Fibrodysplasia ossificans progressiva (FOP) is a debilitating, rare, autosomal dominant disorder of connective tissue characterized by malformed great toes and by progressive endochondral ossification of extra-skeletal sites (e.g., muscles, tendons, fascia) triggered by trauma, soft tissue injury, muscle fatigue, or viral infections. We present three children affected with FOP with this classic clinical presentation, the first reported cases in the Philippines, thus extending the range of classic FOP to new geographic and ethnic locations. Two of the affected children are siblings who have the common ACVR1 R206H mutation associated with classic FOP; this mutation was not found in their parents who are phenotypically unaffected, providing evidence of germline mosaicism in FOP. To our knowledge, this is the first family with genetic testing done showing presence of the classic mutation in affected siblings not seen in the unaffected parents.
Myositis Ossificans

No abstract available.
Myositis Ossificans* ; Myositis*

No abstract available.
Myositis Ossificans* ; Myositis*

Myositis Ossificans is known to be a benign heterotopic pseudomalignant bone formation in muscle and other soft tissue. When it is revealed as a localized form, 75% of the cases are associated with significant blunt trauma. We report a rare case of a nontraumatic ossificans in the lower leg of a 59-year-old woman, which has been spontaneously developed for 15 years.
Female ; Humans ; Leg ; Middle Aged ; Myositis Ossificans* ; Myositis* ; Osteogenesis

A case of myositis ossificans progressiva is reported. The patient, a 22-year -old progressive ossification for 16 years with severe motion limitation. Bone CT and MRI, bone scanning and muscle biopsy showed multiple ossifying lesions in the connective tissue. All labolatory findings are normal. But serum alkaline pbosphatase become worse with disodium etidronate(EHDP) therapy. The case is presented with the review of literatures.
Biopsy ; Connective Tissue ; Humans ; Magnetic Resonance Imaging ; Myositis Ossificans* ; Myositis*

Myositis ossificans is an ossifying inflammatory lesion occurring within skeletal muscle. Myositis ossificans usually arises in the large muscles of the extremities and this lesion is characterized by progression of mineralization from periphery to center. In the early phase, myositis ossificans simulates malignant soft tissue tumor without dense mineralization. Traumatic myositis ossificans in rectus abdominis muscle has been reported worldwide. The radiologic findings of early active myositis ossificans in rectus abdominis muscle are ill defined heterogenous hypoechoic mass on US, hemorrhage, early strong enhancement and early peripheral mineralization on CT and MR.
Extremities ; Hemorrhage ; Muscle, Skeletal ; Muscles ; Myositis Ossificans* ; Myositis* ; Rectus Abdominis*

A calcification mass was incidentally found in the soft tissue of a patient who had a history of trauma to the extremity during examination. The patient had no symptom. The pathological analysis of the mass revealed it was an early-phase synovial sarcoma (SS). The diagnosis was made before the onset of symptoms and proper surgical intervention was performed. Therefore, in case of a <1 cm lesion clinically suspicious of myositis ossificans, SS should be taken into consideration as a possible diagnosis.
Diagnosis ; Extremities ; Femur ; Humans ; Myositis Ossificans ; Myositis ; Sarcoma, Synovial

Eight cases of Myositis Ossificans observed in paralytic patients were studied. The original lesions leading to the paralysis were Cord Injury(4), C.V. A.(2), and Coma of various causes(2). The results were as follows; 1) In half of all, the occurrence of the ossification ranged between 3 and 4 weeks after the initiation of passive exercise. 2) The most frequent site of the lesion was the paraarticular area. 3) To cessation of passive exercise the lesion responded with prompt decrease in size. 4) It seems that as in normal ossification the repair process of aseptic inflammation derived from the bleeding or the hematoma formation may be the main etiological factor of this lesion in paralytic patients whom the passive exercise were forced.
Coma ; Hematoma ; Hemorrhage ; Humans ; Inflammation ; Myositis Ossificans ; Myositis ; Paralysis

Heterotopic mesenteric ossification is a very rare reactive lesion in the small bowel mesentery, and it is related with trauma or surgical operation. It is pathologically characterized by well formed bone trabeculae and prominent osteoblastic rimming and is clinically related to rapid and recurrent bowel obstruction symptoms. This unusual reactive process shares many clinical and pathologic features with myositis ossificans. We report here on a rare case of heterotopic mesenteric ossification in 28-year-old man who underwent a delayed small bowel resection 15 days after trauma.
Adult ; Humans ; Mesentery ; Myositis Ossificans ; Ossification, Heterotopic ; Osteoblasts

Adolescent ; Diagnosis, Differential ; Female ; Humans ; Myositis Ossificans ; diagnosis