Keratic precipitates are deposits of material on the posterior surface of the cornea, which is a relatively common phenomenon in a variety of circumstances both physiological and pathological. Inflammatory cells and uveal pigment in the aqueous show a strong tendency to adhere to one another and to the corneal endothelium, thus forming fine or large deposits. We observed the several kinds of keratic precipitates on the corneal endothelium by flat preoparation method. The character of the keratic precipitates observed in this study was composed of inflammatory cells, erythrocyte, pigment granules derived from the breakdown of red blood cells. In view of the accumulation of the pigment granules into the cytoplasm, it seemed that the endothelium might participate in phagocytosis or secondary changes in the various corneal disease.
Cornea ; Corneal Diseases ; Cytoplasm ; Endothelium ; Endothelium, Corneal ; Erythrocytes ; Phagocytosis

In order to interprete the significance of the vacuolation found in the corneal endothelium, flat preparations of the corneal endothelium were made in human eyes aged from neonate to 72 year. The result were as follows. 1. The endothelial vacuoles were more frequent with the increase in the time of the post-mortem delay. 2. The endothelial vacuoles were more prevalent in aged. 3. The vacuoles in the endothelium were more easily formed in the peripheral area than the central area. 4. Gross vacuolation found in the corneal endothelium was shown to be the result of post mortem degeneration.
Endothelium ; Endothelium, Corneal* ; Humans ; Infant, Newborn ; Vacuoles*

The linear scratching wound was made gently on the corneal epithelium of rabbit with 21 gauge needle under an operating microscope. Impression cytology was performed at 30 minutes, 1, 2, 3 and 4 hour and 1, 2, 3 and 4 day after 0.5% tetracaine drops under an operating microscope. The filter paper was stained with hematoxylin and eosin. At 30 minute post-scratching, a few polymorphonuclear leukocytes appeared on the scratched cornea at 3 eyes (30%). At 3 and 4 hour, numerous polymorphonuclear leukocytes with corneal epithelial cells appeared on the scratched conea. By 3 day, no inflammatory cells were shown on the filter paper in all eyes. These findings suggest that the polymorphonuclear leukocytes could infiltrate on the corneal lesion at 30 minute post-scratching and the inflammatory cells might act even on the minute corneal lesion such as corneal erosion.
Cornea ; Eosine Yellowish-(YS) ; Epithelial Cells ; Epithelium, Corneal ; Hematoxylin ; Needles ; Neutrophils* ; Tetracaine ; Wounds and Injuries*

No abstract available.
Female ; Pregnancy ; Pregnancy, Abdominal*

We observed sisters who showed the classical symptoms and signs of the pulseless disease, which were the absence of the radial pulsation, arteriovenous anastomoses around the optic disc and intermittent dizziness. The main changes in the fundus of them were as follows. 1) wreath-like anastomoses of the central retinal artery and vein around the disc. 2) almost complete disappearance of the visible vessels beyond five disc diameters from the optic disc. 3) multiple microaneurysms and hemorrhages.
Arteriovenous Anastomosis ; Dizziness ; Hemorrhage ; Humans ; Retinal Artery ; Siblings* ; Takayasu Arteritis* ; Veins

Monoclonal gammopathy of undetermined significance(MGUS) is one of the monoclonal plasma cell disorder. According to the recent reports, polyneuropathy associated with MGUS may be treatable disease due to potential relationship between the monoclonal protein and immune-mediated nerve damage. It is reported that plasmapheresis is highly effective in the treatment of polyneuropathy associated with IgG type MGUS. We present 53-year-old male with slowly progressive motor weakness and sensory change since 1 year ago. Electrophysiologic studies were compatible with demyelinating neuropathy showing conduction block and temporal dispersion in upper and lower extremities. Abnormal arc against anti-lamda on serum immunoelectrophoresis and M-band in the gamma region on serum protein electrophoresis were shown. After the combined therapy of plasmapheresis (5 times) and steroid, clinical and electrophysiologic findings were markedly improved. We report a case of demyelinating neuropathy associated with IgG lamda type MGUS, which showed good response to combined therapy of plasmapheresis and steroid.
Electrophoresis ; Humans ; Immunoelectrophoresis ; Immunoglobulin G* ; Lower Extremity ; Male ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance* ; Paraproteinemias* ; Plasma Cells ; Plasmapheresis ; Polyneuropathies

PURPOSE: Cyclodialysis clefts occur when the meridional ciliary muscle fibers become separated from the scleral spur, thereby providing a new drainage pathway of aqueous humor into the suprachoroidal space. Although the mechanism by which cyclodialysis lowers IOP is both of the hyposecretion of aqueous humor and the increased uveoscleral outflow, cyclodialysis clefts do not always cause hypotony. METHODS: The authors retrospectively analyzed the data of 9 eyes of 9 patients who had been diagnosed as traumatic cyclodialysis cleft by gonioscopic examination. RESULTS: Only 4 of the 9 eyes showed hypotony. This hypotony occurred 3 to 13 days (mean 7.3 days) after trauma. Conservative treatment combined with air injection was done in 4 patients with hypotony. In 3 eyes, IOP was normalized 7~10 days after the above treatment. The remaining one eye had an extensive cyclodialysis of 6 o clock and was treated with argon laser. But normalization of IOP was not achieved within the follow up period. Only cyclodialysis clefts of relatively small range were closed spontaneously or with only conservative management. Also posterior synechiae was found in one of the four eyes with hypotony, and was found in three of the four eyes without hypotony. CONCLUSION: Whether hypotony in cyclodialysis patients occur or not depends on the individual ability of scar formation in the cyclodialysis cleft against the anti-proliferative properties of aqueous humor.
Aqueous Humor ; Argon ; Cicatrix ; Drainage ; Follow-Up Studies ; Gonioscopy ; Humans ; Inflammation ; Retrospective Studies

Tuberous sclerosis is an autosomal dominant disorder of cellular differentiation that affect the brain, skin, heart, kidney and other organs. We experienced three cases of tuberous sclerosis that affect multiple organs in mother and two daughters. We report these cases with brief review and related literatures.
Brain ; Heart ; Humans ; Kidney ; Mothers* ; Nuclear Family* ; Skin ; Tuberous Sclerosis*

No abstract available.
Erythrocytes* ; Hematuria*

PURPOSE: This study was performed to investigate the distribution of glycosaminiglycans by the activated retinal neuronal cell on the cultured retinal tissue. METHODS: The retinal tissue was obtained from the donor eyeball without the pathological findings of the retina. The dissected retinal tissue was cultured for 2 weeks in the culture media and reacted with ruthenium red dye to observe the glycosaminoglycans reaction with transmission electron microscopy. RESULTS: The histochemical reaction to ruthenium red on the cultured retina tissue was prominent on the internal limiting membrane, intercellular space between the axons and dendrites at the outer and inner plexiform layers and interphotoreceptor matrix. CONCLUSIONS: These findings suggest that GAGs may be released into the extracellular spaces between the axons and dendrites, which modulate the retinal circuits.
Axons ; Culture Media ; Dendrites ; Extracellular Space ; Glycosaminoglycans* ; Humans ; Membranes ; Microscopy, Electron ; Microscopy, Electron, Transmission ; Retina* ; Retinal Neurons ; Retinaldehyde ; Ruthenium Red ; Tissue Donors