1.Analysis of DNA Ploidy Patterns and Nuclear Morphometry in Diethylnitrosamine Induced Hepatocyte Nodules and Hepatocellular Carcinoma of Rats.
Chan CHOI ; Myung Kwan KIM ; Kwan Mook CHAE ; Eun Cheol KIM ; Hyung Bae MOON
Korean Journal of Pathology 1993;27(3):226-234
This study was designed to answer the question; (1) How does the DNA ploidy pattern change in hepatocarcinogenesis? (2) How does the nuclear morphology change in hepatocarcinogenesis? Diethylnitrosamine(DEN) (16.5 mg per kg) was subcutaneously injected to female Sprague-Dawley rats(150~200g) by weekly interval for 30 weeks. DNA ploidy and parameters of nuclear morphology were measured by image analyser(IBAS 200, Kontron, FRG). The DNA ploidy pattern was divided into three basic patterns(diploid, polyploid, and aneuploid modes). In 8 cases of saline-injected control rats, the DNA histograms showed all polyploid pattern. Inhepatocyte nodules(hyperplastic nodules), DNA diploidy was the most frequent pattern, being followed by polyploid and aneuploid DNA patterns, contrast to hepatocelular carcinomas in which polyploid DNA pattern was most frequently noted being followed by diploid and aneuploid DNA pattern. Although the nuclei of hepatocytes in hepatocyte nodules and hepatocellular carcinomas were larger and more pleomorphic than those of normal hepatocytes, they were as same as those of normal hepatocytes in regard to nuclear hyperchromasia. DNA content, which was increased in hepatocarcinogenesis, was significantly related to the nuclear area.
Female
;
Humans
;
Carcinoma, Hepatocellular
2.Renal metastasis from adenoid cystic carcinoma of salivary gland: report of two cases.
Myung Kwan LIM ; Seung Hyup KIM ; Man Chung HAN
Journal of the Korean Radiological Society 1992;28(5):766-768
Adenoid cystic carcinoma of the major salivary gland is a relatively rare tumor which is well known for its high local recurrence rate and frequent distant metastasis. Metastasis of this tumor to kidney has not been reported previously to our knowledge. We report two cases of renal metastasis from adenoid cystic carcinoma of the salivary gland.
Adenoids*
;
Carcinoma, Adenoid Cystic*
;
Kidney
;
Neoplasm Metastasis*
;
Recurrence
;
Salivary Glands*
3.Dejerine-Sottas Disease: One Case Report
Myung Chul YOO ; In Hoi KOO ; Chong Kwan KIM
The Journal of the Korean Orthopaedic Association 1983;18(2):415-418
A case of hypertrophic interstitial neuropathy in a 32 years old man developed in the median nerve is reported. This is a rare disease characterized by thickened peripheral nerves which may be palpable and visible. This case was treated by excision of transverse carpal ligament and external and internal neurolysis.
Hereditary Sensory and Motor Neuropathy
;
Ligaments
;
Median Nerve
;
Peripheral Nerves
;
Rare Diseases
4.Systolic Time Interval on Hypertension.
Oak Hee KIM ; Kwan Sam KIM ; Myung Shick KIM ; Jong Hoa BAE ; Jung Sang SONG
Korean Circulation Journal 1983;13(1):141-150
The duration of the phases of left ventricular systole was measured from simultaneous recordings of the electrocardiogram, phonocardiogram and carotid arterial pulse tracing using a multichannel photographic system with paper speed at 100 mm per second. Observations were made in 81 male and 66 female patients with hypertension and 41 healthy males and 38 healthy females who served as controls. All hypertension patients were classified by change in funduscopic finding, EKG and grade of diastolic pressure. STI were measured in each group and analysed. The resutls were as follows: 1. The normal PEP/LVET was 0.293 in male and 0.303 in female. 2. In male & female hypertensive patients, all STI were significantly difference to that of normal control except QA2. 3. In male hypertensive patients, the degree of EKG, funduscopic change and diastolic pressure were positive relation to the increase of PEP/LVET.
Blood Pressure
;
Electrocardiography
;
Female
;
Humans
;
Hypertension*
;
Male
;
Systole*
5.Clinical studies on risk factors of preterm delivery.
Ey Seob SIM ; Tae Hyung KIM ; Myung Jin KIM ; Yong Bong KIM ; Sung Kwan PARK
Korean Journal of Perinatology 1993;4(4):504-511
No abstract available.
Risk Factors*
6.Different Patterns of Meniscal Tears in Recent Anterior Cruciate Ligament ( ACL ) Ruptures and Chronic ACL-deficient Knees.
Ryuh Sub KIM ; Myung Ku KIM ; Suk Myun KO ; Kwan Hee LEE ; Dong Hun CHOI
The Journal of the Korean Orthopaedic Association 1999;34(5):905-910
PURPOSE: We tried to outline the incidence and characteristics of meniscal tears in recent lesions and chronic insufficiency of the ACL. MATERIALS AND METHODS: Through this retrospective study of 103 reconstructions of the anterior cruciate ligament (ACL) performed between Jun 1996 to Sep 1998, according to a more accurate evaluation, ACL-deficient knees can be classified into two different stages (recent, chronic injuries). RESULTS: Overall, there was a significantly increasing incidence of meniscal tears in chronic injuries (P<0.05). A predominance of lateral meniscal tears were demonstrated with recent injuries, whereas the incidence of medial meniscal tears increased significantly with chronic injuries (P<0.05). CONCLUSIONS: This study highlights the increase of lateral meniscal lesion in recent ACL rupture and increase of severe meniscal lesion, especially medial meniscus, with progressive worsening of knee instability after an ACL injury. Although not significant, meniscal tears in the recent injuries were more amenable to repair. The results suggest that maximal meniscal preservation is best achieved with ACL reconstruction shortly after injury.
Anterior Cruciate Ligament*
;
Incidence
;
Knee*
;
Menisci, Tibial
;
Retrospective Studies
;
Rupture*
7.An Outbreak of Tsutsugamushi Disease in Vicinity of Taegu City and Kyungpook Province in 1988.
Young Su KWEON ; Jong Ho KIM ; Kwan Ho LEE ; Myung Su HYUN ; Moon Kwan CHUNG ; Hyun Woo LEE ; Myung Weon SHON
Yeungnam University Journal of Medicine 1989;6(1):31-41
Since the first cases of tsutsugamushi disease reported in Korea in 1986, many cases has been reported and its occurrence has been increasing. Only 2 cases has been reported in Taegu city and Kyungpook area. We experienced an outbreak of 26 cases of tsutsugamushi disease in this area and their clinical manifestations are; 1. The outbreak occurred in September to November in 1988 and its peak occurrence was in October. 2. Mean age was 52 years old (18 to 69 years old) and peak incidence was in the 6th decade. 3. Major symptoms and abnormal signs are fever/chills (88%), myalgia (65%), headache (54%), nausea and vomiting (31%), and abdominal pain (27%). The eschar was detected on lower part of body in most of cases, and more frequently in male (M:F 100 vs 58%). 4. Patients were treated with tetracyclines (TC) and/or chlorampenicol (CM) and mean duration of defervescence from initiation of antibiotic therapy was 2.1days with TC and 2.5 days with CM. 5. Complications are 2 cases of meningitis and 1 case of shock, and all cases were recovered without any sequelae. As above, tsutsugamushi disease occurs in Taegu city and Kyung Pook area as other part of Korea and clinical manifestations are similar to other reports.
Abdominal Pain
;
Daegu*
;
Gyeongsangbuk-do*
;
Headache
;
Humans
;
Incidence
;
Korea
;
Male
;
Meningitis
;
Myalgia
;
Nausea
;
Scrub Typhus*
;
Shock
;
Tetracyclines
;
Vomiting
8.Reexpansion pulmonary edema: report of 1 case.
Dong Kwan KIM ; Myung Sub HYUN ; Eun A LEE ; Seung Kyun LIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(9):718-721
No abstract available.
Pulmonary Edema*
9.Idiopathic pulmonary fibrosis vs. pulmonary involvement of collagen vascular disease:HRCT findings.
Myung Kwan LIM ; Jung Gi IM ; Joong Mo AHN ; Ji Hye KIM ; Seon Kyu LEE
Journal of the Korean Radiological Society 1993;29(6):1208-1213
Both idiopathic pulmonary fibrosis (IPF) and pulmonary involvement of collagen vascular disease(CVD) are well known cause of diffuse interstitial lung disease which lead to fibrosis and honeycombing. We analyzed HRCT findings of 33 patients with IPF and 14 patients with CVD in terms of predominant pattern, site of involvement, mediastinal lymph node enlargement, pleural change and pulmonary volume loss. Criteria of mediastinal lymph node enlargement and pleural thickening were 15mm in long diameter and 3mm, respectively. Volume loss of the lung was measured by using hilar height ratio (apex to hilum/hilum to diaphragmatic dome). Mean age was 61 years for IPF and 46 years for CVD and male: female ratio was 27:6, 4:10, respectively. Predominant HRCT pattern was honeycombing for IPF (63%), and ground-glass opacity for CVD (66%) (p=0.001). Predominantly, subpleural involvement was seen in 90% for IPF and 74% for CVD. Mediastinal lymph node enlargement was seen in 47% of the patient with IPF and 14% with CVD (p=0.004). pleural thickening was seen in 97% of the patients with IPF and 42% with CVD (P=0.002), Pleural effusion was seen in 10% of the patients with IPF and 36% with CVD (P=0.009). Hilar height ratio of more than 1.5 was seen in 84% of the patients with IPF and 29% with CVD. In conclusion, our study shows that patients with IPF are prone to have more progressed stage of pulmonary fibrosis than the patients with CVD on HRCT.
Collagen*
;
Female
;
Fibrosis
;
Humans
;
Idiopathic Pulmonary Fibrosis*
;
Lung
;
Lung Diseases, Interstitial
;
Lymph Nodes
;
Male
;
Pleural Effusion
;
Pulmonary Fibrosis
10.Coronary arteriovenous fistula: A case report.
Myung Sub HYUN ; Seung Kyun LIM ; Dong Kwan KIM ; Eun A LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(8):643-645
No abstract available.
Arteriovenous Fistula*