1.Dual time point imaging of FDG PET/CT in a tuberculous spondylodiscitis
HR Abdul Razak ; N Abdul Rahim ; AJ Nordin
Biomedical Imaging and Intervention Journal 2010;6(2):1-3
Dual Time Point Imaging (DTPI) technique is a specialised protocol adopted in 18F-Fluorodeoxyglucose (FDG)
Positron Emission Tomography (PET) imaging. This technique is claimed to be useful in differentiating malignant and
infective lesions. The authors adopted this technique in a patient diagnosed with tuberculous spondylodiscitis and psoas abscess which demonstrated higher Maximum Standardized Uptake Value (SUVmax) during initial scans as compared with those obtained on delayed scans. The SUVmax changes between the two time points are believed to be a valuable finding for chronic granulomatous infective lesions such as tuberculosis.
2.Apoptosis changes and SA-beta galactosidase expression in stress-induced premature senescence (SIPS) model of human skin fibroblasts.
Abdul Rahim N ; Makpol S ; Chua KH ; Yusof YA ; Top GM ; Ngah WZ
The Medical Journal of Malaysia 2008;63 Suppl A():71-72
Stress-induced premature senescence (SIPS) model is in vitro model of cellular aging. In this study, apoptosis was evaluated in SIPS model and in replicative senescent fibroblasts. We also compared the activity of senescence-associated beta-galactosidase (SA-beta gal) as a biomarker of cellular aging. Our results suggested that SIPS model and senescent fibroblasts might share similar mechanism of aging and apoptosis pathway.
3.18F-FDG positron emission tomography/computed tomography and the "underground map" appearance in imaging Horton's arteritis.
N Abdul JALIL ; N Abdul RAHIM ; N Md SHALLEH ; C ROSSETTI
Singapore medical journal 2008;49(7):e178-82
A majority of the clinical use of positron emission tomography (PET)-computed tomography (CT) is related to cancer management. Its application in evaluating inflammatory diseases and pyrexia of unknown origin is becoming popular. We reviewed the fluorine-18-fluorodeoxyglucose PET-CT findings of an 80-year-old woman with nonspecific clinical presentation consisting of generalised malaise, moderately high fever and weight loss. Prior CT and magnetic resonance imaging were not helpful in providing a clinical diagnosis. The diagnosis was Horton's arteritis, and the patient responded well to high-dose steroids.
Aged, 80 and over
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Arteritis
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diagnosis
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Diagnostic Imaging
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methods
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Female
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Fluorodeoxyglucose F18
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Humans
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Image Processing, Computer-Assisted
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Inflammation
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Positron-Emission Tomography
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instrumentation
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methods
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Steroids
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therapeutic use
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Tomography, X-Ray Computed
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methods
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Treatment Outcome