1.Study on the relationship of insulin resistance and early renal injury with genetic factor in the healthy offspring with a family history of essential hypertension
Chinese Journal of Geriatrics 2015;34(6):638-640
Objective To investigate the insulin resistance and microalbuminuria in the healthy offspring with a family history of essential hypertension,in order to explore the relationship between the genetic factor and early renal injury.Methods 69 healthy offsprings with the family history of essential hypertension were randomly recruited as the observation group,35 healthy offsprings without the family history of essential hypertension were considered as the control group.The consecutive 12-hour urine was collected to detect the urinary albumin,and blood biochemical examination was conducted.Results Plasma levels of triglyceride (TG),total cholesterol (TC),glucose,fasting insulin,and urinary albumin excretion rate were higher in observation group than in the control group [(1.07±0.65) mmol/L vs.(0.79±0.52) mmol/L,(4.83±0.78) mmol/L vs.(4.48±0.63) mmol/L,(5.27±0.73) mmol/L vs.(4.94±0.85) mmol/L,(10.63±3.21) mIU/L vs.(7.72±3.35) mIU/L,(45.6±29.5) μg/min vs.(18.6±11.7) μg/min,t=2.259、2.348、2.093、4.381、5.337,all P<0.05].Conclusions Insulin resistance and microalbuminuria occur before hypertension in healthy offsprings with the family history of essential hypertension,and the patients are prone to getting early renal damage,which indicates that heredity is a risk factor for chronic kidney disease.
2.Effects of cornel iridoid glycoside on inflammatory reaction in the brain of traumatic brain injury rat model
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(03):-
AIM:To observe the effects of cornus iridoid glycosides(CIG)on inflammatory reaction especially the inflammatory cytokines in the brain after traumatic brain injury,and to explore the possible mechanisms of its neuroprotective effect.METHODS:SD rats were intragastrically administered with different doses of CIG(30,60 and 120 mg?kg-1?d-1)for 7 d.The traumatic brain injury rat model was induced by improved Feeney's fall weight method,and the brains were taken out 24 h and 72 h after brain injury,respectively.The morphological changes were observed by HE staining in the cerebral cortex.The expressions of inflammatory cytokine tumor necrosis factor-?(TNF-?)and interleukin-1?(IL-1?)were detected by immunohistochemical method.The image processing and statistical analysis were used to measure the number and the area of immunoreactive cells.RESULTS:HE staining showed the pathological changes were serious in the cerebral cortex of model group,and compared with the model group,the pathological changes were obviously reduced in CIG group.The positive immunoreactive cells of TNF-? and IL-1? were mainly distributed around the foci of contusion,the expressions of TNF-? and IL-1? in the model group were significantly higher than those in sham operated group,and the high expressions were sustained from 24 h to 72 h after brain injury.Compared with the model group,the levels of TNF-? and IL-1? in the brain of CIG treatment groups were obviously decreased in a dose-dependent manner and the inhibitory effects of TNF-? and IL-1? were more significant at 72 h after brain injury.CONCLUSION:CIG may have neuroprotective effect on traumatic brain injury through inhibiting the expression of inflammatory cytokines and reducing the inflammatory reaction.
3.Determination of the Baicalin in Pharynx Preparation by HPLC
Journal of Zhejiang Chinese Medical University 2006;0(03):-
[Objective] It is aimed at discovering an effective way of HPLC to detect the content of baicalin in the pharynx preparation.[Method] The column of Hypersil-ODS C18:250mm ? 4.6mm 5?m;the mobile phase:1.5% orthophosphoric acid and 10% methane alcohol;the detection wavelength: 276nm;velocity of flow: 1.0 ml/min;temperature: 40℃;the content is measured in the way of external standard method of apex area.[Result] By this method,baicalin takes on an excellent linearly relation within the range of 25.74?g?ml-1 ~ 514.8?g?ml-1,average recoveries get up to 99.8% and RSD 1.43% respectively.[Conclusion] This way is convenient and rapid,accurate and reliable,able to be used as a method of quality control on such baicalin preparation.
4.Analysis of Anesthetic Sedative Agents Used in Our Hospital during the Period of 2001~2003
China Pharmacy 2001;0(08):-
OBJECTIVE:To evaluate the application situation of anesthetic sedative agents in our hospital.METHODS:11945prescriptions of anesthetic sedative agents in inpatient department of our hospital during the period of2001~2003were statistically analyzed.RESULTS:There were5kinds of commonly used anesthetic sedative agents in3dosage types alto-gether;the anesthetic sedatives agents were mainly used in patients ranging from40~50years old;the drug use index(DUI)of all the kinds were all less than1,with the DUI of the majority at no more than0.5.CONCLUSION:Anesthetic sedative dosage for the treatment of cancer of late stage is lower than one needed,which suggests that sufficient dosage should be given to the cancer suffering patients by the physician.
5.Advance in Animal Models of Traumatic Brain Injury (review)
Chinese Journal of Rehabilitation Theory and Practice 2009;15(10):905-907
Good animal models of traumatic brain injury have a great significance in the pathogenesis research and treatment study. This paper reveiwed development in animal models of traumatic brain injury, including preparation Methods , application range, characteristics and shortcomings of each model.
6.Childhood Budd-Chiari syndrome in 3 cases.
Chinese Journal of Pediatrics 2008;46(10):791-792
Budd-Chiari Syndrome
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Child
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Humans
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Infant
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Male
7. Medication rule of Chinese materia medica in treatment of pulmonary fibrosis based on data mining
Chinese Traditional and Herbal Drugs 2020;51(6):1406-1411
To explore the medication rule of Chinese materia medica (CMM) in the treatment of pulmonary fibrosis, and provide reference for the prevention and treatment of pulmonary fibrosis in the novel coronavirus pneumonia. Using Excel 2013 and SPSS Statistics 23.0, the literatures with the theme of “pulmonary fibrosis” that met the screening criteria were searched, and the association rule analysis was carried out. Frequency analysis showed that the occurrence frequency of Astragali Radix (148, 45.82%), Glycyrrhizae Radix et Rhizoma (124, 38.39%) and Salviae Miltiorrhizae Radix et Rhizoma (102, 31.58%) was the highest in the clinical treatment literature. In the statistics of nature and flavor, warm (10 times, 50.00%) and neutral (six times, 30.00%) were the most common. The highest frequency of meridian tropism was found in the spleen (11 times, 25.58%), lung (10 times, 23.26%) and sweet (11 times, 36.67%). In the analysis of association rules, six groups of TCM combinations with high frequency correlation strength were obtained. The high frequency and high correlation CMM combinations obtained from this data analysis were mainly effective in strengthening the spleen and invigorating qi, and warming the spleen and lung, which can be used to prevent the early patients from developing to the critical stage and prevent the patients from reinfection due to low immunity in the convalescence stage.
8.Effects of Triptolide on Bone and Joint of Mice with Collagen-lnduced Arthritis
Danya MO ; Chunfang LIU ; Na LIN
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(11):-
Objective To observe the effect of triptolide on destruction of bone and joint of collageninduced arthritis (CIA) mouse. Methods Female DBA/1 mice were double immunized at the base of the tail with bovine type Ⅱ collagen (C Ⅱ). CIA mice were randomly divided into model group, methotrexate-treated group and 8.18, 16.36, 32.72 ?g/kg triptolide-treated groups. Performance of arthritis were observed regularly. Combined with radiologieal, histological methods were used, and the number of osteoelasts in bone was evaluated and analyzed with TRAP stainning. Results The clinical score and arthritis incidence of CIA mice were significantly decreased, and the number of osteoelasts in bone cavity reduced by treatment of triptolide. X-ray showed that the surface of bone of each articular was eroded, the joint space was narrow, BMD values of lumbar and knee were decreased compared with normal mice. Triptolide could significantly inhibit the damage of bones and joints of CIA mice, and increase the BMD values of lumbar and knee. Conclusion Triptolide can inhibit the damage of bones and joints of CIA mice.
9.Phylogenetic Tree and Function Analysis of Inflorescence Meristem Identity Gene TFL1
China Biotechnology 2006;0(01):-
TFL1 homologs play important roles in maintaining vegetative growth and inflorescence meristem identity. The plants without the function of this gene usually are flowering earlier. Their normal inflorescence development is inhibited, the inflorescence meristem eventually acquired floral identity, which producing a terminal flower. Up to now, the TFL1 homologs have been isolated from 28 species of plants, including Arabidopsis, Snapdrogen and Tomato. The phylogenic tree of TFL1 proteins is almost accordance with the relative of those plants. The inflorescence identity gene TFL1 interacted with floral meristem identity genes LFY and AP1, so as to retard the transformation from inflorescence identity into floral identity. These meristem identity genes such as TFL1 and LFY can be applied in breeding of earl-flowering cultivars, there also have plenty of potentials in breeding fruit-free plantanus, popular or willows.
10.The Effect of Fentanyl for Patient-controlled Analgesia after Functional Endoscopic Sinus Surgery
Li LI ; Na LIN ; Tianzuo LI
Journal of Medical Research 2006;0(10):-
Objective To observe the analgesic effects and the side effects of fentanyl after the FESS with general anesthesia.Methods 101 adult male patients,ASA Ⅰ~Ⅱ,undergoing elective FESS were divided into two groups randomly,received fentanyl through PCA or no analgesia.The PCA device was set at background infusion 0.1?g/(kg?h),bolus dose 0.4?g/kg?time,lockout time 15 minutes.The maximum dose is 600?g per day.Virtual signs,VAS,Ramsay sedation,dizzy,nausea,vomit and appetite were observed after the operation for two days.Results The VAS of the two groups is significant different in the time of the second morning and 24 hours later after the operation(P