Diabetes mellitus is a common disorder and presents in different ways. Shoulder pain is a common musculoskeletal complaint, especially in middle-aged or older-aged men. While it is widely accepted that diabetics have an increased propensity to develop infections, a diagnosis of osteomyelitis of the humerus as the etiology of constant shoulder pain might be delayed, as occurred in this case study, until patients' develop clear signs of infection. Here, we describe a case of subacute osteomyelitis as the first physical symptom of diabetes; the possibility of osteomyelitis should therefore be investigated in all patients with diabetes mellitus who develop joint or bone-related pain.
Diabetes Mellitus* ; Diagnosis ; Humans ; Humerus ; Joints ; Male ; Osteomyelitis* ; Shoulder Pain

The organ weight is one important indicator to discern normal condition from abnormal in forensic pathology as well as in clinical medicine. This study includes organ weights of Korean population, which can be fundamental sources to be analyzed comparatively with other ethnic groups. Seven organs (heart, lung, liver, kidney, spleen, thyroid gland, and brain), which were harvested from 526 Korean adults (369 males and 157 females) during ordinary postmortem examination, were weighed. All of the organs in males were heavier than those in females. With variables controlled, the organ weights of hearts, spleens, and thyroid glands in males were not different from those in females, and the rest of organs were heavier in males than females. Mean weight of left kidneys was higher than that of right ones (P<0.05). All of the organs but heart became lighter in weight, as one got older. The liver and kidney weights of the middle-aged adults were heavier than those of any other age groups (P<0.05). The weights of all organs except for lungs and cerebrums were more related to body weight than height. These results are considered for useful anatomical data to understand the disease properties in Koreans.
Adult ; Autopsy ; Body Weight ; Cerebrum ; Clinical Medicine ; Ethnic Groups ; Female ; Forensic Pathology ; Heart ; Humans ; Kidney ; Liver ; Lung ; Male ; Organ Size ; Spleen ; Thyroid Gland ; Weights and Measures

BACKGROUND: Anterior cerebellar artery (AICA) occlusion results in vestibular dysfunctions because the AICA supplies the vestibular nuclei (VN) in the brain stem as well as the peripheral vestibular organs in the inner ear. The purpose of this study was to evaluate the expression of immediate-early gene products, a metabolic marker of neural excitation in neurons, by AICA occlusion in the VN of Sprague-Dawley rats. METHODS: After chloral hydrate anesthesia all animals were subjected to unilateral AICA occlusion by using a microsurgical clamp for 30 min to induce a transient ischemia. Unilateral labyrinthectomy was chemically undertaken to eliminate vestibular afferent activity. Immunohistochemical staining and image analysis for cFos, FosB, Krox-24, and JunB proteins were performed 2 hours after AICA occlusion. RESULTS: There was a high expression of cFos protein in the bilateral medial and inferior VN 2 hours after AICA occlusion. AICA occlusion induced minimal changes in cFos protein expression in the lateral and superior VN. Mild to moderate expressions of FosB and JunB protein in VN was observed 2 hours after ischemic injury of the brain stem and inner ear. On the contrary, the number of cFos and FosB immunoreactive neurons significantly decreased in the medial vestibular nucleus ipsilateral to the injured labyrinth 2 hours after AICA occlusion in the UL group. CONCLUSIONS: These results suggest that ischemic afferent activity from the peripheral vestibular apparatus is essential for the expression of immediate-early gene products in the medial and inferior VN of rats following AICA occlusion.
Anesthesia ; Animals ; Arteries* ; Brain Stem ; Chloral Hydrate ; Ear, Inner ; Equipment and Supplies ; Genes, Immediate-Early* ; Ischemia ; Neurons ; Rats ; Rats, Sprague-Dawley* ; Vestibular Nuclei* ; Vestibule, Labyrinth