Humans ; Middle Aged

Background: The shelf life policies for central supply department (CSD) sterilized items and other devices should be determined by the healthcare facility's infection control program. We investigated effect of the sterility integrity of the CSD sterilized packs by wrapping-materials, storage period and environment to modify and extend current shelf-life. Methods: The first phase study was from May to October in 2000 and the second phase study was planned to extend further the shelf-life of the sterile packs from April 2001 to June 2002. Six hundred and fourty packs containing small gauze with four wrapping materials(100 times and 50 times washed two-ply reusable cotton, disposable craft paper, and disposable new pouch bag) and the 104 returned set after their shelf-life were stored on the top or middle of shelves or closed cabinets and storage durations from 1 to 20 weeks in the first phase study. The test packs were collected weekly and cultured in the laboratory. Five hundred seventy-six test packs were prepared with three wrapping materials (except 50 times washed cotton and returned set) and stored in the same location as the First phase study and collected and cultured monthly after three months storage (from July 2001) for one year in the second phase study. The temperature and relative humidity was monitored whenever the test pack was collected. Results: The gauze in the test packs were not contaminated until 154 days in the first study phase and until 423 days in the second phase study. The temperature and relative humidity of storage locations were 25.9degrees C and 55.2% in the first phase study and 26.0degrees C and 45.9% in the second phase study, respectively. Conclusions: There was no difference in the sterility integrity of the test packs with different wrapping materials. storage locations and environments. and storage durations. It was possible to extend shelf-life from two weeks to three and six months in the study hospital.
Delivery of Health Care ; Humidity ; Infection Control ; Infertility

Background: Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure. We investigated the effectiveness of tacrolimus (FK506) and their mechanisms for liver transplant immune tolerance in an outbred rat LT model. Results: To investigate the therapeutic effect of the FK506 on outbred rat LT model, FK506 and postoperative therapy were administered subcutaneously once or twice daily to transplanted rats. Histopathological and immunohistochemical analyses were conducted for all groups. The regulation of inflammatory cytokine signaling in the spleen was analyzed by flow cytometry. FK506 attenuated allograft rejection and increased survival in rat orthotopic liver transplantation models. The FK506-treated group had reduced serum levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Furthermore, FK506 decreased the expression of inflammatory cytokines and the activation of pathogenic Th1 and Th17 cells in the liver. Conclusions Taken together, we revealed that FK506 ameliorated strong allograft rejection in outbred liver transplantation model by anti-inflammatory effect and inhibitory peroperty of pathogenic T cells.