1.Oral quinidine therapy for the maintenance of sinus rhythm after mitral valve surgery.
Tae Jin YUN ; Jong Myung HONG ; Wan Ki BAEK ; Hyuk AHN ; Hurn CHAE ; Joon Ryang RHO ; Chong Whan KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(4):249-254
No abstract available.
Mitral Valve*
;
Quinidine*
2.A Case of Pheochromocytoma Presenting as Stress-Induced Cardiomyopathy with Large Left Ventricular Thrombus.
Duck Hyun JANG ; Jinsik PARK ; Myung Shin KANG ; Tae Hoon KIM ; Dong Hee SHIN ; Ji Hye LEE ; Myung Joon CHAE
Korean Journal of Medicine 2014;87(1):77-80
The clinical presentation of pheochromocytoma is variable. The classic symptoms are headache, diaphoresis, and tachycardia, with paroxysmal hypertension. Other less common cardiovascular manifestations, such as arrhythmias, angina pectoris, acute myocardial infarction, dilated cardiomyopathy, and acute heart failure, have been reported occasionally. We present the case of a middle-aged woman who had stress-induced cardiomyopathy with a left ventricular thrombus, due to the pheochromocytoma. The thrombus was embolized to the aorto-iliac bifurcation during hospitalization. We removed the thrombus by a catheter thromboembolectomy and performed a surgical left adrenalectomy. After the operation, all of her symptoms and the underlying diseases (hypertension, hyperglycemia, heart failure, dyslipidemia) resolved.
Adrenalectomy
;
Angina Pectoris
;
Arrhythmias, Cardiac
;
Cardiomyopathies*
;
Cardiomyopathy, Dilated
;
Catheters
;
Female
;
Headache
;
Heart Failure
;
Hospitalization
;
Humans
;
Hyperglycemia
;
Hypertension
;
Myocardial Infarction
;
Pheochromocytoma*
;
Tachycardia
;
Thrombosis*
3.Cardiovascular beriberi: rare cause of reversible pulmonary hypertension.
Joon Hyuk SONG ; Sang Soo CHEON ; Myung Hwan BAE ; Jang Hoon LEE ; Dong Heon YANG ; Hun Sik PARK ; Yongkeun CHO ; Shung Chull CHAE
Yeungnam University Journal of Medicine 2014;31(1):38-42
Cardiovascular beriberi is caused by thiamine deficiency and usually presents as high cardiac output failure associated with predominantly right-sided heart failure and rapid recovery after treatment with thiamine. Because of its rarity in developed countries, the diagnosis can often be delayed and missed. We recently experienced a case of cardiovascular beriberi with pulmonary hypertension which successfully treated with thiamine infusion. A 50-year-old man with chronic heavy alcoholics was refered to our department for dyspnea with mental change. Echocardiography showed marked right ventricular (RV) dilatation and flattening of the interventricular septum with a D-shaped deformation of the left ventricle. Moderate tricuspid valve regurgitation was found and estimated RV systolic pressure was 52 mm Hg. Because of his confused mentality and history of chronic alcohol intake, neurological disorder due to thiamine deficiency was suspected and intravenous thiamine was administered and he continuously received a daily dose of 100 mg of thiamine. Follow up echocardiography showed marked reduction of RV dilatation and improvement of a D-shaped deformation of the left ventricle. He finally diagnosed as cardiovascular beriberi on the basis of dramatic response to intravenous thiamine. Thiamine deficiency can cause reversible pulmonary hypertension, and can still be encountered in the clinical setting. Thus high index of suspicion is critically needed for diagnosis.
Alcoholics
;
Beriberi*
;
Blood Pressure
;
Cardiac Output, High
;
Developed Countries
;
Diagnosis
;
Dilatation
;
Dyspnea
;
Echocardiography
;
Follow-Up Studies
;
Heart Failure
;
Heart Ventricles
;
Humans
;
Hypertension, Pulmonary*
;
Middle Aged
;
Nervous System Diseases
;
Thiamine
;
Thiamine Deficiency
;
Tricuspid Valve Insufficiency
4.A Case of Therapy-related Acute Lymphoblastic Leukemia with t(11;19)(q23;p13.3) and MLL/MLLT1 Gene Rearrangement.
Byong Joon YOO ; Myung Hyun NAM ; Hwa Jung SUNG ; Chae Seung LIM ; Chang Kyu LEE ; Yun Jung CHO ; Kap No LEE ; Soo Young YOON
The Korean Journal of Laboratory Medicine 2011;31(1):13-17
Therapy-related ALL (t-ALL) is a rare secondary leukemia that develops after chemotherapy and/or radiotherapy for primary malignancies. Chromosomal 11q23 abnormalities are the most common karyotypic alterations in t-ALL. The t(11;19)(q23;p13) aberration is extremely rare and has not been confirmed at the molecular genetic level. Here, we report a case of t-ALL with t(11;19)(q23;p13.3) and MLL-MLLT1 (alias ENL) gene rearrangement confirmed by cytogenetic analysis, multiplex reverse transcription-PCR (multiplex RT-PCR), and DNA sequencing in a patient who had undergone treatment for breast cancer. A 40-yr-old woman developed acute leukemia 15 months after undergoing 6 cycles of adjuvant chemotherapy (doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2), radiation therapy (dose, 5,900 cGy), and anticancer endocrine therapy with tamoxifen. The complete blood cell counts and bone marrow examination showed increased blasts and the blasts showed B lineage immunophenotype (positive for CD19, CD34, and cytoplasmic CD79a). Cytogenetic analysis revealed the karyotype 47,XX,+X,t(11;19)(q23;p13.3)[4]/46,XX[16]. FISH analyses, multiplex RT-PCR, and DNA sequencing confirmed the MLL-MLLT1 gene rearrangement. The patient underwent induction chemotherapy with fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD) and achieved complete remission. Subsequently, she underwent consolidation chemotherapy, but died of brain ischemia in the pons and the region of the middle cerebral artery. To our knowledge, this is the first case report of t-ALL with t(11;19)(q23;p13.3) and the MLL-MLLT1 gene rearrangement.
Adult
;
Antineoplastic Agents/therapeutic use
;
Base Sequence
;
Breast Neoplasms/drug therapy/radiotherapy
;
*Chromosomes, Human, Pair 11
;
*Chromosomes, Human, Pair 19
;
Combined Modality Therapy
;
Cyclophosphamide/therapeutic use
;
Doxorubicin/therapeutic use
;
Female
;
Gene Rearrangement
;
Humans
;
Immunophenotyping
;
Karyotyping
;
Molecular Sequence Data
;
Myeloid-Lymphoid Leukemia Protein/*genetics
;
Neoplasm Proteins/*genetics
;
Nuclear Proteins/*genetics
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics
;
Sequence Analysis, DNA
;
Tamoxifen/therapeutic use
;
Transcription Factors/*genetics
;
*Translocation, Genetic
5.Fabry Cardiomyopathy.
Jae Yong YOON ; Joon Hyuk SONG ; Sang Soo CHEON ; Hyun Jun CHO ; Myung Hwan BAE ; Jang Hoon LEE ; Dong Heon YANG ; Hun Sik PARK ; Yongkeun CHO ; Shung Chull CHAE
Journal of Cardiovascular Ultrasound 2013;21(1):26-29
Fabry disease is a progressive X-linked disorder of glycosphingolipid metabolism caused by a deficiency of the alpha-galactosidase lysosomal enzyme. The partial or complete deficiency of the lysosomal enzyme leads to an accumulation of neutral glycosphingolipids in the vascular endothelium and visceral tissues throughout the body. In the heart, glycosphingolipids deposition causes progressive left ventricular hypertrophy (LVH). We report a case of Fabry disease which was suspected based upon two-dimensional echocardiographic finding of LVH. A 44-year-old man was admitted to evaluation of aggravated exertional dyspnea of two weeks duration. He had been diagnosed with end-stage renal disease of unknown etiology at age 41 followed by renal transplantation that year. He had been treated with oral immunosuppressive agents. On hospital day two, transthoracic echocardiography revealed concentric LVH. Left ventricular systolic function was preserved but diastolic dysfunction was present. Fabry disease was confirmed by demonstration of a low plasma alpha-galactosidase A (alpha-Gal A) activity. Analysis of genomic DNA showed alpha-Gal A gene mutation. The patient was diagnosed with Fabry disease.
alpha-Galactosidase
;
Cardiomyopathies
;
DNA
;
Dyspnea
;
Echocardiography
;
Endothelium, Vascular
;
Fabry Disease
;
Genes, vif
;
Glycosphingolipids
;
Heart
;
Humans
;
Hypertrophy, Left Ventricular
;
Immunosuppressive Agents
;
Kidney Failure, Chronic
;
Kidney Transplantation
;
Neutral Glycosphingolipids
;
Plasma
6.A Retrospective study of the type of patients, the distribution of implant and the survival rate of Xive(R) implant.
Woo Chun MYUNG ; Jung Seok LEE ; Gyung Joon CHAE ; Ui Won JUNG ; Chang Sung KIM ; Kyoo Sung CHO ; Jung Kiu CHAI ; Chong Kwan KIM ; Seong Ho CHOI
The Journal of the Korean Academy of Periodontology 2007;37(3):523-534
This study is an analysis of types of patients and distribution of implant site and survival rate of Xive(R) implant. The following results on patient type, implant distribution and survival rate were compiled from 324 implant cases of 140 patients treated at the periodontal dept. of Yonsei University Hospital and G dental clinic between February 2003 and April 2006. 1. There are no dissimilarities between men and women, with patients in their 30, 40, 50s accounting for 80% of patients and accounted for 82% of implant treatments; the largest share of patients and implant treatments. 2. Mn. posterior area accounted for 57% of implant treatments followed by Mx. posterior area(29%), Mx. anterior area(8%) and Mn. anterior area(6%). 3. Partial edentulous patients treated by single crown and bridge-type prosthesis accounted for 96% and fully edentulous patient accounted for the remaining 4%. 4. The major cause of tooth loss is periodontal disease, followed by dental caries, trauma and congenital missing. 5. The distribution of bone quality for maxillae was 54.2% for typeIII, followed by 30.8% for type II, 15% for typeIV and 0% for typeI. As for mandible, the distribution was 63% for typeII, followed by 34% for typeIII, 2.5% for typeI and 0.5% for typeIV. 6. The distribution of bone quantity for maxillae was 55% for type C, followed by 35% for type B, 8% for type D and 2% for type A. As for mandible, the distribution was 60% for type B, followed by 32% for type C, 7% for type A and 0% for type D. 7. The majority of implants were those of 9.5-13 mm in length(95%) and regular diameter in width(82%). 8. The total survival rate was 98%. The survival rate was 97% in the maxillae region and 99% in the mandible region. 9. The survival rate in typeI was 83%, in typeII was 99%, in typeIII was 97% and in typeIV was 100%. As for the bone quantity, the survival rate in type A and D(100%) was most, followed by type B(99%) and type C(96%). The results showed that Xive(R) implant could be used satisfactorily compare for the other implant system. But we most to approach carefully in certain extreme condition especially with poor bone quality and quantity.
Crowns
;
Dental Caries
;
Dental Clinics
;
Female
;
Humans
;
Male
;
Mandible
;
Maxilla
;
Periodontal Diseases
;
Prostheses and Implants
;
Retrospective Studies*
;
Survival Rate*
;
Tooth Loss
7.The Effect of Primary Percutaneous Coronary Intervention after the Administration of Tirofiban Alone or Tirofiban Combined with Low dose Alteplase in Patients with Acute Myocardial Infarction on ST Elevation Resolution, TIMI Flow and Short-Term Clinical O.
Sang Pil KIM ; Jang Hyun CHO ; Dong Ryeol CHAE ; Sang Min YEOM ; Won Jung JEON ; Su Hyun KIM ; Young Sang O ; Hyuk Seung YANG ; Dong Han KIM ; Yeol BAE ; Joon Young KIM ; Myung Ho JEONG
Korean Circulation Journal 2005;35(5):362-368
BACKGROUND AND OBJECTIVES: The combination of platelet glycoprotein IIb/IIIa inhibitors and a low dose thrombolytic agent may produce early Thrombolysis In Myocardial Infarction (TIMI) 3 flow and a high rate of ST elevation resolution in an ST elevation acute myocardial infarction (STEMI). The clinical effect of tirofiban combined with low dose alteplase, prior to primary percutaneous coronary intervention (PCI) in STEMI, were evaluated on the ST elevation resolution, TIMI flow and 30-day clinical outcomes. SUBJECTS AND METHODS: Following aspirin, clopidogrel and standard heparin, 45 patients with STEMI were randomized into 2 groups; tirofiban administration (Group I; n=23, 64+/-10 years; 15 male) or combined administration of tirofiban with 40 mg alteplase prior to primary PCI (Group II; n=22, 59+/-11 years; 19 male). The pre- and post-interventional TIMI flow grades, ST elevation resolution and bleeding complications were compared between the two groups. The major adverse cardiac events (MACE) were compared between the two groups during 30-days of clinical follow-up. RESULTS: Group II had a higher pre-interventional TIMI flow (TIMI flow> or =2: 34.8% vs. 90.9%, p<0.0001) and rate of ST elevation resolution (49.0+/-27.8% vs. 66.6+/-27.2%, p=0.045) than Group I. A major bleeding complication developed in 1 (5.0%) Group II patient, and minor bleeding complications developed 1 patient from each group (Group I; 9.5% vs. Group II; 10%, p=0.959). CONCLUSION: Combined administration of tirofiban with alteplase prior to primary PCI leads to a higher TIMI flow and more frequent ST elevation resolution, without bleeding complications, compared to a single administration of tirofiban.
Angioplasty
;
Aspirin
;
Blood Platelets
;
Electrocardiography
;
Follow-Up Studies
;
Glycoproteins
;
Hemorrhage
;
Heparin
;
Humans
;
Myocardial Infarction*
;
Percutaneous Coronary Intervention*
;
Thrombolytic Therapy
;
Tissue Plasminogen Activator*
8.Changes of Intracoronary Electrocardiogram by Repeated Occlusion: Repefusion During Percutaneous Transluminal Coronary Angioplasty.
Ju Han KIM ; Joon Woo KIM ; Sung Hee KIM ; Nam Ho KIM ; Woo Suck PARK ; Joo Hyung PARK ; Gwang Chae GILL ; Myung Ho JEONG ; Jeong Gwan CHO ; Jong Chun PARK ; Jung Chaee KANG ; Seung Min PARK
Korean Journal of Medicine 1997;53(3):389-397
OBJECTIVE: Brief epidodes of ischemia have been shown to make the heart more resistant to subsequent ischemia in animal studies(known as ischemic preconditioning, IP). This phenomenon was tested in patients undergoing percutaneous transluminal coronary angioplasty(PTCA). METHODS: Thirteen patients who had significant epicardial coronary stenosis without myocardial infarction, ventricular hypertrophy or conduction defect, received two to four 2-min balloon inflations separated by 5 min of reperfusion. Surface electrocardiogram(S-ECG) and intracoronary electrocardiogram (IC-ECG) from an angioplasty guide wire were recorded before and after balloon inflation. RESULTS: The changes of ST segment were observed in 13 out of 15 lesions on IC-ECG and 7 on S-ECG. The maximal ST changes on IC-ECG and S-ECG were 20.2+/-13.7mm and 1.21.5mm respectively(p<0.01). The time to beginning of ST segment change after balloon inflation were 10.1+/-12.6 seconds and 63.3+/-14.2 seconds on IC-ECG and S-ECG, respectively(p<0.01). The maximal changes of ST segment on IC-ECG during the second inflation were significantly lower than that during the first(20.2+/-13.7 vs 16.312.3mm, p<0.05). However, changes of R wave, T wave and QT interval were not significantly different between two inflations. The recovery time to baseling ECG after initiation of reperfusion were 50.2+/-41.7 seconds and 38.5+/-29.6 seconds for the first inflation and the second, respectively(P<0.05). CONCLUSION: These results suggest that IC-ECG is more sensitive and reliable than S-ECG in detection of myocardial ischemia and that IP may occur during PTCA since ST segment shift is decreased and is normalized earlier at the second balloon inflation compared with the first.
Angioplasty
;
Angioplasty, Balloon, Coronary*
;
Animals
;
Coronary Stenosis
;
Electrocardiography*
;
Heart
;
Humans
;
Hypertrophy
;
Inflation, Economic
;
Ischemia
;
Ischemic Preconditioning
;
Myocardial Infarction
;
Myocardial Ischemia
;
Reperfusion
9.A Case of Life-Threatening Supraventricular Tachycardia Related to Flecainide Toxicity.
Sang Soo CHEON ; Joon Hyuk SONG ; Myung Hwan BAE ; Jang Hoon LEE ; Dong Heon YANG ; Hun Sik PARK ; Shung Chull CHAE
Korean Journal of Medicine 2014;87(1):72-76
Flecainide acetate is a potent class Ic anti-arrhythmic drug with a major sodium channel-blocking effect. Flecainide toxicity can cause myocardial impairment and precipitate circulatory collapse, particularly in patients with renal failure. Electrical and hemodynamic deterioration during flecainide toxicity may not respond to conventional treatments. We report the successful management of flecainide toxicity using extracorporeal membrane oxygenation (ECMO), hemoperfusion, and bicarbonate administration maintaining alkalinity.
Extracorporeal Membrane Oxygenation
;
Flecainide*
;
Hemodynamics
;
Hemoperfusion
;
Humans
;
Renal Insufficiency
;
Shock
;
Sodium
;
Tachycardia, Supraventricular*
10.Infection with Scopulariopsis brevicaulis after Cosmetic Surgery of the Face.
Bong Joon OH ; Myong Jong CHAE ; Duck CHO ; Seung Jung KEE ; Myung Geun SHIN ; Jong Hee SHIN ; Soon Pal SUH ; Dong Wook RYANG
The Korean Journal of Laboratory Medicine 2006;26(1):32-35
Scopulariopsis brevicaulis is a ubiquitous soil saprophyte that commonly causes onychomycosis, accounting for 1-10% of such infections. Rarely, it may be responsible for cutaneous lesions or more severe infections, especially after traumatic or surgical injuries. We report of a 54-year-old female patient who developed facial cellulitis caused by S. brevicaulis, which occurred one year after the patient underwent cosmetic surgery of the face. The patient suffered from febrile sense, pain and a growing mass lesion on her left cheek, which were diagnosed as facial cellulitis associated with foreign material that had been implanted at the time of cosmetic surgery. Three pus cultures from the mass lesion which performed at a week interval yielded the same S. brevicaulis. Surgical removal and drainage by using liposuction procedure resulted in a favorable outcome. To our knowledge this is the first report of S. brevicaulis infection associated with cosmetic surgery in Korea.
Cellulitis
;
Cheek
;
Drainage
;
Female
;
Humans
;
Intraoperative Complications
;
Korea
;
Lipectomy
;
Middle Aged
;
Onychomycosis
;
Scopulariopsis*
;
Soil
;
Suppuration
;
Surgery, Plastic*