1.Effects of Parenteral Carnitine Supplemantation in Very Low Birth Weight Infants Receiving Totla Parentareal Nutrition.
Myoung Jae CHOEY ; Jeong Nyun KIM ; Sung Keun MOON ; Chul Young JUNG
Korean Journal of Perinatology 1998;9(1):19-25
PURPOSE: Carnitine plays a key role in the oxidation of fatty acids by facilitating their transport. As very low birth weight(VLBW) infants receiving total parenteral nutrition(TPN) with limited oral intake are likely to be carnitine-deficient state, they require exogenous supplementation of carnitine, however, effects of it remains controversial. To demonstrate effects of parenteral camitine supplementation on fat metabolism, weight gain and clinical outcome. We analyzed plasma levels of biochemical markers, changes of weight, and incidence of complications in 23 VLBW infants receiving TPN. METHOD: We randomly assigned 23 VLBW infants(<32 wks of gestational age) receiving TPN to carnitine-supplemented(100mg/kg per day) group(n=10) and control(n=13). Plasma total (TC), free(FC), and acyl carnitine(AC) levels and serum cholesterol, triglyceride and free fatty acid levels were measured before and 2 weeks after carnitine supplementation. RESULT: Decrements in TC for 2 weeks were significantly lower in carnitine group(41.6umol/l->32.3umol/l) than control group(46.3umol/l->25.2umol/l)(p<0.05). Changes of FC and AC were similar in both groups. Levels of cholesterol and triglyreride were similar in both groups. Days of regaining birth weight were faster in carnitine group than control group(15.3+/-3.4 vs 20. 8+/-11.1 days)(p<0.05). Rate of weight gain for two weeks were significantly faster than carnitine group than control group(p<0.05). No significant differences in clinical outcome were found. CONCLUSIONS: Carnitine supplementation in VLBW infants receiving TPN has an supportive nutritional regimen in that it reduces decrement in carnitine level and facilitate weight gain.
Biomarkers
;
Birth Weight
;
Carnitine*
;
Cholesterol
;
Fatty Acids
;
Humans
;
Incidence
;
Infant*
;
Infant, Very Low Birth Weight*
;
Metabolism
;
Parenteral Nutrition, Total
;
Parturition
;
Plasma
;
Triglycerides
;
Weight Gain
2.Effect of Position Change on TcPO2 in the Newborns.
Young Pyo CHANG ; Yong Joon SHIN ; Myoung Jae CHOEY ; Beyong Il KIM ; Jung Hwan CHOI ; Chong Ku YUN
Journal of the Korean Pediatric Society 1990;33(4):448-455
No abstract available.
Humans
;
Infant, Newborn*
3.Statistical observation of the infants who were admitted to NICU.
Young Pyo CHANG ; Dong Woo SON ; Soon Mi PARK ; Mi Jung KIM ; Chang Ryul KIM ; Hyee Sub KIM ; Yong Won PARK ; Hye Kyung HAN ; Won Soon PARK ; Myoung Jae CHOEY ; Beyong Il KIM ; Son Moon SHIN
Korean Journal of Perinatology 1993;4(4):480-497