1.Benefits of Angiotensin Receptor Blockade: Preventing Smooth Muscle Cell Senescence and Beyond
Korean Circulation Journal 2019;49(7):627-628
No abstract available.
Angiotensins
;
Muscle, Smooth
;
Myocytes, Smooth Muscle
2.A Case of of Glomangiomyoma Showing Smooth Muscle Cell Proliferation and Mucinous Stromal Change.
Chang Duk KIM ; Jae Hong PARK ; Young Wook RYOO ; Byung Chun KIM ; Kyu Suk LEE
Korean Journal of Dermatology 2001;39(10):1148-1151
Glomus tumors are benign neoplasms that are derived from modified smooth muscle cells known as glomus cells. Histologically, it can be subdivided as glomus tumor proper, glomangioma, and glomangiomyoma according to relative proportions of components. Glomangiomyomas are the least frequent type and their overall architectural pattern may resemble glomus tumor proper or glomangioma, but there is a gradual transition from glomus cells to elongated mature smooth muscle cells. This transition is most obvious in the region surrounding large vessels. We present a case of glomangiomyoma of the left upper arm and the left fourth finger, in which ten-year history of two painful, bluish-colored subcutaneous nodules. On histologic examination, this case showed marked smooth muscle cell proliferation around large vessles and mucinous stromal change.
Arm
;
Fingers
;
Glomus Tumor
;
Mucins*
;
Muscle, Smooth*
;
Myocytes, Smooth Muscle*
4.Inhibition of voltage-dependent K⁺ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone.
Jin Ryeol AN ; Hongliang LI ; Mi Seon SEO ; Won Sun PARK
The Korean Journal of Physiology and Pharmacology 2018;22(5):597-605
In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent K⁺ (Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits. The Kv current amplitude was progressively inhibited by propafenone in a dose-dependent manner, with an apparent IC₅₀ value of 5.04±1.05 µM and a Hill coefficient of 0.78±0.06. The application of propafenone had no significant effect on the steady-state activation and inactivation curves, indicating that propafenone did not affect the voltage-sensitivity of Kv channels. The application of train pulses at frequencies of 1 or 2 Hz progressively increased the propafenone-induced inhibition of the Kv current. Furthermore, the inactivation recovery time constant was increased after the application of propafenone, suggesting that the inhibitory action of propafenone on Kv current is partially use-dependent. Pretreatment with Kv1.5, Kv2.1 or Kv7 inhibitor did not change the inhibitory effect of propafenone on the Kv current. Together, these results suggest that propafenone inhibits the vascular Kv channels in a dose- and use-dependent manner, regardless of Na⁺ channel inhibition.
Coronary Vessels
;
Muscle, Smooth*
;
Myocytes, Smooth Muscle*
;
Propafenone*
;
Rabbits
5.Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K⁻ channels in coronary arterial smooth muscle cells.
Han Sol KIM ; Hongliang LI ; Hye Won KIM ; Sung Eun SHIN ; Mi Seon SEO ; Jin Ryeol AN ; Kwon Soo HA ; Eun Taek HAN ; Seok Ho HONG ; Il Whan CHOI ; Grace CHOI ; Dae sung LEE ; Won Sun PARK
The Korean Journal of Physiology and Pharmacology 2017;21(4):415-421
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K⁺ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC₅₀ value and Hill coefficient for escitalopram-induced inhibition of Kv channels were 9.54±1.33 µM and 0.75±0.10, respectively. Addition of escitalopram did not alter the steady-state activation and inactivation curves, suggesting that the voltage sensors of the channels were not affected. Pretreatment with inhibitors of Kv1.5 and/or Kv2.1 did not affect the inhibitory action of escitalopram on vascular Kv channels. From these results, we concluded that escitalopram decreased the vascular Kv current in a concentration-dependent manner, independent of serotonin reuptake inhibition.
Citalopram*
;
Coronary Vessels
;
Muscle, Smooth*
;
Myocytes, Smooth Muscle*
;
Serotonin*
6.Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.
Sung Eun SHIN ; Hongliang LI ; Han Sol KIM ; Hye Won KIM ; Mi Seon SEO ; Kwon Soo HA ; Eun Taek HAN ; Seok Ho HONG ; Amy L FIRTH ; Il Whan CHOI ; Young Min BAE ; Won Sun PARK
The Korean Journal of Physiology and Pharmacology 2017;21(2):225-232
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K⁺ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC₅₀ value of 2.86±0.52 µM and a Hill coefficient of 0.77±0.1. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not use-dependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentration-dependent and state-independent manner independently of serotonin reuptake.
Coronary Vessels
;
Muscle, Smooth*
;
Myocytes, Smooth Muscle*
;
Nortriptyline*
;
Serotonin
7.The Effect of Midazolam on Outward K+ Channel Currents in Rabbit Cerebral Arterial Smooth Muscle Cells.
Young Chul SHIN ; Jae Hang SHIM ; Woo Jae JEON ; Sang Yoon CHO ; Woo Jong SHIN ; Kyoung Hun KIM ; Jong Hoon YEOM
Korean Journal of Anesthesiology 2007;52(1):67-71
BACKGROUND: Midazolam has a direct relaxing effect on vascular smooth muscle, but the mechanisms that this agent produces muscle relaxation are not fully understood. The current study was performed to identify the effects of the midazolam on K+ channels current in rabbit cerebral arterial smooth muscle cells. METHODS: Whole cell patch-clamp recording technique was used to evaluate the effects of midazolam (0.1 to 100micrometer) on outward K+ channel currents in dispersed rabbit cerebral arterial smooth muscle cells. RESULTS: Outward K+ currents of rabbit cerebral artery smooth muscle cells were voltage-dependent. Midazolam (10, 100micrometer) tested significantly inhibited outward K+ currents in a dose-dependent manner and half-blocking concentration (IC50) was 15.94micrometer at 60 mV. CONCLUSIONS: Midazolam inhibit outward K+ currents of rabbit cerebral arterial smooth muscle cells. Further study will be needed to determine the effect of midazolam on calcium channel current because it is unclear if the inhibitory effect of midazolam on outward K+current induces vasoconstriction.
Calcium Channels
;
Cerebral Arteries
;
Midazolam*
;
Muscle Relaxation
;
Muscle, Smooth*
;
Muscle, Smooth, Vascular
;
Myocytes, Smooth Muscle*
;
Vasoconstriction
8.The Role of MicroRNAs in Vascular Diseases; Smooth Muscle Cell Differentiation and De-Differentiation.
Korean Circulation Journal 2014;44(4):218-219
No abstract available.
MicroRNAs*
;
Myocytes, Smooth Muscle*
;
Vascular Diseases*
9.Giant Piloleiomyoma of the Forehead.
Gun Wook KIM ; Hyun Je PARK ; Hoon Soo KIM ; Su Han KIM ; Hyun Chang KO ; Byung Soo KIM ; Moon Bum KIM
Annals of Dermatology 2011;23(Suppl 2):S144-S146
Cutaneous piloleiomyomas are benign smooth muscle tumors arising from the arrector pili muscles. Piloleiomyomas appear as firm dermal papules of skin color or with a reddish to brown surface, and are commonly located on the extremities. Histologically, these lesions are composed of interlacing bundles of smooth muscle cells in the reticular dermis. Our case presented with an unusually large nodule on the forehead that was accompanied by intermittent pain. Histological analysis was compatible with piloleiomyoma and the lesion showed haphazardly arranged bundles of smooth muscle in the dermis. We describe herein an interesting case of a giant piloleiomyoma occurring on the forehead.
Dermis
;
Extremities
;
Forehead
;
Muscle, Smooth
;
Muscles
;
Myocytes, Smooth Muscle
;
Skin
;
Smooth Muscle Tumor
10.A Case of Acquired Smooth Muscle Hamartoma on the Sole.
Young Min SHIN ; Chan Woo KIM ; Seok Ki MOON ; Dong Hoon SHIN ; Jong Soo CHOI ; Ki Hong KIM
Korean Journal of Dermatology 2006;44(8):1023-1026
Smooth muscle hamartoma (SMH) is a benign proliferation of smooth muscle bundles within the dermis. It arises from either the arrector pili muscles, dartos muscles, smooth muscle cells in blood vessels and lymphatics, muscularis mamillae and areola, or cutaneous adnexa. Acquired smooth muscle hamartoma is very rare, and only 12 cases have been published to date. All reported cases are originated from arrector pili or dartos muscles. Herein, we describe a case of acquired smooth muscle hamartoma which originated from the smooth muscle cells in blood vessels of the right sole. To our knowledge, this is the first reported case which has originated from the smooth muscle cells in blood vessels.
Blood Vessels
;
Dermis
;
Hamartoma*
;
Muscle Cells
;
Muscle, Smooth*
;
Muscles
;
Myocytes, Smooth Muscle