Objective To investigate the variation of thyroid hormone therapy in patients with hypothyroidism before,during and postpartum pregnancy.Methods Thirty-eight patients who suffered from hypothyroidism and had successful pregnancy were collected.Among them,15 cases of hypothyroidism were caused by autoimmune thyroiditis caused,11 cases were induced by thyroid surgery; in 131I treatment induced hypothyroidism were 5 cases,7 patients had unclear reason pregnancy clinical thyroid dysfunctions.Thirty-eight cases of non-pregnant patients with hypothyroidism were also collected as the control group.They achieved efficacy standards by levothyroxine (L-T4) treatment and dose variation of L-T4 was statistically analyzed.Results There was a significant difference before pregnancy,postpartum and different periods of pregnancy.L-T4 dose had a significant increase after pregnancy.At 10-12 weeks,16-18 weeks,22-24 weeks,26-30 weeks,34-36 weeks respectively,L-T4 dose was significantly increasing compared with before pregnancy and postpartum 3 months((110.51 ± 10.42),(113.81 ± 21.04),(108.32 ± 21.01),(105.58 ±21.54),(105.89±10.24),(84.42 ±10.45) and (86.43 ±10.29) μg/L,F=15.631,P＜0.001),but between before and pregnancy postpartum,there was not significantly difference (P ＞ 0.05).Among the various stages of pregnancy,there was also no significant difference; In the patients with hypothyroidism due to thyroid surgery and 131I therapy,L-T4 dose were significantly higher than autoimmune thyroiditis and patients with no clear reason(before,during and after pregnancy,F =4.98,5.15,5.04,P ＜ 0.001).Conclusion Patients with hypothyroidism during pregnancy should increased therapeutic dose of thyroid hormone with average about 30％-40％ of the original dose,and in postpartum,levels before pregnancy could resume.High doses of L-T4 treatment should be taken in patients with hypothyroidism after 131I therapy and after thyroid surgeries.

Through decades of innovation and transcendence,foreign medical universities consistently promoted integration of medicine and humanities and carried out curriculum and teaching reform.Both the ideas and measures are advanced and worthy study.Currently,the development of medical humanities education in China is confronted with difficulties.Medical students need to promote their humanistic quality urgently.The study explored the effective measures to innovate and transcend by analyzing the advancement of foreign medical humanities education and problems of medical humanities education in China.

The different functions of Libsys 5.0 book conservation module were described and the application Libsys 5.0 book conservation module in conservation of new books in our library.

Resveratrol is a polyphenol phytoalexin presents in a variety of plant species.Many studies have shown that resveratrol exerts neuroprotective effects.This article reviewes the neuroprotective mechanisms of resveratrol in cerebral ischemia from the aspects of antiapoptosis,antioxidant and antiinflammatory.

A drill protector which can lock the drilling depth was designed, which is easy and safe.
Equipment Design ; Fracture Fixation ; instrumentation ; Surgical Instruments

Animals ; Humans ; Learning ; drug effects ; Memory ; drug effects ; Metals ; toxicity ; Nervous System ; drug effects

Objective To study the characteristics and clinical value of blink reflex in patients with diabetes mellitus. Methods Blink reflex were measured in 40 diabetes melletus and 30 normal adults. Results The result showed that diabetic group R1, R2 and R2' wave latency was significantly longer than the control group,meanwhile their amplitudes were significantly lower than that of control. And to 112 and R2' extended significantly,which showed that the damage to the central nervous system in diabetes can affect the brain stem. With the extension of duration of diabetes BR abnormal rate gradually increased. Conclusion It was concluded that BR provide an objective and sen-sitive index for the damage of the central nervous system in diabetes.

Objective To compare effect on sealing up tubes by using heparin of 3 different con-centrations and make choice of the suitable concentration.Methods The diabetic patients who needed trocar retain were averagely divided into 3 groups,namely group A,B and C with 10 cases in each group.Heparin concentration was 50 U/ml in group A,75 U/ml in group B,100 U/ml in group C respectively.The recanalization rote was compared between the three groups.Results Statistical significance was observed between group A and group B.The obstruction rate of group A was significantly higher than that of group B(P＜0.05).But there was no significant difference in obstruction rate between group B and group C.Conclusion Heparin concentration of group B was suitable for sealing tubes for diabetic patients.

Breast Neoplasms ; etiology ; genetics ; pathology ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Epithelial Cells ; pathology ; Female ; Fibroadenoma ; genetics ; Humans ; Loss of Heterozygosity ; Phyllodes Tumor ; etiology ; genetics ; pathology ; Stromal Cells ; pathology