Midazolam, rather than diazepam does provide relatively more rapid recovery and more effective amnesia when used to supplement regional anesthesia for ambulatory case. In this study, low dose sufentanil, relatively new synthetic narcotic was administered supplementarily to potentiate the other agent. In human volunteers, depression of respiratory center sensitivity to carbon dioxide from sufentanil is of shorter duration than equipotent doses of fentanyl. Sufentanil has a potency about ten times that of fentanyl, and its duration of action is about one half as long. Concomitant use of low dose of sufentanil and midazolam intravenously for the pretreatment for retrobulbar block in outpatient cataract surgery produced satisfactory analgesia, anxiolysis, sedation, anterograde amnesia and hypnotic effects while preserving the maximal hemodynamic stability with minimal respiratory suppression and rapid recovery in a serverely compromised senile patient population.
Amnesia ; Amnesia, Anterograde ; Analgesia ; Anesthesia, Conduction ; Benzodiazepines ; Carbon Dioxide ; Cataract* ; Depression ; Diazepam ; Fentanyl ; Healthy Volunteers ; Hemodynamics ; Humans ; Hypnotics and Sedatives ; Midazolam* ; Outpatients* ; Respiratory Center ; Sufentanil*

Midazolam, rather than diazepam does provide relatively more rapid recovery and more effective amnesia when used to supplement regional anesthesia for ambulatory case. In this study, low dose sufentanil, relatively new synthetic narcotic was administered supplementarily to potentiate the other agent. In human volunteers, depression of respiratory center sensitivity to carbon dioxide from sufentanil is of shorter duration than equipotent doses of fentanyl. Sufentanil has a potency about ten times that of fentanyl, and its duration of action is about one half as long. Concomitant use of low dose of sufentanil and midazolam intravenously for the pretreatment for retrobulbar block in outpatient cataract surgery produced satisfactory analgesia, anxiolysis, sedation, anterograde amnesia and hypnotic effects while preserving the maximal hemodynamic stability with minimal respiratory suppression and rapid recovery in a serverely compromised senile patient population.
Amnesia ; Amnesia, Anterograde ; Analgesia ; Anesthesia, Conduction ; Benzodiazepines ; Carbon Dioxide ; Cataract* ; Depression ; Diazepam ; Fentanyl ; Healthy Volunteers ; Hemodynamics ; Humans ; Hypnotics and Sedatives ; Midazolam* ; Outpatients* ; Respiratory Center ; Sufentanil*