Lichen scrofulosorum, also known as Tuberculosis cutis lichenoides, is thought as a tuberculid such as Erythema induratum, Papulonecrotic tuberculid, Tuberculosis miliaris disseminata and Lupus miliaris disseminatus faciei. The lesions of Lichen scrofulosorum are pin-head sized or smaller, normal skin or reddish brown colored, arranged in nummular groups, usually on the trunk, where they persist unchanged or undergo spontaneous involution. As a rule, they appear in children who have tuberculosis of the bones or the lymphnodes. We report a case of Lichen scrofulosorum, 13-year old girl, who showed clinically and histologically typical lesions on the trunk. She was highly sensitive to Mantoux test and had tuberculous lymphadenitis of left cervical lymphnodes, but the chest was negative. Many challenges to the tuberculous origin of the tuberculids including Lichen scrofulosorum have prevailed for the last decade, Several studies and reports indicated that healing responses of Erythema induratum and other tuberculids to corticosteroids were more definite than to anti-tuberculosis drugs. But more recently, some reports recommended that anti-tuberculosis drugs were eftective than corticosteroids (in the treatment of Erythema induratum and other tuberculids). In this case anti-tuberculosis treatment with PAS 10gm., INH 400 mg., and streptomycin 1.0 gm. daily for the first one month and then 1.0gm. twice a week has remarkably improved the clinical manifestation in follow-up of three months. While the follow-up period was no enough, we strongly suggest the tuberculous origin of Lichen scrofulosorum.
Adolescent ; Adrenal Cortex Hormones ; Child ; Erythema Induratum ; Female ; Follow-Up Studies ; Humans ; Lichens* ; Skin ; Streptomycin ; Thorax ; Tuberculosis ; Tuberculosis, Cutaneous ; Tuberculosis, Lymph Node

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by renal cyst formation, hypertension, and end-stage renal disease. For many years, ADPKD was considered an adult disease. In fact, it may occur at any time in life including in utero. We experienced a case of ADPKD at 34 weeks of gestation. On ultrasound, both kidnies were enlarged and echogenic. Amniotic fluid index was normal. We discovered a family history of paternal origin. Sonographic findings of bilaterally enlarged and echogenic kidnies without oligohydroamniosis may suggest ADPKD. Renal ultrasound examination of parents is useful in the diagnosis of ADPKD.
Adult ; Amniotic Fluid ; Diagnosis* ; Female ; Humans ; Hypertension ; Kidney Failure, Chronic ; Parents ; Polycystic Kidney, Autosomal Dominant* ; Pregnancy ; Prenatal Diagnosis ; Ultrasonography

Pain management is a major issue in caring of cancer patients. Because pain management cancer patient of does not control effectively. it is important to educate reporting pain and using analgesics for having cancer patient's concerns and anxiety. The purpose of this study was to identify the effect of cancer pain management education on the pain and concerns of pain management in cancer patients. This study was a quasi-experimental as nonequivalent control pretest-post test design. The subjects of this study consisted of 50 (experimental group 25. control group 25) patients hospitalized in K university hospital in Busan. The data were collected from December 1. 2001 to April 12. 2002. The measurement tool for the concerns of pain management had used questionnaires interpretated by Kim(1999) developed by based Ward(1993) and pain nominal scale. The collected data were analyzed frequency. percentage. mean, SD. chi2test, t-test, ANCOVA. The results of this study were as follows: 1. The 1st hypothesis: The experimental group which had received the cancer pain management education were lower than the control group in the score of pain was not supported (p>0.05). 2. The 2nd hypothesis: The experimental group which had received the cancer pain management education were lower than the control group in concerns of pain management was supported (F=5.285, p 0.01). In conclusion. the cancer pain management education can know what was effective to decrease in the concerns of pain management in cancer patients. Therefore. Pain Management Education must be positively utilized in clinical situation.
Analgesics ; Anxiety ; Busan ; Education* ; Humans ; Pain Management* ; Surveys and Questionnaires

Cutis marmirata telangiectatica congenita, first described by van Lohuizen in 1922, is a rare congenital vascular anomaly. This name is still generally used in Europe, but in American literature the most comrnon designation for this disease is generalized congenital phlebectasia. We represent the first reported case of cutis marmorata telangiectatica, congenita in Korea. The patient, 8 months old boy, has generalized cutis marmorata-like reticulated mottlings on his entire skin except the rnucous membranes since birth. He also has complete cleft palate but no other detectable congenital vascular malformation. The skin lesion shows spontaneous gradual improvement from three months of age.
Cleft Palate ; Europe ; Humans ; Infant ; Korea ; Male ; Membranes ; Parturition ; Skin ; Vascular Malformations

BACKGROUND: It is well known that neuronal degeneration can occur after a brief deprivation of energy source. To investigate whether glial astrocyte can induce a phenomenon of delayed cell death after transient energy loss and to see how different are the effects of nifedipine, lidocaine, carnosine and hypothermia on delayed toxicity in astrocyte. METHODS: Human astrocytoma cells (U1242MG) were used in this study. To assess the astrocyte survival during post-ischemic period after transient histotoxic hypoxia, 3-[4,5-dimethylthiazol-2yl]-2,5, diphenyl tetrazolium bromide (MTT) test was used. Compared to MTT test, tryphan blue test was also used to demonstrate membrane damage of affected cells. Studies on intracellular calcium dynamics during ischemic and post-ischemic period were carried out with fluo-3 and flow cytometry system. RESULTS: The percentage survival of astrocyte during post-ischemic period was decreasing with time. Calcium channel blocker nifedipine, sodium and calcium channel blocker lidocaine and free radical scavenger carnosine could not prevent post-ischemic cell damage. But, hypothermia was only an effective method in ameliorating post-ischemic cell death. Intracellular calcium increase during ischemia and post-ischemia was dependent on extracellular calcium influx. CONCLUSIONS: Only hypothermia was effective in reducing astrocyte death during post-ischemia after transient energy depletion. Intracellular calcium alterations during post-ischemia was from extracellular space.
Anoxia* ; Astrocytes* ; Astrocytoma ; Calcium ; Calcium Channels ; Carnosine ; Cell Death ; Extracellular Space ; Flow Cytometry ; Humans ; Hypothermia* ; Ischemia ; Lidocaine ; Membranes ; Neurons ; Nifedipine ; Sodium

No abstract available.
Animals ; Calcitonin Gene-Related Peptide* ; Calcitonin* ; Rats* ; RNA, Messenger*

No abstract available.
Bronchi* ; Rupture*

A case of Kimuras disease was presented. It seemed that this is the first reported case in Korean literature. The patient was 26 years old male having painless slowly growing tumor-like swelling on his left cheek for 5 months. Mild leukocytosis and marked eosinophilia (27%) were noted in routine laboratory tests. Histopathologically numerous well developed lymphoid follicular structures composed of closely packed lymphocytes and histiocytes were seen in the deep dermis and subcutaneous fat tissue. Dense eosinophilic infiltrations in and around the follicles were peculiar picture. The literature was reviewed. Its relation to the similar descriptions in western literature under various diffe'rent headings was discussed;
Adult ; Cheek ; Dermis ; Eosinophilia ; Eosinophils ; Head ; Histiocytes ; Humans ; Leukocytosis ; Lymphocytes ; Male ; Subcutaneous Fat

The object of this study was to determine the difference of radiation effect in different fractional does and to establish optimal fractionation schedule on the whole-abdominal X-ray irradiation. Total 160 mice were irradiated with 150 KVP, 15 mA orthovoltage x-ray machine and two different fractionation (100 cGy/Fr. and 200 cGy/Fr.) were used. Body weight, hemoglobin and WBC count with differential count were analyzed according to the same amount of total dose, same field size and two different fractionation schedules. The results of this study were summarized s follows: There was no significant difference in body weight and hemoglobin concentration by sex or fractional dose. Leukopenic change was prominent in the 3,000 cGy irradiation group and the proportion of decrease was remarkable in the 200 cGy/Fr. Group than 100 cGy/Fr. Group. Progressive decrease of lymphocyte count and reciprocal increase of neutrophil count were noted as dose increment. The effect of the fractional does on WBC count and proportion of lymphocyte were significant. This suggests that judicious selection of fractional dose may be important in clinical radiotherapeutic practice.
Animals ; Appointments and Schedules ; Body Weight* ; Lymphocyte Count ; Lymphocytes ; Mice* ; Neutrophils ; Radiation Effects*

BACKGROUND: Anaerobic bacteria constitute a major part of the normal flora of the human skin, mucous membrane and intestinal tract, and can cause various infections. The incidence of anaerobic infections may differ greatly, depending on each country or hospital. METHODS: We evaluated the recent trends of anaerobic bacteria isolated from clinical specimens at Severance Hospital from 1986 to 1995. Specimens were cultured using thioglycollate medium and phenylethanol blood agar (PEBA) for 2-3 days under anaerobic condition. Identification of organism was based on conventional or commercial kit systems. RESULTS: During this period, a total of 2,664 isolates of anaerobic bacteria were obtained from 2,251 clinical specimens. The average number of anaerobes per specimen was 1.2. The frequent sources of isolation were specimens from the abdomen, followed by soft tissue, and head and neck. B. fragilis (46.3%) was the most frequently isolated gram-negative bacilli, and P. magnus (37.6%) and C. perfringens (18.8%) were the most frequently isolated gram-positive anaerobes. Abdominal, soft tissue, and head and neck infections were frequent clinical conditions. Among the anaerobe-positive specimens, only 16.8% yielded anaerobe alone while the remaining 83.2% revealed mixed infection with aerobic bacteria. CONCLUSIONS: It was concluded that B. fragilis is the most common species among gram-negative bacilli, and that P. magnus is the most common among gram-positive cocci. As well, the anaerobes are frequently isolated from specimens of the abdomen, head and neck, and soft tissue; and anaerobic infections are commonly mixed with aerobic bacteria.
Abdomen ; Agar ; Bacteria, Aerobic ; Bacteria, Anaerobic* ; Bacteroides fragilis ; Coinfection ; Gram-Positive Cocci ; Head ; Humans ; Incidence ; Mucous Membrane ; Neck ; Phenylethyl Alcohol ; Skin