No abstract available.
Acquired Hyperostosis Syndrome* ; Radionuclide Imaging*

No abstract available.
Diabetes Mellitus* ; Humans ; Lower Extremity* ; Radionuclide Imaging* ; Technetium Tc 99m Medronate* ; Vascular Calcification*

No abstract available.
Adenocarcinoma* ; Rectum*

No abstract available.
Lung* ; Perfusion*

Xeroderma pigmentosum, a rare, genetically determined dermatosis, is often cornplicated by malignant chagnes of various types-most commonly, basal-cell epithelioma, squamous cell epithelioma, less frequently malignant meIanoma, keratoacanthoma, fibrosarcoma, and endothelioma have been reported. In Korea, no case has ever been reported in literature except four cases at a symposium for dermatology, two of them complicated by basal-cell epithelioma, and the others by squamous cell epithelioma. This case reported was complicated by squamous cell epithelioma. As one of the anticancer treatments, especially for skin cancer, Bleomycin is, now, drawing the attention for its high therapeutic index with only few side effects. For this case, we injected Rleomycin 15mg at once, twice a week, for 8 weeks, So total injection was 16 times and 240mg of Bleomycin was given in total. While this amount given for this case was not enough for the complete treatment of squamous cell epithelioma, we got the following results: 1. Clinically, the ulcerated lesion of the cancer on the right ala nasi had shrunken in size with reepithelialization at the margin showing clear surface, and 2. microscopically, the atypical cancer cell masses and individual cell keratinizations had been decreased in size and in number, and less remarkable comparing to those in untreated stage at his first visit to the hospital.
Bleomycin* ; Carcinoma* ; Dermatology ; Fibrosarcoma ; Keratoacanthoma ; Korea ; Skin Diseases ; Skin Neoplasms ; Ulcer ; Xeroderma Pigmentosum

PURPOSE: Complete fibrovascular ingrowth within the hydroxyapatite ocular implant is necessary for peg drilling which is performed to prevent infection and to provide motility to the ocular prosthesis. We compared planar bone scintigraphy and SPECT for the evaluation of the vascularization within hydroxyapatite ocular implants. MATERIALS AND METHODS: Seventeen patients (M:F=12:5, mean age: 50.4+/-17.5 years) who had received a coralline hydroxyapatite ocular implant after enucleation surgery were enrolled. Patients underwent Tc-99m MDP planar bone and SPECT imaging by dual head gamma camera after their implant surgery (interval: 197+/-81 days). Uptake on planar and SPECT images was graded visually as less than (grade 1), equal to (grade 2), and greater than (grade 3) nasal bridge activity. Quantitative ratio of implanted to non-implanted intraorbital activity was also measured. Vascularization within hydroxyapatite implants was confirmed by slit lamp examination and ocular movement. RESULTS: All but three patients were considered to be vascularized within hydroxyapatite implants. In visual analysis of planar image and SPECT, grade 1 was noted in 9/18 (50%) and 6/18 (33%), respectively. Grade 2 pattern was 7/18 (39%) and 4/18 (22%), and grade 3 pattern was 2/18 (11%) and 8/18 (44%) respectively. When grade 2 or 3 was considered to be positive for vascularization, the sensitivity of planar and SPECT imaging were 60% (9/15) and 80% (12/15), respectively. In 3 patients with incomplete vascularization, both planar and SPECT showed grade 1 uptake. The orbital activity ratios on planar imaging were not significantly different between complete and incomplete vascularization (1.96+/-0.87 vs 1.17+/-0.08, p>0.05), however, it was significantly higher on SPECT in patients with complete vascularization (8.44+/-5.45 vs 2.20+/-0.87, p<0.05). CONCLUSION: In the assessment of fibrovascular ingrowth within ocular implants by Tc-99m MDP bone scintigraphy, SPECT image appears to be more effective than planar scintigraphy.
Durapatite* ; Eye, Artificial ; Gamma Cameras ; Head ; Humans ; Orbit ; Radionuclide Imaging* ; Technetium Tc 99m Medronate ; Tomography, Emission-Computed, Single-Photon*

No abstract available.
Anxiety* ; Depression* ; Humans ; Kidney Transplantation* ; Kidney* ; Renal Dialysis*

Manganese is an essential element in the body. It is mainly diposited in the liver and to a lesser degree in the basal ganglia of the brain and eliminated through the bile duct. Rapid turnover of manganese in the body makes it difficult to evaluate the manganese exposure in worker, especially in those with irregular or intermittent exposure, like welder. Therefore, conventional biomarkers, including blood and urine manganese can provide only a limited information about the long-term or cumulative exposure to manganese. Introduction of magnetic resonance imaging (MRI) made a progress in the assessment of manganese exposure in the medical conditions related to manganese aculmulation, e. g., relaxation time on MRI due to its paramagnetic property, resulting in high signal intensity(HSI) on T1-weighted image(T1WI) of MRI. Manganese deposition int he brain, therefore, can be visualized as an HSI in the globus pallidus, the substantia nigra, the putamen and the pituitary. Clinical and epidemiologic studies regarding the MRI findings in the cases of occupational and non-occupational manganese exposure were reviewed. Relationships between HSI on T1WI of MRI and age, gender, occupational manganese exposure, and neurological dysfunction were analysed. Relationship between biological exposure indices and HSI on MRI were also reviewed. Literatures were reviewed to establish the relationships between HSI, manganese deposition in the brain, pathologic findings, and neurological dysfunction. HSI on T1WI of MRI reflects regional manganese deposition in the brain. This relationship enables an estimation of regional manganese deposition in the brain by analysing MR signal intensity. Manganese deposition in the brain can induce a neuronal loss in the basal ganglia but functional abnormality is supposed to be related to the cumulative exposure of manganese is relatively too short to reflect the long-term cumulative exposure of manganese in the brain, use of brain MRI for the assessment of exposure in a group of workers seems to be hardly rationalized, while it can be a useful adjunct for the evaluation of manganese exposure in the cases with suspected manganese-related health problems.
Basal Ganglia ; Bile Ducts ; Biomarkers ; Brain* ; Epidemiologic Studies ; Globus Pallidus ; Liver ; Magnetic Resonance Imaging* ; Manganese* ; Neurons ; Putamen ; Relaxation ; Substantia Nigra

No abstract available.
Cystic Adenomatoid Malformation of Lung, Congenital* ; Lung*

No abstract availble