We retrospectively analysed plain radiographs and MR imaging of 16 conventional osteosarcoma cases(8 children, 8 adults) which underwent amputations or limb salvage operations. Pathologic correlation was performed with gross and microscopic sections to evaluate 1) whether the open epiphyseal plate can function as a barrier against transphyseal spread of osteosarcoma and 2) the diagnostic value of MR imaging for the detection of the detection of the epiphyseal involvement of osteosarcoma. In children with open epiphyseal plates, conventional radiographs suggested transphyseal tumor growth in one of eight cases(12.5% and MR imaging in seven cases(87.5%). Pathologic examination confirmed epiphyseal involvement in six of seven cases noted with MR imaging(75%). On the the other hand, in adult patients with closed epiphyseal plates, conventional radiographs showed transphyseal tumor growth in six of eight cases(75%), while MR imaging and pathologic exam demonstrated tumor invasion in all cases(100%). We conclude that open epiphyseal plate does not function as and effective barrier against tumor extension, and MR imaging is an excellent method in detecting the extent of transphyseal tumor growth.
Adult ; Amputation ; Child ; Growth Plate ; Hand ; Humans ; Limb Salvage ; Magnetic Resonance Imaging* ; Methods ; Osteosarcoma* ; Retrospective Studies

A 66 year old man with history of dizziness and occasional headache for a month was found to have right subclavian steal syndrome confirmed by angiogram. Right radial pulse is very weak. Blood pressure on left is 130/70mmHg and on right 70/50. Marked Bruits are audible on right side of neck and shoulder area.
Aged ; Blood Pressure ; Dizziness ; Headache ; Humans ; Neck ; Shoulder ; Subclavian Steal Syndrome*

A 66 year old man with history of dizziness and occasional headache for a month was found to have right subclavian steal syndrome confirmed by angiogram. Right radial pulse is very weak. Blood pressure on left is 130/70mmHg and on right 70/50. Marked Bruits are audible on right side of neck and shoulder area.
Aged ; Blood Pressure ; Dizziness ; Headache ; Humans ; Neck ; Shoulder ; Subclavian Steal Syndrome*

No abstract available.
Helicobacter pylori* ; Helicobacter* ; Urease*

For the morphological analysis of DMBA (9,10-diemethyl-1,2-benzanthracene) induced tumor, thirty Sprague-Dawley rats were received 0.1 ml of a 2% paraffin solution of DMBA into the knee joint cavity, which was repeated three times at an interval of 4 weeks. The induced tumor masses were removed at the 12th week after the first injection. Histological and histochemical examinations (H & E, PAS, alcian blue, Van Gieson, prussian blue, reticulin, PTAH stain) and enzyme histochemical examinations (acid phosphatase, alkaline phosphatase, alpha-naphthyl acetate esterase) were performed. The results were as follows: 1) By the 12th week after the first injection of DMBA, the tumor incidence rate was 20 percent. 2) On histological and histochemical examination, most of the induced tumor disclosed the features of the fibrous histiocytoma originating from mesenchymal cells, and the remains sweat gland adenoma and adenocarcinoma originating from epithelial cells. 3) On enzyme histochemical examination, most of the mesenchymal cell-derived tumor cells showed positive reactions for acid phosphatase and alpha-naphthyl acetate esterase, which were similar characteristic features of enzyme stains as shown in the component cells of fibrous histiocytoma.
Rats ; Animals ; Incidence ; Adenocarcinoma ; Adenoma

To determine the comparative accuracy of two Doppler tests, the findings of 38 patients who had undergone a complete evaluation by supraorbital Doppler test, frontal Doppler test and angiography were studied. When stenosis of 60 percent or more in diameter was considered as a true positive finding, the Doppler tests of 76 internal carotid arteries of the 38 patients showed the following results. Supraorbital Doppler test: eight false positive, three false negative, and 65 correct findings, with an overall accuracy of 85%. The authors, therefore, concluded that the suprorbital Doppler test was more sensitive and accurate than the frontal Doppler test in screening the patients with possible carotid artery occulusive diseases.
Angiography ; Carotid Arteries* ; Carotid Artery, Internal ; Constriction, Pathologic ; Humans ; Mass Screening

Tuberous sclerosis is a rare hereditary anomaly of variable penetrance characterized by mental retardation, epilepsy, and adenoma sebaceum. Pulmonary involvement is uncommon, but, when involve by tuberous sclerosis, it shows characteristic reticulonodular infiltration and cystic changes. Lymphangioleiomyomatosis is a rare disease of unknown cause that affects women of reproductive age. It is characterized by progressive proliferation of smooth muscle in the lung. We experienced one case of pulmonary lymphangioleiomyomatosis associated with tuberous sclerosis in a 26-year-old female patient. This case is reported with a brief of the literature.
Adult ; Angiomyolipoma* ; Epilepsy ; Female ; Humans ; Intellectual Disability ; Lung ; Lymphangioleiomyomatosis* ; Muscle, Smooth ; Penetrance ; Rare Diseases ; Tuberous Sclerosis*

No abstract available.
Ring Chromosomes*

We investigated fifty four patients with spontaneous intracerebral lobar hemorrhage who were admitted to the Seoul National University Hospital Neurology Sercice during a period of five and a half years. Of these patients 25 (46.3%) had hypertension as the probable cause of hemorrhage Of the remaining cases, 12(22.2%) had other etiologies including 5 arteriovenous malforrnations. 3 aneurysms, 2 tumors, 1 Moyamoya disease and 1 superior sagittal sinus thrombosis, while 14(25.2%) had no apparent etiology. But some of them seemed to be due to cerebral amyloid angiopathy or occult vascular malformation. Parietal region was the most frequent site of hemorrage(23 cases, 42.6%). Six cases had multiple intracerebral hematoma. Common clinical manifestations were headache, vomiting, hemiparesis, seizure in order of frequency. Mortality rate was 16.7%, which was correlated with the size of hematoma (P<0.05) and consciousness level at the initial stage (p<0.05). But not with the presence of intraventricular or subarachnoid hemorrhage. Hypertension or age of onset.
Age of Onset ; Aneurysm ; Cerebral Amyloid Angiopathy ; Cerebral Hemorrhage* ; Consciousness ; Headache ; Hematoma ; Hemorrhage ; Humans ; Hypertension ; Mortality ; Moyamoya Disease ; Neurology ; Paresis ; Rabeprazole ; Seizures ; Seoul ; Subarachnoid Hemorrhage ; Superior Sagittal Sinus ; Thrombosis ; Vascular Malformations ; Vomiting

BACKGROUND AND OBJECTIVES: Atrial fibrillation(AF) is the most frequently encountered arrhythmia in clinical practice. Pharmacologic therapy has been advocated for both immediate restoration of sinus rhythm and prevention of recurrent AF. Because conventional antiarrhythmic therapy is often ineffective in maintaining sinus rhythm or is associated with adverse side effects in patients with AF, recent interest has focused on the use of class III antiarrhythmic agents. This study investigated the efficacy and safety of sotalol and amiodarone for conversion of chronic AF and prevention of recurrent AF. MATERIALS AND METHOD: Thirty six patients with AF were firstly received sotalol by prospective study protocol. The patients were classified as having paroxysmal AF(PAF, N=2) or chronic AF(CAF, N=4) based on AF pattern. If the patients with CAF did not convert to sinus rhythm or the patients with PAF recurred in AF, the patients were received second agents(amiodarone). Patients were followed up for one year. RESULTS: Among the 12 patients with PAF receiving sotalol, 10(83.3%) patients remained in normal sinus rhythm for average 9.4+/-3.6 months. Sotalol was replaced by amiodarone in the remaing 2 patients with arrhythmia recurrence and 1 of the 2 patients remained in sinus rhythm during the follow-up period. In the case of 24 patients with CAF, conversion to sinus rhythm was achieved in 5(20.8%) patients with sotalol. Among the patients with CAF who were not respond to sotalol, 17 patients received amiodarone subsquently and 3 patients successfully converted to sinus rhythm. There were no proarrhythmic effects related to both agents during the study period. CONCLUSION: Both sotalol and amiodarone appear to be less effective in the termination of CAF, but sequential use of these two agents seem to be very effective for the prevention of recurrence of PAF.
Amiodarone* ; Arrhythmias, Cardiac ; Atrial Fibrillation* ; Follow-Up Studies ; Humans ; Prospective Studies ; Recurrence ; Sotalol*