Since the introduction of percutaneous coronary interventions, the restenosis has been a major limitation of this therapeutic technique. Until recently, multiple mechanical and pharmacological interventions have proven ineffective in reducing restenosis in a systematic and convincing fashion. Consequently, the interventional community turned their attention to radiotherapy, which has an established role for the treatment of various neoplastic diseases. After several years of extremely rapid development, the first randomized trials of intravascular radiotherapy have been completed with unprecedented success in reducing restenosis after percutaneous coronary interventions. New catheter-based delivery systems for intracoronary use are currently being developed and the first devices for delivery of intravascular radiation therapy have been made commercially available in multiple countries. In response to the growing enthusiasm for this approach, studies on larger populations are needed to determine whether this new strategy will influence the restenosis rate and clinical events after angioplasty and, in a broader sense, the field of interventional cardiology.
Angioplasty ; Cardiology ; Percutaneous Coronary Intervention* ; Radiotherapy

Comparative assessment of left ventricular volume curves using echocardiography, gated radionuclide angiography, and contrast left ventriculography was done in 11 cases of valvular heart disease. The parameters obtained from the left ventricular volume curves are enddiastolic volume (EDV), endsystolic volume(ESV), stroke volume(SV), and ejection fraction(EF). The parameters obtained from derivative curves of the left ventricular volume curves are peak ejection rate(PER), peak filling rate(PFR), time to peak ejection rate(TTPER), and time to peak filling rate(TTPFR). All the parameters(EDV, ESV, SV, and EF) obtained from left ventricular volume curves using three methods relate significantly each to each. The shapes of the left ventricular volume curves obtained from three methods were similar to each other. Without significant differences, noninvasive methods can be applied for serial and repetitive left ventricular volume curve analysis.
Echocardiography* ; Gated Blood-Pool Imaging* ; Heart Valve Diseases ; Stroke

Primary squamous cell carcinoma of the endometrium is exceedingly rare. To be accepted as a primary carcinoma of the endometrium, the tumor must satisfy the criteria estalished by Fluhmann: There must be; 1) no coexisting endometrial adenocarcinoma, 2) no connection between the endometrial tumor and the squamous epithelium of the cervix, and 3) no squamous cell carcinoma of the cervix. We recently experienced a case of primary squamous cell carcinoma of the endometrium covering the submucosal leiomyoma in a 68-year-old female patient. On gross examination a submucosal leiomyoma covered by an irregular, dirty endometrium was found. On histologic examination the endometrium covering the leiomyoma revealed invasive, well differentiated squamous cell carcinoma. The uterine cervix showed no evidence of malignancy. In situ PCR using a probe for HPV 16/18 was negative in the carcinoma tissue.
Adenocarcinoma ; Aged ; Carcinoma, Squamous Cell* ; Cervix Uteri ; Endometrium* ; Epithelium ; Female ; Humans ; Leiomyoma* ; Polymerase Chain Reaction

No abstract available.
Femur* ; Osteomyelitis*

No abstract available.

No abstract available.
Carcinoma, Papillary* ; Mediastinum*

No abstract available.
Carcinoma, Papillary* ; Mediastinum*

A clinical study was made on 434 patients of valvular heart disease admitted to the Seoul National University Hospital during the period of November 1971-February 1978. The results were obtained as follows: 1) The number of valvular heart disease was 434 patients, which accounts for 2.6% of the total hospitalized patients during the same period. The sex incidence of valvular heart disease were female 48.6%, male 51.4%. The incidences of each valvular heart disease were mitral stenoinsufficiency 31.8%, mitral stenosis 24.2%, mitral insufficiency 21.0%, combined valvular heart disease 12.2%, aortic insufficiency 7.1%, aortic stenoinsufficiency 1.6%, pulmonic stenosis 1.4%, and aortic stenosis 0.7%, in order. 61.5% of all were in third to fifth decade in age distribution. 2) The following were found as etiological factors: rheumatic fever 36.4%, atherosclerosis 1.6%, syphilis 0.9%, and unknown and others 61.3%. 3) The main subjective symptoms were dyspnea, palpitation, cough, orthopnea, sputum, chest pain, fatigue, blood tinged sputum, dizziness, and headache. And the main objective finding were hepatomegaly, venous engorgement, edema, pulmonary congestion, thrill, ascites, splenomegaly, malar flush, and finger clubbing. 5) The disturbance of liver function were found in about 30% of valvular heart disease. 6) The abnormalities of electrocardiographic findings were observed as follows: atrial fibrillation 55.1%, ventricular premature beat 15.2%, first degree atrioventricular block 8.5%, incomplete right bundle branch block 4.1%, complete right bundle branch block 1.4%, second degree atrioventricular block 0.9%, and left bundle branch block 0.9%, in rhythm and conduction disturbance, and left ventricular hypertrophy 44%, right ventricular hypertrophy 18.2%, biventricular hypertrophy 4.6%, left atrial enlargement 19.8%, and right atrial enlargement 3.2%, in chamber enlargement.
Age Distribution ; Aortic Valve Stenosis ; Ascites ; Atherosclerosis ; Atrial Fibrillation ; Atrioventricular Block ; Bundle-Branch Block ; Cardiac Complexes, Premature ; Chest Pain ; Cough ; Dizziness ; Dyspnea ; Electrocardiography ; Estrogens, Conjugated (USP) ; Fatigue ; Female ; Fingers ; Headache ; Heart Valve Diseases* ; Hepatomegaly ; Humans ; Hyperemia ; Hypertrophy ; Hypertrophy, Left Ventricular ; Hypertrophy, Right Ventricular ; Incidence ; Liver ; Male ; Mitral Valve Insufficiency ; Mitral Valve Stenosis ; Pulmonary Edema ; Pulmonary Valve Stenosis ; Rheumatic Fever ; Seoul ; Splenomegaly ; Sputum ; Syphilis ; Tolnaftate

This study was undertaken to know the extent of apoptosis, expression of bcl-2 and proliferating cell nuclear antigen (PCNA) in uterine cervical intraepithelial neoplasia (CIN; 15 cases) and invasive carcinoma (27 cases) and to evaluate them as a prognostic marker. Apoptosis was analysed by using the in situ apoptosis detection kit and bcl-2 and PCNA were detected by the immunohistochemical method. The results were as follows: Apoptotic indices (AI) in the invasive carcinoma (mean: 4.3) were 10-times higher than that in the CIN (mean: 0.43). Bcl-2 was expressed 60% of the cases in the dysplastic cells of the CIN II and CIN III, 33.3% of cases in the invasive carcinoma and not expressed in the CIN I except basal cells. The expression of the PCNA was increased by the grades of CIN and was strong in invasive carcinoma. The mean survival time of the patient with invasive carcinoma was significantly decreased in the higher AI index (above 4.3) than in the lower AI index (below 4.3). There was no significant correlation between the extent of apoptosis and the expression of bcl-2. According to the above results, AI are able to be used as an independent prognostic marker in the invasive cervical carcinoma, and bcl-2 and PCNA have an important role in the tumorigenesis of uterine cervical carcinoma.
Apoptosis* ; Carcinogenesis ; Cervical Intraepithelial Neoplasia* ; Humans ; Proliferating Cell Nuclear Antigen* ; Survival Rate

Human papillomavirus (HPV) 16/18 is a causative agent of uterine cervical carcinoma. HPV 16/18 can alter cell cycle regulation through apoptosis. Bcl-2 is an important regulatory gene of apoptosis. A study was done to evaluate the relation between HPV 16/18 and bcl-2 and apoptosis in 21 cases of carcinoma in-situ (CIS), 5 cases of microinvasive carcinoma and 23 cases of invasive squamous cell carcinoma. HPV 16/18 was detected by hybrid capture system (HCS), bcl-2 protein by immunohistochemical method and apoptosis by using the hematoxylin-eosin stained slide. The results were as follows: Expression of the bcl-2 protein was 43% (9/21) in CIS and 26% (6/23) in invasive carcinoma. Expression of the bcl-2 protein was 42% (5/12) in CIS with HPV 16/18 infection, 44% in CIS without HPV 16/18 infection, 20% (2/10) in invasive carcinoma with HPV 16/18 infection and 31% (4/13) in invasive carcinoma without HPV 16/18 infection. Mean apoptotic index (mAI) was 3.36 in CIS, 5.23 in microinvasive and 6.25 in invasive carcinoma. mAI was 3.66 in CIS with HPV 16/18 infection, 2.86 in CIS without HPV 16/18 infection, 6.18 in invasive carcinoma with HPV 16/18 infection and 6.30 in invasive carcinoma without HPV 16/18 infection. Based on these results, we conclude that there are no correlation between HPV infection and bcl-2, and between HPV infection and apoptosis in invasive and in situ carcinoma of the uterine cervix, and apoptosis is increased according to tumor progression.
Apoptosis* ; Carcinoma, Squamous Cell* ; Cell Cycle ; Cervix Uteri* ; Female ; Genes, Regulator ; Humans