1.Role of 5´-AMP-Activated Protein Kinase Activators in Regulating Nuclear Factor Kappa B Signaling.
International Neurourology Journal 2016;20(3):171-171
No abstract available.
NF-kappa B*
;
Protein Kinases*
2.Attenuated Nuclear Factor Kappa B Activity by E7 Protein of Human Papillomavirus Type 2 in Human Epidermal Keratinocytes.
Yun Hee RYU ; Ju Hee HAN ; Ji Hyun LEE ; Soon Young CHOI ; Young Min PARK
Annals of Dermatology 2017;29(3):367-370
No abstract available.
Humans*
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Keratinocytes*
;
NF-kappa B*
3.Function and Activation of NF-kappa B in Immune System.
Korean Journal of Otolaryngology - Head and Neck Surgery 2005;48(3):284-288
No abstract available.
Immune System*
;
NF-kappa B*
4.The Role of NF-kappaB in the TNFalpha-induced Hyperplasia of Synoviocytes Isolated from Patients with Rheumatoid Arthritis.
Jee Hee YOON ; Sung Hee HWANG ; So Yeon MIN ; Ho Yeon KIM
Korean Journal of Immunology 2000;22(3):131-137
No abstract available.
Arthritis, Rheumatoid*
;
Humans
;
Hyperplasia*
;
NF-kappa B*
5.Effects of N-(2-mercapto-2-methylpropanoy1)-L-Cysteine(bucillamine) on the Activation of Nuclear Factor kB induced by TNF-a in Synovial Cells from Patients with Rheumatoid Arthritis.
Jae Bum JUN ; Dae Hyun YOO ; Eunyoung LEE ; Heekwan KOH ; Taehwan KIM ; Jahun JUNG ; Daekook CHANG ; Sancheol BAE ; Yongkeel CHOI ; Seongyoon KIM
The Journal of the Korean Rheumatism Association 1999;6(1):31-43
No abstract available.
Arthritis, Rheumatoid*
;
Humans
;
NF-kappa B
7.Noncanonical NF-κB pathway and hematological malignancies.
Wen-Juan WANG ; Ai-Ning SUN ; Feng GUO
Journal of Experimental Hematology 2010;18(4):1069-1073
Nuclear factor κB (NF-κB), including RelA, RelB, c-Rel, NF-κB1, and NF-κB2, plays a crucial role in immune response, inflammatory reaction, tumorigenesis, and development of peripheral lymphoid organs and lymphocytes. There are two NF-κB activation pathways: canonical pathway (classical pathway) and noncanonical pathway (alternative pathway). Previous studies focused on the effects of the canonical NF-κB pathway (mainly p50-RelA) in hematological malignancies. Recently, the noncanonical NF-κB pathway (mainly p52-RelB) is gradually taken importance in pathogenesis of hematological malignancies. Understanding the relations of the noncanonical pathway with hematological malignancies would provide a new therapeutic approach for these diseases. This review focuses on the noncanonical NF-κB signaling transduction pathway and its relation to hematologic malignancies.
Hematologic Neoplasms
;
metabolism
;
Humans
;
NF-kappa B
;
metabolism
;
NF-kappa B p50 Subunit
;
metabolism
;
NF-kappa B p52 Subunit
;
metabolism
;
Signal Transduction
8.CKD-712, (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-kappaB Activation and Augments Akt Activation during TLR4 Signaling.
Jeonggi LEE ; Eun Jeong YANG ; Jeon Soo SHIN ; Dal Hyun KIM ; Sung Sook LEE ; In Hong CHOI
Immune Network 2011;11(6):420-423
Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS stimulation. Activation of NF-kappaB was assessed by promoter assay. The activation of ERK, JNK, p38, IRF3 and Akt was measured by western blotting. CKD-712 inhibited the NF-kappaB signaling triggered by LPS. The activation of ERK, JNK, p38 or IRF3 was not inhibited by CKD-712. On the contrary the activation of these molecules was augmented slightly. The activation of Akt with stimulation of LPS was also enhanced with CKD-712 pre-treatment at lower concentration, but was inhibited at higher concentration. We suggest that during TLR4 signaling CKD-712 inhibits NF-kappaB activation. However, CKD-712 augmented the activation of Akt as well as Map kinases. Therefore, we suggest that CKD-712 might have a role as an immunomodulator.
Blotting, Western
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HEK293 Cells
;
NF-kappa B
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Phosphotransferases
;
Tetrahydroisoquinolines
9.Increased Proliferating Activity of Endometrium in Endometriosis.
Young Ah KIM ; Mi Ran KIM ; Dong Wook PARK ; Sung Hee AHN ; Kyung Joo HWANG ; Doo Young CHANG ; Eung Soo LEE
Korean Journal of Obstetrics and Gynecology 2004;47(7):1334-1341
OBJECTIVE: We investigated the expression of Ki-67, NF-kappa B, and COX-2 in endometrial tissue, and the incidence of polyps by hysteroscopic biopsy with or without endometriosis. METHODS: The study group was 92 patients with endometriosis and the control group was 90 patients without endometriosis. The subjects were 20 samples. The 10 samples consisted of eutopic endometrium with endometriosis. The control subjects were 10 samples of normal endometrium. Expression of Ki-67, NF-kappa B, and COX-2 was immunohistochemically investigated by polyclonal antibody. RESULTS: Endometrial polyps were found in 53 of 92 (57.6%) women with endometriosis but only in 15 of 90 (16.7%) women without endometriosis. High expression of Ki-67 was shown in eutopic endometrium with endometriosis. The expression of NF-kappa B and COX-2 was increased in eutopic endometrium with endometriosis, but normal endometrium showed lower expression. CONCLUSION: The increase of endometrial polyps and hyperexpression of NF-kappa B, COX-2, Ki-67 could explain that proliferation activity of eutopic endometrium with endometriosis is increased.
Biopsy
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Endometriosis*
;
Endometrium*
;
Female
;
Humans
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Incidence
;
NF-kappa B
;
Polyps
10.Advances of study on activation of nuclear factor kappaB in hematological malignancies and its mechanism--review.
Guang-Ping WANG ; Zhen-Hua QI ; Fang-Ping CHEN
Journal of Experimental Hematology 2005;13(3):518-523
The nuclear factor kappa B(NF-kappaB) plays a crucial role in inflammatory, immune response, embryo development, cell proliferation and apoptosis, cell cycle control as well as tumorgenesis. In recent years, a variety of investigations have demonstrated that NF-kappaB was closely associated with the pathogenesis of hematological malignancies such as leukemia, lymphoma and multiple myeloma. Nowadays, increasingly attention has been paid to the studies on the activation and its mechanism of NF-kappaB in the hematogenic malignancies. So that, in this article, progress on these aspects is reviewed.
Hematologic Neoplasms
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metabolism
;
pathology
;
Humans
;
NF-kappa B
;
metabolism