No abstract available.
Glucose* ; Humans ; Infant, Newborn* ; Metabolism*

No abstract available.
Autoradiography* ; Brain* ; Rats, Wistar* ; Receptors, Muscarinic*

No abstract available.
Breast Neoplasms* ; Breast*

No abstract available.
Antibodies, Monoclonal* ; Blood Cells*

The authors did clinical analysis for 37 cases, ranging from 5 to 13 year old of age and following result obtained. 1. In group I partial involved type had brightful prognosis even in the neglected the cases. 2. Ischeal brace did not give any help to group II & III but in group I, it gave some help to the prognosis. 3. In untreated cases of old age group developed early arthritic changes. 4. The inital radiological bony changes in early L-C-P. cases was the demineralization of the subchondral area and subsequently subohondral vaccum phenomena followed.
Braces ; Humans ; Prognosis

No abstract available.
Peutz-Jeghers Syndrome*

No abstract available.
Primary Myelofibrosis*

PURPOSE: Supraventricular tachycardia(SVT) is the most frequent symptomatic arrhythmia in children. We performed this study to disover the SVT mechanisms, age at SVT onset, symptoms and ECG findings of SVT and effect of adenosine on SVT. METHODS: We studied 57 patients(male : 30, female : 27, age : 1 day-15.8 years) who had been admitted or transferred due to SVT from January, 1997 to March, 2001. Retrospectively we reviewed their medical records, ECG and electrophysiologic study findings. RESULTS: Of the total 57 patients, the mechanisms of SVT(including atrial flutter) were atrioventricular reentrant tachycardia(AVRT) in 36(63%) patients, atrioventricular node reentrant tachycardia(AVNRT) in 9(16%) patients, ectopic atrial tachycardia(EAT) in 6(11%) patients, multifocal atrial tachycardia(MAT) in 3(5%) patients and atrial flutter(AF) in 3(5%) patients. Of the 12 primary atrial tachycardias(including EAT, MAT and AF), 11 tachycardias began before 1 year of age. The SVT occured before 1 year of age in 21(37%) patients, at 1 to 5 years of age in 7(12 %) patients, at 5 to 10 years of age in 19(33%) patients and after 10 years of age in 10(18%) patients. In symptomatic SVT, the frequent symptoms were palpitation, chest discomfort and chest pain, gastrointestinal symptoms including nausea and abdominal pain, dizziness and dyspnea in decreasing frequency. P wave was discernible in 31(86%) of the 36 AVRT patients and 5(56%) of the 9 AVNRT patients. Adenosine was effective in 19(91%) of 21 AVRT or AVNRT patients. No significant side effect resulted from was occured by rapid bolus intravenous injection of adenosine. CONCLUSION: AVRT was most frequent in pediatric SVT patients. SVT frequently occured before 1 year of age and at 5 to 10 years of age. Primary atrial tachycardia mainly occured before 1 year of age.
Abdominal Pain ; Adenosine ; Arrhythmias, Cardiac ; Atrioventricular Node ; Chest Pain ; Child ; Dizziness ; Dyspnea ; Electrocardiography* ; Female ; Humans ; Injections, Intravenous ; Medical Records ; Nausea ; Retrospective Studies ; Tachycardia ; Tachycardia, Supraventricular* ; Thorax

PURPOSE: MEN1 gene mutation causes multiple endocrine neoplasia type 1. It also suggests that somatic MEN1 gene mutation plays a role in sporadic endocrine tumor. In this study, we examined whether somatic mutations of MEN1 gene are responsible for sporadic parathyroid tumors and correlate with clinical manifestations of parathyroid tumors. METHODS: Somatic mutation of MEN1 gene in the formalin-fixed, paraffin-embedded parathyroid tumor tissue from 8 adenomas, 2 carcinomas and 1 hyperplasia were analyzed by direct sequencing. Clinicopathological parameters were reviewed from medical records and compared with the mutational data. RESULTS: Eight of eleven (73%) sporadic parathyroid tumors had somatic MEN1 mutations of 14 different types. In the 14 types, 13 were a point mutation which is composed of 8 missense mutations, 2 nonsense mutations and 3 silent mutations. One of 14 types is a frameshift deletion of 27 base pairs in exon 2. Somatic mutation was frequent in the exon 2 and exon 10. Four types of polymorphism were found. There was no correlation between the presence of mutations and clinicopathological phenotype of parathyroid tumors. CONCLUSION: This result suggests that somatic mutation of MEN1 gene plays a definite role in sporadic parathyroid tumor formation.
Adenoma ; Base Pairing ; Codon, Nonsense ; Exons ; Hyperplasia ; Medical Records ; Multiple Endocrine Neoplasia Type 1 ; Mutation, Missense ; Phenotype ; Point Mutation

No abstract available.
Child* ; Epilepsy* ; Humans