Bone scan measuring bone metastasis were analysed in fifty five patients diagnosed as malignant tumor, seven were primary bone tumor and forty eight were metastatic tumor, who treated in Kyung Hee Hospital from March 1981 to January 1982. The results were as follows: l. In 55 patients, positive bone scan were found in 76.4% of the patients and positive X-ray were found in 56.4%. 2. 7 patients with primary bone tumor showed all positive bone scan, 45 patients with metastatic tumor showed positive bone in 72.9%. 3. Among the patients with metastatic tumor who no clinical symptoms, positive bone scan were found in 59.3% and positive X-ray in 26%. 4. Most common metastatic site was femur in primary bone tumor and vertebra in metastatic tumor. 5. In 48 patients of metastatic tumor, positive bone scan within negative X-ray were found in 56%, negative bone scan within positve X-ray were found in 5%. 6 The lesions showed clod area on bone scan were considered of positive finding as compared with clinical symptom and X-ray finding.
Diagnosis ; Femur ; Humans ; Neoplasm Metastasis ; Spine

Computed Tomograms of 45 patients with or without lung mass were reviewed to determine the characteristics of the major and minor fissures. Also pulmonary vascular distibutions were analyzed to localize each pulmonary lobe. The results were as follows; 1. Each major fissure area was imaged frequently as lucent band, less frequently dense band. 2. The minor fissure areas were imaged as oval or triangular lucent zones. The oval or triangularlucent zones were as same frequency. 3. Avascular planes without above mentioned lucent zones were also correspond to minor fissure areas. 4. Slices of avascular zones were observated between pulmonary arteries to posterior segment or apicoposterior segment of upper lobe and to superior segement of lower lobe on both lungs.
Humans ; Lung ; Pulmonary Artery

Both cervical vestibular evoked myogenic potential (cVEMP) and ocular VEMP (oVEMP) are irreplaceable tools in the current vestibular science, but they have many drawbacks. For example, the test-retest reliability of the asymmetry ratio is inadequate for both tests. The American Academy of Neurology noted that there is insufficient evidence to determine whether cVEMP and oVEMP can accurately identify vestibular function specifically related to the saccule/utricle. One of the most important factors underlying the variability of cVEMP seems to be the control of, and compensation for, baseline muscle contraction power. Reasons for variability in oVEMP include a poor signal to noise ratio, the angle of superior gaze, effective and controlled presentation of stimuli, intracranial pressure, and electrode location. Many of these shortcomings could be improved by further development of recording methods and devices. This article examines the reasons for the insufficient reliability of VEMP and proposes avenues for improvement of VEMP recording systems.
Compensation and Redress ; Electrodes ; Intracranial Pressure ; Muscle Contraction ; Neurology ; Reproducibility of Results ; Signal-To-Noise Ratio ; Vertigo

BACKGROUND AND OBJECTIVES: The long-term effect of tinnitus retraining therapy (TRT) is excellent while its short-term effect is known to be inferior to tinnitus making (TM). In this regard, we mixed TRT (mTRT) by combining TRT and TM to improve the short-term effect of TRT. This study evaluated the short-term effect of the mTRT and also compared the clinical efficacy between mTRT and TM. SUBJECTS AND METHOD: Twenty patients who underwent mTRT due to chronic subjective tinnitus were included in this study. Sound therapy of the mTRT was performed with mixed noise of broadband noise and narrow band noise. The broadband noise was used for TRT and the narrow band noise was used for TM. During the first month of mTRT, sound therapy was mainly composed of narrow band noise. During the second month, the proportion of broadband noise was gradually increased to 2/3. After 3 months, only the broadband noise was applied. Tinnitus Handicap Inventory (THI), Visual Analog Scale (VAS) on annoyance and the tinnitus awareness duration (hr/day) was checked as the outcome measures. The outcome was also compared between mTRT and TM. RESULTS: The THI score decreased significantly from 41.8+/-24.3 to 27.3+/-25.6 after mTRT. The VAS (from 5.9+/-1.4 to 4.7+/-1.8) and the tinnitus awareness duration (from 18.5+/-8.2 to 12.6+/-10.7) also showed a significant improvement after treatment. When the treatment outcome was compared between mTRT and TM, there was no significant difference. CONCLUSION: mTRT seems to be effective in relieving the discomfort of tinnitus. Similar short-term outcomes can be expected from mTRT as they did in TM.
Humans ; Noise ; Outcome Assessment (Health Care) ; Tinnitus ; Treatment Outcome

Recent advances in neuroscience and precise electric stimulation have enabled us to deliver complex signals to the central nervous system. But most of the successful electric stimulation devices such as cochlear implant and deep brain stimulation require surgery. Considering that most of the patients with hearing loss have a significant residual hearing, it is not feasible to open up the round window and insert an electrode in a functional cochlea. The concept of non-invasive electric stimulation of the auditory system may have a role in the future to overcome this unmet need in the clinic. Until now, many researchers have tried to delivery speech signal to the brain by means of non-invasive electric stimulation. Trans-cranial electric stimulation have most extensively been studied and interesting outcomes have recently been published. Some studied were able to prove that the envelope of the speech can be delivered by non-invasive electric stimulation. This new technology is called speech entrainment. By inducing speech entrainment, researchers were able to enhance the speech recognition score in noisy environments. But there are also some limitations in this approach. For instance, the time delay of the auditory sound and brain entrainment must be matched which is quite challenging. Although some limitation needs to be resolved, recent advancements in this new field is very interesting. More developments will follow in the next few years that can help patients with hearing loss in the near future.

OBJECTIVES: From our previous study about the weak expressions of potassium-chloride (KCC2) and sodium-potassium-2 chloride (NKCC1) co-transporters in the lateral superior olive (LSO) in circling mice, we hypothesized that partially damaged cochlea of circling mice might be a cause of the weak expressions of KCC2 or NKCC1. To test this possibility, we reproduced the altered expressions of KCC2 and NKCC1 in the LSO of rats, whose cochleae were partially destroyed with kanamycin. METHODS: Rat pups were treated with kanamycin from postnatal (P)3 to P8 (700 mg/kg, subcutaneous injection, twice a day) and sacrificed for immunohistochemical analysis, scanning electron microscope (SEM) and auditory brain stem response. RESULTS: The SEM study revealed partially missing hair cells in P9 rats treated with kanamycin, and the hearing threshold was elevated to 63.8+/-2.5 dB SPL (4 ears) at P16. Both KCC2 and NKCC1 immunoreactivities were more prominent in control rats on P16. On 9 paired slices, the mean densities of NKCC1 immunoreactivities were 118.0+/-1.0 (control) and 112.2+/-1.2 (kanamycin treated), whereas those of KCC2 were 115.7+/-1.5 (control) and 112.0+/-0.8 (kanamycin treated). CONCLUSION: We concluded that weak expressions of KCC2 and NKCC1 in circling mice were due to partial destruction of cochleae.
Animals ; Brain Stem ; Cochlea ; Electrons ; Hair ; Hearing ; Injections, Subcutaneous ; Kanamycin ; Mice ; Neurons ; Olea ; Rats ; Symporters

No abstract available.
Noise* ; Tinnitus*

Only a few tests can evaluate the function of the saccule and inferior vestibular nerve. Vestibular-evoked myogenic potentials (VEMP) are inhibitory potentials recorded in the contracting muscles, usually in the sternocleidomastoids (SCM), when sound stimuli are applied. A disynaptic pathway originating in the saccule is known to mediate VEMP. The main pathway of saccule-induced inhibitory postsynaptic potentials to ipsilateral SCM motoneurons seems to be the medial vestibulospinal tract which descends within the medial longitudinal fasciculus. VEMP have been applied to determine saccular function in many disorders involving the peripheral vestibular apparatus. However, the characteristics and the diagnostic values of VEMP require further exploration in central vestibulopathies. In this review, the basic principles and recording methods of VEMP are overviewed. We will also review VEMP responses found in central as well as peripheral vestibular disorders. Despite several issues that need further elucidation, such as the exact neural pathway mediating VEMP, aging effects on VEMP, and normalization of the muscle contraction during the recording, VEMP allows us exclusive information on the function of saccule and its neural pathway, which cannot be provided by other vestibular function tests.
Aging ; Brain Stem ; Cerebellum ; Contracts ; Inhibitory Postsynaptic Potentials ; Muscle Contraction ; Muscles ; Negotiating ; Neural Pathways ; Saccule and Utricle ; Vertigo ; Vestibular Function Tests ; Vestibular Nerve ; Vestibule, Labyrinth

Vestibular evoked myogenic potential (VEMP) has developed as a broadly applied vestibular function test in clinics from its introduction in 1992. In the past, there was only one well known VEMP protocol, which is cervical VEMP, however recently ocular VEMP is also popular. Therefore, clarifying the VEMP recording protocol (cervical VEMP or ocular VEMP) before discussing the VEMP result has become essential. There is considerable difference regarding this VEMP test from other vestibular function tests. VEMP is thought to be assessing the functions of the otolith organs (utricle and saccule) which are evoked by acoustic stimulus. Cervical VEMP is valuable since this is the only available test method which could speculate the function of the saccule and inferior vestibular nerve. Still, there's less clearly understood part regarding the central pathway of VEMP. However, many clinicians and researchers participating in vestibular research speculate that this functional test will have a more dominant role in the near future. Here we describe the basic principles and methodological considerations regarding VEMP recording.
Acoustics ; Evoked Potentials ; Otolithic Membrane ; Saccule and Utricle ; Vestibular Evoked Myogenic Potentials ; Vestibular Function Tests ; Vestibular Nerve