1.The effects of porcelain primers on the bonding of composite resins to porcelain.
Myung Ju BACK ; Ju Mi PARK ; Tae Seong BAE ; Charn Woon PARK
The Journal of Korean Academy of Prosthodontics 1992;30(1):55-64
No abstract available.
Composite Resins*
;
Dental Porcelain*
2.14 Cases with Acute Diffuse Alopecia Areata.
Seung Ju BACK ; Myung IM ; Chang Deok KIM ; Young Joon SEO ; Jeung Hoon LEE ; Jang Kyu PARK
Korean Journal of Dermatology 2007;45(9):884-889
BACKGROUND: Acute diffuse alopecia areata (AA) was described as a unique AA which mimics anagen effluvium, or in which the initial hair loss is diffuse and followed by total denudation of scalp within several weeks or months. In spite of its peculiar clinical feature, there was neither further characterization nor known effective treatment for this form of AA. OBJECTIVE: To evaluate the characteristic clinical findings of acute diffuse AA and confirm the effect of high dose methyl prednisolone therapy. METHODS: The medical records of 13 patients with acute diffuse AA between January 2002 and April 2006 at the Department of Dermatology, Chungnam National University Hospital were reviewed. All patients were treated with high dose methylprednisolone therapy. RESULTS: Of the 13 patients who completed the study, 8 patients (61.5%) were male and 5 patients (38.5%) were female. The mean age was 29.6 years old. The progress of hair loss stopped 2.4 weeks on average after initial treatment and newly emerging hairs were recognized 4.1 weeks on average after initial treatment. 84.6% (11/13) of patients showed terminal hair growth, and 46.2% (6/13) of patients completely responded to this therapy. CONCLUSION: Acute diffuse alopecia areata can occur in male as well as in female patients. High dose methylprednisolone therapy appears to be effective in patients with rapidly progressing acute diffuse alopecia areata to prevent the progression of the disease.
Alopecia Areata*
;
Alopecia*
;
Chungcheongnam-do
;
Dermatology
;
Female
;
Hair
;
Humans
;
Male
;
Medical Records
;
Methylprednisolone
;
Prednisolone
;
Scalp
3.Epigenetic Modulation of Gene Expression during Keratinocyte Differentiation.
Seung Ju BACK ; Myung IM ; Kyung Cheol SOHN ; Dae Kyoung CHOI ; Ge SHI ; Nam Ji JEONG ; Young LEE ; Young Joon SEO ; Chang Deok KIM ; Jeung Hoon LEE
Annals of Dermatology 2012;24(3):261-266
BACKGROUND: Epigenetic modulation of gene expression occurs by various methods, including DNA methylation and histone modification. DNA methylation of specific genes may affect the chromatin structure, preventing access by the transcriptional machinery. Although gene expression is dramatically changed during keratinocyte differentiation, there is no evidence of epigenetic modulation during the process of epidermal stratification. OBJECTIVE: We investigated whether epigenetic modulation is involved in keratinocyte differentiation-specific gene regulation. METHODS: We used trypsin to produce epidermal fragmentation (named T1-T4) and performed a morphological analysis using hematoxylin-eosin stain and cytokeratin expression based on reverse transcription polymerase chain reaction. We then constructed a DNA methylation microarray. RESULTS: Each epidermal fragment showed morphological features of the epithelial layer. T1 represented the basal layer, T2 was the spinous layer, T3 was the granular layer, and T4 was the cornified layer. The level of the K14 proliferation marker was increased in the T1 fraction, and the level of K10 differentiation marker was increased in the T2-T4 fractions. Using a methylation microarray with the T1 and T4 fractions, we obtained many hypermethylated and hypomethylated genes from differentiated keratinocytes. CONCLUSION: The importance of epigenetic modulation in target gene expression during keratinocyte differentiation is identified.
Cell Differentiation
;
Chromatin
;
DNA Methylation
;
Epigenomics
;
Gene Expression
;
Histones
;
Keratinocytes
;
Keratins
;
Methylation
;
Polymerase Chain Reaction
;
Reverse Transcription
;
Trypsin
4.High Dose Chemotherapy with Autologous Stem Cell Transplantation on Multiple Myeloma.
Jae Hoon LEE ; Soo Mee BANG ; Seok LEE ; Hyun Soo KIM ; Jin Seok AHN ; Eun Kyung CHO ; Jung Ae LEE ; Myung Ju AHN ; Deog Yeon JO ; Tae You KIM ; Young Suk PARK ; Sung Soo YOON ; Hong Back LEE ; Cheolwon SUH ; Chu Myoung SEONG ; Soon Nam LEE ; Hwi Joong YOON ; Samyong KIM ; Chul Soo KIM ; Seonyang PARK ; Kyung Sam CHO ; Byoung Kook KIM ; Hugh Chul KIM ; Chan H PARK ; Sang Hee KIM
Korean Journal of Hematology 1999;34(2):306-316
No abstract available.
Drug Therapy*
;
Multiple Myeloma*
;
Stem Cell Transplantation*
;
Stem Cells*