No abstract available.
Drug Therapy* ; Lymphoma*

We studied germination activities of fungus conidiospores in active growth phase using the hanging slide culture method, then investigated the inhibitory effects of two antifungal agents(Tolnaftate and Clotrimazole) on germination activities. The fungal strains used in this study were Trichophyton (T.) rubrum, T. mentagrophytes and Candida (C.) albicans. Each strain was cultured on the Sabouraud's glueose agar plate and examined daily for detection of active growth phase of conidiospores (blastospores in C. albicans). After the conidiospores reached to active growth phase the activated spores were inoculated in one drop of Sabouraud's glucose broth on the cover glass and the hanging slide cultures were performed. The mean hermination rates of T. rubrum and T. nentagrophytes were 87.5% and 78% respectively in 72 hours. In C.albicans the average germination rate was 85.7% after cultivation for 24 hours, this germination rate was much faster than that of T.rubrum and T.mentagrophytes. For detection of miniman inhibitory concentration (MIC) of the antifungal agents to germination activities the antifungal agents were diluted with Sabouraud's glucose broth to various concentration and hanging slide culture was performed with the media containing the antifungal remedies. The minimal concentration of antifungal agents in which the conidiospores could completely not be germinated was denoted to minimal inhibitory concentration. The MIC of Tolnaftate to T.rubrum and T.mentagrophytes were 0.0.1ug/ml. The MIC of Cloirimazole to T. rubrum and T.mentagrophytes were 0.1ug/ml and to C. albicans was 1ug/ml. This results were similar to the previous reports by other investigators. This is a new method that could be applicated for evaluation of antifungal activities of antifungal agents.
Agar ; Antifungal Agents* ; Candida ; Fungi ; Germination* ; Glass ; Glucose ; Humans ; Research Personnel ; Spores ; Tolnaftate ; Trichophyton

The route of transmission of leprosy is still unclear, Recently some authors proposed ge possibility that the bacilli discharged from nasal mucosa might be the source of infection in leprosy. This study was undertaken to evaluate the histopathologic findings of nasal mucosa in 24 fresh untreated patients with leprosy using hematoxyline and eosin stain, and Ziehl-Neelsen stain. Among 24 cases. under clinical observation, 10 cases(41,7%) complain of nasal stuffiness, 8 cases (33. 3%) has congestion, 1 case(4. 2%) was crusted and 1 case(4.2%) was ulcerated. 2 Bacterial index of nasal mucosal smear showed that 16 cases were positive, - 15 cases were 1+, 7 cases were 2+, 2 cases 3+ and 1 case was 4+ Linder H.E. stain, the histopathologic findings of (he inferior turbinate of nasal mucosa showed that 22 cases were cystic dilatation of mucous glands, 1) cases were granuloma with foamy cells cells and 14 cases were epidermal atrophy. TJnder Ziehl-Neelsen stain bacterial index of nasal mucosal biopsy showed that 21 cases were positive 3 cases were 3+, 7 cases were 4+6 cases were 5+ and 5 cases were 6+. As above results, the histopathologic findings of nasal mucosa were similar to the skin lesions of leprosy.
Atrophy ; Biopsy ; Dilatation ; Eosine Yellowish-(YS) ; Estrogens, Conjugated (USP) ; Granuloma ; Hematoxylin ; Humans ; Leprosy* ; Nasal Mucosa* ; Skin ; Turbinates ; Ulcer

We present a case of generalized congenital ichthyosiform dermatosis associated with neurosensory hearing loss, neovascularization of corneas, partial alopecia and abnormalities of nails and teeth on a 26 years old female patient. This case is strictly similar to the previously reported cases. The combination of these abnormalities was stuggested to be a new syndrome by some authors. This case is the first reported case in Korea, although in the literature we could find several cascs with similar patterns of malformations.
Adult ; Alopecia ; Cornea ; Deafness* ; Female ; Hearing Loss ; Humans ; Keratitis* ; Korea ; Skin Diseases* ; Tooth

It has been known that immobilization of patient caused by chronic illness, orthopedic or neurological conditions can be one of etiological factorof urinary stone The authors have recently experienced a case of renal sand filling the pelviwalycea1 system simulating renal staghorn calculus which wasspontaneously flushed out following excessive fluid intake and forced mobilization. This patient had stones in the contralateral kidney and ureter.
Calculi* ; Chronic Disease ; Humans ; Immobilization ; Kidney* ; Orthopedics ; Silicon Dioxide* ; Ureter ; Urinary Calculi

The authors present a case of Marcus Gunn syndrome associated with paresis of the superior rects muscle. This 25 yrs. old R.O.K Soldier had hypotropia and Complete ptosed eye lid of the right side which was elevated in association with Opennig of the mouth and lateral movement of the jaw to the left side since birth. We have treated him surgically, such as complete resection of the levator muscle and then attachment of the upper eye lid to the frontalis muscle with the technic of Friedenwald-Guyton.
Humans ; Jaw ; Military Personnel ; Mouth ; Paresis ; Parturition

No abstract available.
Sleep Disorders, Circadian Rhythm*

No abstract available.
Korea* ; Parkinson Disease*

For comparison of clinical classification of leprosy to histopathologic classification, a detailed histopathologic study, using hematoxylin and eosin stain and Ziehl-Neelsen stain, was done on 72 fresh uncomplicated cases of leprosy. The clinical classification was done using the criteria of Ridley and Jopling (1966), and the microscopic features were classified according to Ridley's(1974) definition. Clinical classification revealed that 8 of total 72 patients had tuberculoid(TT), 9 had borderline tuberculoid (BT), 5 had borderline(BB), 10 had borderline lepromatous.(BL), and 31 had lepromatous leprosy(LL). Nine patients were claasified as indeterminate(I) group. Histopathologic classification showed that 3 cases presented tuberculoid(TT), 10 presented borderline tuberculoid(BT), 4 presented borderline(BB), 9 presented borderline lepromatous(BL), 20 presented subpolar leprornatous(LLs), and 10 presented polar lepromatous(LLp) histopathologic characteristics, Sixteen cases were classified as indeterminate(I) leprosy by histopathologic findings. On comparison of clinical classification to histopathologic classification, the two were in consonance with each other in 50 cases(69.4%) and the disparity between them was noticed in 22 cases(30.6%). Among the 22 cases which showed disparity, there was a shift of one step either towards the tuberculoid or lepromatous end of the spectrum in 15 cases, and ihe remaining 7 cases were classified as indeterminate group beaause of nonspecific histopathologic changes.
Classification* ; Eosine Yellowish-(YS) ; Hematoxylin ; Humans ; Leprosy* ; Leprosy, Paucibacillary

No abstract available.
Ear, Middle*