INTRODECTION: In order to improve medical education through the introduction of a concept of comprehensive health care of a community, an area surrounding the University Campus was chosen for the Community Health Service Project. It has been on operation for last 4 years with its major emphasis on family planning services, and maternal and child health care. The major objectives of this survey at the area are to obtain: 1) The demographic data, 2) The health need and trend of medical care. 3) The attitude and practice in maternity care to be used for further improvement of the planning and the services of the project. Population and Survey Method: Out of three Dongs of the Community Health Service Area, only two Dongs namely Changchun and Yonhee were selected for the survey. Total number of households and population in the area studied was 3.683 and 21,857 respectively. An interview was performed with questionnaire schedule which was recorded by interviewers. This includes the degree of utilization of health services provided by the Community Health Service Program such as family planning, prenatal care during their last pregnancy, delivery history and complications of the delivery as well as the incidence of illnesses in general. Prior to the interview, all interviewers were trained for interviewing technique for two days. The survey was carried out during the period from October December 1967. RESUTLS: 1) Demographic Data : 41.3% of the population studied were children under age 15 and only 3.5% were over 60 years of age. Crude birth rate and crude death rate of this area studied during the period of November 1966-October 1967 were 20.5 and 7.7 respectively. Infant mortality rate during the same period was 35.9. 50.4% of the 2,832 households fell into the category of middle class, 39.8% to the lower class and 9.5% to the upper class in economic condition. 19.8% of 2,832 householders had no formal education, 22.7% primary school, and 57.5% middle or higher school education. 2) Health Status and Utilization of the Community Health Service: Those who suffered from many illnesses during the month of October, 1967 were 690(4.6% of 14,891 persons). Classification of these patients into the type of disease shown respiratory diseases 27.4%, gastrointestinal diseases 18.1%, tuberculosis 10.9%, skin and genitourethral diseases 4.5% and gynecologic patients 4.5%. Only 55.9% of the patients received medical care at hospital or doctor's clinic. But among TB and gynecologic patients, 70.7% and 72.4% were treated at medical facilities. 10.6% of 2,832 householders interviewed has ever utilized the Community Health Service Program provided by the Yonsei Medical School. Classifying these clients into the type of service, 35.9% utilized the wellbaby clinic, 31.0% the family planning clinic, 14.7% the home delivery care, and the rest utilized other services such as the premarital guidance clinic and the sanitary inspection service. 3) Maternity Care: 23.6% of 2,151 deliveries were done at medical facilities such as hospital, private clinic, while 76.4% were done at home. Acceptance rate of prenatal care was 32.6% as whole, but 49.6 of 774 women who had the prenatal care service had their deliveries at medical facility. 45.1% of total deliveries were attended by medical and or paramedical personnel. 75.8% of the deliveries of those received prenatal care were attended by medical and or paramedical personnel while only 27.8% of the deliveries of those who did not have prenatal care attended by medical and or paramedical personnel. 49.8% of deliveries of the upper class, 29.8% of the middle class and 9.9% of the lower class were attended by medical and or paramedical personnel. 6.2, 3.3% and 24.8% of mothers reported about their experience of edema, coma and fever during the period of trimester of pregnancy and puerperium. 4) Family Planning: The rate of practice of family planning was 27.9%. 31.7% of them were by IUD, 20.9% by oral pill, 15.2% by sterilization and the rest by traditional methods. Those women who had 3 to 4 children had highest(30.2%). Practice rate among the various methods of family planning, oral pill was the most popular method to whom had 2 or less children. In relation between the practicing rate of family planning and living standard, the upper, middle and lower class practiced 37.5, 29.4 and 19.9% respectively.
Allied Health Personnel ; Appointments and Schedules ; Birth Rate ; Child ; Child Health ; Classification ; Coma ; Community Health Services* ; Comprehensive Health Care ; Surveys and Questionnaires ; Edema ; Education ; Education, Medical ; Family Characteristics ; Family Planning Services ; Female ; Fever ; Gastrointestinal Diseases ; Health Services ; Health Surveys* ; Hospitals, Private ; Humans ; Incidence ; Infant ; Infant Mortality ; Mortality ; Mothers ; Postpartum Period ; Pregnancy ; Prenatal Care ; Surveys and Questionnaires ; Schools, Medical ; Seoul* ; Skin ; Socioeconomic Factors ; Sterilization ; Tuberculosis

461 cases of renal biopsy specimens were summerized correlated with their light microscopic and immunofluorescence findings, which obtained from Jan. 1981 to Jul. 1986 at Department of Pathology, Kyung Hee School of Medicine, The results were as follws: 1) The incidence of IgM nephropathy was about 5.8% of the primary glomerulopathy. 2) Sex distribution showed male preponderance with male: female ratio of 1.7:1. 3) Age distribution were 0-9 years 7.4%, 10-19 years 29.6%, 20-29 years 37.0%, 30-39 years 7.4%, 40-49 years 7.4% and 50-59 years 11.1%. 4) The clinical symptoms were gross hematuria 7.4%, microscopic hematuria 59.2%, proteinuria (nonnephrotic) 37.0%, nephrotic syndrome 55.5%, hypertension 7.8% and edema 59.2%. 5) 9 cases (33.3%) had past histories of upper respiratory infections. 6) The distributions of the light microscopic deagnosis were minimal histologic change 11 cases (40.7%), focal glomerulonephritis 7 cases (25.9%), measangial proliferative glomerulonephritis 5 cases (18.5%), focal and segmental glomerulosclerosis 1 case (3.7%) and poststreptococla glomerulonephritis 1 case (3.7%). 7) Immunofluorescence study showed significant diffuse mesangial granular deposits of IgM and C3 in all of the 27 cases. 8) It was demonstrated that in the patients with nephrotic syndrome, the prognosis for the patients with IgM deposition were less favorable than those without IgM deposition.
Female ; Male ; Humans ; Incidence ; Biopsy

For the purpose of ascertaining the status of physical growth and health status of the University students, an intensive survey was conducted by the authors towards a total of 1,250 (Male 792, Female 458) who passed the written entrance examination at the Kyung Hee University in 1972. The items included the measurements on physical growth, various physical and nutritional indices, status of visual distourbance, dental status and tuberculosis. The findings and results can be summarized as follows ; 1. Physical Growth and Development. i) The average of body height by anthropometric was 169.39+/-5.05cm in male and 157.45+/-4.43cm in female. ii) The averages of body weight by sex were 59.42+/-6.47Kg and 51.81+/-5.21Kg, respectively. iii) The averages of chest-girth were 87.18+/-5.30cm and 80.51+/-4.53cm. iv) The averages of sitting-height were 92.21+/-2.79cm and 86.28+/-2.57cm. In all cases the male measurements were higher than female. 2. Various ludices about Physical Growth and Development; i) Relative body weight by sex were 35.08and 32.91, relative chestgirth 51.47 and 51.13, and relative sitting-height 54.43, 54.79, respectively. ii) Rohrer index was 1.222 in males and 1.327 in females, Kaup index 2.071 and 2.089, Verveck index 86.54 and 84.04, and Pelidisi index 91.15 and 93.08, respectively. 3. Status of visual distourbance. The vision of the students under 0.8 with Landolt's testing chart was 45.4% in left eye and 46.6% in right eye (male : 44.4% and 45.7%, female : 47.2% and 48.0%), while under 0.6in both visions was 41.0% and 40.5% (male 40.8% and 40.7%, female : 41.5% and 40.2%),respectively. 4. Dental Status. Out of total 19.4% (male 19.2%, female 19.6%) had gingivitis, the female incidence rate of gingivitis was higher than male. Average number of teeth in each subjects was 29.6 teeth; male had 29.9 teeth and female had 29.1 teeth. The caries rate was 78.9%(male 75.6%, female 84.5%), the female caries rate was higher than male. The average number of i) Caries per tooth rate was 8.5% in male and 9.2% in female, ii) Missing per tooth rate was 0.3% and 0.2%, iii) Filling per tooth rate was 3.9% and 4.2%, in all cases, the female incidences were higher than the male. The average number of D.M.F. was 3.8 teeth in male and 4.0 teeth in female, female was higher than male. The average rate of D.M.F. was 12.7% in male and 13.7 in female, female was higher than male. 5. Pulmonary infiltration. Among the total, 53 students were diagnosed as pulmonary infiltration (tuberculosis), of whom 51 were minimal cases, one were moderately advanced case and one were far advanced case.
Body Height ; Body Weight ; Female ; Gingivitis ; Growth and Development ; Humans ; Incidence ; Male ; Nutrition Assessment ; Tooth ; Tuberculosis

For the purpose of ascertaining the status of physical growth and health status of the University students, an intensive survey was conducted by the authors towards a total of 1,250 (Male 792, Female 458) who passed the written entrance examination at the Kyung Hee University in 1972. The items included the measurements on physical growth, various physical and nutritional indices, status of visual distourbance, dental status and tuberculosis. The findings and results can be summarized as follows ; 1. Physical Growth and Development. i) The average of body height by anthropometric was 169.39+/-5.05cm in male and 157.45+/-4.43cm in female. ii) The averages of body weight by sex were 59.42+/-6.47Kg and 51.81+/-5.21Kg, respectively. iii) The averages of chest-girth were 87.18+/-5.30cm and 80.51+/-4.53cm. iv) The averages of sitting-height were 92.21+/-2.79cm and 86.28+/-2.57cm. In all cases the male measurements were higher than female. 2. Various ludices about Physical Growth and Development; i) Relative body weight by sex were 35.08and 32.91, relative chestgirth 51.47 and 51.13, and relative sitting-height 54.43, 54.79, respectively. ii) Rohrer index was 1.222 in males and 1.327 in females, Kaup index 2.071 and 2.089, Verveck index 86.54 and 84.04, and Pelidisi index 91.15 and 93.08, respectively. 3. Status of visual distourbance. The vision of the students under 0.8 with Landolt's testing chart was 45.4% in left eye and 46.6% in right eye (male : 44.4% and 45.7%, female : 47.2% and 48.0%), while under 0.6in both visions was 41.0% and 40.5% (male 40.8% and 40.7%, female : 41.5% and 40.2%),respectively. 4. Dental Status. Out of total 19.4% (male 19.2%, female 19.6%) had gingivitis, the female incidence rate of gingivitis was higher than male. Average number of teeth in each subjects was 29.6 teeth; male had 29.9 teeth and female had 29.1 teeth. The caries rate was 78.9%(male 75.6%, female 84.5%), the female caries rate was higher than male. The average number of i) Caries per tooth rate was 8.5% in male and 9.2% in female, ii) Missing per tooth rate was 0.3% and 0.2%, iii) Filling per tooth rate was 3.9% and 4.2%, in all cases, the female incidences were higher than the male. The average number of D.M.F. was 3.8 teeth in male and 4.0 teeth in female, female was higher than male. The average rate of D.M.F. was 12.7% in male and 13.7 in female, female was higher than male. 5. Pulmonary infiltration. Among the total, 53 students were diagnosed as pulmonary infiltration (tuberculosis), of whom 51 were minimal cases, one were moderately advanced case and one were far advanced case.
Body Height ; Body Weight ; Female ; Gingivitis ; Growth and Development ; Humans ; Incidence ; Male ; Nutrition Assessment ; Tooth ; Tuberculosis

Timolol malate, a potent beta-adrenergic antagonist, reduced intraocular pressure. The use of timolol malate ophthalmic solution was reduced intraocular pressure without pupillary alteration, alteration of anterior chamber and fluctuating myopia and hyperemia compaired with other reducing agents. We compair the effects of timolol maleate ophthalmic solution with pilocarpine and epinephirine solution in the view of the changes in intraocular pressure. We divided 30 white rabbits randomly into 3 groups, group 1 was 0.5% timolol malate, group 2 was 2% pilocarpine, and group 3 was 0.5% epinephrine. Each solution was instilled one drop on right eyes daily. and cheeked intraocular pressure after 15 minitues, 1 hour, 3 hours, 8 hours and 24 hours for 1 week duration. We evaluated the statistical significance of all changes according to the T-test and P-value. The results of observation as follow; In group I, the mean intraocular pressures was reduced 1 hour, 3 hours, 8 hours after instillation and the effect lasted 24 hours after dropping(p<0.05). In group 2, the similar result as group 1, but lasting effect was shorter than group 1 (p<0.05). In group 3, the mean intr.a.ocular pressure was reduced 8 hours after instillation (p<0.05). And compair with group 1 and group 2 we no statistical significance (p>0.05).
Anterior Chamber ; Cheek ; Epinephrine ; Hyperemia ; Intraocular Pressure ; Myopia ; Pilocarpine ; Rabbits ; Reducing Agents ; Timolol*

BACKGROUND/AIMS: Pancreatic cancer has a very poor prognosis, and early diagnosis is a way to increase the survival rate of patients. The purpose of this study was to develop pancreatic cancer-specific peptides for imaging studies. METHODS: Three pancreatic cancer cell lines, MIA PaCa-2, UACC-462, and BxPC-3, and a control cell line, CCD841, were used. Biopannings were performed on MIA PaCa-2 using a phage display library. After this, the peptides were synthesized and labeled with fluorescein isothiocyanate (FITC). Immunocytochemistry (ICC), enzyme-linked immunosorbent assay (ELISA), and fluorescence-activated cell sorter (FACS) were performed to examine the specific binding. To examine its therapeutic applications, a photosensitizer, chlorin e6 (Ce6), was conjugated on the peptide and photodynamic therapy was performed. Cell survival was investigated using a [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay. RESULTS: After three biopannings, the phages were amplified from 1.4×104 to 3.2×105 plaque-forming units. The most strongly binding phage was selected from the ELISA and ICC results. FITC-labeled peptide, M5, in the three pancreatic cancer cell lines showed significantly higher immunofluorescence in the ICC experiments than that of CCD841. The higher binding ability to MIA PaCa-2 cells was confirmed from FACS analysis, which showed a right shift compared to CCD841. M5 bound to Ce6 showed a significantly lower cell survival rate than that of Ce6 alone in photodynamic therapy, which was observed consistently as a change in the tumor size and fluorescence intensity in MIA PaCa-2 cell-implanted animal models. CONCLUSIONS: This study showed that the noble peptide, M5, binds specifically to the pancreatic cancer cell line, MIA PaCa-2. The M5 peptide has potential use in future optical diagnostic and therapeutic purposes.
Bacteriophages ; Cell Line ; Cell Survival ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Fluorescein ; Fluorescence ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Models, Animal ; Pancreatic Neoplasms ; Peptides ; Photochemotherapy ; Prognosis ; Survival Rate

BACKGROUND/AIMS: Pancreatic cancer has a very poor prognosis, and early diagnosis is a way to increase the survival rate of patients. The purpose of this study was to develop pancreatic cancer-specific peptides for imaging studies.METHODS: Three pancreatic cancer cell lines, MIA PaCa-2, UACC-462, and BxPC-3, and a control cell line, CCD841, were used. Biopannings were performed on MIA PaCa-2 using a phage display library. After this, the peptides were synthesized and labeled with fluorescein isothiocyanate (FITC). Immunocytochemistry (ICC), enzyme-linked immunosorbent assay (ELISA), and fluorescence-activated cell sorter (FACS) were performed to examine the specific binding. To examine its therapeutic applications, a photosensitizer, chlorin e6 (Ce6), was conjugated on the peptide and photodynamic therapy was performed. Cell survival was investigated using a [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay.RESULTS: After three biopannings, the phages were amplified from 1.4×104 to 3.2×105 plaque-forming units. The most strongly binding phage was selected from the ELISA and ICC results. FITC-labeled peptide, M5, in the three pancreatic cancer cell lines showed significantly higher immunofluorescence in the ICC experiments than that of CCD841. The higher binding ability to MIA PaCa-2 cells was confirmed from FACS analysis, which showed a right shift compared to CCD841. M5 bound to Ce6 showed a significantly lower cell survival rate than that of Ce6 alone in photodynamic therapy, which was observed consistently as a change in the tumor size and fluorescence intensity in MIA PaCa-2 cell-implanted animal models.CONCLUSIONS: This study showed that the noble peptide, M5, binds specifically to the pancreatic cancer cell line, MIA PaCa-2. The M5 peptide has potential use in future optical diagnostic and therapeutic purposes.
Bacteriophages ; Cell Line ; Cell Survival ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Fluorescein ; Fluorescence ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Models, Animal ; Pancreatic Neoplasms ; Peptides ; Photochemotherapy ; Prognosis ; Survival Rate

Isolated angiitis of the central nervous system is a rare clinicopathologic entity characterized by vasculitis restricted to the vessels of central nervous system without other apparent systemic vasculitis. It manifests headache, higher cortical dysfunction. focal neurologic dysfunction and cranial nerve palsies. We experienced a case of isolated angiitis of the central nervous system in 6 year-old girl who was admitted to out unit because of headache, hemiparesis and altered consciousness. The laboratory test for blood, urine, and cerebrospinal fluid are all within normal ranges. There was no evidence of systemic vasculitis. The contrast enhanced brain CT scan showed low densities along the left cerebellar hemisphere and posterior aspect of temporal lobe without enhancement, and left lateral internal carotid angiogram showed poorly contrast filling along the territory of left posterior cerebral artery due to narrowing or ischemic changes of the vessels. Axial T2WI (TR/TE, 2190/80) of magnetic resonance imaging showed multiple scattered high signal intensities at left pons with cerebellar hemisphere and diffuse high signal intensity along the left occipital lobe with enlarged surrounding gyral patterns, and axial T1WI(TR/TE, 665/25) showed intense gyral pattern contrast enhancement along the left occipital lobe. Steroid was tried with apparent benefit. We report a case of isolated angiitis of central nervous system with review of literature.
Brain ; Central Nervous System ; Cerebrospinal Fluid ; Child ; Consciousness ; Cranial Nerve Diseases ; Female ; Headache ; Humans ; Magnetic Resonance Imaging ; Nervous System* ; Neurologic Manifestations ; Occipital Lobe ; Paresis ; Pons ; Posterior Cerebral Artery ; Reference Values ; Systemic Vasculitis ; Temporal Lobe ; Tomography, X-Ray Computed ; Vasculitis*

No abstract available.
Acrocephalosyndactylia*

BACKGROUND: Although congenital anomalies of the coronary arteries are rare, which may cause serious clinical problems in diagnostic or surgical procedures, the accurate knowlegde and understanding of these are essential. We are to assess the clinical and angiographic characteristics of congenital anomalies of the coronary arteries detected in adulthhood. METHODS: We retrospectively analyzed a total of 67 cases of primary congenital anomalies of the coronary arteries with particular emphasis in angiographic findings in corelation with the clinical and surgical findings, reviewing 16,099 coronary angiography performed during last 6 years in three institutes. RESULTS: The incidence of congenital anomalies of the coronary arteries detected in coronary angiography was 0.4% and all were primary anomalies, among which major anomalies were 53 cases(79%) and minor anomalies were 14 cases(21%). Twenty-nine cases had associated cardiac defects. Among them congenital heart disease were 10 cases(34%), valvular heart disease were 10 cases(34%), coronary atherosclerotic disease were 8 cases(28%) and hypertrophic obstructive cardiomyopathy was 1 cases(4%). The coronary artery fistula were 40 cases, which was the most common anomaly among major group and the communication between coronary artery and bronchial artery were 6 cases, which was the most common one among minor group. Myocardial ischemia was observed in 49% of major and in 29% of minor anomalies. CONCLUSION: We are reporting 67 cases of the congenital anomalies of the coronary arteries detected in adulthood with the clinical and the angiographic characteristics. We suggest that new modified classification of the congenital coronary anomalies is necessary, because symptoms and signs of myocardial ischemia were observed in a significant number of patients among minoranomaly group.
Academies and Institutes ; Bronchial Arteries ; Cardiomyopathy, Hypertrophic ; Classification ; Coronary Angiography ; Coronary Vessels* ; Fistula ; Heart Defects, Congenital ; Heart Valve Diseases ; Humans ; Incidence ; Myocardial Ischemia ; Retrospective Studies