No abstract available.
Humans ; Infant, Newborn*

Gorham's syndrome is a rare disorder involing a proliferation of vascular channels associated with extensive loss of bony matrix. It starts in bone, but it may secondarily involve soft tissue and adjacent bones. Although the osteolysis usuakky arrests spontaneously, its biologic behavior is difficult to predict. The mechanism of steolysis is unkown, and the role of osteoclasts is controverwial We have experienced one case of Gorham's syndrome affecting the scapula and clavicle, which is reported in this paper with brief review of literature.
Clavicle ; Osteoclasts ; Osteolysis ; Scapula

The aims of treatment of children with CDH untreated until walking age should be to reestablish the mechanics of the hip joint and avoid complications, especially avascular necosis, thus delaying the devlopment of osteoarthritis. In the child who is first seen between the ages of one and three years, considerable controversy still exists as to the merit of closed versus operative management. The average 29.3 months follow-up results in fifty congenitally dislocated hips in forty-five children with were between six and thirty-six months old when treatment was begun have been reviewed at the Department of Orthopaedic Surgery, In Je University, College of Medicine, Paik Hospital from June, 1979 to Aug, 1989. The results of this study were as follows: 1. Factors affecting method of treatment were age, degree of dislocation and acetabular index; A. Age 1) The children below ages of 18 months were treatment by closed reduction. 2) The children below ages of 18 months were treatment by open reduction with concomittant procedures. B. Degree of dislocation: Open reduction was more frequently reguired in higher degree of dislocation. C. Acetabular index: It was little influenced on method of treatment. 2. The complications were persisten subuxation (3 cases), temporary irregular ossification (16 cases) and avascular necrosis (1 cases).
Acetabulum ; Child ; Dislocations ; Follow-Up Studies ; Hip ; Hip Joint ; Humans ; Mechanics ; Methods ; Necrosis ; Osteoarthritis ; Walking

PURPOSE: To report and assess the clinical symptoms and signs, which are the most reliable for diagnosis of acute anterior cruciate ligament (ACL) injury. MATERIALS AND METHODS: We analyzed 79 patients who were confirmed to have an ACL rupture by arthroscopy from January 1995 to December 1999. The T-test was used for statistical analysis. RESULTS: There is no statistical difference of frequency of the clinical symptoms and signs of the ACL ruptures. The most frequent clinical symptom is pain, and sign is hemarthrosis. The Lachman test is the most sensitive test of acute ACL rupture in our cases. CONCLUSION: To increase the accuracy of clinical diagnosis of ACL injury, repeated and accurate history taking and physical examination including above symptoms and signs are important.
Anterior Cruciate Ligament ; Arthroscopy ; Diagnosis* ; Hemarthrosis ; Humans ; Knee Joint* ; Knee* ; Physical Examination ; Rupture

PURPOSE: To analyse clinical result of total knee arthroplasty without patellar resurfacing who had moderate to severe patellofemoral arthritis. MATERIALS AND METHODS: Unilateral knee joints of 54 cases, diagnosed to be moderate to severe patellofemoral arthritis on the basis of Ahlback's radiographic evaluation score of patella on preoperative plain radiography among the patients undergone the total knee arthroplasty due to primary degenerative osteoarthritis at this hospital between January 2000 and March 2004, were subject to this study. Patellar resurfacing was not performed in any cases. Likewise, the knee score of Hospital for Special Surgery and Feller's patellar score were used in clinical assessment preoperatively, and was used two years after the operation. RESULTS: The knee score of Hospital for Special Surgery was increased from 55.1 (35~78) to 82.8 (67~95), and also Feller's patellar score was increased from 19.1 (11~24) to 28.3 (18~30) after operation. Mild anterior knee pain was observed in 5 cases (9.3%) after the operation, but medication was needed in just 2 cases. The 42 cases (77.8%) could normally go up and down stairs without holding the rail. CONCLUSION: The total knee arthroplasty without patellar resurfacing, performed for the patients diagnosed with moderate to severe patellofemoral arthritis related with the indication for patellar resurfacing, derived satisfactory outcomes.
Arthritis* ; Arthroplasty* ; Humans ; Knee Joint ; Knee* ; Osteoarthritis ; Patella ; Radiography

PURPOSE: To evaluate the clinical and radiologic results in patients with total knee arthroplasty without patellar resur- facing. Subject and Method: In this study, 64 cases of total knee arthroplasty without patellar resurfacing were performed nonselectively by a single surgeon from January 2000 to January 2004, and followed up for more than 2 years(range, 24~72 months). The clinical results according to Hospital for Special Surgery knee score and Feller's patellar score, and radiological evaluations about patellar subluxation were analyzed for the correlation of the two results. RESULT: HSS score improved from 54 to 83 points, and Feller's patellar score improved from 18 to 27 after surgery. In preoperative radiologic evaluation, 61 cases(95.3%) were assessed as 'open laterally', the average patellofemoral index was 1.4(0.6~2.5) and the lateral patellar displacement was 1.2mm. In the latest follow-up, 56 cases(87.5%) were assessed as 'open laterally', the average patellofemoral index was 1.5(0.5~3) and the lateral patellar displacement was 1.5(0~8)mm. In comparison between the clinical and radiologic results, no statistic significance was noted in their correlation(p>0.05). CONCLUSION: Total knee arthroplasty without patellar resurfacing was performed nonselectively, satisfactory clinical outcome was observed despite radiologic changes such as patellar subluxation and displacement. It was considered that there was no significance in correlation between radiological changes and clinical results.
Arthroplasty* ; Follow-Up Studies ; Humans ; Knee* ; Patella* ; Patellofemoral Joint

OBJECTIVES: The aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma (NPC). METHODS: Forty-four NPC patients who underwent 18F-FDG PET/CT for initial staging work-up before concurrent chemoradiotherapy (CCRT) were retrospectively evaluated. Maximum standardized uptake value (SUV), mean SUV, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors were measured. The prognostic significance and predictive performance of these parameters were assessed by Cox proportional hazards regression analysis and time-dependent receiver operating characteristics (ROC) curve analysis. RESULTS: Multivariate analysis showed that American Joint Committee on Cancer stage 7th edition (hazard ratio [HR], 1.525; 95% confidence interval [CI], 1.062 to 2.188; P=0.022), and TLG (HR, 7.799; 95% CI, 2.622 to 23.198; P< or =0.001) were independent predictive factors associated with decreased disease-free survival (DFS). Time-dependent ROC curve analysis indicated that TLG was a better predictor of DFS than MTV (P=0.008). CONCLUSION: The TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patients with NPC treated with CCRT.
Chemoradiotherapy* ; Disease-Free Survival ; Electrons* ; Fluorodeoxyglucose F18 ; Glycolysis ; Humans ; Joints ; Multivariate Analysis ; Positron-Emission Tomography ; Positron-Emission Tomography and Computed Tomography ; Prognosis ; Retrospective Studies ; ROC Curve ; Tumor Burden

No abstract available.

BACKGROUND: Calcium antagonists are highly effective agents for lowering high blood pressure and play a very important role in the treatment of Patient with ischemic heart disease and various other cardiovascular disorder. Manidipine, a dihydropyridine-type ccalcium channel blocker, is a potent relaxant of the arteriolar smooth muscle. We studied ths new calcium channel blocker to evaluated the efficacy and safety in patients with essectial hypertension. METHODS: Twenty patients(ten women and ten men;range of age, 30-66 years old)with mild-to-moderate essential hypertension were enrolled in this study. After a placebo run-in phase of two weeks duration, 5mg-20mg manidipine once daily orally was administered for eight weeks. RESULTS: 1) At the end of 8 weeks of manidipine therapy, systolic and diastolic blood pressure were significantly reduced from 160.1+/-11.8/105.5+/-5.1mmHG in sitting, 160.1+/-12.1/104.5+/-5.4mmHG in supine, 157.1+/-17.0/104.1+/-5.3mmHg in standing to 128.4+/-10.1/85.2+/-5.7mmHg in sitting, 129.1+/-10.2/84.2+/-5.9mmHg in supine, 128.1+/-12.8/86.7+/-5.9mmHg in standing(p<0.01). 2) The pulse rate did dnot change significantly. 3) The reduction of mean systolic and diastolic blood pressur at the end of 8 weeks were 31.5+/-14.5/20.3+/-7.4mmHg in sitting. 4) There was no serious side effect except mild symptom, mild headache(6 casem 30%) and facial flushing(1 case, 5%). CONCLUSION: These results indicate that manidipine is an effective and safe antihypertensive agent in the treatment of mild and moderate essential hypertension.
Blood Pressure ; Calcium ; Calcium Channels ; Female ; Heart Rate ; Humans ; Hypertension* ; Muscle, Smooth ; Myocardial Ischemia

The therapeutic applications of Soft Contact Lenses including its optical use are most popular, devices in Ophthalmological field. The presoaked soft contact lenses (Bionite Lens) by 1% pilocarpine,10% phenylnephrine. 1% homatropine, and 1% atropine for 4 minutes are inserted into the albino rabbit and the size of pupil was measured using mm. caliper under the dim red light in the dark room. Hourly measurements were carried out and were stopped in each subject when the pupil size of both eyes had returned to normal. The pupil size of control group, which only the above drug were instilled into the conjunctival cuI de sac, was also measured as the same method. As conclusion using soft contact lens in the therapeutic purpose, it potentiate the effect of medication and prolong the time of drug effect compared with the control groups.
Atropine ; Contact Lenses, Hydrophilic* ; Miotics* ; Mydriatics* ; Pupil