No abstract available.
Evoked Potentials, Auditory, Brain Stem* ; Hearing* ; Humans ; Infant*

No abstract available.
Apoptosis* ; Lung*

The thirty eight newborn infants with periventricular leukomalacia who were admitted to the neonatal intensive care unit of Gil General Hospital from March 1, 1988 to June 30, 1991, were investigated for ultrasonographic findings, risk factors and neurological outcome. The results were as follows: 1) There were 38 cases of PVL including 21 echogenic flarings and 17 cystic PVL's. 2) Mean birth weight was 2,250 gm and mean gestational age was 35 week. 3) Mean detection timing was 4th day in echogenic flarings and 18th day in cystic PVL's. 4) PVL's were located in the parietal region in 1 case and fronto-parieto-occipital in 3 cases. 5) Mean cyst size was 6 mm. 6) Multiple logistic regression analysis for the risk factors of PVL showed that low birth weight, apnea and seizure were the most significant contributing factors (p<0.05). 7) In the follow-up study of cystic PVL's, 7 cases showed improvement, 7 cases developed into multicystic encephalomalacia and 3 cases developed into atrophy. 8) Neurodevelopmental outcome of cystic PVL's showed nomal; 6.2%, minor neurodevelopmental defect; 43.8%, major neurodevelopmental defect; 31.2% and death; 18.8%. 9) Neurosonographic predictability for neurodevelopemental sequelae by cystic PVL's showed sensitivity; 63.6%%, specificity; 98.0%, positive predictive value; 92.8% and accuracy; 88.2%. 10) Major neurodevelopmental defect was more frequent, cyst size being larger and location being more extensive (p<0.05).
Apnea ; Atrophy ; Birth Weight ; Encephalomalacia ; Follow-Up Studies ; Gestational Age ; Hospitals, General ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Intensive Care, Neonatal ; Leukomalacia, Periventricular* ; Logistic Models ; Rabeprazole ; Risk Factors* ; Seizures ; Sensitivity and Specificity

PURPOSE: Aim of this study is to obtain the normal values of pulmonary function test (PFT) in newborn babies according to their postconceptional age and to detect changes in PFT values of neonatal lung diseases including respiratory distress syndrome and meconium aspiration pneumonia. METHODS: PFT was performed in 60 newborn babies who were admitted in the neonatal intensive care unit and newborn nurseries of Inje University Sanggye Paik Hospital from 2002. 11. 1. to 2003. 10. 31. The PFT data of 20 respiratory distress syndrome (RDS) and 20 meconium aspiration pneumonia patients during the same period were analyzed and compared with normal values of similar postconceptional age group to find what kind of changes in PFT values occur in patient groups. PFT values including compliance (C), resistance (R), functional residual capacity (FRC), tidal volume (TV), percent volume to peak flow (%V-PF) were measured. RESULTS: 1) In PCA 30-32 week newborns, C:1.22+/-0.43 (mL/cmH2O), R:0.12+/-0.07 (cmH2O/mL/sec), FRC:20.9+/-12.7 (mL/kg), TV:7.1+/-3.6 (mL/kg), In PCA 33-36 week newborns, C:1.81+/-0.76 (mL/cmH2O), R:0.09+/-0.04 (cmH2O/mL/sec), FRC:23.3+/-14.1 (mL/ kg), TV:7.3+/-4.3 (mL/kg). In PCA 37-42 week newborns, C:2.08+/-0.57 (mL/cmH2O), R:0.08+/-0.06 (cmH2O/mL/sec), 28.3+/-13.4 (mL/kg), TV:8.5+/-4.1 (mL/kg). 2) In RDS patients of PCA 30-36 week, C:0.08+/-0.02 (mL/cmH2O), FRC:12.3+/-4.3 (mL/kg), %V-PF:0.27+/-0.11. These values were significantly decreased comparing with normal PFT values of newborns with similar postconceptional age (P<0.05). CONCLUSIONS: Lung compliance and FRC of normal newborns increased with increase of their postconceptional age. In RDS patients compliance, FRC and %V-PF were significantly decreased comparing with normal newborns with similar postconceptional age.
Compliance ; Functional Residual Capacity ; Humans ; Infant, Newborn* ; Intensive Care, Neonatal ; Lung Compliance ; Lung Diseases ; Meconium Aspiration Syndrome ; Nurseries ; Passive Cutaneous Anaphylaxis ; Pneumonia ; Reference Values* ; Respiratory Function Tests* ; Tidal Volume

No abstract available.
Septo-Optic Dysplasia*

No abstract available.
Diagnosis* ; Sepsis*

No abstract available.
Hemorrhage* ; Humans ; Infant* ; Infant, Very Low Birth Weight*

Neonatal hyperbilirubinemia is a significant risk factor for the developemtn of otoneurologic disorder. Hyperbilirubinemia resulting in kernicterus produces widespread neuronal damage with the most common sites of staining and destruction involving the hippocampus, basal ganglia and the brainstem nuclei in the floor of the fourth ventricle, including the dorsal cochlear nucleus. ABR may be a useful tool for the monitoring early bilirubin toxicity and postcteric sequelae in infants. This study attempts to evaluate the clinical neurodevelopmental outcome in hyperbilirubnemic infants requiring exchange transfusion through the assessment of ABR. Eight hyperbilirubinemic neonates with severely abnormal ABR findings and twelve hyperbilirubinemic neonates with normal ABR findings were studied to assess their neurodevelopemental outcome. The results were as follows; 1) There were 8 severely abnormal ABR cases, including 5 cases of bilateral flat wave and 3 cases of unilateraly elevated hearing throeshold. 2) The major cause of hyperbilirubinemia was ABO incompatibility(65%) 3) Significant clinical finding associated with severely abnormal ABR was kernicterus(p<0.05) 4) Significant laboratory findings associated with severely abnormal ABR were lower levels of hemoglobin and hematocrit(p<0.05) 5) 2 cases of bilateraly flat ABR and 3 cases of unilaterally elevated hearing threshold could be classified into sensorineural type hearing defect by latency-intensity function curve. 6) At the follow up tests of 3 cases of bilaterally flat ABR, 2 cases showed no change and 1 case showed mild improvement. 7) Among 5 follow up cases of severely abnormal BR, only 1 case showed normal neurodevelopmental outcome, 3 cases showed major neurodevelopmental defect and 1 case showed minor neurodeveoplemental defect. Among them, 1 case has had definite hearing disability.
Basal Ganglia ; Bilirubin ; Brain Stem ; Cochlear Nucleus ; Evoked Potentials, Auditory, Brain Stem* ; Follow-Up Studies ; Fourth Ventricle ; Hearing ; Hippocampus ; Humans ; Hyperbilirubinemia* ; Hyperbilirubinemia, Neonatal ; Infant ; Infant, Newborn* ; Kernicterus ; Neurons ; Risk Factors

Neonatal hyperbilirubinemia is a significant risk factor for the developemtn of otoneurologic disorder. Hyperbilirubinemia resulting in kernicterus produces widespread neuronal damage with the most common sites of staining and destruction involving the hippocampus, basal ganglia and the brainstem nuclei in the floor of the fourth ventricle, including the dorsal cochlear nucleus. ABR may be a useful tool for the monitoring early bilirubin toxicity and postcteric sequelae in infants. This study attempts to evaluate the clinical neurodevelopmental outcome in hyperbilirubnemic infants requiring exchange transfusion through the assessment of ABR. Eight hyperbilirubinemic neonates with severely abnormal ABR findings and twelve hyperbilirubinemic neonates with normal ABR findings were studied to assess their neurodevelopemental outcome. The results were as follows; 1) There were 8 severely abnormal ABR cases, including 5 cases of bilateral flat wave and 3 cases of unilateraly elevated hearing throeshold. 2) The major cause of hyperbilirubinemia was ABO incompatibility(65%) 3) Significant clinical finding associated with severely abnormal ABR was kernicterus(p<0.05) 4) Significant laboratory findings associated with severely abnormal ABR were lower levels of hemoglobin and hematocrit(p<0.05) 5) 2 cases of bilateraly flat ABR and 3 cases of unilaterally elevated hearing threshold could be classified into sensorineural type hearing defect by latency-intensity function curve. 6) At the follow up tests of 3 cases of bilaterally flat ABR, 2 cases showed no change and 1 case showed mild improvement. 7) Among 5 follow up cases of severely abnormal BR, only 1 case showed normal neurodevelopmental outcome, 3 cases showed major neurodevelopmental defect and 1 case showed minor neurodeveoplemental defect. Among them, 1 case has had definite hearing disability.
Basal Ganglia ; Bilirubin ; Brain Stem ; Cochlear Nucleus ; Evoked Potentials, Auditory, Brain Stem* ; Follow-Up Studies ; Fourth Ventricle ; Hearing ; Hippocampus ; Humans ; Hyperbilirubinemia* ; Hyperbilirubinemia, Neonatal ; Infant ; Infant, Newborn* ; Kernicterus ; Neurons ; Risk Factors

Neonatal lupus(NL) is characterized by typical clinical features and the presence of maternal auto- antibodies. The principal serologic markers of NL are anti-Ro/SSA or anti-La/SSB maternal auto- antibodies, which are transferred across the placenta and can be detected for the first few months of the affected child. The major clinical manifestations are cardiac disease, notably congenital heart block, and cutaneous lupus lesions. Hepatobiliary disease is relatively rare clinical manifestation of NL. We experienced a case of NL with abnormal liver function test and skin lesion.
Antibodies ; Child ; Heart Block ; Heart Diseases ; Humans ; Infant, Newborn ; Liver Function Tests* ; Liver* ; Placenta ; Skin*