3.Histopathological changes post cryoablation in canine myocardium.
Jin-zhi FENG ; Fang WANG ; Gang CHEN ; Wei-dong MENG ; Ji-xiang XUE ; Bao-gui SUN
Chinese Journal of Cardiology 2006;34(9):829-832
OBJECTIVEThe purpose of this study was to observe histopathological changes post cryoablation in canine myocardium, to characterize the specific ablation lesion post cryoablation.
METHODSCryothermal ablation was applied on myocardium (both epicardium and endocardium) of 14 mongrel dogs with different ablation parameters (-25 degrees C x 4 min, -50 degrees C x 4 min, -75 degrees C x 4 min, -75 degrees C x 2 min, -75 degrees C x 6 min, -75 degrees C x 8 min). Lesion dimensions and histopathologic changes were observed.
RESULTSThe discrete, sharply delimited lesions were detected in cryoablated myocardium. Histologically, cryoablation in all temperatures studied induced heterogeneous necrosis of the myocardium. Lesion dimensions are related to freezing time and temperature.
CONCLUSIONCryoablation is a feasible and preferably choice for clinical application due to its controllable myocardium lesions.
Animals ; Catheter Ablation ; Cryosurgery ; Dogs ; Endocardium ; pathology ; Myocardium ; pathology
6.Echocardiographic diagnosis for ventricular non-compaction cardiomyopathy in foetus and the pathologically comparative study.
Jia ZHOU ; Leiqi TIAN ; Qichang ZHOU ; Shi ZENG ; Jiawei ZHOU ; Rongsen ZHANG ; Hai TONG
Journal of Central South University(Medical Sciences) 2015;40(7):754-759
OBJECTIVE:
To evaluate the echocardiographic diagnosis for ventricular non-compaction cardiomyopathy (NCCM) in foetus and to analyze the pathologic features of NCCM.
METHODS:
A total of 9 patients with fetal NCCM were examined by prenatal echocardiography from 2004 to 2013, which was compared with postnatal echocardiography or autopsy to analyze the fetal characteristic of myocardial ultrastructure.
RESULTS:
The results of echocardiography displayed an excessive muscle trabecular meshwork and muscle trabecular crypt, and the ventricular myocardium and non-compaction/compaction ratio was ≥2.0. Among the 9 fetuses of NCCM, 6 fetuses were involved in left ventricle, 2 in both left and right ventricles and 1 in right ventricle. Two fetuses were confirmed by postnatal echocardiography, the remaining 7 patients were chosen to terminate their pregnancies, which were confirmed by autopsy later. Muscle biopsies revealed the abnormal myocardial mitochondria, sarcomeres and myocardial fibrosis.
CONCLUSION
It is feasible to accurately diagnose NCCM by prenatal echocardiography. Fetal NCCM most often involves the left ventricle, but it can involve the right ventricle or both, too. The myocardial ultrastructure of fetal NCCM possesses certain unique characteristics, such as the low maturation of the mitochondria, sarcomeres and myocardial fibers.
Cardiomyopathies
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diagnosis
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Echocardiography
;
Fetus
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Heart Ventricles
;
pathology
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Humans
;
Myocardium
;
pathology
7.Role of Circulating Fibrocytes in Cardiac Fibrosis.
Rong-Jie LIN ; Zi-Zhuo SU ; Shu-Min LIANG ; Yu-Yang CHEN ; Xiao-Rong SHU ; Ru-Qiong NIE ; Jing-Feng WANG ; Shuang-Lun XIE ;
Chinese Medical Journal 2016;129(3):326-331
OBJECTIVEIt is revealed that circulating fibrocytes are elevated in patients/animals with cardiac fibrosis, and this review aims to provide an introduction to circulating fibrocytes and their role in cardiac fibrosis.
DATA SOURCESThis review is based on the data from 1994 to present obtained from PubMed. The search terms were "circulating fibrocytes " and "cardiac fibrosis ".
STUDY SELECTIONArticles and critical reviews, which are related to circulating fibrocytes and cardiac fibrosis, were selected.
RESULTSCirculating fibrocytes, which are derived from hematopoietic stem cells, represent a subset of peripheral blood mononuclear cells exhibiting mixed morphological and molecular characteristics of hematopoietic and mesenchymal cells (CD34+/CD45+/collagen I+). They can produce extracellular matrix and many cytokines. It is shown that circulating fibrocytes participate in many fibrotic diseases, including cardiac fibrosis. Evidence accumulated in recent years shows that aging individuals and patients with hypertension, heart failure, coronary heart disease, and atrial fibrillation have more circulating fibrocytes in peripheral blood and/or heart tissue, and this elevation of circulating fibrocytes is correlated with the degree of fibrosis in the hearts.
CONCLUSIONSCirculating fibrocytes are effector cells in cardiac fibrosis.
Coronary Disease ; pathology ; Fibroblasts ; physiology ; Fibrosis ; pathology ; Heart Failure ; pathology ; Humans ; Hypertension ; pathology ; Myocardium ; pathology
8.Pulmonary Carcinosarcoma with Intracardiac Extension: a Case Report.
Ye-qi SUN ; Peng CHEN ; Qiang ZHAO
Chinese Medical Sciences Journal 2015;30(3):193-195
Adult
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Carcinosarcoma
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pathology
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Female
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Heart Neoplasms
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pathology
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Humans
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Lung Neoplasms
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pathology
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Myocardium
;
pathology
9.Further understanding on myocardial damage in the early stage post severe burn and its clinical significance.
Chinese Journal of Burns 2016;32(5):257-259
A series of studies demonstrated that myocardial damage and cardiac dysfunction occurs immediately following severe burn, even before significant reduction in blood volume due to increased capillary permeability. Such myocardial damage and cardiac dysfunction leads to cardiac deficiency, and it is a precipitating factor for burn shock and ischemic/hypoxic injury. In recent years, many experimental and clinical studies elucidated the pathogenesis and confirmed the clinical importance of prevention and treatment of"shock heart"in the early stage post severe burn.
Burns
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pathology
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therapy
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Heart
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physiopathology
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Humans
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Hypoxia
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pathology
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Myocardium
;
pathology
;
Shock
;
pathology
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