No abstract available.
Glucose* ; Humans ; Infant, Newborn* ; Metabolism*

No abstract available.
Failed Back Surgery Syndrome*

No abstract available.
Peutz-Jeghers Syndrome*

No abstract available.
Primary Myelofibrosis*

OBJECTIVE: This study was performed to develop a program for predicting individual cancer risk and to validate its discrimination power between case and control groups. METHODS: The author used the five databases for searching journals about risk factors of six major cancers in Koreans: stomach, liver, colorectal, breast, uterine cervix and lung cancer. The risk models were selected from journals presenting a multivariate linear logistic regression analysis. The baseline hazards which had no risk factors were calculated, and a cancer risk assessment program was developed using relative risks based on risk factors' combination and baseline hazards. Case-control study was performed for five years to validate the program. RESULTS: The discrimination power between case and control was 0.827 in stomach cancer, 0.949 in liver cancer, 0.594 in colorectal cancer, 0.587 in breast cancer, 0.708 in uterine cervix cancer and 0.663 in lung cancer. The estimated cancer probabilities were higher in all case groups compared to the control groups. CONCLUSION: The developed program is considered to be a valid tool for estimating probabilities of cancer development in Koreans. It is expected to be useful for the assessment of individual cancer risks, the selection of screening tools and preventive options for risk reduction.
Breast ; Breast Neoplasms ; Case-Control Studies ; Cervix Uteri ; Colorectal Neoplasms ; Discrimination (Psychology) ; Female ; Liver ; Liver Neoplasms ; Logistic Models ; Lung Neoplasms ; Mass Screening ; Risk Assessment ; Risk Factors ; Risk Reduction Behavior ; Stomach ; Stomach Neoplasms

No abstract available.
Child* ; Epilepsy* ; Humans

No abstract available.
Lung Injury* ; Lung* ; Paraquat*

We have analyzed the patients who were admitted to ICU for postoperative care for over 36 hours and/or respiratory problems from July, 1981 to June 1982. 1) The total number of patients was 339, 198(57%) male and 146(43%) female. The mortality rate was 43.7% 2) Overall morality rate of patients in ICU was 49.7% and the 5th decade had the highest mortality rate. 3) The number of the patients who needed respiratory support was 217. 4) The number and type of airways were: orotracheal(174 cases, 96.4%), nasotracheal(9 cases, 4.1%) and trachestomy(34cases, 9.4%). 5) In the course of ventilator support, 72 patients (33.2%) among 217 could be weaned away from the ventilator. 6) The Mortality rate of ventilator supported patients was 59.9%(130). The mortality rate according to the type of the ventilator used was as follows: in Bird 73.2%, in Bourns 71.4% and in Servo 34.2%.
Birds ; Female ; Humans ; Male ; Morals ; Mortality ; Postoperative Care ; Ventilators, Mechanical

PURPOSE: To evaluate the characteristic CT findings of neuroblastoma, we studied neurobalstomas. METHODS AND MATERIALS: We analysed CT findings of available 25 cases among pathologically proved 51 neurobalstomas from Jan. 1983 to Sept. 1990. RESULTS: The most frequent site of origin is adrenl gland (40%) and the second is retroperitoneum (32%) and the third ismediastinum (16%). Characteristic CT findings are as follows:Calcifications within the tumor is detected in 86% of abdominal neuroblastomas and 50% of mediastinal origin. Hemorrhagic and necrotic changes within the tumor is noted at 86% in the tumor of abdominal origin and 25% in mediastinal neuroblastomas. Contrast enhanced study showed frequently septated enhanced appearance with/without solid contrast enhancement. Encasements of major great vessels such as aorta and IVC with/without displacement by metastatic lymphnodes or tumor are frequently seen in 90% of abdominal neuroblastomas. Multiple lymphadenopathy are detected in 95% of abdominal neurobalstomas and 25% of mediastinal neuroblastomas. The most common organ of contiguous direct invasion is kidney in 6 cases and the next one is liver but intraspinal canal invasion is also noted in 2 cases. CONCLUSION: We concluded that diagnosis of neuroblastoma would be easily obtained in masses of pediatric group from recognition of above characteristic findings.
Aorta ; Diagnosis ; Kidney ; Liver ; Lymphatic Diseases ; Neuroblastoma*

PURPOSE: The cell cycle control system is necessary for the normal growth and differentiation of cells. The purposes of this study were to compare CD99 expression with a known intracellular marker of a specific cell cycle and to evaluate the potential of CD99 as surface marker for this cell cycle. METHODS: We induced arrest of the cell cycle in fetal lung fibroblast by contact inhibition or serum deprivation from culture media. We activated peripheral blood lymphocytes with the treatment of phytohemagglutinin (PHA) and interleukin-2 (IL-2). Next, we synchronized the cell cycle of peripheral blood lymphocytes to the late G1 phase with rapamycin. According to their CD99 expression, the peripheral blood lymphocytes were separated by magnetic bead and analyzed by Western blotting. RESULTS: CD99 expression in fetal lung fibroblast rapidly decreased in cell cycle arrest and recovered soon after G1 activation of the cell cycle. By analyzing chronologic changes of CD99 expression and PI-histogram, we found CD99 expression decreased after passing the G1 checkpoint. G1/S transition was interrupted by potent immunosuppresant, rapamycin. IL-2 receptor remained high after rapamycin treatment in the activated lymphocytes, whereas CD99 expression and propium iodide decreased as compared with the same condition without rapamycin. This suggested that CD99 expression was decreased in the late G1 phase. Retinoblastoma gene (Rb) and CDK-2 are necessary for G1/S transition. We found both of these in CD99+ lymphocyte through Western blotting only. Cyclin B, which has an important role in S/G2/M transition, was only found in CD99-activated lymphocytes. CONCLUSION: CD99 may be a G1 phase specific surface marker.
Blotting, Western ; Cell Cycle Checkpoints ; Cell Cycle* ; Contact Inhibition ; Culture Media ; Cyclin B ; Fibroblasts ; G1 Phase ; Genes, Retinoblastoma ; Interleukin-2 ; Lung ; Lymphocytes ; Receptors, Interleukin-2 ; Sirolimus