This study was aimed to clarify the effects of systemic kainic acid (KA) administration (10 mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical method (modified ABC method). The results were as follows: 1) In the anterior and posterior cingulate cortex, somatostatin immunoreactive neurons were not observed in 2,6,10days after treatment of KA including control group except Cg 1 showing some somatostatin immunoreactive neurons in 10days and control groups. 2) In the insular cortex, somatostatin immunoreactive neurons also were not observed in any groups except AIV showing few somatostatin immunoreactive neurons in control group. 3) In the perirhinal cortex, few somatostatin immunoreactive neurons were observed in 2 days and 6 days groups. In control group, a number of somatostatin immunoreactive neurons observed. 4) A strong decrease of somatostatin immunoreactive neurons were observed in the frontal, arietal, temporal and occipital cortex 2 days after treatment of KA. Initially decreased somatostatin immunoreactive neurons had recovered to control 10 days after treatment. 5) Distribution of the somatostatin immunoreactive neurons was observed marked difference according to the cortical areas. Somatostatin immunoreactive neurons in isocortex were more increased in number than the allcotex by control study. The changes in somatostatin immunoreactive neurons after systemic treament of KA were marked in 2 days and 6 days, but these had recovered to control 10 days the treatment of KA. It suggested the normalization of the cerebral function 10 days after seizure. According to the cerebral cortex, the different distribution of somatostatin immunoreactive neurons in number was observed.
Animals ; Cerebral Cortex* ; Gyrus Cinguli ; Kainic Acid* ; Neurons* ; Rats* ; Seizures ; Somatostatin*

No abstract available.

No abstract available.
Abortion, Spontaneous* ; Cytogenetics* ; Female ; Humans ; Pregnancy

Fractures of the hip are usually classified first according to their anatomic location. Isolated fractures of the lesser or greater trochanter are not common and rarely requir surgery, Femoral neck fractures, intertrochanteric fractures, and subtrochanteric fractures are common categories that usually require open reduction and internal fixation. These fractures most often occur in elderly patients. The prognosis of these three major categories of hip fractures seems to be entirely different because of their anatomic characteristics. Seventy three cases of hip fractures were experienced at the Department of Orthopedic Surgery, Eul-Ji General Hospital over the period from Jan. 1975 to Aug. 1980 and the following results were obtained. 1. Of the 73 hip fractures, femoral neck fractures were 28 cases (38.5%), intertrochanteric fractures were 23 cases (31.5%), subtrochanteric fractures 11 cases (15%), and acetabular, fractures 11 cases (15%). 2. Traffic accident was the major cause of hip fractures in our series. 42 cases (57.2%) were caused by traffic accident, whereas 27 cases (37.0%) by a fall from the height. 3. Hip fractures occured most frequently in the age group from 31 to 50 years (53.5%). Male to female ratio was 2:1. 4. Cases caused by traffic accident visited hospital earlier than the others. 5. The most common type was Garden's type IV (53.6%) in the femoral neck fractures, Boyd-Griffins type Il (47.8%) in the intertrochanteric fractures, and Fielding's type II (54.5%) in the subtrochanteric fractures. 6. Metal devices used to fix hip fractures were Knowles pin, Jewett nail plate, compression hip screw, plate and screws, and Kuntscher nail. Internal fixation was done anatomical reduction has been achieved in stable fractures, and Dimon-Hughston reduction in unstable fractures. 7. Postoperative cast immobillzation was performed in 13 cases of 21 femoral neck fractures, 15 cases of 22 intertrochanteric fractures and 6 cases of 11 subtrochanteric fractures. The average duration of immobilization was 10 to 12 weeks. 8. Incidence of avascular necrosis in femoral neck fractures was 16.7%, nonunion in intertrochanteric fractures was 11.8%, and nonunion is subtrochanteric fractures was 12.5%.
Accidents, Traffic ; Acetabulum ; Aged ; Clinical Study ; Female ; Femoral Neck Fractures ; Femur ; Hip Fractures ; Hip ; Hospitals, General ; Humans ; Immobilization ; Incidence ; Male ; Necrosis ; Orthopedics ; Prognosis

PURPOSE: Atrial ectopic tachycardia (AET) in older children and adult is characterized by being chronic, incessant and intractable. However, the nature of infantile AET is not defined yet. The purpose of this study was to evaluate our experience of infantile AET. METHODS: We retrospectively reviewed the medical records of 13 infants (mean onset age, 2.8 +/- 2.3 months) diagnosed at Seoul National University Children's Hospital from June, 1988 to June, 1996. Multifocal atrial tachycardia (AT) and postoperative AT were excluded. RESULTS: AET was presented with congestive heart failure in 8, fast heart rate in 4 and associated cardiac defect in 1. During tachycardia, atrial rates ranged 150-300 beats/min (mean +/- SD, 214 +/- 45 beats/min). Four had associated cardiac anomalies: atrial septal defects in 3, multiple cardiac tumor associated with tuberous sclerosis in 1. All infants with AET were received medical therapy: digoxin (D) only (4), D+beta-blocker (1), D+amiodarone (4), D+flecainide (3), D+amiodarone+flecainide+beta-blocker (1). Conventional drug with digoxin was partially effective. In intractable 7 cases, combination of D, amiodarone and/or class Ic drug (flecainide) was necessary to control AET. This medical regimen suppressed AET in all. During follow up (mean +/- SD, 37.1 +/- 15.8 months), all except 1 recovered from AET. In 1 with large atrial septal defect, AET could be controlled only after operation. A case died of sepsis. CONCLUSION: In this study, infantile AET showed good prognosis and resolved during follow up. Medical management was possible in all cases. However, proper selection and combination of complex antiarrhythmic drug, including amiodarone and class Ic drugs were necessary to control AET in almost all the cases.
Adult ; Age of Onset ; Amiodarone ; beta-Aminoethyl Isothiourea ; Child ; Digoxin ; Follow-Up Studies ; Heart Failure ; Heart Neoplasms ; Heart Rate ; Heart Septal Defects, Atrial ; Humans ; Infant* ; Medical Records ; Prognosis ; Retrospective Studies ; Seoul ; Sepsis ; Tachycardia ; Tachycardia, Ectopic Atrial* ; Tuberous Sclerosis

On July 5, 1980, the first in-training examination for Korean orthopaedic residents was performed to give each of them an evaluation of his general level of orthopaedic knowledge, and to provide their program directer with a comparative basis for evaluation of their programs in various subject areas. Forty one of the 42 residency programs in this country presented in the examination. The results of the examination and the survey of public opinion performed after the examination are as follows. 1. Two hundreds and ninety one of the 312 Korean orthopaedic residents at all level of training participated in the examination, so that the participation rate was 93.3 percent. According to the survey, the respondents wanted to continue the in-training examination in 77 percent. 2. The examination was not sufficient in its reliability because the questions were small in number, and it was deficient in its objectivity since there were 40 percent of the subjective questions. The test was not enough in its practicability because the questions of applying the knowledge clinically such as problem solving one were relatively insufficient in its number. 3. The mean scores of the. residents are increasing regularly with increasing years, which can be interpreted as the questions are somewhat adequate for the test and the orthopaedic training in Korea is efficient one. But the standard deviations of each mean is large, which means the residents level of the orthopaedic knowledge and his training are greatiy varied. The scores of the senior residents are not yet reach a plateau and the scores of the junior residents are inferior to that of the 1966 American counterpart. 4. According to the survey, the majority wants to open the questions with their referencies after the examination, but wants to neither open his score nor reflect his score in that of the Korean orthopaedic board examination.
Internship and Residency ; Korea ; Problem Solving ; Public Opinion ; Surveys and Questionnaires

Recently, the incidence of open fracture of tibial shaft has risen as a result of rapid increase in automobile and industrial accidents. The open fracture of tibial shaft is extremely difficult to treat and has a greater incidence of osteomyelitis, delayed union and nonunion. One hundred and forty two patients (146 cases) of the open fractures of tibial shaft were treated and managed at the Department of Orthopedic Surgery, Hanyang University Hospital from May, 1972 to May, 1984. The results were as follows; 1. In 43.2% of all cases, ordinary culture test for open wound was positive and staphylococcus was predominant. 2. A relatively same rate of fracture union was shown in any portion of tibial shaft. 3. A better prognosis of the fracture type was shown in the oblique, transverse and spiral fracture than in the comminuted and segmental fracture. 4. According to the classification of Ellis, the higher delayed and nonunion rate was shown in major severity group than moderate and minor ones. 5. In minor and moderate severity group, the relatively same rate of fracture union was shown in conservative or operative treatment, but in major severity group, conservative treatment was better than operative treatment. 6. In upper 1/3 and middle 1/3 of the tibia, the relatively same delayed and nonunion rate was shown in conservative or operative treatment and lower 1/3 of the tibia, the high delayed and non-union rate was shown in operative treatment. 7. In comminuted, oblique and transverse fracture, the high delayed and nonunion rate was shown in operative treatment, but in other type of fracture, the relatively same delayed and nonunion rate was shown.
Accidents, Occupational ; Automobiles ; Classification ; Clinical Study ; Fractures, Open ; Humans ; Incidence ; Orthopedics ; Osteomyelitis ; Prognosis ; Staphylococcus ; Tibia ; Wounds and Injuries

No abstract available.
Plants, Medicinal*

In order to provide more effective and personalized healthcare services to patients and healthcare professionals, intelligent active knowledge management and reasoning systems with semantic interoperability are needed. Technological developments have changed ubiquitous healthcare making it more semantically interoperable and individual patient-based; however, there are also limitations to these methodologies. Based upon an extensive review of international literature, this paper describes two technological approaches to semantically interoperable electronic health records for ubiquitous healthcare data management: the ontology-based model and the information, or openEHR archetype model, and the link to standard terminologies such as SNOMED-CT.
Aluminum Hydroxide ; Carbonates ; Delivery of Health Care ; Electronic Health Records ; Electronics ; Electrons ; Humans ; Knowledge Management ; Semantics

No abstract available.
Antibodies*