There have been reported some important findings in immunology of psoriasis, such as lower than normal level of IgM, defective humoral immune, responsiveness to newly administered antigens during cytotoxic drug therapy, lower than normal incidence of active sensitization with DNCB, prolonged skin heterograft survival and presence of anti-IgG antibody in peripheral lymphocytes. These findings are strongly suggestive of some humoral as well as cellular immunne dysfunction in patients with psoriasis. The present study was undertaken to evaluate the therapeutic effectiveness of BCG, a potent nonspecific immune stimulator, in patierts with psoriasis. Total 41 cases of more than 2 years' duration of illness and with widespread involvement and having had history of various previous treatment were slelcted at the Department of Dermatology, National Medical Center during October, 1973 and October, 1974, Liquid BCG(manufactured by NIH, Korea) was administered intradermally in a starting dose of 0.1 ml(0.01 mg in dry weight) weekly. The dosage of BCG was increased to 0.3 or 0.5ml after 3 or 5 injections and this dosage was maintained until some clinical changes were observed. The mean injection time to each patient was 20. 7.The results were as follows: 1. Eighteen cases showed no therapeutic response or aggravation of the lesions. 2. Six cases showed good therapeutic effect, resulting in only a few small lesions remained on elbows, knees or scalp areas. 3. Fourteen cases showed excellent therapeutic effect, that is complete disappearance of the lesions. During 2 to 6 months'follow up period, 7 cases showed relapse and the remainders are still under observation. The mechanism of influence of BCG on the clinical course of psoriatic patients is not determined, however, possible mechanism was discussed.
Allergy and Immunology ; Dermatology ; Dinitrochlorobenzene ; Drug Therapy ; Elbow ; Heterografts ; Humans ; Immunoglobulin M ; Incidence ; Knee ; Lymphocytes ; Mycobacterium bovis* ; Psoriasis* ; Recurrence ; Scalp ; Skin

No abstract available.
Humans ; Nitroblue Tetrazolium* ; Skin* ; Tuberculosis, Cutaneous*

Lichen striatus is an uncommon nonspecific inflammatory cutaneous disease of unknown etiology occuring as unilateral and linear distribution on extremities and healing spontaneously within a few months to a year. Clinically it is composed of small licbenoid papules which tend to be grouped and coalesced to form either a continuous or an interrupted hypopigmented band and is not usually accompanied by any subjective symptoms. The principal histologic features are an infiltrate composed of lymphocytes and histiocytes around papillary vessels and usually also around, some of the deeper vessels and skin appendages and consequent secondary changes of the epidermis. We present the results of clinical and histopathologic observation in 19 patients with lichen striatus observed at Department of Dermatology, National Medical Center and Seoul National University Hospital during 4 years period from l972 to 1976 which would be the first recorded report on this rare disease in Korea. 1. Clinieal Observation.' Among the 19 patients, 10 were female and 9 were male; 15 were under 10 years of age and 4 were over 10 years of age. Duration of the eruption varied from 1 week to 4 years and average duration was 9.6 months at the time of the first visit. It was unilateral in all cases and affected the upper extremities in 9 and the lower extremities in 8 instances. The eruption extended onto the upper part of the trunk in 2 cases. Only 3 patients had a history of mild intermittent itching sensation. Characteristically, the eruption consisted of grouped, linear, slightly scaling flat polygonal papules with varying degrees of hypopigmentation, extending at least onethird of the length of an extremity. . Histopathologic observation: Skin biopsy was performed in 13 cases. The epiderrnal changes consist of mild diffuse hyperkeratosis (13 cases), focal parakeratosis (5 cases), varying degree of atrophy of malpighian layer (7 cases), mild acanthosis (2 cases), intercellular and intracellular edema (8 cases), exocytosih of lymphocytes (7 cases), focal basal cell disruption (11 cases), and dyskeratotic cells (colloid body) (2 cases). Dermal changes include mild to moderate perivaacular lymphocytic and histiocytic infiltrate rnostly on the level of papillary dermis. Also, there was chronic infIammatory cell infiltrate around hair follicle and sweat glands and ducts in 7 cases respectively, which seems to be peculiar in this disease. Overall histologic findings in our cases are generally consistent with those of the primary phase of the so-called lichenoid tissue reaction of Pinkus, The possible pathogenetic mechanism of the linear eruption and immunobiologic interpretation of the lichenoid tissue reaction were literally reviewed.
Atrophy ; Biopsy ; Dermatology ; Dermis ; Edema ; Epidermis ; Extremities ; Female ; Hair Follicle ; Histiocytes ; Humans ; Hypopigmentation ; Korea ; Lichens* ; Lower Extremity ; Lymphocytes ; Male ; Parakeratosis ; Pruritus ; Rare Diseases ; Sensation ; Seoul ; Skin ; Sweat Glands ; Upper Extremity

The majority of the cysts developed in pancreas are inflammatory pseudocyst but neoplastic cysts are rarely encountered Especially, mucinous cystadenoma which was begun and originated from epithelial cell of pancreatic duct is difficult to differentiate from pseudocysts by preoperative clinical, laboratory and radiologic findings. Mucinous cystadenoma has a malignant potentiality, so complete excision of cystadenoma is the treatment of choice. Recently, we experienced one case of mucionus cystadenoma in 37 year-old female, we report it with a review of the literature.
Adult ; Cystadenoma ; Cystadenoma, Mucinous* ; Epithelial Cells ; Female ; Humans ; Mucins* ; Pancreas* ; Pancreatic Ducts

No abstract available.
Acrosome Reaction* ; Acrosome* ; Male ; Semen*

Antihypertensive effect and side effect of Tripamide(Normonal(R)) was studied in 22 cases of essential hypertension using 15mg once daily regimen for average period of 9 weeks. 1) Antihypertensive effect Average reduction of 25mmHg in systolic and 19mmHg in systolic and 19 mmHg in diastolic pressure was observed and reduction rate was 15.7% and 17.6% respectively. The overall effect rate was 86%. The blood pressure lowered significantly in 1 week of treatment both in systolic and diastolic pressure and the extent of fall in systolic pressure approached near the level of maximum reduction in 2 weeks of administration and that of diastolic after 5 weeks of treatment. 2) Laboratory tests and side effect There was no significant changes in individual and mean value of Na, K, Cl, BUN, creatinine, uric acid, fasting blood sugar, cholesterol, GOT, GPT studied before and after treatment except one case showing elevation of uric acid. No significant side effect was observed during trial except of 2 cases of transient diuretic effect.
Blood Glucose ; Blood Pressure ; Cholesterol ; Creatinine ; Diuretics ; Fasting ; Hypertension ; Uric Acid

Asymmetrical Septal Hypertrophy(ASH), Characterized by interventricular septal hypertrophy, is not an uncommon cardiac disease. Arrythmia occuring in ASH are supraventricular tachycardia, atrial premature beats, and ventricular premature beats. In about 10% of patients, there is a short P-R interval and a partial delta wave, suggestive of a variant of the Wolff-Parkinson-White syndrome. We reported here a case of ASH associated with W-P-W syndrome and paroxysmal atrial fibrillation with review of pertinent literatures.
Arrhythmias, Cardiac ; Atrial Fibrillation* ; Cardiac Complexes, Premature ; Heart Diseases ; Humans ; Hypertrophy* ; Tachycardia, Supraventricular ; Wolff-Parkinson-White Syndrome

Asymmetrical Septal Hypertrophy(ASH), Characterized by interventricular septal hypertrophy, is not an uncommon cardiac disease. Arrythmia occuring in ASH are supraventricular tachycardia, atrial premature beats, and ventricular premature beats. In about 10% of patients, there is a short P-R interval and a partial delta wave, suggestive of a variant of the Wolff-Parkinson-White syndrome. We reported here a case of ASH associated with W-P-W syndrome and paroxysmal atrial fibrillation with review of pertinent literatures.
Arrhythmias, Cardiac ; Atrial Fibrillation* ; Cardiac Complexes, Premature ; Heart Diseases ; Humans ; Hypertrophy* ; Tachycardia, Supraventricular ; Wolff-Parkinson-White Syndrome

Purpose: We analyzed the clinical factors and surgical outcomes of patients with intermittent exotropia exhibiting high hyperopia and emmetropia. Methods: Patients with intermittent exotropia who underwent strabismus surgery and were followed-up for at least one year between April 1999 and January 2018 were retrospectively reviewed. The patients were divided into two groups according to their preoperative spherical equivalent refractive error (SERE): a high hyperopia group (≥+4.00 diopters [D], group 1) and an emmetropia group (+0.50 to -0.50 D, group 2). The surgical outcomes of the groups were compared. Results: We enrolled 74 patients, of whom 24 and 50 were included in groups 1 and 2, respectively. In group 1, the mean SERE was +5.00 D (+4.00 to +8.00 D) in the more affected eye and +2.81 D (+0.00 to +7.25 D) in the better eye. In group 1, the changes in SERE at one year after surgery were as follows: +1.24 D in the worse eye and +0.90 D in the better eye (both, p < 0.001). The mean exodeviation at one day postoperatively for distance and near were -1.25 prism diopters (PD) and 0.21 PD, respectively, in group 1, and -4.62 PD and -2.16 PD in group 2. Thus, group 1 exhibited less exodeviation in terms of both distance and near than did group 2 on day one postoperatively. However, no significant group difference was evident at one year postoperatively. Conclusions The surgical outcomes of intermittent exotropia patients with high hyperopia did not differ from those of patients with emmetropia.

PURPOSE: To evaluate the relation of the location and cell type of lung cancer to the location and degree in coexistent emphysema on high-resolution computed tomography (HRCT) scans. MATERIALS AND METHODS: Ninety-eight of 209 lung cancer patients having HRCT scans were retrospectively analyzed to assess the total lung emphysema and peritumoral regional emphysema. Single and primary lung cancers were included. The clinical data, including sex, age, smoking history and the pathologic cancer subtype, were recorded to correlate with the HRCT findings. The lobar distribution, central-peripheral predominance, surrounding parenchymal abnormality for cancer, cephalocaudal predominance, and subtype for emphysema were analyzed on HRCT. Using a CT scoring method, we scored the whole lung emphysema and peritumoral emphysema, and correlated the grading of emphysema with pulmonary functional values. RESULTS: Sixty-nine of 98 patients with lung cancer (71%) had emphysema. Lung cancer with emphysema was significantly higher in men than in women, and was significantly related to smoking. The mean age of cancer patients without emphysema was significantly lower than that of cancer patients with emphysema (68 yrs vs. 61 yrs, p=0.0006). Emphysema of grade I (0-25%) was found in 52 cases, grade II (25-50%) in 15, and grade III (50-75%) in 2. Total emphysema score was paralleled to peritumoral emphysema score in 64.3%, while the remaining patients had a higher peritumoral emphysema score (grade II or III) than total emphysema score (grade 0 or I). There was no statistical correlation in the developmental location between the emphysema and the lung cancer (significant correlation was only noted in grade II group of total emphysema score). The incidence of non-small cell carcinoma tended to be higher than that of small cell carcinoma in the two groups. CONCLUSION: The possibility of lung cancer in patients with pulmonary nodule, coexisting emphysema, and especially in elderly patients having a history of smoking must be clarified on HRCT. The location or type of lung cancer was not significantly correlated to the location or the degree of coexistent emphysema.
Aged ; Carcinoma, Small Cell ; Emphysema* ; Female ; Humans ; Incidence ; Lung Neoplasms* ; Lung* ; Male ; Pulmonary Emphysema ; Research Design ; Retrospective Studies ; Smoke ; Smoking