1.Hyalinizing Trabecular Carcinoma of the Thyroid Gland: A report of two cases.
Kyu Yun JANG ; Joo Heon KIM ; Myoung Ja CHUNG ; Woo Sung MOON ; Myoung Jae KANG
Korean Journal of Pathology 2000;34(4):318-322
We report two cases of hyalinizing trabecular carcinoma (HTC) of the thyroid gland. These two patients were euthyroid women aged 36 and 65 years of age. The tumors were encapsulated and measured 0.8 and 4.0 cm in diameter, respectively. Histologically, the tumors were composed of a compact proliferation of cells in a lobular and trabecular pattern with an intervening hyalinized, fibrotic vascular stroma. Occasionally the cells were arrayed in microfollicles. Multiple and serial sections showed cords of tumor cells invading into the capsule in both cases and vascular invasion in one case. These findings suggested that HTCs are a malignant counterpart of hyalinizing trabecular adenoma, similar to conventional follicular tumor. Positive immunostaining of tumor cells for thyroglobulin and negative staining for high molecular weight cytokeratin, cytokeratin 19, neuron specific enolase, chromogranin, and synaptophysin allowed distinction from medullary carcinoma. Even though HTCs are an heterogeneous group of tumors, the present two cases are probably variants of follicular carcinoma rather than papillary carcinoma.
Adenoma
;
Carcinoma, Medullary
;
Carcinoma, Papillary
;
Female
;
Humans
;
Hyalin*
;
Keratin-19
;
Keratins
;
Molecular Weight
;
Negative Staining
;
Phosphopyruvate Hydratase
;
Synaptophysin
;
Thyroglobulin
;
Thyroid Gland*
2.Association Between Hypertension Management and Blood Pressure Screening Among Adults in 30s and 40s.
Myoung Un OH ; Mona CHOI ; Gwang Suk KIM ; Sung SUNWOO
Korean Journal of Health Promotion 2013;13(2):61-68
BACKGROUND: Although adults in 30s and 40s are at risk for hypertension management due to low rates of awareness, treatment, and control of hypertension, there has been a lack of study on hypertension management for this population. Thus, the purpose of this study is to examine blood pressure screening and other associated factors with hypertension management in terms of awareness, control, and treatment. METHODS: Secondary data analysis was performed on the data from the Fourth Korea National Health and Nutrition Examination Survey in 2007-2009. To examine whether blood pressure screening affects hypertension management in 929 subjects aged 30s and 40s with hypertension. Other factors, such as socio-demographics, health status, and health behaviors, were also included for data analysis. Chi-square test and multiple logistic regression analysis were carried out using SAS 9.1. RESULTS: Hypertension awareness rates were high in those who had diabetes mellitus (odds ratio [OR] 2.23; 95% confidence interval [CI] 1.27-3.90), self-rated their health status as poor (OR 2.89; 95% CI 1.82-4.58), and received a blood pressure check up (OR 5.96; 95% CI 2.90-12.25). Hypertension treatment rates were high in women (OR 2.50; 95% CI 1.47-4.27), and high in those who had diabetes mellitus (OR 2.59; 95% CI 1.49-4.47), self-rated their health status as poor (OR 2.53; 95% CI 1.54-4.14), self-reported as past smoker (OR 2.01; 95% CI 1.22-3.29), and received a blood pressure check up (OR 12.64; 95% CI 4.87-32.77). Hypertension control rates were high in women (OR 2.47; 95% CI 1.29-4.72), and high in those who self-reported as past smoker (OR 2.46; 95% CI 1.35-4.50), and received a blood pressure check up (OR 9.24; 95% CI 3.15-27.15). CONCLUSIONS: For effective hypertension management in 30s and 40s, we should encourage this population to have a regular blood pressure screening.
Adult
;
Aged
;
Blood Pressure
;
Diabetes Mellitus
;
Female
;
Health Behavior
;
Humans
;
Hypertension
;
Korea
;
Logistic Models
;
Mass Screening
;
Nutrition Surveys
;
Phenothiazines
;
Statistics as Topic
3.Adrenogenital Syndrome with Congenital Adrenal Hyperplasia.
Myoung Sung MOON ; Kwang Nam KIM ; Woo Gill LEE
Journal of the Korean Pediatric Society 1984;27(5):511-515
No abstract available.
Adrenal Hyperplasia, Congenital*
;
Adrenogenital Syndrome*
4.The Distribution of HLA Antigens and Haplotypes in Koreans.
Hyun Soo KIM ; Yoo Sung HWANG ; Myoung Hee PARK
Korean Journal of Clinical Pathology 1997;17(6):1109-1123
BACKGROUND: The HLA system is known to be the most polymorphic genetic system in human and there are characteristic racial differences in the distribution of HLA antigens, alleles, and haplotypes. This study was performed to examine the frequency of HLA antigens, alleles and haplotypes in Koreans. METHODS: Two thousand healthy Koreans registered for unrelated bone marrow donors were subject to the study. HLA-A, B and C antigens were typed by the serological method, and HLA-DR DNA typing (low resolution) was done by PCR and reverse hybridization. HLA allele and haplotype frequencies and linkage disequilibrium values were calculated by the maximun likelihood method using the computer program of the 11th International Histocompatibility Workshop. RESULTS: HLA antigens identified in 2000 Koreans were 14 in A locus, 33 in B locus, 8 in C locus and 12 in DR locus. Alleles showing frequencies of more than 10% in decreasing order of frequency In each HLA locus were A2, A24, A33, All, B44, B62; CBL, Cw3, Cwl, Cw7, DR4, DR2, DRl3, DR8, and DR9. Among A-B, C-B, B-DR 2-locus haplotypes, A33-B44, A30-B13, Al-B37, Cwl-B54, Cw4-B62, B7-DR1, B37-DR10 showed strong positive linkage disequilibrium (Chi-square > 1000). The most common A-B-DR haplotypes in Koreans occurring at frequency of more than 2% were A33-B44-DRl3 (4.8%), A33-B58-DRl3 (3.2%), A33-B44-DR7 (2.6%), All-B62-DR4 (2.3%), A24-B7-DR1 (2.3%), and A30-Bl3-DR7 (2.1%) Comparison of the distribution of A-B-DR haplotypes among east Asian populations reveals that Koreans are most close to Japanese, but show higher degree of polymorphism in the distribution of HLA haplotypes compared to Japanese. CONCLUSIONS: The results obtained in this study can be used as basic data for Koreans in the fields of organ transplantation, disease association studies and anthropologic studies.
Alleles
;
Asian Continental Ancestry Group
;
Bone Marrow
;
DNA Fingerprinting
;
Education
;
Haplotypes*
;
Histocompatibility
;
HLA Antigens*
;
HLA-A Antigens
;
HLA-DR Antigens
;
Humans
;
Linkage Disequilibrium
;
Organ Transplantation
;
Polymerase Chain Reaction
;
Tissue Donors
;
Transplants
5.Treatment Strategy for Staphylococcus aureus Bacteremia.
Han Kim SUNG ; Don Oh MYOUNG ; Won Choe KANG
Korean Journal of Infectious Diseases 2002;34(6):380-390
No abstract available.
Bacteremia*
;
Staphylococcus aureus*
;
Staphylococcus*
6.Eccrine spiradenoma: A report of two cases.
Woo Sung MOON ; Dong Geun LEE ; Myoung Ja JEONG ; Myoung Jae KANG ; Ho Yeul CHOI ; Sang Ho KIM
Korean Journal of Pathology 1993;27(4):402-406
Eccrine spiradenomas are clinically characterized by a solitary, tender mass and they are situated on the upper parts of the body, predominantly on the ventral aspect. We herein report two cases of eccrine spiradenoma in 35-year-old man and 53-year-old woman, which located on upper extremity and inguinal region. The masses are round, well circumscribed and measuring 0.7x0.5x0.5 cm, 5x4.5x3 cm in size, respectively. Histopathologically, the tumor consists of masses of two types of cells, intensely staining cells and pale staining cells, usually arranged in chains, cords and pseudoglands. Immunostainings for low molecular cytokeratin, high molecular cytokeratin, carcinoembryonic antigen, and S-100 protein show positivity in neoplastic cells. Electron microscopically, the tumor was composed of three types of cells, i. e. 1) round or ovoid tumor cells in shape with scanty cytoplasm and poorly developed intracytoplasmic orgenelles, 2) spindle shaped dark cells interconnected by desmosomes, 3) large epithelial cells with abundant cytoplasm and cytoplasmic intermediate filaments which formed glandular structures. The large epithelial cells joint each other by desmosomal attachments and luminal cells featured small numbers of microvilli, but either secretory granules nor ductal type granules were noticed.
Female
;
Male
;
Humans
7.Augmentin-Induced Coagulation Abnormalities as Measured by Thromboelastography.
Sung Geun YOON ; Eun Mi KIM ; Myoung Hye PARK ; Ho Sung KWAK
Korean Journal of Anesthesiology 1997;33(5):912-917
BACKGROUND: Antibiotics are used prophylactically in surgery to prevent postoperative infection. However, antibiotics administered in large doses can cause a bleeding diathesis as a result of platelet dysfunction. We wondered whether these antibiotics might impair platelet function by interfering with the initial step of platelet activation: the binding of agonists to their specific receptors on the platelet surface. METHODS: In 30 patients (male 18, women 12) undergoing primary elective knee arthroscopic surgery, the whole blood coagulation system was prospectively evaluated before, and 10 and 40 minutes after administration of 1 g of augmentin. All patients who had abnormal preoperative coagulation profiles or who received anticoagulant or antiplatelet, antibiotics therapy within 7 days prior to surgery were precluded. RESULTS: At 10 minutes after augmentin administration 25 of 30 patients had a significant impairment in all phases of whole blood coagulation as monitored by thromboelastography. In contrast, three of 30 patients had a significantly decreased coagulation time. Two of 30 patients had no significant changes of TEG variables. TEG variables were restored toward baseline in fourty minutes after augmentin administration. CONCLUSIONS: Augmentin can cause a significant but transient change in the viscoelastic properties of blood. Coagulation parameters of the TEG should be measured prior to augmentin administration to prevent and prospect a bleeding diathesis as a result of platelet dysfunction.
Amoxicillin-Potassium Clavulanate Combination
;
Anti-Bacterial Agents
;
Arthroscopy
;
Blood Coagulation
;
Blood Platelets
;
Disease Susceptibility
;
Female
;
Hemorrhage
;
Humans
;
Knee
;
Platelet Activation
;
Prospective Studies
;
Thrombelastography*
8.Study of Brain Atrophy in Korean.
O Yoon KWON ; Sun Keun JUNG ; Sung Yoon KIM ; Myoung Ho KIM
Journal of the Korean Neurological Association 1983;1(2):17-20
449 hospital patients with no pathologic brain CT findings, 30 yrs of age or older, were selected for the study of cerebral atrophy during the 30 months, from January 1980 to June 1983, at dept. of internal medicine, Hanyang Univ. hospital & following results were obtained. 1) Thoses in male group, A gradually progressive increase in the degree of cerebral atrophy score in the 3rd, 4th & late 5th decades was followed by a dramatic increase in the late 6th & 7th decades. 2) Those in female group, A gradually progressive increase in the degree of cerebral atrophy.
Atrophy*
;
Brain*
;
Female
;
Humans
;
Internal Medicine
;
Male
9.Study of Brain Atrophy in Korean.
O Yoon KWON ; Sun Keun JUNG ; Sung Yoon KIM ; Myoung Ho KIM
Journal of the Korean Neurological Association 1983;1(2):17-20
449 hospital patients with no pathologic brain CT findings, 30 yrs of age or older, were selected for the study of cerebral atrophy during the 30 months, from January 1980 to June 1983, at dept. of internal medicine, Hanyang Univ. hospital & following results were obtained. 1) Thoses in male group, A gradually progressive increase in the degree of cerebral atrophy score in the 3rd, 4th & late 5th decades was followed by a dramatic increase in the late 6th & 7th decades. 2) Those in female group, A gradually progressive increase in the degree of cerebral atrophy.
Atrophy*
;
Brain*
;
Female
;
Humans
;
Internal Medicine
;
Male
10.Comparative study of triflusal and ticlopidine on anti-platelet aggregatory effect and side effects.
Hyeon Gak KIM ; Jong Sung KIM ; Myoung Chong LEE
Journal of the Korean Neurological Association 1998;16(1):21-27
BACKGROUND AND PURPOSE: Platelet aggregation plays an important role in thrombogenesis. Thus antiplatelet agents, such as aspirin and ticlopidine, have been in usage to prevent for recurrent ischemic stroke. Triflusal is known to selectively inhibit cyclooxygenase in platelet rather than in vessel wall. And thus can be more beneficial in its antiplatelet aggregatory effect. There has been no comparative study between triflusal and ticlopidine on its antiplatelet aggregatory effect and side effects till now. Our comparative study between these two agents is to provide useful information on clinical utilization. METHODS: Triflusal(900mg/day) and ticlopidine(500mg/day) were administered in 31 and 37 patients, who suffered from acute ischemic stroke. Their efficacy in platelet aggregation and the incidence of clinical and laboratory side effects were compared in one week and one month after the administration of the drugs. RESULTS: Platelet aggregation was more effectively inhibited in triflusal group, especially induced by collagen or epinephrine(p<0.01). No significant difference was noted in the incidence of side effects in both groups. In five patients of the ticlopidine group, the drug was withdrawn due to skin rash and/or increased liver enzymes. CONCLUSION: Triflusal had more effectively inhibited platelet aggregation in this study. Severe side effects even requiring discontinuation of the drug were noted in five patients of ticlopidine group.
Aspirin
;
Blood Platelets
;
Collagen
;
Exanthema
;
Humans
;
Incidence
;
Liver
;
Platelet Aggregation
;
Platelet Aggregation Inhibitors
;
Prostaglandin-Endoperoxide Synthases
;
Stroke
;
Ticlopidine*