No abstract available in English.

The purpose of the present study is to assess the effect of aging on left ventricular filling function and the relation between Doppler parameters of LV filling and radius/thickness ratio in an normal population and in hypertensive patients with left ventricular hypertrophy. We underwent M-mode echocardiography and pulsed Doppler measurement of the LV inflow in 123 normal controls and 78 hypertensive patinets with LVH. The results were as follows; 1) In hypertensive patients with LVH, the peak early velocity(60.9+/-13.5cm/sec)was significantly decreased, and the peak atrial velocity(78.9+/-19.6cm/sec)was significantly increased than that in normal controls(78.1+/-15.7cm/sec, 60.2+/-13.1cm/sec, P<0.005, respectively). 2) In the normal controls, peak early velocity correlated well with age(r=-0.388, -0.595, P<0.005, respectively), but not with radius/thickness ratio. 3) In the hypertensive patients with LVH, peak early velocity and the ratio of early to atrial velocity correlated with redius/thickness ratio (r=0.274 P<0.05, r=0.367 P<0.005, respectively), but not with age. In conclusion early LV diastolic filling is reduced and systolic is augmented, probably reflecting alteration in myocardial siffness with normal aging, whereas in chronic LVH, changes in radius/thickness ratio is more important determinants of ventricular compliance, overriding the effects of age.
Aging ; Compliance ; Echocardiography ; Humans ; Hypertrophy, Left Ventricular*

PURPOSE: More effective diagnosis and treatment through a survey on clinical aspect for the last 5 years and interrelation between cold agglutinin titer and mycoplasma antibody titer of Mycoplasma pneumoniae pneumonia. METHODS: 369 patients hospitalized in the department of pediatrics of Chung Goo Sung Shim Hospital for the 5 years from January 1990 to December 1994 have been surveyed, which diagnosed to be Mycoplasma pneumoniae pneumoniaby physical findings or chest x-ray findings with the titer of 1:64 in cold agglutinin test or the titer of 1:80 in Mycoplasma antibody test or forefold increase of any one or both of 2 titers in follow-up tes RESULTS: 1) More cases were found in 1990(76 cases, 20.6%) and 1994(181 cases, 49%) and the monthly distribution showed irregular fluctuations. Male to female ratio was 1:1.2 and high incidence was in the age of 3 to 5 years(27.9%), but 46 cases(12.5%) affected the infants below 1 year old. 2) Cough, fever, sputum were the most chief complaints. More moist rales, pharyngial injection, wheezing were found in physical examination. 86.7% of pneumonic infiltration were found in x-ray findings, 35.8% of which were both lung infiltration. The most common affected site was Rt. lower lobe and then Lt lower lobe and then followed by Rt. upper lobe. 71.8% of the whole cases were hospitalized for 5-8 days. 3) EM administration started 10-12 days after the onset in 29.3%. Mean duration of hospitalization of the cases administrated within 6 days from onset was 7.5+/-2 days, which was shorter than 8.4+/-3.5-that of the cases administrated after 6days from onset. The observation on those duration meant little atatistically(p>0.1) 4) The measure of Mycoplasma antibody titer in 142 cases among 245 positive cold agglutinin test case showed 61.3% of positive ratio. Positive ratio of cold agglutinin test peaked from 13th to 15th day after onset(89%) and went down(33%) after 19th day. Positive ratio of Mycoplasma antibody titer was at its summit(91%) from 7th to 9th day and went down(63%) after 16th day. decreased to 63% after 16 days. 264 cases tested simultaneously for cold agglutinin titer and Mycoplasma antibody titer. Titers of each simultaneous test for cold agglutinin and Mycoplasma antibody were in proportion each other(p<0.005, N=264, r=0.51). CONCLUSIONS: Mycoplasma pneumoniae pneumonia prevailed every 4 years(1990, 1994) and monthly distribution had been irregular. The most cases were found at age of 4 and 5. Mycoplasma antibody titer seems more effective for early diagnosis for Mycoplasma antibody titer showed high positive rate earlier and the rate went down earlier than cold agglutinin titer. The earlier diagnosis and treatment are required because of tendency of later erythromycin administration.
Child* ; Cough ; Diagnosis ; Early Diagnosis ; Erythromycin ; Female ; Fever ; Follow-Up Studies ; Hospitalization ; Humans ; Incidence ; Infant ; Lung ; Male ; Mycoplasma pneumoniae* ; Mycoplasma* ; Pediatrics ; Physical Examination ; Pneumonia* ; Pneumonia, Mycoplasma* ; Respiratory Sounds ; Sputum ; Thorax

Pain caused by chronic pancreatitis is medically intractable and resistant to conventional interventional or surgical treatment. We report a case of spinal cord stimulation (SCS) for intractable pain due to chronic pancreatitis. The patient had a history of nonalcoholic chronic pancreatitis and multiple emergency room visits as well as repeated hospitalization including multiple nerve block and morphine injection for 3 years. We implanted surgical lead at T6-8 level on this patient after successful trial of percutaneous electrode. The patient experienced a decreased visual analog scale (VAS) scores for pain intensity and amount of opioid intake. The patient was followed for more than 14 months with good outcome and no further hospitalization. From our clinical case, spinal cord stimulation on intractable pain due to chronic pancreatitis revealed moderate pain control outcome. We suggest that SCS is an effective, noninvasive treatment option for abdominal visceral pain. Further studies and long term follow-up are needed to fully understand the effect of SCS on abdominal visceral pain.
Electrodes ; Emergencies ; Follow-Up Studies ; Hospitalization ; Humans ; Morphine ; Nerve Block ; Pain, Intractable ; Pancreatitis, Chronic ; Spinal Cord ; Spinal Cord Stimulation ; Visceral Pain

PURPOSE: To evaluate the radiologic findings and detectability of parathyroid masses in ultrasonograph computed tomography(CT), and radionuclide study(201TI-99mTc pertechnetate subtraction scintigraphy). MATERIALS AND METHODS: Surgically-proven 11 cases with parathyroid masses consisted of adenoma(n=8), adenomatous hyperplasia(n:2) and adenocarcinoma(n:l) were retrospectively analyzed. We performed US in all cases, CT in 8 cases, and radionuclide study in 7 cases. The parathyroid masses were analysed in regard to anatomic localization and imaging appearance on three modalities. RESULTS: Ten of the 11 parathyroid masses(91%) were located posterior to the thyroid gland and the remainder in the left superior mediastinum. Nine of the 11 cases(82%) were detected on US. The majority were well-defined hypoechoic mass on US. Six of the 8 cases(75%) were detected on CT scan. In the precontrst CT, all of the 8 masses were hypodense as compared with thyroid gland and most showed mild enhancement on post-contrast CT. Six of the 7 cases(86%) were detected on RI study as hot nodule. CONCLUSION: The typical radiological findings of the parathyroid mass were well-defined ovoid or round hypoechoic mass on US, hypodense mass with variable contrast enhancement on CT, and hot nodule on radionuclide study. US was a convenient and reliable imaging modality in detecting parathyroid masses. Improved diagnostic accuracy could be achieved with complementary CT scan and radionuclide study in addition to ultrasonography.
Mediastinum ; Retrospective Studies ; Sodium Pertechnetate Tc 99m ; Thyroid Gland ; Tomography, X-Ray Computed ; Ultrasonography

No abstract available.
Pubic Bone* ; Technetium Tc 99m Medronate*

PURPOSE: A new continuous cell line, NBL-K1, was established in tissue culture from a Korean child with stage IV neuroblastoma, arising from the adrenal gland, which had normal urinary excretion of VMA and HVA and diagnosed by light and electron microscope. METHODS: Clinical characteristics of patient was high ferritin level, normal neuron specific enolase, and normal urinary VMA and HVA. The small tissue specimen obtained from surgically resected tumor was minced with a mosquito scissors and scalpels and cultured in L-15 medium with 17% FBS (37oC and 5% CO2). Chromosome analysis was performed from bone marrow cell culture with a method of high resolution banding using methotrexate and thymidine and TGT staining. Chromosomes were analyzed by ISCN. The N-myc amplification was checked by N-myc primers, PCR, and gel electrophoresis. RESULTS: The cells were attached to the bottom of culture flask on 4th day of culture and composed of a small and elongated cell body with relatively abundant granules in cytoplasm and oval shaped nucleus with one prominent nucleoli and slender nerve-like fiber. Cell clumps were observed on 10th day of culture. The morphology was changed to round cell when trypsin was added. The chromosome analysis revealed two kinds of hyperdiploidy. No cell contained homogeneously stained region (HSR). But numerous double minutes (DMs) were observed. N- myc oncogene of the NBL-K1 was not amplified. The cultured cells with many black immunobeads around the surface considered to be the neuroblastoma cells. CONCLUSION: The characteristic Korean neuroblastoma cell line (NBL K-1) was estblished for the future studies of in vitro chemosensitivity test, monoclonal antibody and xenograft.
Adrenal Glands ; Antibodies, Monoclonal ; Bone Marrow Cells ; Cell Line* ; Cells, Cultured ; Child ; Culicidae ; Cytoplasm ; Electrophoresis ; Ferritins ; Genes, myc ; Heterografts ; Humans ; Methotrexate ; Neuroblastoma* ; Phosphopyruvate Hydratase ; Polymerase Chain Reaction ; Thymidine ; Trypsin

OBJECTIVE: The petrosal meningiomas involving the middle cranial fossa through the Meckel's cave represent a difficult surgical challenge. We report our experience of removing these lesions through the suboccipital approach combined with a technique that expose the Meckel's cave by removing the bony prominence located above the porus of the internal acoustic meatus, called the suprameatal tubercle, and the surrounding bone. METHODS: Between the period of January 1999 and October 2001, a total of seven patients with petrosal meningiomas involving the Meckel's cave were operated upon using suboccipital suprameatal approach. In the supine position, suboccipital craniotomy was performed. The main mass located predominantly within the cerebellopontine angle(CPA) was removed using intradural approach. The suprameatal tubercle was drilled-out to expose the Meckel's cave. And then, the tumor extended into the middle cranial fossa through the Meckel's cave was removed. RESULTS: In every case, the tumor extending into the Meckel's cave was exposed well. The tumors were completely removed in all patients without serious complications. CONCLUSION: We believe that suboccipital suprameatal approach offers a safe and effective method to remove some selected lesions of the CPA area extended into the middle cranial fossa through the Meckel's cave without the need for complex procedures, if the main mass is located predominantly in the CPA area.
Acoustics ; Cranial Fossa, Middle ; Craniotomy ; Humans ; Meningioma* ; Supine Position

PURPOSE: Ganglioglioma is a rare primary brain tumor usually found in the temporal lobe. The purpose of thisstudy is to describe the characteristic MR findings of temporal lobe ganglioglioma. MATERILA AND METHODS: Over aseven-year period, ten patients with cerebral ganglioglioma were evaluated at our institution. Seven cases oftemporal lobe ganglioma were found ; six of these involved men, and one, a woman ; their mean age was 29.6 years.In three patients, Gd-DTPA-enhanced T1 weighted images were also obtained. We retrospectively analysed the MRIfindings with respect to location, size, cortical involvement, margin, cystic change, degree of enhancement, MRsignal intensity, calcification and peritumoral change. RESULTS: In five cases, tumors were located within thetemporal lobe. In one, a tumor extended from the temporal lobe to the thalamus, and in one from the temporal lobeto the thalamus and cerebral peduncle. All temporal gangliogliomas measured 1.6-3.8cm in their greatestdiameter(mean diameter, 2.7cm). In all cases, the cortices were involved with the maintenance of gyriform. Thetumor margin was ill defined in five cases and well defined in two. Tumors showed multiple small cystic changes infour cases, a large cyst in two, and a solid nodule in one. In three cases in which contrast media wasadministered, no lesions were enhanced. On T1-weighted images, iso-signal intensities were seen in five cases andhigh signal intensities in two. On T2-weighted images, the corresponding figures were five and two. On MRI, tumorcalcification and calvarial erosion were each detected in two cases. CONCLUSION: In patients with temporal lobeepilepsy in whom cortical solid or cystic and poorly enhanced lesions were seen on brain MRI, and in whomaccociated findings such as calcification and or adjacent bony erosion were noted, ganglioglioma must beconsidered.
Brain ; Brain Neoplasms ; Contrast Media ; Female ; Ganglioglioma* ; Humans ; Magnetic Resonance Imaging* ; Male ; Retrospective Studies ; Tegmentum Mesencephali ; Temporal Lobe* ; Thalamus

Cerebrospinal fluid otorrhea is a rare disease entity, especially when brought on by spontaneous causes. The site of leakage should be identified to treat the disorder effectively. Various localizing modality was suggested in the literatures. Intrathecal gadolinium-enhanced magnetic resonance imaging identifies the small leakage site easily and correctly. Hydroxyapatite cement is a calcium phosphate-based material that forms dense paste mixed with water or sodium phosphate solution. Hydroxyapatite cement is remarkable for its excellent biocompatability in interacting with the native bone to osseointergrate with the surrounding bone. We report on our experience of successfully treating a patient with the cerebrospinal fluid leak from the congenital inner ear anomaly using the hydroxyapatite cement.
Calcium ; Cerebrospinal Fluid ; Cerebrospinal Fluid Otorrhea ; Durapatite* ; Ear, Inner* ; Humans ; Magnetic Resonance Imaging ; Rare Diseases ; Sodium ; Water