In order to study the development of fungal keratitis in wearing of the soft contact lenses contaminated with fungus in various conditions of the cornea, we contaminated the soft contact lenses with Candida albicans, and then placed them on the corneas in rabbits. The rabbits were divided into 4 groups(each 8 eyes). In group 1, dexamethasone was injected subconjunctivally once a day for 4 days and the corneal epithelium was removed 7mm in diameter. In group 2, dexamethasone was injected subconjunctivally once a day for 4 days without removal of the corneal epithelium. In group 3, the corneal epithelium was removed 7mm in diameter without subconjunctival injection of dexamethasone. In group 4, normal corneas were used as a control. The corneas were observed daily with slit-lamp. After 10 days, the infected corneas were examined with light microscope. Keratitis was developed in 5 eyes in group 1(5/8), 3 eyes in group 2(3/8), 2 eyes in group 3(2/8). But keratitis was not developed in group 4. Light microscopic examination showed active invasion of C, albicans forming pseudohyphae into the cornea associated with severe inflammation in group 1 and 2, but it showed mild inflammation and only a small number of C, albicans in the superficial cornea in group 3. In this study, it was found that immunosuppressed and de-epithelialized corneas are susceptible to C, albicans.
Candida albicans* ; Candida* ; Contact Lenses, Hydrophilic* ; Cornea ; Dexamethasone ; Epithelium, Corneal ; Fungi ; Inflammation ; Keratitis* ; Rabbits

No abstract available.
Humans ; Hypoglycemia* ; Infant* ; Infant, Newborn* ; Iron*

Hand tumorsare many and varied, although benign tumors are common. The pathology and histology of these tumors are not unlike these characteristics of the tumor when it occurs elsewhere. Early diagnosis and proper treatment of all hand tumors have been emphasized since the growth of tumors and pain can cause disturbance of intrinsic function of the hand. For the period of 10 years from 1977 to 1986, 105 cases of hand tumor were treated surgically and the results of clinical observation were as follows ; l. Among 105 cases, benign tumor was 101 cases(96.2%) Bone origin tumor was 20 cases, in which enchondroma and enchondromatosis were 17 cases(70%). Soft tissue origin tumor was 85 cases, in which ganglion was 54 cases(63.5%). 2. Among 105 cases, 42 cases were male and 63 cases were female. In age distribution, it showed even distribution. 3. In the duration of wymptom, 51 cases were below 1 year(48.6%). 4. The tumor occured 85 cases in soft tissue, 14 in phalanx, 7 in metacarpal and 1 in carpal bone. 5. The tumors were treated by excision or curettage and bone graft with good improvement, but postoperatively recurred in 2 cases of Hemangioma. Ampuation was performed in 3 cases of malignant tumors without recurrence.
Age Distribution ; Carpal Bones ; Chondroma ; Clinical Study ; Curettage ; Early Diagnosis ; Enchondromatosis ; Female ; Ganglion Cysts ; Hand ; Hemangioma ; Humans ; Male ; Pathology ; Recurrence ; Transplants

The purpose of early reduction and internal fixation of the trochanteric fracture is early mobilization and reducing the complication rate. The morbidity and mortality rates remain high in elderly patients with this type of injury. This is due to reduced tolerance to prolonged bed rest, lenghy operation, and massive soft tissue dissection and blood loss. We feel the Ender method has the advantages of ease performance, decreased operating time, and immediate weight bearing in most cases. Total 23 cases of trochanteric fracture of the femur was treated at the Department of Orthopaedic Surgery of National Medical Center during the period from June, 1985 to December, 1987. The results were as follows : l. Out of 23 patients, 16 patients were female and the mean age was 71 year old. 2. The most common cause was the injury from slip down. 3. By the Tronzo classification, the most common type was type III. (14 cases) 4. The average duration from accident to operation was 4.5 days and average blood loss was 210 ml during operation. 5. The average bony union was obtained in 16.4 wks. 6. For prevention of distal pin migration, we performed circumferential wiring through the eye of distal pin in 6 cases and resulted in no migration until complete bony union.
Aged ; Bed Rest ; Classification ; Early Ambulation ; Female ; Femur ; Fracture Fixation, Intramedullary ; Humans ; Methods ; Mortality ; Weight-Bearing

One hundred and two patients with fracture of the tibial shaft were treated conservatively at the Department of Orthopaedic Surgery, National Medical Center from 1977 to 1982. In this article, we have analyzed early and late influencing factors upon healing process of the tibial shaft fractures treated with conservative methods. Early factors: Age, fracture type, initial displacement, comminution, open fracture, ipsilateral fibular fracture and associated injuries. Late factors: Interval between accident & final manipulation, distraction of fracture site after skeletal traction, and condition of final apposition. Also, we had the result that the mean healing time of tibial shaft fx. was 17.9 weeks by conservative treatment.
Clinical Study ; Fractures, Open ; Humans ; Traction

BACKGROUND: The prevalence of ovat hyperthyroidism ar hypothyroidism has been estimated up to 5% in the general populatian. Subclinical hyperthyroidism and subclinical hypothyroidism have pevalences of approximately 1% and 6%, ectively. The prevalence of hypothyroidism may be associated with excessive intake of iodine in iodine sufficient areas. Therefore, we assumed the prevalence of thyroid dysfunction in Karea might be different from those af Western cauntries. However, thete have been no surveys to examine the prevalence of thyroid dysfunction in Karea. We performed the study to investigate the prevalence of thyrotoxicosis and hypothyroidism in Korean adults. METHODS: This study was performed in 15019 subjects (8275 men, 6744 women; between 17 and 87 years of age) visited in health promotion center of Samsung Medical Center for 12 months in 1996. Serum T3, T4, and TSH concentrations were measured with RIA or IRMA using commercial kits. History of thyroid dysfunction and current medication were obtained from medical records. The criteria for thyrotoxicosis were TSH level below than 0.30 mU/L and increased T3 or T4 levels (T3 > 3.1 nmol/L or T4 > 152 nmol/L). Patients who had TSH level above than 5.0 mU/L and T4 level below than 77 nmol/L met the criteria for hypothyroidism. RESULTS: The prevalence of thyrotoxicosis was 5.5/1000 population (men 3.6/1000, women 7.7/1000) with peak prevalence in fifth decade. The prevalence of previously undiagnosed thyrotoxicosis was 4.0/1000 (men 2.9/1000, women 5.3/1000). The prevalence of hypothyroidism was 2.8/1000 population (men 1.1/1000, women 4.9/1000) with peak prevalence in seventh decade. The prevalence of previously undiagnosed hypothyroidism was 1.6/1000 (men 0.6/1000, women 2.S/1000). The prevalence of subclinical thyrotoxicosis was 12.4/1000 population (men 11.8/1000, women 13.0/1000). The prevalence of subclinical hypothyroidism was 18.2/1000 population (men 11.2/1000, women 26.7/1000) which frequency was increased with age. CONCLUSION: Although the prevalence of thyrotoxicosis and hypothyroidism was not significantly different from those of other countries, it was lower than expected and female preponderance is not significant. The prevalence of subclinical thyrotoxicosis and subclinical hypothyroidism was lower than those of other countries. The prevalence of subclinical hypothyroidism was higher in women and old ages. (J Kor Soc Endecrinol 14:301~313, 1999)
Adult ; Female ; Health Promotion ; Humans ; Hyperthyroidism ; Hypothyroidism* ; Iodine ; Male ; Medical Records ; Prevalence* ; Thyroid Gland ; Thyrotoxicosis*

A rare case of uterine lipoleiomyoma is reported with presentation of computed tomography, histomorphologic and immunohistochemical findings. This tumor is predominantly lipomatous with an admixture of smooth muscle fiber and hyalinized fibrous tissue. Immunohistochemical study revealed a positive reaction of S-100 protein in fat cells and desmin in smooth muscle fibers. Its histogenesis also has been discussed.

Plantar fibromatosis is a benign fibroproliferative disorder of plantar fascia with rare incidence, the etiology of which is still controversial with several etiological propositions such as trauma, infection, autoimmune disease. Hereby we report a case of 45 year-old male patient with pathologically confirmed bilateral plantar fibromatosis, found after bilateral calcaneal fractures.
Autoimmune Diseases ; Calcaneus ; Fascia ; Fibroma* ; Humans ; Incidence ; Male ; Middle Aged

Ultrasonograms of proven liver abscesses in 44 patients were analysed. In ulltrasonography prior to otherdiagnostic approach, 38 patients(86.4%) were accurately diagnosed as liver abscess with correlation of clinicalsymptoms. The outline of abscess is smoothly defined. oval and round in 19 patients, irregularly and ill-definedin 25 patients. Only in 5 patients echogenic capsules are demonstrated. The internal echogenecity is variable;they are predominantly echo-free in 14, predominantly low-echo in 25 and predominantly echogenic, similar to solidtumor in 2 patients . 36 patients who were treated by medication only and combined needle aspiration had follow-up ultrasonography within 3 weeks since initial treatment. 33 patients were ultrasonically and clinically improved.Only one patients died of sepsis after needle aspiration and 2 patients were discharged without any sign ofimprovement.
Abscess ; Capsules ; Follow-Up Studies ; Humans ; Liver Abscess ; Liver ; Needles ; Sepsis ; Ultrasonography

Postoperative vertigo after tympanomastoidectomy can be attributed to several causes such as inner ear damage due to excessive ossicle handling, labyrinthitis, BPPV resulting from vibration of drilling, iatrogenic lateral semicircular canal damage, and perilymphtic fistula. Differential diagnosis is critical for the proper management and prognosis of accompanied sensorineural hearing loss, but it may be difficult in some cases. Especially it is quite difficult to distinguish between the serous and suppurative labyrinthitis. In this article we present a case with simultaneous serous labyrinthitis and BPPV. The patient developed whirling vertigo and hearing loss on the 5th day after tympanomastoidectomy. After conservative treatment with steroid and antibiotics, his hearing recovered to preoperative level. We retrospectively reviewed the pitfalls to make a correct diagnosis in this patient and the serial change in nystagmus during the treatment period. The usefullness of the rotation chair test to predict the prognosis of sensorineural hearing loss in labyrinthitis was also discussed.
Anti-Bacterial Agents ; Diagnosis, Differential ; Ear, Inner ; Fistula ; Handling (Psychology) ; Hearing ; Hearing Loss ; Hearing Loss, Sensorineural ; Humans ; Labyrinthitis ; Mandrillus ; Prognosis ; Retrospective Studies ; Semicircular Canals ; Vertigo ; Vibration