Acute appendicitis is the most common operative disease in general surgery, but it is not also rate disease to see in other clinical department such as Internal Medicine and Obstetric and Gynecology, because it reqnires to differenciate from many other diseases which have similar symptoms. Expecially, because the clipical aymptoms of acute appendicitis are not typieal in children, elderly, and women, it is hard to be diagnosed as acute appendicitis and it is often misdiagnosed as other disease. We performed colonoscopy due to be interpretated aa one of the colon diseases rather than acute appendicitis. But in colonoscopic findings, there were hyperemie and edematous change on the appendiceal orifice of cecum(cherry or acorn shape). So we report 5 cases of acute appendicitis diagnosed br colonoscopy.
Aged ; Appendicitis* ; Child ; Colon ; Colonoscopy* ; Female ; Gynecology ; Humans ; Internal Medicine

There are rare but serious complications-especially risk of paraplegia when instrumentation by surgery is used to correct a spinal deformity. Wake-up tests may be necessary during scoliosis or kyphosis surgery to ensure that spinal function remains intact. We tried four spinal fusions for ankylosing spondylitis of a 62 year-old woman. We were not able to fix the rod for fusion because of a presenting positive wake-up test in the previous two prone-positioned operations. In last operation we decided on normotensive anesthesia with fentanyl-propofol in a lateral decubitus position, and then surgical instrumentation was completed after we made sure of a negative weak-up test. There were no postoperative sequelae. The lateral approach to the thoracic disc space during spinal fusion may produce minimum disruption of the normal spinal musculoskeletal anatomy, avoid retraction of the spinal cord and preserve the neurovascular bundle and the segmental radicular arteries to the spinal cord.
Anesthesia ; Arteries ; Congenital Abnormalities ; Female ; Humans ; Kyphosis ; Middle Aged ; Paraplegia ; Scoliosis ; Spinal Cord ; Spinal Fusion* ; Spondylitis, Ankylosing ; Surgical Instruments

The author analyzed 177 consecutive cases of saccular, ruptured intracranial aneurysms admitted to the Department of Neurosurgery in Korea University Hospital during the period from August 1983 to July 1987. the results of analysis were summarized as follows. 1) Mean age of the patients was 50.4 years. 2) Incidence of clinical vasospasm was 27.2%(46/177) and of rebleeding was 10.7%(19/177). 3) Surgery was done for patients which accounts for 57.6% of all patients. Functional recovery was noted in 84 of the these surgically treated patients(84.6%). 4) The prognostic factors are age, hypertension, size of aneurysm, site of aneurysm, preoperative neurological state, vasospasm, hydrocephalus, rebleeding, timing of operation, multiplicity. 5) The mean size of aneurysms was 6.9mm. The direction of aneurysms was variable, but most of them pointed in the direction of blood flow in afferent arteries.
Aneurysm ; Arteries ; Humans ; Hydrocephalus ; Hypertension ; Incidence ; Intracranial Aneurysm* ; Korea ; Neurosurgery

The author analyzed 177 consecutive cases of saccular, ruptured intracranial aneurysms admitted to the Department of Neurosurgery in Korea University Hospital during the period from August 1983 to July 1987. the results of analysis were summarized as follows. 1) Mean age of the patients was 50.4 years. 2) Incidence of clinical vasospasm was 27.2%(46/177) and of rebleeding was 10.7%(19/177). 3) Surgery was done for patients which accounts for 57.6% of all patients. Functional recovery was noted in 84 of the these surgically treated patients(84.6%). 4) The prognostic factors are age, hypertension, size of aneurysm, site of aneurysm, preoperative neurological state, vasospasm, hydrocephalus, rebleeding, timing of operation, multiplicity. 5) The mean size of aneurysms was 6.9mm. The direction of aneurysms was variable, but most of them pointed in the direction of blood flow in afferent arteries.
Aneurysm ; Arteries ; Humans ; Hydrocephalus ; Hypertension ; Incidence ; Intracranial Aneurysm* ; Korea ; Neurosurgery

No abstract available.
Animals ; Muscle, Smooth, Vascular* ; Nitric Oxide* ; Rats*

The clinical trial was carried out with carteolol in 30 patients with essential hypertension. The results were as follows : 1) Before medication and after 2,4,6 and 8 weeks of medications, the overall average systolic and diastolic blood pressure were 175+/-17.7/105+/-9.3, 144+/-8.9/92+/-6.9, 143+/-11.2/90+/-6.6, 141+/-8.4/88+/-6.9, and 142+/-9.0/88+/-7.1 mmHg. As a result, blood pressure significantly fell with carteolol treatment. 2) In 80+/- of all cases, marked or moderate degree of hypotnesive effect was observed within 2 weeks of treatment. 3) Before medication and after 2, 4, 6 and 8 weeks of medication, the overall average heart rates were 75+/-11.8, 73+/-9.0, 71+/-8.7, 71+/-8.2 and 71+/-8.6 beats/minute. There was no significant changes in heart rates before and after treatment. 4) Dizziness or fatigability were complained in 4 patients (13+/-) each while receiving carteolol. These side effects were mild in 3 patients, but one patient discontinued treatment due to dizziness. On the basis of these results, carteolol was evaluated to be promising hypotensive drug.
Blood Pressure ; Carteolol* ; Dizziness ; Heart Rate ; Humans ; Hypertension

Hydroxyurea is an antineoplastic agent with selective cytotoxicity for cells in the DNA synthesizing phase, or S phase, of the cell cycle. It is commonly used in the treatment of myeloproliferative disorders, e.g., chronic myelogenous leukemia, essential thrombocythemia and polycythemia vera. Its major adverse reactions are reversible and dose dependent marrow suppression and gastroenteric disturbances. Cutaneous side effects such as erythema, hyperpigmentation, lichen planus-like dermatitis, nail discoloration and alopecia, atropy of the skin occur, especially with long-term treatment. Painful leg ulcers in association with hydroxyurea have only rarely been reported. The ulcers were usually extremely painful and typically located near the malleoli but were occasionally found over the tibia, on the dorsal aspect of the feet, calves, knees, heels, and hands. Any minor trauma could precipitate skin breakdown and ulceration and these ulcers tended to heal slowly. No consistent correlation between the dose or duration of hydroxyurea therapy and the occurrence of ulcers. Complete wound healing was achieved by simply discontinuing treatment with hydroxyurea. We describe 2 patients who developed spontaneous painful lower leg ulcers during long-term hydroxyurea therapy for a myeloproliferative disorder(chronic myelogenous leukemia and essential thrombo cythemia). All ulcers were painful and typically located both lateral malleoli. These ulcers healed only after hydroxyurea was withdrawn and with conservative therapy including manual debridement and occlusive dressing.
Alopecia ; Bone Marrow ; Cell Cycle ; Debridement ; Dermatitis ; DNA ; Erythema ; Foot ; Hand ; Heel ; Humans ; Hydroxyurea ; Hyperpigmentation ; Knee ; Leg Ulcer* ; Leg* ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Leukemia, Myeloid ; Lichens ; Myeloproliferative Disorders ; Occlusive Dressings ; Polycythemia Vera ; S Phase ; Skin ; Thrombocythemia, Essential ; Tibia ; Ulcer ; Wound Healing

BACKGROUND: The purpose of this study was to investigate the effects of the subthalamic nucleus (STN) deep brain stimulation (DBS) on the phonation and articulation of patients with Parkinson's disease (PD). METHODS: Seven PD patients who underwent bilateral STN DBS were included. The patients were asked to make and sustain the vowel sounds /a/ and /i/ as long as possible and to repeat nonsense syllables, /pa/, /ta/, /ka/ and /pataka/ as quickly as possible for 3 seconds. When the patients were administered levodopa `on' and `off' treatments, we evaluated the effect of DBS on the maximum phonation time (MPT), jitter (pitch perturbation), shimmer (intensity perturbation), tremor index and diadochokinetic rate (DDK). In each condition, using a Unified Parkinson's Disease Rating Scale score, we also measured the motor disability of the patients. RESULTS: During levodopa `off', both the DBS and levodopa treatment caused significant prolongation of the MPT of the vowels /a/ and /i/. Acoustic analysis showed that DBS had an effect on shimmer only when the patients were levodopa `off'. At the articulatory level, no significant changes were found in the diadochokinetic rate under any conditions. However, there was a correlation between the amount of improvement of voice tremor and sum of UPDRS scores measuring `tremor at rest' and `postural tremor'. CONCLUSIONS: In patients with advanced PD, STN DBS improves phonation, but had limited effects on articulation.
Acoustics ; Deep Brain Stimulation* ; Humans ; Levodopa ; Parkinson Disease* ; Phonation* ; Subthalamic Nucleus* ; Tremor ; Voice

Meningioma is the second most common primary intraspinal tumor. Most spinal meningiomas are located in the intradural extramedullary space and extradural meningiomas are less common. It is quite rare for this tumor to be found in the spinal epidural space of a child. These tumors may be easily confused as a malignant neoplasm because a metastatic lesion commonly located in the epidural space. We report a case of spinal epidural meningioma in a 12-year-old girl. Magnetic resonance findings led to the preoperative diagnosis of a metastatic lesion. The patient underwent total resection of the mass lesion and laminoplasty. She showed an excellent neurological recovery.
Child* ; Diagnosis ; Epidural Neoplasms ; Epidural Space ; Female ; Humans ; Meningioma* ; Spine*

BACKGROUND: Myoclonus-dystonia is a rare familial disease characterized by autosomal dominant inheritance, nonor slowly progressive axial myoclonus combined with dystonic posture, normal electroencephalography (EEG) finding, and dramatic response to alcohol intake. METHODS: Clinical manifestations were studied in a family with myoclonus-dystonia. Response to alcohol intake was investigated in affected adult patients. Brain magnetic resonance imaging (MRI) and other laboratory examination were performed in 3 patients. RESULTS: Eight (male: 5, female: 3) of the 14 biological family members through 4 generations were found to be affected by myoclonus-dystonia on neurological examinations. Another 5 members (male: 3, female: 2) were suspected to be affected in family history. All eight affected members showed axial myoclonus affecting the neck, trunk, and proximal muscles of the limbs. Six of them also had dystonia affecting the neck or the distal part of the arm. Myoclonus and dystonia were ameliorated dramatically after small dose of alcohol intake. Brain MRI, EEG study, and ophthalmologic examination showed no abnormalities. CONCLUSIONS: Our patients showed clinical features compatible with myoclonus-dystonia. This is the first Korean family with myoclonus-dystonia.
Adult ; Arm ; Brain ; Dystonia ; Electroencephalography ; Extremities ; Family Characteristics ; Female ; Humans ; Magnetic Resonance Imaging ; Muscles ; Myoclonus ; Neck ; Neurologic Examination ; Posture ; Wills