Anterior ischemic optic neuropathy is due to acute ischemia of the anterior part of the optic nerve, whose main source of blood supply is from the posterior ciliary circulation, either by direct branches or through the peripapillary choroid, with minor and differing contributions from other sources. The clinical features are charaterized by sudden visual impairment, optic nerve related visual field defect and optic disc edema. For pathogenetic as well as therapeutic reasons, these patient can be subdivided into two major subgroups: a nonarteritic group, an arteritic group. The authors experienced a case of AION, which occurred in a young male, probably arteritic. So, the literature of the AION was briefly reviewed and the purpose of this review is to increase awareness of this not uncommon condition.
Choroid ; Edema ; Humans ; Ischemia ; Male ; Optic Nerve ; Optic Neuropathy, Ischemic ; Vision Disorders ; Visual Fields

BACKGROUND :Although clinicopathologic differences have been described between Epstein-Barr virus (EBV)-positive and negative gastric adenocarcinomas, the pathogenetic basis for these differences remains unclear. In this study, efforts were made to confirm that expression of EBV-latent membrane protein (LMP1) and immunohistochemical characteristics of EBVpositive gastric adenocarcinomas. METHODS: We investigated genomic deletion, and RNA & protein expression of the EBV-LMP1, as well as immunohistochemical protein expression of transforming growth factor (TGF)-beta1, TGF-bata RII, p21, p16, E2F1, thymidylate synthase, and NF-kappaB in relation to EBV positive gastric adenocarcinoma. RESULTS: A total of 38 Epstein-Barr Virus Encoded RNA-positive and 80 negative gastric carcinomas were examined. A 30 bp DNA deletion in the EBV-LMP1 gene, initiating at codon 342, was detected in 94.4% of EBVpositive cases. By RT-PCR and western blotting, EBV-LMP1 mRNA and protein expressions were absent in all cases, re-gardless of DNA deletion. No significant differences in TGF-bata1, TGF-betaRII, p21, NF-kappaB, E2F1, or thymidylate synthase expression were identified. However, the decreased expression of p16 was found in 84.2% of EBV-positive carcinomas, relative to only 57.5% of EBV-negative tumors (p=0.024). CONCLUSION: EBV-LMP1 DNA deletion, mRNA and protein losses are highly prevalent in EBV-positive gastric adenocarcinoma among Korean patients, along with decreased p16 expression.
Adenocarcinoma* ; Blotting, Western ; Codon ; DNA ; Herpesvirus 4, Human* ; Humans ; Membrane Proteins* ; Membranes* ; NF-kappa B* ; RNA ; RNA, Messenger ; Stomach Neoplasms ; Thymidylate Synthase* ; Transforming Growth Factors*

PURPOSE: This is to examine the neurodevelopmental outcomes of very low birth weight (VLBW) infants by Korean infant developmental screening test. METHODS: 29 VLBW infants and 39 normal term infants, at their corrected age of 1 to 3 years, were included for the study. Risk factors which influence neurodevelopmental outcomes were analyzed. RESULT: The mean levels of developmental quotients for VLBW infants were lower than those of term infants (P<0.001); gross motor 99.3+/-27.28 vs. 121.3+/-19.08, fine motor 95.9+/-27.22 vs. 118.3+/-17.77, social-personality 100.2+/-28.01 vs. 126.3+/-21.31, language 99.5+/-27.34 vs. 120.1+/-18.82, cognitive-adaptive 101.4+/-28.60 vs. 122.7+/-19.59, and total developmental quotient is 99.3+/-27 vs. 121.7+/-19.18. Nevertheless, the mean levels of the individual developmental quotients for VLBW infants were in normal range. There were five VLBW infants (17%) those who scored lower than 80, also showed neurologic sequelae. The infants who had the more risk factors during hospitalization scored the less developmental quotient (R(2)=0.35, P=0.01). CONCLUSION: Although the mean levels of the individual developmental quotient for VLBW infants, assessed by Korean infant developmental screening test, were lower than those of term infants, they are in normal range.
Child ; Child Development* ; Hospitalization ; Humans ; Infant* ; Infant, Very Low Birth Weight* ; Mass Screening* ; Reference Values ; Risk Factors

PURPOSE: Natural killer cells (NKC) and dendritic cells(DC) have non-specific cytotoxic effect against various tumor such as breast cancer, colorectal cancer and lung cancer. However, the relationsjip between the infiltration of these cells and the prognosis of gastric cancer has not yet been elucidated. Therefore the aim of this study is to assess the prognostic impact of NKC and DC infiltration in gastric cancer patient. METHODS: Ninety-seven patients who had undergone a gastrectomy (radical subtotal gastrectomy or radical total gastrectomy) at Yonsei Wonju Christian Hospital between Jan. 1995 and Dec. 1995 were enrolled in the study. Immunohistochemical staining was performed for evaluation of NKC infiltration with CD57 antibody and of DC infiltration with S-100 protein. In DC, the number of S-100 protein positive DC was graded as either low dendritic cell infiltration(0 to 20) or high dendritic cell infiltration (over 20 cells) under high power microscopy (x400 HPF). In NKC, a total of 25 areas containing pericancerous tissue were selected for determining the number of NKC infiltration, after which patients were classified as either low NKC infiltraion (0 to 25) or high NKC infiltration (over 25 cells). The Kaplan-Meier method was used to obtain survival curve and multivariated analysis were performed using Cox regression model. RESULTS: The 5-year survival rate was 75.0% in patients with high infiltration of NKC, 45.3% in those with low infiltration of NKC, 80.0% in those with high infiltration of DC and 43.8% in those with low infiltration of DC. These results were statistically different (P<0.01). However multivariate analysis did not show NKC and DC infiltration to be significant prognostic factors. CONCLUSION: NKC and DC intratumoral infiltration of gastric cancer was positively correlated with survival in this study. Although the prognostic significances of NKC and DC intratumoral infiltration were P<0.01 in both NKC and DC in univariated analysis, these results were not permitted as independent prognostic factors in multivariated analysis.
Breast Neoplasms ; Colorectal Neoplasms ; Dendritic Cells* ; Gangwon-do ; Gastrectomy ; Humans ; Killer Cells, Natural* ; Lung Neoplasms ; Microscopy ; Multivariate Analysis ; Prognosis ; S100 Proteins ; Stomach Neoplasms* ; Survival Rate

In 1938, Jarcho and Levin initially described shortening of the trunk, prominent occiput, broad forehead, multiple vertebral defects and ribs anomaly, short neck, increased anteroposterior chest diameter, lordosis, kyphoscoliosis. After that, Jarcho-Levin syndrome is an eponym that has been used to describe a variety of clinical phenotypes. We examined a girl who was suspected as suffering from Jarcho-Levin syndrome because she had shortening of the trunk, multiple vertebral defects and ribs anomaly, short neck, increased anteroposterior chest diameter, lordosis, kyphoscoliosis. We report a case of Jarcho-Levin syndrome with intrathoracic kidney, and review related literature.
Animals ; Eponyms ; Female ; Forehead ; Humans ; Kidney* ; Lordosis ; Neck ; Phenotype ; Ribs ; Thorax

Enterobacter cloacae, a gram negative bacillus is an increasingly frequent cause of nosocomial pediatric infection. It can cause infection of postsurgical wounds, meningitis, and infection of the gastrointestinal, urinary, and respiratory tracts. Newborn infants often are colonized by Enterobacter species in the gastrointestina tract or respiratory tract soon after birth, and a acquisition of hospital strains in immunocompromised newborn infants is common. Neonatal pneumonia has been associated with many infectious agents. Pneumatocele, a cyst-like lesion that develops within the lung parenchyma, is an unusual complication of pneumonia in the neonate, especially in the preterm neonate. Pneumatocele has been reported to occur with Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Streptococcus pneumoniae, and Pseudomonas aeruginosa infections. We describe 2 cases of premature neonates with pneumonia and subsequent pneumatocele formation caused by Enterobacter cloacae.
Bacillus ; Colon ; Enterobacter cloacae* ; Enterobacter* ; Escherichia coli ; Humans ; Infant, Newborn* ; Klebsiella pneumoniae ; Lung ; Meningitis ; Parturition ; Pneumonia ; Pseudomonas aeruginosa ; Respiratory System ; Staphylococcus aureus ; Streptococcus pneumoniae ; Wounds and Injuries

BACKGROUND AND OBJECTIVES: Deafness is the most common sensory deficit and hereditary defect in human populations. The present study investigated the causative gene in circling mice using the complementation test. In addition, the phenotypes and histopathologic findings in circler mice, spinner mice, and compound heterozygote mice were analyzed to elucidate the mechanism of causative gene in inner ear deafness. MATERIALS AND METHOD: In order to analyze inner ear pathology in time sequence for the circler mice, spinner mice, and compound heterozygote, five groups of the homozygous mutants of different ages were used: 10, 18, 21, 35, and 90 days old. The organs of Corti and spiral ganglion neurons in the basal and middle turns were included for quantification. For the preparation of genomic DNA, tail tissues were used. RESULTS: The hair cells in the organ of Corti degenerated in a time-dependent manner. In the basal and middle turns, the volume ratio of spiral ganglion neurons significantly decreased as the mutant aged. RT-PCR analysis indicated that transmembrane inner ear (Tmie) was absent in the case of circler mice, similar to spinner mouse of which is defective Tmie gene. Therefore the variations may be a result from strain-specific allelic differences of the Chr 9 Tmie gene itself (allelic heterogeneity). CONCLUSION: The cir mutant is a suitable mouse model for neuroepithelial defects. PCR and RT-PCR analyses suggest that the Tmie transcript is absent in circler mice. This model represents another candidate for human genetic hearing loss.
Animals ; Deafness* ; DNA ; Ear, Inner ; Genes, Recessive ; Genetic Complementation Test ; Hair ; Hearing Loss ; Heterozygote ; Humans ; Mice* ; Models, Animal ; Neurons ; Organ of Corti ; Pathology ; Phenotype ; Polymerase Chain Reaction ; Spiral Ganglion ; Tail

In 2015, rapid human immunodeficiency virus (HIV) testing was implemented in all 25 public health centers in Seoul. During March and December 2015, 20,987 rapid HIV tests were performed, of which 116 (0.5%) were positive. Compared to those of the period before application of the rapid HIV test in place of conventional enzyme immunoassay method, the number of HIV tests performed and the number of positive results increased by sevenfold and twofold, respectively. In conclusion, expansion of the provision of rapid HIV tests in public health centers increased the number of voluntary HIV tests.
HIV* ; Humans* ; Immunoenzyme Techniques ; Korea ; Methods ; Public Health* ; Seoul*

In 2015, rapid human immunodeficiency virus (HIV) testing was implemented in all 25 public health centers in Seoul. During March and December 2015, 20,987 rapid HIV tests were performed, of which 116 (0.5%) were positive. Compared to those of the period before application of the rapid HIV test in place of conventional enzyme immunoassay method, the number of HIV tests performed and the number of positive results increased by sevenfold and twofold, respectively. In conclusion, expansion of the provision of rapid HIV tests in public health centers increased the number of voluntary HIV tests.
HIV* ; Humans* ; Immunoenzyme Techniques ; Korea ; Methods ; Public Health* ; Seoul*

Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis of unknown etiology, characterized by multi-organ involvement. ECD is usually diagnosed on the basis of characteristic radiologic and histopathological findings. Lesions may be skeletal and/or extraskeletal in location, and may include the skin, lung, heart, and central nervous system. We describe here a 68-year-old man with multiple yellowish plaques and a pinkish nodule on his face and scalp. He had been previously diagnosed with diabetes insipidus, and recently complained of coughing and dyspnea. Imaging studies showed multiple osteosclerotic lesions of the bones, a moderate amount of pericardial effusion, and multifocal infiltrative lesions in the perirenal space. Histopathological examination of the skin lesions revealed dermal infiltration of foamy histiocytes with multinuclear giant cells. Moreover, laparoscopic biopsy of the perirenal tissue revealed fibrosis with infiltrating foamy histiocytes being CD68-positive and S100-negative. Based on these findings, he was diagnosed with ECD with extraskeletal manifestations, and treated with interferon-alpha.
Aged ; Biopsy ; Central Nervous System ; Cough ; Diabetes Insipidus ; Dyspnea ; Erdheim-Chester Disease ; Fibrosis ; Giant Cells ; Heart ; Histiocytes ; Histiocytosis ; Humans ; Interferon-alpha ; Lung ; Pericardial Effusion ; Scalp ; Skin