No abstract available.
Lymphoma*

A clinical evaluation was made on patients with urethral strictures, who had been admitted to the Department of Urology, Kyungpook National University Hospital during 7 years periods from January, 1977 to December, 1983. The results were as follows: 1. Out of total 1979 inpatients, 105 were male patients with urethral strictures, giving rate of 5.4% 2. The most frequently involved age group was the 4th. decade being 24.7% of total and 64.6% was seen in age group of 20 to 49 years. 3. Trauma was the most frequent cause of urethral strictures(81%), followed in order of frequency by iatrogenic(11.4 %), inflammatory and post-operative cause. 4. Out of 121 patients with urethral trauma during the study period, urethral strictures were developed in 85 (70.2 %). According to the initial managements of urethral trauma, the incidence of stricture was 74.5% in the suprapubic cystostomy, 78.6% in the primary realignment and 55.9% in the Foley`s catheterization. 5. The treatment modality was surgical intervention in 54 patients and conservative management in 51. Success rates were 90.7% in surgical intervention and 84.3% in conservative managements. Success rate according to the permanent urethroplasty was 93.7% in the perineal end to end anastomosis (30 out of 32 patients), 70% in the transpubic urethroplasty (7 out of 10) and 100% in the Badenoch pull through procedure(4) and realignment(5). 6. As to the late complications, restructure was observed in 7 patients, impotence in 4, false tract in 3 and incontinence in 1.
Catheterization ; Catheters ; Constriction, Pathologic ; Cystostomy ; Erectile Dysfunction ; Gyeongsangbuk-do ; Humans ; Incidence ; Inpatients ; Male ; Urethral Stricture* ; Urology

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases. In addition to its remarkable pharmacologic actions, the physiological roles of FGF21 include the maintenance of energy homeostasis in the body in conditions of metabolic or environmental stress. The expression of FGF21 is induced in multiple organs in response to diverse physiological or pathological stressors, such as starvation, nutrient excess, autophagy deficiency, mitochondrial stress, exercise, and cold exposure. Thus, the FGF21 induction caused by stress plays an important role in adaptive response to these stimuli. Here, we highlight our current understanding of the functional importance of the induction of FGF21 by diverse stressors as a feedback mechanism that prevents excessive stress.
Autophagy ; Fibroblast Growth Factors ; Homeostasis ; Insulin Resistance ; Liver ; Metabolic Diseases* ; Mitochondria ; Obesity ; Pharmacologic Actions ; Starvation

BACKGROUND: Excessive iodine intake increases the occurrence of autoimmune thyroid disorders by enhancing immunogenecity of iodine-rich thyroglobulin, In Korea, most of postpartum women take a large amount of iodine-rich seaweed. Although the excessive iodine intake may affect the thyroid function, only a few reports were available concering iodine intake, especially on postpartum period. METHODS: A prospective study was undertaken in 146 of normal delivered postpartum women. Dietary intake and urinary excretion of iodine, serum T3, T4, TSH, anti-TPO Ab and anti-Tg Ab were measured before and 1, 6, 12 and 24 weeks after delivery. Iodine intake was analyzed by one-to-one interview using 24hr recall and food frequency questionnaire. RESULTS: 1. PPT was occurred in 6 (10.3%) postparturn women, It presented as hypothyroidism alone in 1 (16.7%), transient thyrotoxicosis followed by hypothyroidisrn in 3 (50.0%), and thyrotoxicosis alone in 2 (33.3%) of the follwed-up patients. 2. During pregnancy, no difference was found in age, serum T3, T4 and TSH between PPT and normal thyroid function group. 3. In PPT group, anti-TPO and anti-Tg Ab were significantly higher than those of normal thyroid function group during pregnancy, and their sensitivity for PPT was 40% and 33%, respectively. But there was no correlation between dietary iodine intake and the titer of thyroid auto-antibodies. 4. There was no correlation between pre and post-partum dietary iodine intake and occurrence of PPT. CONCLUSION: In Korea, the incidence of PPT was slightly higher than other nations. The sensitivity of thyroid auto-antibodies was too low to use for prediction of PPT. Pre and post-partum iodine intake had no effect on the occurrence of PPT and post-partum thyroid function.
Female ; Humans ; Hypothyroidism ; Incidence ; Iodine ; Korea ; Postpartum Period ; Postpartum Thyroiditis* ; Pregnancy ; Prospective Studies ; Surveys and Questionnaires ; Seaweed ; Thyroglobulin ; Thyroid Gland ; Thyrotoxicosis

A vesical diverticulum is an abnormal pouch or sac lined with vesical mucosa protruding through the bladder wall. Most vesical diverticula are seen in elderly men in association with bladder outlet obstruction. Occasionally in children, primary or congenital vesical diverticulum is developed with no underlying disease, which produce many urologic problems. Herein we recently experienced one case of the congenital vesical diverticulum in 8-day-old male infant with hydronephrosis and dysuria.
Aged ; Child ; Diverticulum* ; Dysuria ; Humans ; Hydronephrosis ; Infant* ; Male ; Mucous Membrane ; Urinary Bladder ; Urinary Bladder Neck Obstruction

PURPOSE: To evaluate regional differences in relative metabolite ratios in the normal human brain by 1H MRspectroscopy (MRS), and compare the spectral quality obtained by the automated prescan method (PROBE) and themanual method. MATERIALS AND METHODS: Localized 1H MRS was performed on a GE 1.5T SIGNA MRI/MRS system (version5.5) with active shielded gradients. For 20 normal volunteers aged 8-47 years, spectral parameters were adjustedby the auto-prescan routine provided by a PROBE package(N=34)and manually (N=33). Five regions of the human brainwere examined (N=PROBE,manual): frontal white matter(N=6,10), parietal white matter(N=8,9), basal ganglia(N=6,5),thalamus(N=4,5), and cerebellum(N=4,4). For all spectra, a STEAM localization sequence with three-pulse CHESS H2Osuppression was used, with the following acquisition parameters: TR=3.0 sec, TE=30 msec, TM=13,7 msec, SW=2500Hz,SI=2048 pts, AVG=48, and NEX=2. RESULTS: A total of 61 reliable spectra were obtained by PROBE (28/34=82%success) and by the manual method (33/33=100% success). Regional differences in the spectral patterns of the fiveregions were clearly demonstrated by both PROBE and the manual methods. For prescanning, the manual method tookslightly longer than PROBE (3-5 mins and 2 mins,respectively). There were no significant differences in spectralpatterns and relative metabolic ratios between the two methods. However, auto-prescan by PROBE seemed to be veryvulnerable to slight movement by patients, and in three cases, an acceptable spectrum was thus not obtained. CONCLUSION: PROBE is a highly practical and reliable method for single voxel 1H MRS of the human brain; the twomethods of prescanning do not result in significantly different spectral patterns and the relative metaboliteratios. PROBE, however, is vulnerable to slight movement by patients, and if the success rate for obtainingquality spectra is to be increased, regardless of the patient's condition and the region of the brain, it must beused in conjunction with the manual method.
Brain* ; Healthy Volunteers ; Humans* ; Magnetic Resonance Spectroscopy* ; Rabeprazole ; Steam

Acute necrotizing pancreatitis often progresses into infection, sepsis, multiorgan failure and then, mortality and morbidity which are very high. From January 1988 to December 1996, 14 patients with surgically proved acute necrotizing pancreatitis at the Department of Surgery, Catholic University were analysed. 1) The patients consisted of 12 men and 2 women ranging in age from 27 to 74 years. 2) The ethiological factors included excessive alcohol abuse in 8 patients, biliary tract disease in 2 patients and unknown in 4 patients. 3) In clinical findings, the majority of the patients complained of sudden severe upper abdominal pain, nausea and vomiting, tachycardia, and abdominal distension. 4) Serum amylase level did not increase in 50% although the necrosis was severe, but aspartate transaminase increased in 13 cases. The lactic dehydrogenase and C-reactive protein increased in all tested cases. 5) In regards to diagnostic methods, computerized tomography was highly effective in getting early diagnosis and in finding the complications. 6) Early necrosectomy and drainage procedure was safe and effective. 7) Postoperative complications included pulmonary complications in 3 patients, pancreas fistula in 2, pancreas pseudocyst in 2, acute renal failure in 2, Diabetes mellitus in 2, gastrointestinal bleeding 1, and subphrenic abscess in 1 case. 8) Mortality rate was 36 %. In conclusion, computerized tomography may be used for early detection of acute necrotizing pancreatitis;. Aspartate transaminase, Lactate dehydrogenase and C-reactive protein may be good diagnostic and prognostic indicators upon admission. Necrosectomy and drainage should be chosen as the best surgical treatment in acute necrotizing pancreatitis patients.
Abdominal Pain ; Acute Kidney Injury ; Alcoholism ; Amylases ; Aspartate Aminotransferases ; Biliary Tract Diseases ; C-Reactive Protein ; Diabetes Mellitus ; Drainage ; Early Diagnosis ; Female ; Fistula ; Hemorrhage ; Humans ; L-Lactate Dehydrogenase ; Male ; Mortality ; Nausea ; Necrosis ; Oxidoreductases ; Pancreas ; Pancreatitis, Acute Necrotizing* ; Postoperative Complications ; Sepsis ; Subphrenic Abscess ; Tachycardia ; Vomiting

Although subtemporal amygdalohippocampectomy is the ideal approach for pure mesial temporal lobe epilepsy from the view point that it can resect amygdala, hippocampusis, and parahippocampal gyrus selectively, this approach has not gained wide popularity due to shortcomings such as temporal lobe retraction and possible injury to temporal lobe draining veins. We analized surgical anatomy on MRI scan of 20 persons for the purpose of modifing the subtemporal approach to overcome the inherent shortcomings. The distance from temporal pole to anterior margin of temporal horn was 29.8+/-5mm(range, 28.5-31mm). Anterior margin of hippocampus was located 1.8+/-9mm(range, 1-3mm) anterior to dorsum sella. The length of hippocampus to the level of posterior margin of cerebral peduncle was 25.6+/-4mm. External auditary meatus divided the hippocampus, from anterior to the level of posterior margin of cerebral peduncle, in the ratio of 1.52: 1. On the coronal image through interpeduncular cistern, the distance between lateral margin of temporal lobe and collateral sulcus was 40.6+/-.3mm(37-45mm). On the coronal image through interpeduncular cistern and through the external auditary meatus, the height from temporal base to the choroidal fissure was 30.0+/-.7mm and 21.3+/-.5mm, respectively, and the angle between temporal base line and a line from collateral sulcus to choroidal fissure was 45.7+/-.6 degree and 33.2+/-.9 degree, respectively. In conclusion, our results indicate that external auditary meatus(EAM) is anatomical landmark for subtemporal amygdalohippocampectomy, and skull base approach focused on either EAM or anterior to EAM is necessary to minimize morbidity due to temporal lobe retraction and draining vein injury.
Amygdala ; Animals ; Choroid ; Epilepsy ; Epilepsy, Temporal Lobe ; Hippocampus ; Horns ; Humans ; Magnetic Resonance Imaging* ; Parahippocampal Gyrus ; Skull Base ; Tegmentum Mesencephali ; Temporal Lobe ; Veins

PURPOSE: It has been reported that c-erbB-2 overexpression is associated with a resistance to tamoxifen therapy in many trials, but this is controversial. The aim of this study was to evaluate the c-erbB-2 status, and the response to tamoxifen, in breast cancer patients. METHODS: We enrolled 294 patients who had been treated with tamoxifen, 261 (88.8%) were ER and 33 PR positive respectively. The expressions of c-erbB-2 were analyzed using immunohistochemical methods. The median follow up was 36 months. We medical records retrospectively reviewed, and the recurrence rate analyzed and compared with other prognostic factors and survival rates, according to the c-erbB-2 status. RESULTS: The mean age of the patients was 45.23+/-10.47 (20~83). The incidence of invasive ductal carcinomas, invasive lobular carcinomas and DCIS were 91.2, 4.8 and 4.1%, respectively. The recurrence rate was 10.9% (32/294), and 22 of 225 (9.8%) in ER/PR (+/+), 7 of 36 (19.4%) in ER/PR (+/-) and 3 of 33 (9.1%) in ER/PR (-/+). The recurrence rates, according to the TNM stages 0, I, IIa, IIb, III were 0, 5.4, 6.5, 15.2 and 36.7%, respectively (P=0.000). The recurrence rates, according to the c-erbB-2 stati, were 16.5 and 8.4% in the positive and negative groups, respecively (P=0.039). The nuclear grade was higher in the c-erbB-2 positive group than in the negative group, but there was no relationship between the c-erbB-2 status and the other prognostic factors, such as axillary lymph node status, TNM stage or histological grade. The overall and disease free survivals were significantly shorter in the c-erbB-2 positive than the negative group (P<0.05). CONCLUSION: The patients with tumors positive for c-erbB-2 had shorter overall and disease free survivals, compared to patients with tumors negative for c-erbB-2, when treated with tamoxifen. Overexpression of c-erbB-2 may reduce the efficacy of tamoxifen therapy, although our number of patients was small and the follow up relatively short.
Breast Neoplasms* ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular ; Follow-Up Studies ; Humans ; Incidence ; Lymph Nodes ; Medical Records ; Recurrence ; Retrospective Studies ; Survival Rate ; Tamoxifen*

Immune complex formation has been recently emphasized as an important pathogenetic mechanism of hepatitis B virus associated glomerulonephritis (HBGN), but little are known on the role of cell- mediated immunity in that disease. In this study, we measured lymphocyte subsets of the blood samples from three groups(HBGN group, healthy control group, hepatitis B group without renal disease) by flow cytometry in order to clarify abnormalities in immune regulatory system of HBGN. The results were as follows: 1) To compare between HBGN and healthy control group, the proportion of CD4+ cells were higher for HBGN than for healthy control but that of B lymphocytes were lower for HBGN than for healthy control. Between HBGN and hepatitis B group without renal disease, the proportion of B lymphocytes were higher for HBGN but that of NK cells were lower for HBGN(P<0.05). 2) To compare the male data of the three groups, the percentage of CD4+ cells in HBGN group were higher and the percentage of B lymphocytes were lower than healthy control. Between HBGN group and hepatitis B group without renal disease, no significant difference were noted in CD4+ cells, CD8+ cells, B lymphocytes, NK cells and CD4/CD8 ratio (P<0.05). 3) HBGN patients with membraneous nephropathy (MN) showed higher proportion of CD4+ cells than those with membranoproliferative glomerulonephritis (MPGN)(P<0.05). But, no difference was observed between HBGN patients with and without nephrotic syndrome. Nor between HBGN patients with and without HBe antigenemia. In conclusion, above result implies the pathogenetic role of cell-mediated immunity in HBGN. Analysis of lymphocyte subsets for each stage of HBGN, together with the assay of lymphocyte activation markers is required in the future.
Antigen-Antibody Complex ; B-Lymphocytes ; Flow Cytometry ; Glomerulonephritis* ; Glomerulonephritis, Membranoproliferative ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans ; Immunity, Cellular ; Killer Cells, Natural ; Lymphocyte Activation ; Lymphocyte Subsets* ; Lymphocytes* ; Male ; Nephrotic Syndrome