Ectopic pregnancies are unsuccessful pregnancies that result from implantation of fertilized ovum occurring inan aberrant area. Aside from an emergency case, the early diagnosis of ectopic pregnancy is very difficultparticularly in a case with insidious onset and mild clinical manifestations. Early diagnosis not only reduces thedanger, but also simplifies the management of ectopic pregnancy. Ultrasonography has been an indispensablediagnostic tool in obstetrics and Gynecology. In the authors' experience, clinical suspected ectopic pregnancy wasone of the common indications for performing ultrasonography. Since Kobayashi et al. reported the appearances ofextopic preganancy utilizing bistable B-scan ultrasonography, the ultrasonic findings of ectopic pregnancy havebeen reported by many authors. But, its accuracy and reliablity in the diagnosis of ectopic pregancy are stillopen to controversy. The authors studied 65 cases of clinically suspected ectopic pregnancy with Picker 80 L grayscale ultrasonography from Aug. 1982 to Jun. 1983. There were 29 confirmed cases, of which 15 were proved to haveextopic pregnancy and 14 were proved to have disease other than ectopic pregnancy by surgical andhistopathological study or by laparoscopy and histopatholoigcal study or by laparoscopy and follow up study. 29confirmed cases were reviewed. The resuls were as follows; 1. Among 15 ectopic pregnancies, there were 12ampullary pregnancies, 2 isthmic pregnancies and 1 interstitial pregancy. Among 14 cases of no ectopic pregnancy,there were 5 intrauterine pregnancies, 3 myoma uteri, 2 P.I.D., and 1 case of dermoid cyst, cystic teratoma,h-mole and tubal hematoma due to previous tubal ligation, respectively. 2. The age distribution of ectopicpregnancy was from 22 to 41 years. The common clinical manifestations of extopic pregnancy were lower abdominalpain (73.3%), vaginal spotting or bleeding (73.3%) and amenorrhea(66.7%). 3. Positive results of urine immunologicpregnancy test was 28.6% in ectopic pregnancy. 4. Ultrasonic findings of ectopic preganncy were as follows; 1) Nointrauterine gestational sac was observed in all cases except 1 interstitial pregnancy. Intrauterine fluidcollection was observed in 3 cases. Uterine displacement was observed in 10 cases. 2) Among 5 cases of rupturedtubal pregnancy, we observed predominantly cystic adnexal mass in 3 cases, mixed echogenic adnexal mass in 2cases, and cul-de-sac fluid in all cases. Among 9 cases of unruptured tubal pregnancy, we observed predominantlycystic adnexal mass in 2 cases, mixed echogenic adnexal mass in 7 cases, and cul-de- sac fluid in 3 cases. 3) Anechodense ring like structure was observed outside the uterus in 9 cases of tubal pregnancy. 4) In the case ofinterstitial pregnancy, eccentrically located gestational sac with overlying thin myometrium was observed withinthe uterus. 5) Fetal heart activity was noted outside the uterus with real time scanning in only 1 case of ectoicpregnancy. 5. Of 19 sonographically ectopic pregnancies, a correct positive ultrasonic diagnosis was made n 14cases (73.7%). Of 29 confirmed cases, overall diagnostic accuracy of ultrasound was 79.3%. 6. By demonstrationintrauterine pregnancy or disease other than ectopic pregnancy such as myoma uteri, homole or ovarian cyst,ectopic pregnancy was ultrasonically excluded in 10 cases. Among above 10 cases, 1 case of ultasonically bilateralovarian cyst was proved to have ruptured tubal pregnancy combined with ovarian cyst. The accuracy of ultrasonicexclusion of ectopic pregnancy was 90%. In the authors'experience, ultrasonography was very helpful in theexclusion of extopic pregnancy.
Age Distribution ; Animals ; Dermoid Cyst ; Diagnosis ; Early Diagnosis ; Emergencies ; Female ; Fetal Heart ; Follow-Up Studies ; Gestational Sac ; Gynecology ; Hematoma ; Hemorrhage ; Laparoscopy ; Metrorrhagia ; Mice ; Myoma ; Myometrium ; Obstetrics ; Ovarian Cysts ; Pregnancy ; Pregnancy ; Pregnancy, Ectopic ; Pregnancy, Interstitial ; Pregnancy, Tubal ; Sterilization, Tubal ; Ultrasonics ; Ultrasonography ; Uterus ; Zygote

No abstract available.
Child* ; Humans

PURPOSE:Growth hormone(GH) therapy is very effective for the treatment of short stature, but it is unconvenient that GH should be injected daily because of short half-life. Sustained-release forms of GH preparation is needed for better compliance. This study aimed to measure peak pattern and duration of release of hGH from solid microparticles using sodium hyaluronate. METHODS:In group 1, hGH(EutropinTM) 285microg/kg was injected subcutaneously to 2 Jindo dogs everyday for 7 days. In group 2, hGH solution(EutropinTM) was continuously infused subcutaneously for 12 hours a day for the first 2 days via mini pump(minimed co.) and then for 24 hours a day thereafter until 7th day with the rate of 11.9microg/kg/hr. In group 3, dose of 2mg/kg hGH in sustained-release formulation using sodium hyaluronate, was injected subcutaneously to 3 Jindo dogs. In group 4, two dose levels of 1mg/kg and 2mg/kg hGH in sustained-release formulation using sodium hyaluronate, were injected subcutaneously to each group of 4 Beagle dogs. To evaluate side reactions from continuous injection of sodium hyaluronate, sustained release form of hGH 2mg/kg was injected to 4 Beagle dogs once a week for 4 weeks and compared to 4 control Beagle dogs. Blood samples were withdrawn half- hourly for 6 hour and 2-4 times a day thereafter in Jindo dogs and at 6hr, 12hr, 22hr in the first day and twice a day(at 9:00, 16:00 O'clock) for the following 6 days. RESULTS:In group 1, peak GH conc. of 122+/-27ng/ml was observed at 1 hour after hGH(EutropinTM) 285microg/kg injection and 1/2 of peak GH conc. at 4 hour. and decreased to 2ng/ml at 24 hour. GH AUC(Area under curve) was 670(ng/ml.hr). In group 2, initial steady state GH conc. of 25ng/ml occurred after 6 hour, however, GH conc. decreased gradually to 16ng/ml at the 7th day. GH AUC based on th initial steady state GH conc. was 600(ng/ml.hr). In group 3(Jindo dogs), GH conc. was peaked at 12 hour and 1/2 of peak GH conc at 30-46 hour and decreased to baseline at 70 hour. GH AUC was 2173(ng/ml.hr). In group 4(Beagle dog), peak GH concentrations of 56+/-7ng/ml and 108+/-12ng/ml were observed at 12 hour for the doses of 1mg/ kg and 2mg/kg, respectively and 1/2 of peak GH conc at 48 hour and decreased to baseline at 80 hour. GH AUC was 3560(ng/ml.h) for 2mg/kg treated dogs. Serum IGF-1 was increased to peak levels of 520ng/ml, and 580ng/ml for the doses of 1mg/kg 2mg/kg, respectively, and persisted above the baseline till 120 hour. There was no specific side reaction during experimental period. CONCLUSION: Sustained-release form of hGH with sodium hyaluronate released GH for 70-80 hour with the peak level lower than that resulted from the conventional aqueous formulation of the equivalent dose, and higher concentration IGF-I maintained for 120 hour after injection above baseline. More extensive study is needed to permit for new therapeutic application.
Animals* ; Area Under Curve ; Compliance ; Dogs ; Growth Hormone* ; Half-Life ; Hyaluronic Acid ; Insulin-Like Growth Factor I ; Polymers

PURPOSE: This study was to explore the effects of breast cancer education for college students on their mother's breast cancer screening promotion. METHODS: This study used a one-group pretest and posttest design. Data were collected from September to November, 2007 from a sample of 80 college students and their mothers using a survey questionnaire, which asked about demographic variables, concerns over health and breast cancer, communication, stage of change and attitude (pros and cons) related to breast cancer, and confidence in breast self-examination. The college students received education about breast cancer for 50 minutes and then they educated their mothers about breast cancer. Data were analyzed with descriptive statistics and paired t-test. RESULTS: The mean age of the college students was 22.0 years, and that of their mothers 49.4 years with a range from 43 to 58 years. After receiving education on breast cancer, there were significant changes in the mean scores of concerns about health and breast cancer, communication, pros in mammography, and confidence in practicing breast self-examination. CONCLUSION: This study indicates that education on breast cancer to mothers through their college-age daughters is effective and can be utilized to promote breast cancer screening for women.
Breast Neoplasms* ; Breast Self-Examination ; Breast* ; Education ; Female ; Health Education* ; Humans ; Mammography ; Mass Screening* ; Mothers ; Nuclear Family ; Students, Nursing ; Surveys and Questionnaires

PURPOSE: Purpose of study was to analyze the research articles in the Journal of Korean Oncology Nursing in order to provide an direction for the future research. METHODS: This study analyzed 93 studies published in the Journal of Korean Oncology Nursing, from its beginning year to the year 2007, according to the research objectives. The frame of evaluation included years and types of publication, the theoretical frameworks, research design, subject, data collection method, keyword analysis by MeSH. RESULTS: 45.2% of studies was non-degree based studies. 95.7% of studies was not described theoretical framework in the articles. 71.0% was utilized a non-experimental design. 57% of subjects in researches was patients. 76.3% of studies were used the questionnaire for data collection. Concepts as human, nursing, and health were consistently appeared in research. But concepts of environment has been insufficiently conducted. CONCLUSION: Researches in the Journal of Korean Oncology Nursing has been changed in methodology and the topics of research for the last 7 yr. It progresses in both quantity and quality. But, it is necessary to conduct research founded on theoretical background, various research design, variability of study subjects and topics as supported by scientifically and empirically.
Data Collection ; Humans ; Korea ; Medical Oncology ; Nursing Research ; Publications ; Surveys and Questionnaires ; Research Design

No abstract available.
Centrifugation, Density Gradient* ; Humans* ; Spermatozoa*

No Abstract Available.
Cell Line* ; Humans* ; Vascular Endothelial Growth Factor A*

No Abstract Available.
Cell Line* ; Humans* ; Vascular Endothelial Growth Factor A*

The history of surgical treatment of cataract extends back at least Before Christ. In 1748 Jacques Daviel, French ophthalmic surgeon, was attempted to cataract extraction with modern operating techniques and since then development of operation methods, techniques and instruments were contributed to recovery of the loss of vision. Although the occurrence of during and postoperative complications of cataract extraction diminish, cataract complications still remain troublesome in the minds of cataract operators. The authors reported the result of hyphema in the many complications of cataract extraction for the 7 of the 47 eyes(42 cases), which were operated from January 1976 to August 1977, using the sex, types of cataract, age, methods of operation, onset and procedure.
Cataract Extraction* ; Cataract* ; Hyphema* ; Postoperative Complications

Leukocytes, when subjected to phagocytic, immunologic or chemical stimuli, are known to exhibit a sequence of morphological and biochemical events which lead to the production of H₂, O₂, O₂⁻, and even OH as well as the secretion of various lysosomal lytic enzymes into the extracellular environments. It was been proposed that some antiinflammatory drugs may exert their therapeutic effects by inhibiting the production of reactive oxygen species or by abrogating the effects of reactive oxygen species ontissue components. In the present study, effects of various quenchers and antiinflammatory drugs were observed on the changes of viscosity of hyaluronate and collagen gelation by oxygen radicals generated by xanthine and xanthine oxidase. Quenching effects of antiinflammatory drugs on reactive oxygen species were also observed with gas chromatography. 1. Decrease of viscosity of hyaluronate and inhibition of collagen gelation by xanthine and xanthine oxidase were inhibited by various quenchers. 2. Several oxygen radical quenchers and antiinflammatory drugs did not affect viscosity of hyaluronate and collagen gelation. 3. Reactive ouygen species generated by xanthine and xanthine oxidase affected both viscosity of hyaluronate and collagen gelation with similar pattem. Therefore, in this study quenching effects of antiinflammatory drugs on reactive oxygen species have been examined by observing viscosity changes of hyaluronate. Sodium salicylate, acetylsalicylic acid, indomethacin and hydrocortisone affected viscosity changes of hyalumnate by xanthine and xanthine oxidase. The pattem of inhibition of hyaluronate degradation by these drugs were comparable to the inhibition produced by OH scavengers and singlet oxygen quencher. 4. To danonstrate the generation of OH ethylene was determined from methional incubated with xanthine and xanthine oxidase according to gas chromatography method. Xanthine and xanthine oxidase produced ethylene fmm methional and the production was inhibited by antiinflammatory drugs. The result obtained in this study suggest that action of antiinflammatory drugs may, to some event, be attributed to their ability to intercept reactive oxygen species in addition to inhibition of synthesis of prostaglandin.
Aspirin ; Chromatography, Gas ; Collagen ; Hydrocortisone ; Indomethacin ; Leukocytes ; Methods ; Oxygen ; Reactive Oxygen Species ; Singlet Oxygen ; Sodium Salicylate ; Therapeutic Uses ; Viscosity ; Xanthine ; Xanthine Oxidase